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Q9UGN4

- CLM8_HUMAN

UniProt

Q9UGN4 - CLM8_HUMAN

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Protein

CMRF35-like molecule 8

Gene
CD300A, CMRF35H, IGSF12, HSPC083
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.3 Publications

GO - Molecular functioni

  1. phosphatidylethanolamine binding Source: UniProt
  2. phosphatidylserine binding Source: UniProt
  3. protein binding Source: UniProt
  4. signaling receptor activity Source: UniProt

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. immune system process Source: UniProtKB-KW
  3. negative regulation of activation of JAK2 kinase activity Source: UniProt
  4. negative regulation of B cell proliferation Source: UniProt
  5. negative regulation of B cell receptor signaling pathway Source: UniProt
  6. negative regulation of eosinophil activation Source: UniProt
  7. negative regulation of eosinophil migration Source: UniProt
  8. negative regulation of fibroblast proliferation Source: UniProt
  9. negative regulation of MAP kinase activity Source: UniProt
  10. negative regulation of mast cell activation involved in immune response Source: UniProt
  11. negative regulation of mast cell degranulation Source: UniProt
  12. negative regulation of neutrophil activation Source: UniProt
  13. negative regulation of NK T cell activation Source: UniProt
  14. negative regulation of phagocytosis, engulfment Source: UniProt
  15. positive regulation of phosphoprotein phosphatase activity Source: UniProt
  16. regulation of T cell receptor signaling pathway Source: UniProt
  17. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 8
Short name:
CLM-8
Alternative name(s):
CD300 antigen-like family member A
CMRF-35-H9
Short name:
CMRF35-H9
CMRF35-H
IRC1/IRC2
Immunoglobulin superfamily member 12
Short name:
IgSF12
Inhibitory receptor protein 60
Short name:
IRp60
NK inhibitory receptor
CD_antigen: CD300a
Gene namesi
Name:CD300A
Synonyms:CMRF35H, IGSF12
ORF Names:HSPC083
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:19319. CD300A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 180163Extracellular Reviewed predictionAdd
BLAST
Transmembranei181 – 20121Helical; Reviewed predictionAdd
BLAST
Topological domaini202 – 29998Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProt
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 299282CMRF35-like molecule 8PRO_0000014682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 103 Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Modified residuei293 – 2931Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated on tyrosine.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UGN4.
PeptideAtlasiQ9UGN4.
PRIDEiQ9UGN4.

PTM databases

PhosphoSiteiQ9UGN4.

Expressioni

Tissue specificityi

Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.3 Publications

Gene expression databases

ArrayExpressiQ9UGN4.
BgeeiQ9UGN4.
CleanExiHS_CD300A.
GenevestigatoriQ9UGN4.

Organism-specific databases

HPAiHPA011645.

Interactioni

Subunit structurei

Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.

Protein-protein interaction databases

STRINGi9606.ENSP00000353259.

Structurei

Secondary structure

1
299
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 278
Beta strandi32 – 376
Helixi40 – 423
Beta strandi45 – 517
Beta strandi54 – 574
Beta strandi61 – 666
Beta strandi70 – 723
Beta strandi75 – 806
Helixi81 – 833
Beta strandi85 – 928
Helixi95 – 973
Beta strandi99 – 1068
Beta strandi117 – 1259

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q87X-ray1.70A/B/C19-125[»]
ProteinModelPortaliQ9UGN4.
SMRiQ9UGN4. Positions 22-128.

Miscellaneous databases

EvolutionaryTraceiQ9UGN4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 123105Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD300 family.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42608.
HOVERGENiHBG100050.
InParanoidiQ9UGN4.
KOiK06719.
OMAiYSVIRKT.
OrthoDBiEOG7FFMST.
PhylomeDBiQ9UGN4.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UGN4-1) [UniParc]FASTAAdd to Basket

Also known as: IRC1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWLPWALLLL WVPGCFALSK CRTVAGPVGG SLSVQCPYEK EHRTLNKYWC    50
RPPQIFLCDK IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT 100
YWCGVDTPWL RDFHDPVVEV EVSVFPASTS MTPASITAAK TSTITTAFPP 150
VSSTTLFAVG ATHSASIQEE TEEVVNSQLP LLLSLLALLL LLLVGASLLA 200
WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP LQEKPAPPRE 250
VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT 299
Length:299
Mass (Da):33,201
Last modified:February 20, 2007 - v2
Checksum:i978461DA87E86269
GO
Isoform 2 (identifier: Q9UGN4-2) [UniParc]FASTAAdd to Basket

Also known as: IRC1c

The sequence of this isoform differs from the canonical sequence as follows:
     14-126: Missing.

