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Protein

DNA polymerase lambda

Gene

POLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.2 Publications

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei312Schiff-base intermediate with DNA1
Binding sitei386dCTPCombined sources1 Publication1
Metal bindingi427ManganeseCombined sources1 Publication1
Metal bindingi429ManganeseCombined sources1 Publication1
Metal bindingi490ManganeseCombined sources1 Publication1
Binding sitei513dCTPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi417 – 420dCTP bindingCombined sources1 Publication4
Nucleotide bindingi426 – 429dCTP bindingCombined sources1 Publication4

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: UniProtKB
  • lyase activity Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • DNA replication Source: UniProtKB
  • double-strand break repair via nonhomologous end joining Source: Reactome
  • nucleotide-excision repair Source: UniProtKB
  • somatic hypermutation of immunoglobulin genes Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, DNA synthesis

Keywords - Ligandi

DNA-binding, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09346-MONOMER.
BRENDAi4.2.99.B1. 2681.
ReactomeiR-HSA-5693571. Nonhomologous End-Joining (NHEJ).
SABIO-RKQ9UGP5.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase lambda (EC:2.7.7.7, EC:4.2.99.-)
Short name:
Pol Lambda
Alternative name(s):
DNA polymerase beta-2
Short name:
Pol beta2
DNA polymerase kappa
Gene namesi
Name:POLL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9184. POLL.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi312K → A: Reduces dRP lyase activity by over 90%. 1 Publication1
Mutagenesisi505Y → A: No effect on polymerase activity. Reduces terminal transferase activitites. 1 Publication1
Mutagenesisi506F → G or R: Strongly reduces polymerase and terminal transferase activitites. 1 Publication1

Organism-specific databases

DisGeNETi27343.
OpenTargetsiENSG00000166169.
PharmGKBiPA33504.

Chemistry databases

ChEMBLiCHEMBL5367.

Polymorphism and mutation databases

BioMutaiPOLL.
DMDMi17367126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187831 – 575DNA polymerase lambdaAdd BLAST575

Proteomic databases

EPDiQ9UGP5.
PaxDbiQ9UGP5.
PeptideAtlasiQ9UGP5.
PRIDEiQ9UGP5.

PTM databases

iPTMnetiQ9UGP5.
PhosphoSitePlusiQ9UGP5.

Expressioni

Tissue specificityi

Expressed in a number of tissues. Abundant in testis.

Gene expression databases

BgeeiENSG00000166169.
CleanExiHS_POLL.
ExpressionAtlasiQ9UGP5. baseline and differential.
GenevisibleiQ9UGP5. HS.

Interactioni

Subunit structurei

Binds PCNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-10320765,EBI-10175124
FSD2A1L4K14EBI-10320765,EBI-5661036
KRT40Q6A1623EBI-10320765,EBI-10171697
KRTAP10-7P604093EBI-10320765,EBI-10172290
MAGEA12Q6FHH83EBI-10320765,EBI-10178394
PNMA1Q8ND903EBI-10320765,EBI-302345
SSX2IPQ9Y2D83EBI-10320765,EBI-2212028
TFCP2Q128003EBI-10320765,EBI-717422
TFIP11Q9UBB93EBI-10320765,EBI-1105213
TRIM23P364063EBI-10320765,EBI-740098

Protein-protein interaction databases

BioGridi118155. 37 interactors.
DIPiDIP-48999N.
IntActiQ9UGP5. 33 interactors.
MINTiMINT-3079892.
STRINGi9606.ENSP00000299206.

Chemistry databases

BindingDBiQ9UGP5.

