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Q9UGM1

- ACHA9_HUMAN

UniProt

Q9UGM1 - ACHA9_HUMAN

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Protein
Neuronal acetylcholine receptor subunit alpha-9
Gene
CHRNA9, NACHRA9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.2 Publications

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: Ensembl
  2. calcium channel activity Source: UniProtKB-KW

GO - Biological processi

  1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  2. inner ear morphogenesis Source: Ensembl
  3. positive regulation of cytosolic calcium ion concentration Source: MGI
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-9
Alternative name(s):
Nicotinic acetylcholine receptor subunit alpha-9
Short name:
NACHR alpha-9
Gene namesi
Name:CHRNA9
Synonyms:NACHRA9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:14079. CHRNA9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 237212Extracellular Reviewed prediction
Add
BLAST
Transmembranei238 – 26225Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28719Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32322Helical; Reviewed prediction
Add
BLAST
Topological domaini324 – 457134Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei458 – 47619Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 479454Neuronal acetylcholine receptor subunit alpha-9
PRO_0000000371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 169 By similarity
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi219 ↔ 220Associated with receptor activation By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UGM1.
PaxDbiQ9UGM1.
PRIDEiQ9UGM1.

PTM databases

PhosphoSiteiQ9UGM1.

Expressioni

Tissue specificityi

Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.3 Publications

Gene expression databases

BgeeiQ9UGM1.
CleanExiHS_CHRNA9.
GenevestigatoriQ9UGM1.

Interactioni

Subunit structurei

Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.

Protein-protein interaction databases

BioGridi120731. 2 interactions.
STRINGi9606.ENSP00000312663.

Structurei

3D structure databases

ProteinModelPortaliQ9UGM1.
SMRiQ9UGM1. Positions 29-349.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306809.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9UGM1.
KOiK04810.
OMAiSYCAQYK.
OrthoDBiEOG72JWGV.
PhylomeDBiQ9UGM1.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UGM1-1 [UniParc]FASTAAdd to Basket

« Hide

MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE    50
DTDKVLNVTL QITLSQIKDM DERNQILTAY LWIRQIWHDA YLTWDRDQYD 100
GLDSIRIPSD LVWRPDIVLY NKADDESSEP VNTNVVLRYD GLITWDAPAI 150
TKSSCVVDVT YFPFDNQQCN LTFGSWTYNG NQVDIFNALD SGDLSDFIED 200
VEWEVHGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY IVNLLIPCVL 250
ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG 300
KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWARVV ILKYMSRVLF 350
VYDVGESCLS PHHSRERDHL TKVYSKLPES NLKAARNKDL SRKKDMNKRL 400
KNDLGCQGKN PQEAESYCAQ YKVLTRNIEY IAKCLKDHKA TNSKGSEWKK 450
VAKVIDRFFM WIFFIMVFVM TILIIARAD 479
Length:479
Mass (Da):54,807
Last modified:October 5, 2010 - v2
Checksum:iAA6B46B559D6111D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961R → Q.
Corresponds to variant rs10024518 [ dbSNP | Ensembl ].
VAR_031151
Natural varianti315 – 3151A → V.
Corresponds to variant rs55633891 [ dbSNP | Ensembl ].
VAR_060996
Natural varianti442 – 4421N → S.3 Publications
Corresponds to variant rs10009228 [ dbSNP | Ensembl ].
VAR_025425

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243342 mRNA. Translation: CAB65091.1.
AY123244 Genomic DNA. Translation: AAM74523.1.
AC118275 Genomic DNA. Translation: AAY40986.1.
BC113549 mRNA. Translation: AAI13550.1.
BC113575 mRNA. Translation: AAI13576.1.
AF227732 mRNA. Translation: AAF61920.1.
CCDSiCCDS3459.1.
RefSeqiNP_060051.2. NM_017581.3.
UniGeneiHs.272278.

Genome annotation databases

EnsembliENST00000310169; ENSP00000312663; ENSG00000174343.
GeneIDi55584.
KEGGihsa:55584.
UCSCiuc003gva.2. human.

Polymorphism databases

DMDMi308153406.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243342 mRNA. Translation: CAB65091.1 .
AY123244 Genomic DNA. Translation: AAM74523.1 .
AC118275 Genomic DNA. Translation: AAY40986.1 .
BC113549 mRNA. Translation: AAI13550.1 .
BC113575 mRNA. Translation: AAI13576.1 .
AF227732 mRNA. Translation: AAF61920.1 .
CCDSi CCDS3459.1.
RefSeqi NP_060051.2. NM_017581.3.
UniGenei Hs.272278.

3D structure databases

ProteinModelPortali Q9UGM1.
SMRi Q9UGM1. Positions 29-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120731. 2 interactions.
STRINGi 9606.ENSP00000312663.

Chemistry

BindingDBi Q9UGM1.
ChEMBLi CHEMBL2184.
DrugBanki DB00184. Nicotine.
GuidetoPHARMACOLOGYi 469.

PTM databases

PhosphoSitei Q9UGM1.

Polymorphism databases

DMDMi 308153406.

Proteomic databases

MaxQBi Q9UGM1.
PaxDbi Q9UGM1.
PRIDEi Q9UGM1.

Protocols and materials databases

DNASUi 55584.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310169 ; ENSP00000312663 ; ENSG00000174343 .
GeneIDi 55584.
KEGGi hsa:55584.
UCSCi uc003gva.2. human.

Organism-specific databases

CTDi 55584.
GeneCardsi GC04P040337.
H-InvDB HIX0031380.
HGNCi HGNC:14079. CHRNA9.
MIMi 605116. gene.
neXtProti NX_Q9UGM1.
PharmGKBi PA26493.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306809.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi Q9UGM1.
KOi K04810.
OMAi SYCAQYK.
OrthoDBi EOG72JWGV.
PhylomeDBi Q9UGM1.
TreeFami TF315605.

Enzyme and pathway databases

Reactomei REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Miscellaneous databases

GeneWikii CHRNA9.
GenomeRNAii 55584.
NextBioi 60096.
PROi Q9UGM1.
SOURCEi Search...

Gene expression databases

Bgeei Q9UGM1.
CleanExi HS_CHRNA9.
Genevestigatori Q9UGM1.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
    Sgard F., Charpantier E., Bertrand S., Walker N., Caput D., Graham D., Bertrand D., Besnard F.
    Mol. Pharmacol. 61:150-159(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHRNA10, TISSUE SPECIFICITY, VARIANT SER-442.
    Tissue: Embryo.
  2. "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene."
    Lustig L.R., Peng H.
    Cytogenet. Genome Res. 98:154-159(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-442.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-442.
  5. "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity."
    Nguyen V.T., Ndoye A., Grando S.A.
    Am. J. Pathol. 157:1377-1391(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-476, FUNCTION, TISSUE SPECIFICITY.
  6. "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
    Peng H., Ferris R.L., Matthews T., Hiel H., Lopez-Albaitero A., Lustig L.R.
    Life Sci. 76:263-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACHA9_HUMAN
AccessioniPrimary (citable) accession number: Q9UGM1
Secondary accession number(s): Q14CY7, Q4W5A2, Q9NYV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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