Show »
Length:186
Mass (Da):20,640
Checksum:i00D5E9379190EEEE
GO
Isoform 3 (identifier: Q9UGN4-3) [UniParc]FASTAAdd to Basket

Also known as: IRC1b

The sequence of this isoform differs from the canonical sequence as follows:
     14-209: Missing.

Show »
Length:103
Mass (Da):11,870
Checksum:iB65239E9760E47AB
GO
Isoform 4 (identifier: Q9UGN4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-126: Missing.
     223-258: Missing.

Show »
Length:150
Mass (Da):16,517
Checksum:iED357EBD18A30FF0
GO

Sequence cautioni

The sequence AAF28906.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAF28906.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111R → Q.2 Publications
Corresponds to variant rs2272111 [ dbSNP | Ensembl ].
VAR_030797

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 209196Missing in isoform 3. VSP_010558Add
BLAST
Alternative sequencei14 – 126113Missing in isoform 2 and isoform 4. VSP_010559Add
BLAST
Alternative sequencei223 – 25836Missing in isoform 4. VSP_041246Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 292VG → W in AAD01646. 1 Publication
Sequence conflicti28 – 292VG → W in AAF89957. 1 Publication
Sequence conflicti39 – 391E → Q in AAF89957. 1 Publication
Sequence conflicti189 – 1891L → M in AAF28906. 1 Publication
Sequence conflicti193 – 1931L → M in AAF28906. 1 Publication
Sequence conflicti209 – 2091K → KWIK in AAD01646. 1 Publication
Sequence conflicti260 – 2601S → F in AAF28906. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238323 mRNA. Translation: CAB66145.1.
AJ010101 mRNA. Translation: CAB52291.1.
AJ010102 mRNA. Translation: CAB52292.1.
AJ010103 mRNA. Translation: CAB52293.1.
AJ224864 mRNA. Translation: CAB55347.1.
AF020314 mRNA. Translation: AAD01646.1.
AF176991
, AF176985, AF176986, AF176987, AF176988, AF176989, AF176990 Genomic DNA. Translation: AAF89957.1.
AF161346 mRNA. Translation: AAF28906.1. Sequence problems.
AC079325 Genomic DNA. No translation available.
BC032352 mRNA. Translation: AAH32352.1.
CCDSiCCDS32720.1. [Q9UGN4-1]
CCDS58590.1. [Q9UGN4-2]
RefSeqiNP_001243770.1. NM_001256841.1. [Q9UGN4-2]
NP_009192.2. NM_007261.3. [Q9UGN4-1]
UniGeneiHs.9688.

Genome annotation databases

EnsembliENST00000310828; ENSP00000308188; ENSG00000167851. [Q9UGN4-2]
ENST00000360141; ENSP00000353259; ENSG00000167851. [Q9UGN4-1]
ENST00000361933; ENSP00000354564; ENSG00000167851. [Q9UGN4-3]
ENST00000392625; ENSP00000376401; ENSG00000167851. [Q9UGN4-4]
GeneIDi11314.
KEGGihsa:11314.
UCSCiuc002jkv.4. human. [Q9UGN4-1]
uc002jkw.4. human. [Q9UGN4-2]
uc010dfr.4. human. [Q9UGN4-4]
uc010dfs.4. human. [Q9UGN4-3]

