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Q9UGM5

- FETUB_HUMAN

UniProt

Q9UGM5 - FETUB_HUMAN

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Protein

Fetuin-B

Gene

FETUB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: InterPro
  2. metalloendopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. binding of sperm to zona pellucida Source: UniProtKB
  2. negative regulation of endopeptidase activity Source: UniProtKB
  3. single fertilization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Keywords - Biological processi

Fertilization

Protein family/group databases

MEROPSiI25.061.

Names & Taxonomyi

Protein namesi
Recommended name:
Fetuin-B
Alternative name(s):
16G2
Fetuin-like protein IRL685
Gugu
Gene namesi
Name:FETUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3658. FETUB.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 382367Fetuin-BPRO_0000008899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)1 Publication
Disulfide bondi93 ↔ 104PROSITE-ProRule annotation
Disulfide bondi117 ↔ 137PROSITE-ProRule annotation
Glycosylationi136 – 1361N-linked (GlcNAc...)1 Publication
Disulfide bondi151 ↔ 154PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi216 ↔ 224PROSITE-ProRule annotation
Disulfide bondi237 ↔ 254PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGM5.
PRIDEiQ9UGM5.

PTM databases

PhosphoSiteiQ9UGM5.

Expressioni

Tissue specificityi

Liver and testis.

Developmental stagei

2-fold increase toward the end of the menstrual cycle.1 Publication

Gene expression databases

BgeeiQ9UGM5.
CleanExiHS_FETUB.
ExpressionAtlasiQ9UGM5. baseline and differential.
GenevestigatoriQ9UGM5.

Organism-specific databases

HPAiHPA035132.

Interactioni

Protein-protein interaction databases

BioGridi117944. 1 interaction.
MINTiMINT-6629887.
STRINGi9606.ENSP00000265029.

Structurei

3D structure databases

ProteinModelPortaliQ9UGM5.
SMRiQ9UGM5. Positions 154-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 138114Cystatin fetuin-B-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 255107Cystatin fetuin-B-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation
Contains 2 cystatin fetuin-B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG87310.
GeneTreeiENSGT00530000063413.
HOGENOMiHOG000059646.
HOVERGENiHBG051608.
InParanoidiQ9UGM5.
OMAiVQYLPDL.
PhylomeDBiQ9UGM5.
TreeFamiTF333729.

Family and domain databases

InterProiIPR025764. Cystatin_Fetuin_B.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamiPF00031. Cystatin. 2 hits.
[Graphical view]
SMARTiSM00043. CY. 2 hits.
[Graphical view]
PROSITEiPS51530. CYSTATIN_FETUIN_B. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UGM5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR
60 70 80 90 100
DINKDRKDGY VLRLNRVNDA QEYRRGGLGS LFYLTLDVLE TDCHVLRKKA
110 120 130 140 150
WQDCGMRIFF ESVYGQCKAI FYMNNPSRVL YLAAYNCTLR PVSKKKIYMT
160 170 180 190 200
CPDCPSSIPT DSSNHQVLEA ATESLAKYNN ENTSKQYSLF KVTRASSQWV
210 220 230 240 250
VGPSYFVEYL IKESPCTKSQ ASSCSLQSSD SVPVGLCKGS LTRTHWEKFV
260 270 280 290 300
SVTCDFFESQ APATGSENSA VNQKPTNLPK VEESQQKNTP PTDSPSKAGP
310 320 330 340 350
RGSVQYLPDL DDKNSQEKGP QEAFPVHLDL TTNPQGETLD ISFLFLEPME
360 370 380
EKLVVLPFPK EKARTAECPG PAQNASPLVL PP
Length:382
Mass (Da):42,055
Last modified:June 27, 2006 - v2
Checksum:iC73977793A30AF8A
GO
Isoform 2 (identifier: Q9UGM5-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     76-112: Missing.

Show »
Length:345
Mass (Da):37,823
Checksum:i387D794BBA530139
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → F in AAR22507. (PubMed:15499407)Curated
Sequence conflicti9 – 91L → P in AAH74734. (PubMed:15489334)Curated
Sequence conflicti18 – 192AM → KL in CAB62538. (PubMed:10947975)Curated
Sequence conflicti179 – 1791N → K in AAH74734. (PubMed:15489334)Curated
Sequence conflicti303 – 3031S → P in AAI14617. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331S → P.
Corresponds to variant rs34522046 [ dbSNP | Ensembl ].
VAR_049061
Natural varianti202 – 2021G → S.
Corresponds to variant rs6785067 [ dbSNP | Ensembl ].
VAR_024449
Natural varianti360 – 3601K → R.
Corresponds to variant rs7999 [ dbSNP | Ensembl ].
VAR_049062

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 11237Missing in isoform 2. 1 PublicationVSP_047135Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242928 mRNA. Translation: CAB62538.1.
AF534529 mRNA. Translation: AAQ10515.1.
AY373820 mRNA. Translation: AAR22507.1.
AB017551 mRNA. Translation: BAA78341.1.
AK315309 mRNA. Translation: BAG37713.1.
AC068631 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78186.1.
BC069670 mRNA. Translation: AAH69670.1.
BC069820 mRNA. Translation: AAH69820.1.
BC074734 mRNA. Translation: AAH74734.1.
BC114616 mRNA. Translation: AAI14617.1.
CCDSiCCDS3279.1. [Q9UGM5-1]
RefSeqiNP_055190.2. NM_014375.2. [Q9UGM5-1]
UniGeneiHs.81073.

Genome annotation databases

EnsembliENST00000265029; ENSP00000265029; ENSG00000090512. [Q9UGM5-1]
ENST00000382136; ENSP00000371571; ENSG00000090512. [Q9UGM5-2]
ENST00000450521; ENSP00000404288; ENSG00000090512. [Q9UGM5-1]
GeneIDi26998.
KEGGihsa:26998.
UCSCiuc003fqn.3. human. [Q9UGM5-1]

Polymorphism databases

DMDMi109940079.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242928 mRNA. Translation: CAB62538.1 .
AF534529 mRNA. Translation: AAQ10515.1 .
AY373820 mRNA. Translation: AAR22507.1 .
AB017551 mRNA. Translation: BAA78341.1 .
AK315309 mRNA. Translation: BAG37713.1 .
AC068631 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78186.1 .
BC069670 mRNA. Translation: AAH69670.1 .
BC069820 mRNA. Translation: AAH69820.1 .
BC074734 mRNA. Translation: AAH74734.1 .
BC114616 mRNA. Translation: AAI14617.1 .
CCDSi CCDS3279.1. [Q9UGM5-1 ]
RefSeqi NP_055190.2. NM_014375.2. [Q9UGM5-1 ]
UniGenei Hs.81073.

3D structure databases

ProteinModelPortali Q9UGM5.
SMRi Q9UGM5. Positions 154-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117944. 1 interaction.
MINTi MINT-6629887.
STRINGi 9606.ENSP00000265029.

Protein family/group databases

MEROPSi I25.061.

PTM databases

PhosphoSitei Q9UGM5.

Polymorphism databases

DMDMi 109940079.

Proteomic databases

PaxDbi Q9UGM5.
PRIDEi Q9UGM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265029 ; ENSP00000265029 ; ENSG00000090512 . [Q9UGM5-1 ]
ENST00000382136 ; ENSP00000371571 ; ENSG00000090512 . [Q9UGM5-2 ]
ENST00000450521 ; ENSP00000404288 ; ENSG00000090512 . [Q9UGM5-1 ]
GeneIDi 26998.
KEGGi hsa:26998.
UCSCi uc003fqn.3. human. [Q9UGM5-1 ]

Organism-specific databases

CTDi 26998.
GeneCardsi GC03P186353.
HGNCi HGNC:3658. FETUB.
HPAi HPA035132.
MIMi 605954. gene.
neXtProti NX_Q9UGM5.
PharmGKBi PA28099.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87310.
GeneTreei ENSGT00530000063413.
HOGENOMi HOG000059646.
HOVERGENi HBG051608.
InParanoidi Q9UGM5.
OMAi VQYLPDL.
PhylomeDBi Q9UGM5.
TreeFami TF333729.

Miscellaneous databases

GeneWikii Fetuin-B.
GenomeRNAii 26998.
NextBioi 35501907.
PROi Q9UGM5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UGM5.
CleanExi HS_FETUB.
ExpressionAtlasi Q9UGM5. baseline and differential.
Genevestigatori Q9UGM5.

Family and domain databases

InterProi IPR025764. Cystatin_Fetuin_B.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view ]
Pfami PF00031. Cystatin. 2 hits.
[Graphical view ]
SMARTi SM00043. CY. 2 hits.
[Graphical view ]
PROSITEi PS51530. CYSTATIN_FETUIN_B. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetus.
  2. "Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity."
    Hsu S.J., Nagase H., Balmain A.
    Genome 47:931-946(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "H16G2, a gene specifically expressed in the liver."
    Aihara T., Miyoshi Y., Nakamura Y.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37 AND ASN-136.
    Tissue: Plasma.
  9. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFETUB_HUMAN
AccessioniPrimary (citable) accession number: Q9UGM5
Secondary accession number(s): B2RCW6
, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9Y6Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3