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Q9UGM5 (FETUB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fetuin-B
Alternative name(s):
16G2
Fetuin-like protein IRL685
Gugu
Gene names
Name:FETUB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Liver and testis.

Developmental stage

2-fold increase toward the end of the menstrual cycle. Ref.9

Sequence similarities

Belongs to the fetuin family.

Contains 2 cystatin fetuin-B-type domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UGM5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UGM5-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     76-112: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 382367Fetuin-B
PRO_0000008899

Regions

Domain25 – 138114Cystatin fetuin-B-type 1
Domain149 – 255107Cystatin fetuin-B-type 2

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Ref.8
Glycosylation1361N-linked (GlcNAc...) Ref.8
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond93 ↔ 104 By similarity
Disulfide bond117 ↔ 137 By similarity
Disulfide bond151 ↔ 154 By similarity
Disulfide bond216 ↔ 224 By similarity
Disulfide bond237 ↔ 254 By similarity

Natural variations

Alternative sequence76 – 11237Missing in isoform 2.
VSP_047135
Natural variant331S → P.
Corresponds to variant rs34522046 [ dbSNP | Ensembl ].
VAR_049061
Natural variant2021G → S.
Corresponds to variant rs6785067 [ dbSNP | Ensembl ].
VAR_024449
Natural variant3601K → R.
Corresponds to variant rs7999 [ dbSNP | Ensembl ].
VAR_049062

Experimental info

Sequence conflict41L → F in AAR22507. Ref.2
Sequence conflict91L → P in AAH74734. Ref.7
Sequence conflict18 – 192AM → KL in CAB62538. Ref.1
Sequence conflict1791N → K in AAH74734. Ref.7
Sequence conflict3031S → P in AAI14617. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: C73977793A30AF8A

FASTA38242,055
        10         20         30         40         50         60 
MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY 

        70         80         90        100        110        120 
VLRLNRVNDA QEYRRGGLGS LFYLTLDVLE TDCHVLRKKA WQDCGMRIFF ESVYGQCKAI 

       130        140        150        160        170        180 
FYMNNPSRVL YLAAYNCTLR PVSKKKIYMT CPDCPSSIPT DSSNHQVLEA ATESLAKYNN 

       190        200        210        220        230        240 
ENTSKQYSLF KVTRASSQWV VGPSYFVEYL IKESPCTKSQ ASSCSLQSSD SVPVGLCKGS 

       250        260        270        280        290        300 
LTRTHWEKFV SVTCDFFESQ APATGSENSA VNQKPTNLPK VEESQQKNTP PTDSPSKAGP 

       310        320        330        340        350        360 
RGSVQYLPDL DDKNSQEKGP QEAFPVHLDL TTNPQGETLD ISFLFLEPME EKLVVLPFPK 

       370        380 
EKARTAECPG PAQNASPLVL PP 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: 387D794BBA530139
Show »

FASTA34537,823

References

« Hide 'large scale' references
[1]"Fetuin-B, a second member of the fetuin family in mammals."
Olivier E., Soury E., Ruminy P., Husson A., Parmentier F., Daveau M., Salier J.-P.
Biochem. J. 350:589-597(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetus.
[2]"Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity."
Hsu S.J., Nagase H., Balmain A.
Genome 47:931-946(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]"H16G2, a gene specifically expressed in the liver."
Aihara T., Miyoshi Y., Nakamura Y.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Tongue.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[8]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37 AND ASN-136.
Tissue: Plasma.
[9]"Fetuin-B, a liver-derived plasma protein is essential for fertilization."
Dietzel E., Wessling J., Floehr J., Schafer C., Ensslen S., Denecke B., Rosing B., Neulen J., Veitinger T., Spehr M., Tropartz T., Tolba R., Renne T., Egert A., Schorle H., Gottenbusch Y., Hildebrand A., Yiallouros I. expand/collapse author list , Stocker W., Weiskirchen R., Jahnen-Dechent W.
Dev. Cell 25:106-112(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242928 mRNA. Translation: CAB62538.1.
AF534529 mRNA. Translation: AAQ10515.1.
AY373820 mRNA. Translation: AAR22507.1.
AB017551 mRNA. Translation: BAA78341.1.
AK315309 mRNA. Translation: BAG37713.1.
AC068631 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78186.1.
BC069670 mRNA. Translation: AAH69670.1.
BC069820 mRNA. Translation: AAH69820.1.
BC074734 mRNA. Translation: AAH74734.1.
BC114616 mRNA. Translation: AAI14617.1.
CCDSCCDS3279.1. [Q9UGM5-1]
RefSeqNP_055190.2. NM_014375.2. [Q9UGM5-1]
UniGeneHs.81073.

3D structure databases

ProteinModelPortalQ9UGM5.
SMRQ9UGM5. Positions 154-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117944. 1 interaction.
MINTMINT-6629887.
STRING9606.ENSP00000265029.

Protein family/group databases

MEROPSI25.061.

PTM databases

PhosphoSiteQ9UGM5.

Polymorphism databases

DMDM109940079.

Proteomic databases

PaxDbQ9UGM5.
PRIDEQ9UGM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265029; ENSP00000265029; ENSG00000090512. [Q9UGM5-1]
ENST00000382136; ENSP00000371571; ENSG00000090512. [Q9UGM5-2]
ENST00000450521; ENSP00000404288; ENSG00000090512. [Q9UGM5-1]
GeneID26998.
KEGGhsa:26998.
UCSCuc003fqn.3. human. [Q9UGM5-1]

Organism-specific databases

CTD26998.
GeneCardsGC03P186353.
HGNCHGNC:3658. FETUB.
HPAHPA035132.
MIM605954. gene.
neXtProtNX_Q9UGM5.
PharmGKBPA28099.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87310.
HOGENOMHOG000059646.
HOVERGENHBG051608.
InParanoidQ9UGM5.
OMAVQYLPDL.
PhylomeDBQ9UGM5.
TreeFamTF333729.

Gene expression databases

ArrayExpressQ9UGM5.
BgeeQ9UGM5.
CleanExHS_FETUB.
GenevestigatorQ9UGM5.

Family and domain databases

InterProIPR025764. Cystatin_Fetuin_B.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamPF00031. Cystatin. 2 hits.
[Graphical view]
SMARTSM00043. CY. 2 hits.
[Graphical view]
PROSITEPS51530. CYSTATIN_FETUIN_B. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFetuin-B.
GenomeRNAi26998.
NextBio35501907.
PROQ9UGM5.
SOURCESearch...

Entry information

Entry nameFETUB_HUMAN
AccessionPrimary (citable) accession number: Q9UGM5
Secondary accession number(s): B2RCW6 expand/collapse secondary AC list , E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9Y6Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM