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Q9UGI8

- TES_HUMAN

UniProt

Q9UGI8 - TES_HUMAN

Protein

Testin

Gene

TES

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.3 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testin
    Alternative name(s):
    TESS
    Gene namesi
    Name:TES
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14620. TES.

    Subcellular locationi

    Cytoplasm. Cell junctionfocal adhesion
    Note: Detected along actin stress fibers.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. focal adhesion Source: UniProtKB-SubCell
    3. nucleus Source: UniProt
    4. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi328 – 3281C → A: Abolishes interaction with ACTL7A. 1 Publication
    Mutagenesisi391 – 3911C → A: Abolishes localization at focal adhesions. 1 Publication

    Organism-specific databases

    PharmGKBiPA37906.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421TestinPRO_0000075906Add
    BLAST

    Proteomic databases

    MaxQBiQ9UGI8.
    PaxDbiQ9UGI8.
    PeptideAtlasiQ9UGI8.
    PRIDEiQ9UGI8.

    PTM databases

    PhosphoSiteiQ9UGI8.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9UGI8.
    BgeeiQ9UGI8.
    CleanExiHS_TES.
    GenevestigatoriQ9UGI8.

    Organism-specific databases

    HPAiCAB003690.
    HPA015269.
    HPA018123.

    Interactioni

    Subunit structurei

    Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.5 Publications

    Protein-protein interaction databases

    BioGridi117572. 23 interactions.
    IntActiQ9UGI8. 18 interactions.
    MINTiMINT-2821159.
    STRINGi9606.ENSP00000350937.

    Structurei

    Secondary structure

    1
    421
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni302 – 3043
    Beta strandi305 – 3073
    Beta strandi313 – 3164
    Beta strandi319 – 3213
    Helixi323 – 3253
    Turni329 – 3313
    Beta strandi338 – 3436
    Beta strandi346 – 3494
    Helixi350 – 3567
    Turni362 – 3643
    Beta strandi365 – 3684
    Beta strandi374 – 3774
    Beta strandi380 – 3834
    Turni384 – 3874
    Turni392 – 3943
    Beta strandi404 – 4063
    Beta strandi409 – 4135
    Helixi414 – 4185

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IYBX-ray2.35E/F/G/H357-421[»]
    2XQNX-ray2.62T296-421[»]
    ProteinModelPortaliQ9UGI8.
    SMRiQ9UGI8. Positions 233-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UGI8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 199108PETPROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 29764LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 35961LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini362 – 42160LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 4625Cys-richAdd
    BLAST

    Domaini

    The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.1 Publication

    Sequence similaritiesi

    Belongs to the prickle / espinas / testin family.Curated
    Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
    Contains 1 PET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG272178.
    HOGENOMiHOG000231628.
    HOVERGENiHBG001038.
    InParanoidiQ9UGI8.
    OMAiVKLPREM.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiQ9UGI8.
    TreeFamiTF313265.

    Family and domain databases

    Gene3Di2.10.110.10. 3 hits.
    InterProiIPR010442. PET_domain.
    IPR027683. Testin.
    IPR001781. Znf_LIM.
    [Graphical view]
    PANTHERiPTHR24211:SF1. PTHR24211:SF1. 1 hit.
    PfamiPF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 3 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UGI8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE    50
    HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA 100
    KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL 150
    AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA 200
    QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI 250
    YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR 300
    CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK 350
    PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG 400
    QKFMPVEGMV FCSVECKKRM S 421
    Length:421
    Mass (Da):47,996
    Last modified:May 1, 2000 - v1
    Checksum:iAB9FF6669C50D492
    GO
    Isoform 2 (identifier: Q9UGI8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:412
    Mass (Da):46,910
    Checksum:iC97A6D97364B3569
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321K → E in BAB13846. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti221 – 2211A → V.
    Corresponds to variant rs2272193 [ dbSNP | Ensembl ].
    VAR_050170

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform 2. 2 PublicationsVSP_003122

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260225 Genomic DNA. Translation: AAG17635.1.
    AF260225 Genomic DNA. Translation: AAG17636.1.
    AF245356 mRNA. Translation: AAG17612.1.
    AF245357 mRNA. Translation: AAG17613.1.
    AJ250865 mRNA. Translation: CAB65119.1.
    AK021575 mRNA. Translation: BAB13846.1.
    AK291802 mRNA. Translation: BAF84491.1.
    AC073130 Genomic DNA. Translation: AAQ93367.1.
    CH236947 Genomic DNA. Translation: EAL24365.1.
    BC001451 mRNA. Translation: AAH01451.1.
    CCDSiCCDS5763.1. [Q9UGI8-1]
    CCDS5764.1. [Q9UGI8-2]
    RefSeqiNP_056456.1. NM_015641.3. [Q9UGI8-1]
    NP_690042.1. NM_152829.2. [Q9UGI8-2]
    UniGeneiHs.592286.
    Hs.664957.

