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Protein

Neuronal acetylcholine receptor subunit alpha-9

Gene

CHRNA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).Curated3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174343-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-9
Alternative name(s):
Nicotinic acetylcholine receptor subunit alpha-9
Short name:
NACHR alpha-9
Gene namesi
Name:CHRNA9
Synonyms:NACHRA9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:14079. CHRNA9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 237ExtracellularSequence analysisAdd BLAST212
Transmembranei238 – 262HelicalSequence analysisAdd BLAST25
Transmembranei269 – 287HelicalSequence analysisAdd BLAST19
Transmembranei302 – 323HelicalSequence analysisAdd BLAST22
Topological domaini324 – 457CytoplasmicSequence analysisAdd BLAST134
Transmembranei458 – 476HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi55584.
OpenTargetsiENSG00000174343.
PharmGKBiPA26493.

Chemistry databases

ChEMBLiCHEMBL2184.
DrugBankiDB00898. Ethanol.
DB00674. Galantamine.
DB00184. Nicotine.
GuidetoPHARMACOLOGYi469.

Polymorphism and mutation databases

BioMutaiCHRNA9.
DMDMi308153406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000037126 – 479Neuronal acetylcholine receptor subunit alpha-9Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi155 ↔ 1691 Publication
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi219 ↔ 2201 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UGM1.
PaxDbiQ9UGM1.
PeptideAtlasiQ9UGM1.
PRIDEiQ9UGM1.

PTM databases

iPTMnetiQ9UGM1.
PhosphoSitePlusiQ9UGM1.

Expressioni

Tissue specificityi

Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.3 Publications

Gene expression databases

BgeeiENSG00000174343.
CleanExiHS_CHRNA9.
GenevisibleiQ9UGM1. HS.

Interactioni

Subunit structurei

Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.1 Publication

Protein-protein interaction databases

BioGridi120731. 73 interactors.
DIPiDIP-61053N.
STRINGi9606.ENSP00000312663.

Chemistry databases

BindingDBiQ9UGM1.

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 39Combined sources10
Beta strandi49 – 51Combined sources3
Beta strandi56 – 71Combined sources16
Turni72 – 75Combined sources4
Beta strandi76 – 93Combined sources18
Helixi96 – 98Combined sources3
Turni99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Helixi109 – 111Combined sources3
Beta strandi117 – 119Combined sources3
Beta strandi134 – 138Combined sources5
Beta strandi140 – 154Combined sources15
Beta strandi156 – 158Combined sources3
Beta strandi164 – 177Combined sources14
Turni180 – 182Combined sources3
Beta strandi183 – 191Combined sources9
Beta strandi201 – 207Combined sources7
Beta strandi209 – 217Combined sources9
Turni218 – 220Combined sources3
Beta strandi224 – 235Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D01X-ray1.80A26-237[»]
4UXUX-ray1.71A/B26-237[»]
4UY2X-ray2.70A/B26-237[»]
ProteinModelPortaliQ9UGM1.
SMRiQ9UGM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9UGM1.
KOiK04810.
OMAiMGMDSGD.
OrthoDBiEOG091G0R20.
PhylomeDBiQ9UGM1.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UGM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE
60 70 80 90 100
DTDKVLNVTL QITLSQIKDM DERNQILTAY LWIRQIWHDA YLTWDRDQYD
110 120 130 140 150
GLDSIRIPSD LVWRPDIVLY NKADDESSEP VNTNVVLRYD GLITWDAPAI
160 170 180 190 200
TKSSCVVDVT YFPFDNQQCN LTFGSWTYNG NQVDIFNALD SGDLSDFIED
210 220 230 240 250
VEWEVHGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY IVNLLIPCVL
260 270 280 290 300
ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG
310 320 330 340 350
KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWARVV ILKYMSRVLF
360 370 380 390 400
VYDVGESCLS PHHSRERDHL TKVYSKLPES NLKAARNKDL SRKKDMNKRL
410 420 430 440 450
KNDLGCQGKN PQEAESYCAQ YKVLTRNIEY IAKCLKDHKA TNSKGSEWKK
460 470
VAKVIDRFFM WIFFIMVFVM TILIIARAD
Length:479
Mass (Da):54,807
Last modified:October 5, 2010 - v2
Checksum:iAA6B46B559D6111D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03115196R → Q.Corresponds to variant rs10024518dbSNPEnsembl.1
Natural variantiVAR_060996315A → V.Corresponds to variant rs55633891dbSNPEnsembl.1
Natural variantiVAR_025425442N → S.3 PublicationsCorresponds to variant rs10009228dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243342 mRNA. Translation: CAB65091.1.
AY123244 Genomic DNA. Translation: AAM74523.1.
AC118275 Genomic DNA. Translation: AAY40986.1.
BC113549 mRNA. Translation: AAI13550.1.
BC113575 mRNA. Translation: AAI13576.1.
AF227732 mRNA. Translation: AAF61920.1.
CCDSiCCDS3459.1.
RefSeqiNP_060051.2. NM_017581.3.
UniGeneiHs.272278.

