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Protein

Fetuin-B

Gene

FETUB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological processFertilization

Protein family/group databases

MEROPSiI25.061.

Names & Taxonomyi

Protein namesi
Recommended name:
Fetuin-B
Alternative name(s):
16G2
Fetuin-like protein IRL685
Gugu
Gene namesi
Name:FETUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000090512.11.
HGNCiHGNC:3658. FETUB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26998.
OpenTargetsiENSG00000090512.
PharmGKBiPA28099.

Polymorphism and mutation databases

BioMutaiFETUB.
DMDMi109940079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000000889916 – 382Fetuin-BAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi93 ↔ 104PROSITE-ProRule annotation
Disulfide bondi117 ↔ 137PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi151 ↔ 154PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 224PROSITE-ProRule annotation
Disulfide bondi237 ↔ 254PROSITE-ProRule annotation
Glycosylationi289O-linked (GalNAc...) threonineBy similarity1
Glycosylationi292O-linked (GalNAc...) threonineBy similarity1
Modified residuei315PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UGM5.
PeptideAtlasiQ9UGM5.
PRIDEiQ9UGM5.

PTM databases

iPTMnetiQ9UGM5.
PhosphoSitePlusiQ9UGM5.

Expressioni

Tissue specificityi

Liver and testis.

Developmental stagei

2-fold increase toward the end of the menstrual cycle.1 Publication

Gene expression databases

BgeeiENSG00000090512.
CleanExiHS_FETUB.
ExpressionAtlasiQ9UGM5. baseline and differential.
GenevisibleiQ9UGM5. HS.

Organism-specific databases

HPAiHPA035132.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA84EBI-13049494,EBI-6942903

Protein-protein interaction databases

BioGridi117944. 1 interactor.
IntActiQ9UGM5. 1 interactor.
MINTiMINT-6629887.
STRINGi9606.ENSP00000265029.

Structurei

3D structure databases

ProteinModelPortaliQ9UGM5.
SMRiQ9UGM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 138Cystatin fetuin-B-type 1PROSITE-ProRule annotationAdd BLAST114
Domaini149 – 255Cystatin fetuin-B-type 2PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEMR. Eukaryota.
ENOG4111K2W. LUCA.
GeneTreeiENSGT00530000063413.
HOGENOMiHOG000059646.
HOVERGENiHBG051608.
InParanoidiQ9UGM5.
OMAiRKDGYVL.
OrthoDBiEOG091G0Y4O.
PhylomeDBiQ9UGM5.
TreeFamiTF333729.

Family and domain databases

CDDicd00042. CY. 2 hits.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR025764. Cystatin_Fetuin_B.
IPR001363. Prot_inh_fetuin_CS.
PfamiView protein in Pfam
PF00031. Cystatin. 2 hits.
SMARTiView protein in SMART
SM00043. CY. 2 hits.
PROSITEiView protein in PROSITE
PS51530. CYSTATIN_FETUIN_B. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR
60 70 80 90 100
DINKDRKDGY VLRLNRVNDA QEYRRGGLGS LFYLTLDVLE TDCHVLRKKA
110 120 130 140 150
WQDCGMRIFF ESVYGQCKAI FYMNNPSRVL YLAAYNCTLR PVSKKKIYMT
160 170 180 190 200
CPDCPSSIPT DSSNHQVLEA ATESLAKYNN ENTSKQYSLF KVTRASSQWV
210 220 230 240 250
VGPSYFVEYL IKESPCTKSQ ASSCSLQSSD SVPVGLCKGS LTRTHWEKFV
260 270 280 290 300
SVTCDFFESQ APATGSENSA VNQKPTNLPK VEESQQKNTP PTDSPSKAGP
310 320 330 340 350
RGSVQYLPDL DDKNSQEKGP QEAFPVHLDL TTNPQGETLD ISFLFLEPME
360 370 380
EKLVVLPFPK EKARTAECPG PAQNASPLVL PP
Length:382
Mass (Da):42,055
Last modified:June 27, 2006 - v2
Checksum:iC73977793A30AF8A
GO
Isoform 2 (identifier: Q9UGM5-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     76-112: Missing.

Show »
Length:345
Mass (Da):37,823
Checksum:i387D794BBA530139
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → F in AAR22507 (PubMed:15499407).Curated1
Sequence conflicti9L → P in AAH74734 (PubMed:15489334).Curated1
Sequence conflicti18 – 19AM → KL in CAB62538 (PubMed:10947975).Curated2
Sequence conflicti179N → K in AAH74734 (PubMed:15489334).Curated1
Sequence conflicti303S → P in AAI14617 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04906133S → P. Corresponds to variant dbSNP:rs34522046Ensembl.1
Natural variantiVAR_024449202G → S. Corresponds to variant dbSNP:rs6785067Ensembl.1
Natural variantiVAR_049062360K → R. Corresponds to variant dbSNP:rs7999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04713576 – 112Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242928 mRNA. Translation: CAB62538.1.
AF534529 mRNA. Translation: AAQ10515.1.
AY373820 mRNA. Translation: AAR22507.1.
AB017551 mRNA. Translation: BAA78341.1.
AK315309 mRNA. Translation: BAG37713.1.
AC068631 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78186.1.
BC069670 mRNA. Translation: AAH69670.1.
BC069820 mRNA. Translation: AAH69820.1.
BC074734 mRNA. Translation: AAH74734.1.
BC114616 mRNA. Translation: AAI14617.1.
CCDSiCCDS3279.1. [Q9UGM5-1]
CCDS82884.1. [Q9UGM5-2]
RefSeqiNP_001295006.1. NM_001308077.1. [Q9UGM5-2]
NP_001295008.1. NM_001308079.1.
NP_055190.2. NM_014375.2. [Q9UGM5-1]
XP_011510983.1. XM_011512681.2. [Q9UGM5-1]
UniGeneiHs.81073.

Genome annotation databases

EnsembliENST00000265029; ENSP00000265029; ENSG00000090512. [Q9UGM5-1]
ENST00000382136; ENSP00000371571; ENSG00000090512. [Q9UGM5-2]
ENST00000450521; ENSP00000404288; ENSG00000090512. [Q9UGM5-1]
GeneIDi26998.
KEGGihsa:26998.
UCSCiuc003fqn.3. human. [Q9UGM5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFETUB_HUMAN
AccessioniPrimary (citable) accession number: Q9UGM5
Secondary accession number(s): B2RCW6
, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9Y6Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 27, 2006
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families