    Genome annotation databases

    EnsembliENST00000358204; ENSP00000350937; ENSG00000135269. [Q9UGI8-1]
    ENST00000393481; ENSP00000377121; ENSG00000135269. [Q9UGI8-2]
    GeneIDi26136.
    KEGGihsa:26136.
    UCSCiuc003vho.3. human. [Q9UGI8-1]

    Polymorphism databases

    DMDMi17380320.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260225 Genomic DNA. Translation: AAG17635.1 .
    AF260225 Genomic DNA. Translation: AAG17636.1 .
    AF245356 mRNA. Translation: AAG17612.1 .
    AF245357 mRNA. Translation: AAG17613.1 .
    AJ250865 mRNA. Translation: CAB65119.1 .
    AK021575 mRNA. Translation: BAB13846.1 .
    AK291802 mRNA. Translation: BAF84491.1 .
    AC073130 Genomic DNA. Translation: AAQ93367.1 .
    CH236947 Genomic DNA. Translation: EAL24365.1 .
    BC001451 mRNA. Translation: AAH01451.1 .
    CCDSi CCDS5763.1. [Q9UGI8-1 ]
    CCDS5764.1. [Q9UGI8-2 ]
    RefSeqi NP_056456.1. NM_015641.3. [Q9UGI8-1 ]
    NP_690042.1. NM_152829.2. [Q9UGI8-2 ]
    UniGenei Hs.592286.
    Hs.664957.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IYB X-ray 2.35 E/F/G/H 357-421 [» ]
    2XQN X-ray 2.62 T 296-421 [» ]
    ProteinModelPortali Q9UGI8.
    SMRi Q9UGI8. Positions 233-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117572. 23 interactions.
    IntActi Q9UGI8. 18 interactions.
    MINTi MINT-2821159.
    STRINGi 9606.ENSP00000350937.

    PTM databases

    PhosphoSitei Q9UGI8.

    Polymorphism databases

    DMDMi 17380320.

    Proteomic databases

    MaxQBi Q9UGI8.
    PaxDbi Q9UGI8.
    PeptideAtlasi Q9UGI8.
    PRIDEi Q9UGI8.

    Protocols and materials databases

    DNASUi 26136.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358204 ; ENSP00000350937 ; ENSG00000135269 . [Q9UGI8-1 ]
    ENST00000393481 ; ENSP00000377121 ; ENSG00000135269 . [Q9UGI8-2 ]
    GeneIDi 26136.
    KEGGi hsa:26136.
    UCSCi uc003vho.3. human. [Q9UGI8-1 ]

    Organism-specific databases

    CTDi 26136.
    GeneCardsi GC07P115850.
    HGNCi HGNC:14620. TES.
    HPAi CAB003690.
    HPA015269.
    HPA018123.
    MIMi 606085. gene.
    neXtProti NX_Q9UGI8.
    PharmGKBi PA37906.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272178.
    HOGENOMi HOG000231628.
    HOVERGENi HBG001038.
    InParanoidi Q9UGI8.
    OMAi VKLPREM.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi Q9UGI8.
    TreeFami TF313265.

    Miscellaneous databases

    ChiTaRSi TES. human.
    EvolutionaryTracei Q9UGI8.
    GeneWikii Testin.
    GenomeRNAii 26136.
    NextBioi 48175.
    PROi Q9UGI8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UGI8.
    Bgeei Q9UGI8.
    CleanExi HS_TES.
    Genevestigatori Q9UGI8.

    Family and domain databases

    Gene3Di 2.10.110.10. 3 hits.
    InterProi IPR010442. PET_domain.
    IPR027683. Testin.
    IPR001781. Znf_LIM.
    [Graphical view ]
    PANTHERi PTHR24211:SF1. PTHR24211:SF1. 1 hit.
    Pfami PF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 3 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2."
      Tatarelli C., Linnenbach A., Mimori K., Croce C.M.
      Genomics 68:1-12(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    2. "The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein."
      Tobias E.S., Hurlstone A.F.L., MacKenzie E., McFarlane R., Black D.M.
      Oncogene 20:2844-2853(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Embryo and Prostate.
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    7. "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions."
      Garvalov B.K., Higgins T.E., Sutherland J.D., Zettl M., Scaplehorn N., Koecher T., Piddini E., Griffiths G., Way M.
      J. Cell Biol. 161:33-39(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF CYS-391, INTERACTION WITH ENAH; ZYX; VASP; ACTIN FIBERS; ALPHA-ACTININ AND PXN.
    8. "TES is a novel focal adhesion protein with a role in cell spreading."
      Coutts A.S., MacKenzie E., Griffith E., Black D.M.
      J. Cell Sci. 116:897-906(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ZYX; GRIP1; ENAH AND TALIN, SUBCELLULAR LOCATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Human ALKBH4 interacts with proteins associated with transcription."
      Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
      PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALKBH4.
    11. "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding."
      Boeda B., Briggs D.C., Higgins T., Garvalov B.K., Fadden A.J., McDonald N.Q., Way M.
      Mol. Cell 28:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 357-421 IN COMPLEX WITH ZINC IONS AND ENAH.
    12. "Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A."
      Boeda B., Knowles P.P., Briggs D.C., Murray-Rust J., Soriano E., Garvalov B.K., McDonald N.Q., Way M.
      J. Biol. Chem. 286:11543-11554(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 296-421 IN COMPLEX WITH ZINC IONS; ENAH AND ACTL7A, MUTAGENESIS OF CYS-328, SUBUNIT.

    Entry informationi

    Entry nameiTES_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGI8
    Secondary accession number(s): A4D0U6, Q9GZQ1, Q9HAJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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