Genome annotation databases

EnsembliENST00000310169; ENSP00000312663; ENSG00000174343.
GeneIDi55584.
KEGGihsa:55584.
UCSCiuc003gva.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243342 mRNA. Translation: CAB65091.1.
AY123244 Genomic DNA. Translation: AAM74523.1.
AC118275 Genomic DNA. Translation: AAY40986.1.
BC113549 mRNA. Translation: AAI13550.1.
BC113575 mRNA. Translation: AAI13576.1.
AF227732 mRNA. Translation: AAF61920.1.
CCDSiCCDS3459.1.
RefSeqiNP_060051.2. NM_017581.3.
UniGeneiHs.272278.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D01X-ray1.80A26-237[»]
4UXUX-ray1.71A/B26-237[»]
4UY2X-ray2.70A/B26-237[»]
ProteinModelPortaliQ9UGM1.
SMRiQ9UGM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120731. 73 interactors.
DIPiDIP-61053N.
STRINGi9606.ENSP00000312663.

Chemistry databases

BindingDBiQ9UGM1.
ChEMBLiCHEMBL2184.
DrugBankiDB00898. Ethanol.
DB00674. Galantamine.
DB00184. Nicotine.
GuidetoPHARMACOLOGYi469.

PTM databases

iPTMnetiQ9UGM1.
PhosphoSitePlusiQ9UGM1.

Polymorphism and mutation databases

BioMutaiCHRNA9.
DMDMi308153406.

Proteomic databases

MaxQBiQ9UGM1.
PaxDbiQ9UGM1.
PeptideAtlasiQ9UGM1.
PRIDEiQ9UGM1.

Protocols and materials databases

DNASUi55584.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310169; ENSP00000312663; ENSG00000174343.
GeneIDi55584.
KEGGihsa:55584.
UCSCiuc003gva.2. human.

Organism-specific databases

CTDi55584.
DisGeNETi55584.
GeneCardsiCHRNA9.
H-InvDBHIX0031380.
HGNCiHGNC:14079. CHRNA9.
MIMi605116. gene.
neXtProtiNX_Q9UGM1.
OpenTargetsiENSG00000174343.
PharmGKBiPA26493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9UGM1.
KOiK04810.
OMAiMGMDSGD.
OrthoDBiEOG091G0R20.
PhylomeDBiQ9UGM1.
TreeFamiTF315605.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174343-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Miscellaneous databases

ChiTaRSiCHRNA9. human.
GeneWikiiCHRNA9.
GenomeRNAii55584.
PROiQ9UGM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174343.
CleanExiHS_CHRNA9.
GenevisibleiQ9UGM1. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA9_HUMAN
AccessioniPrimary (citable) accession number: Q9UGM1
Secondary accession number(s): Q14CY7, Q4W5A2, Q9NYV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.