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 39Combined sources3
Helixi41 – 43Combined sources3
Turni50 – 52Combined sources3
Beta strandi55 – 57Combined sources3
Helixi60 – 67Combined sources8
Beta strandi82 – 85Combined sources4
Beta strandi87 – 89Combined sources3
Helixi91 – 97Combined sources7
Beta strandi108 – 111Combined sources4
Helixi112 – 120Combined sources9
Helixi127 – 129Combined sources3
Beta strandi247 – 250Combined sources4
Helixi254 – 269Combined sources16
Helixi273 – 287Combined sources15
Beta strandi289 – 291Combined sources3
Helixi296 – 300Combined sources5
Helixi307 – 318Combined sources12
Beta strandi319 – 321Combined sources3
Helixi323 – 327Combined sources5
Helixi332 – 339Combined sources8
Helixi346 – 354Combined sources9
Helixi360 – 366Combined sources7
Helixi371 – 378Combined sources8
Turni379 – 381Combined sources3
Helixi382 – 384Combined sources3
Helixi389 – 404Combined sources16
Beta strandi411 – 414Combined sources4
Helixi416 – 419Combined sources4
Beta strandi423 – 433Combined sources11
Beta strandi435 – 438Combined sources4
Turni439 – 442Combined sources4
Helixi444 – 453Combined sources10
Beta strandi457 – 462Combined sources6
Beta strandi466 – 468Combined sources3
Beta strandi472 – 477Combined sources6
Beta strandi480 – 483Combined sources4
Beta strandi487 – 493Combined sources7
Helixi496 – 498Combined sources3
Helixi499 – 507Combined sources9
Helixi510 – 522Combined sources13
Beta strandi525 – 527Combined sources3
Beta strandi532 – 535Combined sources4
Turni540 – 542Combined sources3
Beta strandi544 – 546Combined sources3
Beta strandi549 – 551Combined sources3
Helixi556 – 562Combined sources7
Helixi570 – 573Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NZPNMR-A242-327[»]
1RZTX-ray2.10A/E/I/M245-575[»]
1XSLX-ray2.30A/E/I/M242-575[»]
1XSNX-ray1.95A242-575[»]
1XSPX-ray2.20A242-575[»]
2BCQX-ray1.65A242-575[»]
2BCRX-ray1.75A242-575[»]
2BCSX-ray2.20A242-575[»]
2BCUX-ray2.20A242-575[»]
2BCVX-ray2.00A242-575[»]
2GWSX-ray2.40A/E/I/M242-575[»]
2JW5NMR-A34-135[»]
2PFNX-ray1.90A242-575[»]
2PFOX-ray2.00A242-575[»]
2PFPX-ray2.10A242-575[»]
2PFQX-ray2.10A242-575[»]
3C5FX-ray2.25A/B242-575[»]
3C5GX-ray2.20A/B242-575[»]
3HW8X-ray1.95A242-575[»]
3HWTX-ray1.95A242-575[»]
3HX0X-ray3.00A/F/K/P242-575[»]
3MDAX-ray2.03A252-575[»]
3MDCX-ray2.00A252-575[»]
3MGHX-ray2.40A/C242-462[»]
A/C472-575[»]
3MGIX-ray2.60A242-462[»]
A472-575[»]
3PMLX-ray2.60A/B242-575[»]
3PMNX-ray2.20A242-575[»]
3PNCX-ray2.00A242-575[»]
3UPQX-ray1.95A242-575[»]
3UQ0X-ray2.14A242-575[»]
3UQ2X-ray2.25A242-575[»]
4FO6X-ray2.01A242-575[»]
4K4GX-ray2.15A/E/I/M245-575[»]
4K4HX-ray2.10A/E/I/M245-575[»]
4K4IX-ray2.25A/E/I/M245-575[»]
4X5VX-ray2.15A251-575[»]
4XA5X-ray1.90A251-575[»]
4XQ8X-ray2.80A/B242-575[»]
4XRHX-ray3.00A/B242-575[»]
4XUSX-ray2.40A251-575[»]
5CA7X-ray2.52A/B242-575[»]
5CB1X-ray3.30A/B250-575[»]
5CHGX-ray2.90A/B242-575[»]
5CJ7X-ray2.90A/B242-575[»]
5CP2X-ray2.36A/B242-575[»]
5CR0X-ray2.75A/B242-575[»]
5CWRX-ray2.50A/B250-575[»]
5DDMX-ray2.80A/B242-575[»]
5DDYX-ray3.36A/C/E/G242-575[»]
5DKWX-ray2.69A/B249-575[»]
5IIIX-ray1.80A242-575[»]
5IIJX-ray1.72A242-575[»]
5IIKX-ray1.98A242-575[»]
5IILX-ray1.96A242-575[»]
5IIMX-ray1.94A242-575[»]
5IINX-ray2.15A242-575[»]
5IIOX-ray2.08A/E/I/M242-575[»]
ProteinModelPortaliQ9UGP5.
SMRiQ9UGP5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UGP5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 132BRCTPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 279DNA binding1 PublicationAdd BLAST15
Regioni345 – 348DNA binding1 Publication4
Regioni420 – 429Involved in primer bindingBy similarity10
Regioni466 – 505DNA binding1 PublicationAdd BLAST40

Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated
Contains 1 BRCT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2534. Eukaryota.
COG1796. LUCA.
GeneTreeiENSGT00530000063002.
HOGENOMiHOG000007787.
HOVERGENiHBG002788.
InParanoidiQ9UGP5.
KOiK03512.
OMAiNTHGCKM.
OrthoDBiEOG091G03V5.
PhylomeDBiQ9UGP5.
TreeFamiTF103011.

