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Q9UGM1

- ACHA9_HUMAN

UniProt

Q9UGM1 - ACHA9_HUMAN

Protein

Neuronal acetylcholine receptor subunit alpha-9

Gene

CHRNA9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.2 Publications

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: Ensembl
    2. calcium channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
    2. inner ear morphogenesis Source: Ensembl
    3. positive regulation of cytosolic calcium ion concentration Source: MGI
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-9
    Alternative name(s):
    Nicotinic acetylcholine receptor subunit alpha-9
    Short name:
    NACHR alpha-9
    Gene namesi
    Name:CHRNA9
    Synonyms:NACHRA9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:14079. CHRNA9.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. plasma membrane Source: Reactome
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26493.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 479454Neuronal acetylcholine receptor subunit alpha-9PRO_0000000371Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 169By similarity
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi219 ↔ 220Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UGM1.
    PaxDbiQ9UGM1.
    PRIDEiQ9UGM1.

    PTM databases

    PhosphoSiteiQ9UGM1.

    Expressioni

    Tissue specificityi

    Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.3 Publications

    Gene expression databases

    BgeeiQ9UGM1.
    CleanExiHS_CHRNA9.
    GenevestigatoriQ9UGM1.

    Interactioni

    Subunit structurei

    Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.

    Protein-protein interaction databases

    BioGridi120731. 2 interactions.
    STRINGi9606.ENSP00000312663.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UGM1.
    SMRiQ9UGM1. Positions 29-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 237212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 457134CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei238 – 26225HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47619HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306809.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiQ9UGM1.
    KOiK04810.
    OMAiSYCAQYK.
    OrthoDBiEOG72JWGV.
    PhylomeDBiQ9UGM1.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UGM1-1 [UniParc]FASTAAdd to Basket

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    MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE    50
    DTDKVLNVTL QITLSQIKDM DERNQILTAY LWIRQIWHDA YLTWDRDQYD 100
    GLDSIRIPSD LVWRPDIVLY NKADDESSEP VNTNVVLRYD GLITWDAPAI 150
    TKSSCVVDVT YFPFDNQQCN LTFGSWTYNG NQVDIFNALD SGDLSDFIED 200
    VEWEVHGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY IVNLLIPCVL 250
    ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG 300
    KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWARVV ILKYMSRVLF 350
    VYDVGESCLS PHHSRERDHL TKVYSKLPES NLKAARNKDL SRKKDMNKRL 400
    KNDLGCQGKN PQEAESYCAQ YKVLTRNIEY IAKCLKDHKA TNSKGSEWKK 450
    VAKVIDRFFM WIFFIMVFVM TILIIARAD 479
    Length:479
    Mass (Da):54,807
    Last modified:October 5, 2010 - v2
    Checksum:iAA6B46B559D6111D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961R → Q.
    Corresponds to variant rs10024518 [ dbSNP | Ensembl ].
    VAR_031151
    Natural varianti315 – 3151A → V.
    Corresponds to variant rs55633891 [ dbSNP | Ensembl ].
    VAR_060996
    Natural varianti442 – 4421N → S.3 Publications
    Corresponds to variant rs10009228 [ dbSNP | Ensembl ].
    VAR_025425

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243342 mRNA. Translation: CAB65091.1.
    AY123244 Genomic DNA. Translation: AAM74523.1.
    AC118275 Genomic DNA. Translation: AAY40986.1.
    BC113549 mRNA. Translation: AAI13550.1.
    BC113575 mRNA. Translation: AAI13576.1.
    AF227732 mRNA. Translation: AAF61920.1.
    CCDSiCCDS3459.1.
    RefSeqiNP_060051.2. NM_017581.3.
    UniGeneiHs.272278.

    Genome annotation databases

    EnsembliENST00000310169; ENSP00000312663; ENSG00000174343.
    GeneIDi55584.
    KEGGihsa:55584.
    UCSCiuc003gva.2. human.

    Polymorphism databases

    DMDMi308153406.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243342 mRNA. Translation: CAB65091.1 .
    AY123244 Genomic DNA. Translation: AAM74523.1 .
    AC118275 Genomic DNA. Translation: AAY40986.1 .
    BC113549 mRNA. Translation: AAI13550.1 .
    BC113575 mRNA. Translation: AAI13576.1 .
    AF227732 mRNA. Translation: AAF61920.1 .
    CCDSi CCDS3459.1.
    RefSeqi NP_060051.2. NM_017581.3.
    UniGenei Hs.272278.

    3D structure databases

    ProteinModelPortali Q9UGM1.
    SMRi Q9UGM1. Positions 29-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120731. 2 interactions.
    STRINGi 9606.ENSP00000312663.

    Chemistry

    BindingDBi Q9UGM1.
    ChEMBLi CHEMBL2184.
    DrugBanki DB00674. Galantamine.
    DB00184. Nicotine.
    GuidetoPHARMACOLOGYi 469.

    PTM databases

    PhosphoSitei Q9UGM1.

    Polymorphism databases

    DMDMi 308153406.

    Proteomic databases

    MaxQBi Q9UGM1.
    PaxDbi Q9UGM1.
    PRIDEi Q9UGM1.

    Protocols and materials databases

    DNASUi 55584.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310169 ; ENSP00000312663 ; ENSG00000174343 .
    GeneIDi 55584.
    KEGGi hsa:55584.
    UCSCi uc003gva.2. human.

    Organism-specific databases

    CTDi 55584.
    GeneCardsi GC04P040337.
    H-InvDB HIX0031380.
    HGNCi HGNC:14079. CHRNA9.
    MIMi 605116. gene.
    neXtProti NX_Q9UGM1.
    PharmGKBi PA26493.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306809.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi Q9UGM1.
    KOi K04810.
    OMAi SYCAQYK.
    OrthoDBi EOG72JWGV.
    PhylomeDBi Q9UGM1.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

    Miscellaneous databases

    GeneWikii CHRNA9.
    GenomeRNAii 55584.
    NextBioi 60096.
    PROi Q9UGM1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UGM1.
    CleanExi HS_CHRNA9.
    Genevestigatori Q9UGM1.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
      Sgard F., Charpantier E., Bertrand S., Walker N., Caput D., Graham D., Bertrand D., Besnard F.
      Mol. Pharmacol. 61:150-159(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHRNA10, TISSUE SPECIFICITY, VARIANT SER-442.
      Tissue: Embryo.
    2. "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene."
      Lustig L.R., Peng H.
      Cytogenet. Genome Res. 98:154-159(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-442.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-442.
    5. "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity."
      Nguyen V.T., Ndoye A., Grando S.A.
      Am. J. Pathol. 157:1377-1391(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-476, FUNCTION, TISSUE SPECIFICITY.
    6. "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
      Peng H., Ferris R.L., Matthews T., Hiel H., Lopez-Albaitero A., Lustig L.R.
      Life Sci. 76:263-280(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACHA9_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGM1
    Secondary accession number(s): Q14CY7, Q4W5A2, Q9NYV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3