Polymorphism databases

DMDMi126302534.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238323 mRNA. Translation: CAB66145.1 .
AJ010101 mRNA. Translation: CAB52291.1 .
AJ010102 mRNA. Translation: CAB52292.1 .
AJ010103 mRNA. Translation: CAB52293.1 .
AJ224864 mRNA. Translation: CAB55347.1 .
AF020314 mRNA. Translation: AAD01646.1 .
AF176991
, AF176985 , AF176986 , AF176987 , AF176988 , AF176989 , AF176990 Genomic DNA. Translation: AAF89957.1 .
AF161346 mRNA. Translation: AAF28906.1 . Sequence problems.
AC079325 Genomic DNA. No translation available.
BC032352 mRNA. Translation: AAH32352.1 .
CCDSi CCDS32720.1. [Q9UGN4-1 ]
CCDS58590.1. [Q9UGN4-2 ]
RefSeqi NP_001243770.1. NM_001256841.1. [Q9UGN4-2 ]
NP_009192.2. NM_007261.3. [Q9UGN4-1 ]
UniGenei Hs.9688.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q87 X-ray 1.70 A/B/C 19-125 [» ]
ProteinModelPortali Q9UGN4.
SMRi Q9UGN4. Positions 22-128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353259.

PTM databases

PhosphoSitei Q9UGN4.

Polymorphism databases

DMDMi 126302534.

Proteomic databases

PaxDbi Q9UGN4.
PeptideAtlasi Q9UGN4.
PRIDEi Q9UGN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310828 ; ENSP00000308188 ; ENSG00000167851 . [Q9UGN4-2 ]
ENST00000360141 ; ENSP00000353259 ; ENSG00000167851 . [Q9UGN4-1 ]
ENST00000361933 ; ENSP00000354564 ; ENSG00000167851 . [Q9UGN4-3 ]
ENST00000392625 ; ENSP00000376401 ; ENSG00000167851 . [Q9UGN4-4 ]
GeneIDi 11314.
KEGGi hsa:11314.
UCSCi uc002jkv.4. human. [Q9UGN4-1 ]
uc002jkw.4. human. [Q9UGN4-2 ]
uc010dfr.4. human. [Q9UGN4-4 ]
uc010dfs.4. human. [Q9UGN4-3 ]

Organism-specific databases

CTDi 11314.
GeneCardsi GC17P072462.
HGNCi HGNC:19319. CD300A.
HPAi HPA011645.
MIMi 606790. gene.
neXtProti NX_Q9UGN4.
PharmGKBi PA142672149.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42608.
HOVERGENi HBG100050.
InParanoidi Q9UGN4.
KOi K06719.
OMAi YSVIRKT.
OrthoDBi EOG7FFMST.
PhylomeDBi Q9UGN4.
TreeFami TF334441.

Miscellaneous databases

EvolutionaryTracei Q9UGN4.
GeneWikii CD300A.
GenomeRNAii 11314.
NextBioi 42979.
PROi Q9UGN4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UGN4.
Bgeei Q9UGN4.
CleanExi HS_CD300A.
Genevestigatori Q9UGN4.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells."
    Cantoni C., Bottino C., Augugliaro R., Morelli L., Marcenaro E., Castriconi R., Vitale M., Pende D., Sivori S., Millo R., Biassoni R., Moretta L., Moretta A.
    Eur. J. Immunol. 29:3148-3159(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, PHOSPHORYLATION.
    Tissue: Lymphoid tissue.
  2. "IRC1 isoforms."
    Cantoni C., Biassoni R.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-111.
    Tissue: Lymphoid tissue.
  3. "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor."
    Green B.J., Clark G.J., Hart D.N.J.
    Int. Immunol. 10:891-899(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  4. "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17."
    Clark G.J., Green B.J., Hart D.N.J.
    Tissue Antigens 55:101-109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION.
  5. "Human partial CDS cloned from CD34+ stem cells."
    Zhang Q.H., Ye M., Zhou J., Shen Y., Wu X.Y., Guan Z.Q., Wang L., Fan H.Y., Mao Y.F., Dai M., Huang Q.H., Chen S.J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Umbilical cord blood.
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood.
  8. "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells."
    Bachelet I., Munitz A., Moretta A., Moretta L., Levi-Schaffer F.
    J. Immunol. 175:7989-7995(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, TISSUE SPECIFICITY.
  9. "The crystal structure of IRp60 ectodomain."
    Dimasi N., Marquez J.A.
    Submitted (JUN-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 19-128.
  10. "Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility."
    Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L., Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.
    Hum. Genet. 112:34-41(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-111.

Entry informationi

Entry nameiCLM8_HUMAN
AccessioniPrimary (citable) accession number: Q9UGN4
Secondary accession number(s): A8MW96
, O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UMS9, Q9UMT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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