Family and domain databases

CDDicd00141. NT_POLXc. 1 hit.
Gene3Di1.10.150.110. 1 hit.
3.30.210.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR002054. DNA-dir_DNA_pol_X.
IPR019843. DNA_pol-X_BS.
IPR010996. DNA_pol_b-like_N.
IPR028207. DNA_pol_B_palm_palm.
IPR018944. DNA_pol_lambd_fingers_domain.
IPR022312. DNA_pol_X.
IPR002008. DNA_pol_X_beta-like.
IPR027421. DNA_pol_X_lyase_dom.
IPR029398. PolB_thumb.
[Graphical view]
PfamiPF14792. DNA_pol_B_palm. 1 hit.
PF14791. DNA_pol_B_thumb. 1 hit.
PF10391. DNA_pol_lambd_f. 1 hit.
PF14716. HHH_8. 1 hit.
[Graphical view]
PRINTSiPR00869. DNAPOLX.
PR00870. DNAPOLXBETA.
SMARTiSM00483. POLXc. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00522. DNA_POLYMERASE_X. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR
60 70 80 90 100
TGIGRARAEL FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL
110 120 130 140 150
PQLPPGAQLV KSAWLSLCLQ ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD
160 170 180 190 200
ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ KAKEAPNTQA QPISDDEASD
210 220 230 240 250
GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV CAQPSSQKAT
260 270 280 290 300
NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
310 320 330 340 350
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ
360 370 380 390 400
MWYQQGFRSL EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ
410 420 430 440 450
KAAQAFNSGL LCVACGSYRR GKATCGDVDV LITHPDGRSH RGIFSRLLDS
460 470 480 490 500
LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP GPGRRHRRLD IIVVPYSEFA
510 520 530 540 550
CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT HGCKVGPGRV
560 570
LPTPTEKDVF RLLGLPYREP AERDW
Length:575
Mass (Da):63,482
Last modified:May 1, 2000 - v1
Checksum:iFD9196A1C94923C4
GO
Isoform 2 (identifier: Q9UGP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MDPRGILKAFPKRQKIHADASS → MLMHHQKYLQRFLGGKREKKQK
     23-297: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,839
Checksum:iB67B993D5EC4A47C
GO

Sequence cautioni

The sequence BAB14050 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138Y → C in AAG22519 (PubMed:10887191).Curated1
Sequence conflicti298E → G in AAH68529 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020268221T → P.Corresponds to variant rs3730463dbSNPEnsembl.1
Natural variantiVAR_020269438R → W.1 PublicationCorresponds to variant rs3730477dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565401 – 22MDPRG…ADASS → MLMHHQKYLQRFLGGKREKK QK in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_05654123 – 297Missing in isoform 2. 1 PublicationAdd BLAST275

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131890 mRNA. Translation: CAB65074.1.
AF161019 mRNA. Translation: AAF27541.1.
AF283478 mRNA. Translation: AAG22519.1.
AF525924 Genomic DNA. Translation: AAM77696.1.
AL627424 Genomic DNA. Translation: CAI41032.1.
CH471066 Genomic DNA. Translation: EAW49759.1.
CH471066 Genomic DNA. Translation: EAW49760.1.
CH471066 Genomic DNA. Translation: EAW49766.1.
CH471066 Genomic DNA. Translation: EAW49768.1.
BC003548 mRNA. Translation: AAH03548.2.
BC068529 mRNA. Translation: AAH68529.1.
AK022476 mRNA. Translation: BAB14050.1. Different initiation.
CCDSiCCDS7513.1. [Q9UGP5-1]
CCDS76332.1. [Q9UGP5-2]
RefSeqiNP_001167555.1. NM_001174084.1. [Q9UGP5-1]
NP_001167556.1. NM_001174085.1.
NP_001295311.1. NM_001308382.1. [Q9UGP5-2]
NP_037406.1. NM_013274.3. [Q9UGP5-1]
XP_006717840.1. XM_006717777.1. [Q9UGP5-2]
XP_011537953.1. XM_011539651.1. [Q9UGP5-1]
UniGeneiHs.523230.

