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Protein
Submitted name:

IkappaBalpha

Gene

IkBa

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
IkappaBalphaImported
Gene namesi
Name:IkBaImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 8355Sequence analysisPRO_5004334303Add
BLAST

Proteomic databases

PaxDbiQ9UGJ5.
PeptideAtlasiQ9UGJ5.

Expressioni

Gene expression databases

BgeeiQ9UGJ5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000216797.

Structurei

3D structure databases

ProteinModelPortaliQ9UGJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7373ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UGJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HTCLHLASIH GYLGIVELLV SLGADVNAQE PCNGRTALHL AVDLQNPDLV
60 70 80
SLLLKCGADV NRVTYQGYSP YQLTWGRPST RIQ
Length:83
Mass (Da):9,056
Last modified:May 1, 2000 - v1
Checksum:i37C8BEDAB8336EF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249290 Genomic DNA. Translation: CAB65113.1.
UniGeneiHs.81328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249290 Genomic DNA. Translation: CAB65113.1.
UniGeneiHs.81328.

3D structure databases

ProteinModelPortaliQ9UGJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216797.

Proteomic databases

PaxDbiQ9UGJ5.
PeptideAtlasiQ9UGJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.

Miscellaneous databases

ChiTaRSiNFKBIA. human.

Gene expression databases

BgeeiQ9UGJ5.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Clonal deleterious mutations in the IkappaB alpha gene in the malignant cells in Hodgkin's lymphoma."
    Jungnickel B., Staratschek-Jox A., Brauninger A., Spieker T., Wolf J., Diehl V., Hansmann M.L., Rajewsky K., Kuppers R.
    J. Exp. Med. 191:395-402(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UGJ5_HUMAN
AccessioniPrimary (citable) accession number: Q9UGJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.