Genome annotation databases

EnsembliENST00000299206; ENSP00000299206; ENSG00000166169. [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169. [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169. [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169. [Q9UGP5-2]
GeneIDi27343.
KEGGihsa:27343.
UCSCiuc001ktg.2. human. [Q9UGP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131890 mRNA. Translation: CAB65074.1.
AF161019 mRNA. Translation: AAF27541.1.
AF283478 mRNA. Translation: AAG22519.1.
AF525924 Genomic DNA. Translation: AAM77696.1.
AL627424 Genomic DNA. Translation: CAI41032.1.
CH471066 Genomic DNA. Translation: EAW49759.1.
CH471066 Genomic DNA. Translation: EAW49760.1.
CH471066 Genomic DNA. Translation: EAW49766.1.
CH471066 Genomic DNA. Translation: EAW49768.1.
BC003548 mRNA. Translation: AAH03548.2.
BC068529 mRNA. Translation: AAH68529.1.
AK022476 mRNA. Translation: BAB14050.1. Different initiation.
CCDSiCCDS7513.1. [Q9UGP5-1]
CCDS76332.1. [Q9UGP5-2]
RefSeqiNP_001167555.1. NM_001174084.1. [Q9UGP5-1]
NP_001167556.1. NM_001174085.1.
NP_001295311.1. NM_001308382.1. [Q9UGP5-2]
NP_037406.1. NM_013274.3. [Q9UGP5-1]
XP_006717840.1. XM_006717777.1. [Q9UGP5-2]
XP_011537953.1. XM_011539651.1. [Q9UGP5-1]
UniGeneiHs.523230.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NZPNMR-A242-327[»]
1RZTX-ray2.10A/E/I/M245-575[»]
1XSLX-ray2.30A/E/I/M242-575[»]
1XSNX-ray1.95A242-575[»]
1XSPX-ray2.20A242-575[»]
2BCQX-ray1.65A242-575[»]
2BCRX-ray1.75A242-575[»]
2BCSX-ray2.20A242-575[»]
2BCUX-ray2.20A242-575[»]
2BCVX-ray2.00A242-575[»]
2GWSX-ray2.40A/E/I/M242-575[»]
2JW5NMR-A34-135[»]
2PFNX-ray1.90A242-575[»]
2PFOX-ray2.00A242-575[»]
2PFPX-ray2.10A242-575[»]
2PFQX-ray2.10A242-575[»]
3C5FX-ray2.25A/B242-575[»]
3C5GX-ray2.20A/B242-575[»]
3HW8X-ray1.95A242-575[»]
3HWTX-ray1.95A242-575[»]
3HX0X-ray3.00A/F/K/P242-575[»]
3MDAX-ray2.03A252-575[»]
3MDCX-ray2.00A252-575[»]
3MGHX-ray2.40A/C242-462[»]
A/C472-575[»]
3MGIX-ray2.60A242-462[»]
A472-575[»]
3PMLX-ray2.60A/B242-575[»]
3PMNX-ray2.20A242-575[»]
3PNCX-ray2.00A242-575[»]
3UPQX-ray1.95A242-575[»]
3UQ0X-ray2.14A242-575[»]
3UQ2X-ray2.25A242-575[»]
4FO6X-ray2.01A242-575[»]
4K4GX-ray2.15A/E/I/M245-575[»]
4K4HX-ray2.10A/E/I/M245-575[»]
4K4IX-ray2.25A/E/I/M245-575[»]
4X5VX-ray2.15A251-575[»]
4XA5X-ray1.90A251-575[»]
4XQ8X-ray2.80A/B242-575[»]
4XRHX-ray3.00A/B242-575[»]
4XUSX-ray2.40A251-575[»]
5CA7X-ray2.52A/B242-575[»]
5CB1X-ray3.30A/B250-575[»]
5CHGX-ray2.90A/B242-575[»]
5CJ7X-ray2.90A/B242-575[»]
5CP2X-ray2.36A/B242-575[»]
5CR0X-ray2.75A/B242-575[»]
5CWRX-ray2.50A/B250-575[»]
5DDMX-ray2.80A/B242-575[»]
5DDYX-ray3.36A/C/E/G242-575[»]
5DKWX-ray2.69A/B249-575[»]
5IIIX-ray1.80A242-575[»]
5IIJX-ray1.72A242-575[»]
5IIKX-ray1.98A242-575[»]
5IILX-ray1.96A242-575[»]
5IIMX-ray1.94A242-575[»]
5IINX-ray2.15A242-575[»]
5IIOX-ray2.08A/E/I/M242-575[»]
ProteinModelPortaliQ9UGP5.
SMRiQ9UGP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118155. 37 interactors.
DIPiDIP-48999N.
IntActiQ9UGP5. 33 interactors.
MINTiMINT-3079892.
STRINGi9606.ENSP00000299206.

Chemistry databases

BindingDBiQ9UGP5.
ChEMBLiCHEMBL5367.

PTM databases

iPTMnetiQ9UGP5.
PhosphoSitePlusiQ9UGP5.

Polymorphism and mutation databases

BioMutaiPOLL.
DMDMi17367126.

Proteomic databases

EPDiQ9UGP5.
PaxDbiQ9UGP5.
PeptideAtlasiQ9UGP5.
PRIDEiQ9UGP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299206; ENSP00000299206; ENSG00000166169. [Q9UGP5-1]
ENST00000370162; ENSP00000359181; ENSG00000166169. [Q9UGP5-1]
ENST00000370169; ENSP00000359188; ENSG00000166169. [Q9UGP5-1]
ENST00000628479; ENSP00000485885; ENSG00000166169. [Q9UGP5-2]
GeneIDi27343.
KEGGihsa:27343.
UCSCiuc001ktg.2. human. [Q9UGP5-1]

Organism-specific databases

CTDi27343.
DisGeNETi27343.
GeneCardsiPOLL.
HGNCiHGNC:9184. POLL.
MIMi606343. gene.
neXtProtiNX_Q9UGP5.
OpenTargetsiENSG00000166169.
PharmGKBiPA33504.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2534. Eukaryota.
COG1796. LUCA.
GeneTreeiENSGT00530000063002.
HOGENOMiHOG000007787.
HOVERGENiHBG002788.
InParanoidiQ9UGP5.
KOiK03512.
OMAiNTHGCKM.
OrthoDBiEOG091G03V5.
PhylomeDBiQ9UGP5.
TreeFamiTF103011.

Enzyme and pathway databases

BioCyciZFISH:HS09346-MONOMER.
BRENDAi4.2.99.B1. 2681.
ReactomeiR-HSA-5693571. Nonhomologous End-Joining (NHEJ).
SABIO-RKQ9UGP5.

Miscellaneous databases

EvolutionaryTraceiQ9UGP5.
GeneWikiiDNA_polymerase_lambda.
GenomeRNAii27343.
PROiQ9UGP5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166169.
CleanExiHS_POLL.
ExpressionAtlasiQ9UGP5. baseline and differential.
GenevisibleiQ9UGP5. HS.

Family and domain databases

CDDicd00141. NT_POLXc. 1 hit.
Gene3Di1.10.150.110. 1 hit.
3.30.210.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR002054. DNA-dir_DNA_pol_X.
IPR019843. DNA_pol-X_BS.
IPR010996. DNA_pol_b-like_N.
IPR028207. DNA_pol_B_palm_palm.
IPR018944. DNA_pol_lambd_fingers_domain.
IPR022312. DNA_pol_X.
IPR002008. DNA_pol_X_beta-like.
IPR027421. DNA_pol_X_lyase_dom.
IPR029398. PolB_thumb.
[Graphical view]
PfamiPF14792. DNA_pol_B_palm. 1 hit.
PF14791. DNA_pol_B_thumb. 1 hit.
PF10391. DNA_pol_lambd_f. 1 hit.
PF14716. HHH_8. 1 hit.
[Graphical view]
PRINTSiPR00869. DNAPOLX.
PR00870. DNAPOLXBETA.
SMARTiSM00483. POLXc. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00522. DNA_POLYMERASE_X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOLL_HUMAN
AccessioniPrimary (citable) accession number: Q9UGP5
Secondary accession number(s): D3DR76
, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.