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Q9UGH3

- S23A2_HUMAN

UniProt

Q9UGH3 - S23A2_HUMAN

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Protein
Solute carrier family 23 member 2
Gene
SLC23A2, KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  1. L-ascorbate:sodium symporter activity Source: Ensembl
  2. L-ascorbic acid transporter activity Source: UniProtKB
  3. nucleobase transmembrane transporter activity Source: ProtInc
  4. sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
  5. sodium-dependent multivitamin transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. L-ascorbic acid metabolic process Source: UniProtKB
  2. L-ascorbic acid transport Source: UniProtKB
  3. molecular hydrogen transport Source: UniProtKB
  4. nucleobase transport Source: ProtInc
  5. nucleobase-containing compound metabolic process Source: ProtInc
  6. response to oxidative stress Source: Ensembl
  7. small molecule metabolic process Source: Reactome
  8. transepithelial L-ascorbic acid transport Source: UniProtKB
  9. vitamin metabolic process Source: Reactome
  10. vitamin transmembrane transport Source: GOC
  11. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Nucleobase transporter-like 1 protein
Sodium-dependent vitamin C transporter 2
Short name:
hSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:SLC23A2
Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:10973. SLC23A2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini9 – 110102Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Reviewed prediction
Add
BLAST
Topological domaini132 – 1398Extracellular Reviewed prediction
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Topological domaini161 – 1611Cytoplasmic Reviewed prediction
Transmembranei162 – 18221Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 21836Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Topological domaini240 – 26627Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei267 – 28418Helical; Reviewed prediction
Add
BLAST
Topological domaini285 – 2884Extracellular Reviewed prediction
Intramembranei289 – 30214Helical; Reviewed prediction
Add
BLAST
Topological domaini303 – 3097Extracellular Reviewed prediction
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Topological domaini331 – 37141Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 41725Extracellular Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST
Topological domaini439 – 46123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei462 – 48221Helical; Reviewed prediction
Add
BLAST
Topological domaini483 – 4853Extracellular Reviewed prediction
Transmembranei486 – 50621Helical; Reviewed prediction
Add
BLAST
Topological domaini507 – 51610Cytoplasmic Reviewed prediction
Transmembranei517 – 53721Helical; Reviewed prediction
Add
BLAST
Topological domaini538 – 54710Extracellular Reviewed prediction
Transmembranei548 – 56821Helical; Reviewed prediction
Add
BLAST
Topological domaini569 – 65082Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basal plasma membrane Source: Ensembl
  3. basolateral plasma membrane Source: UniProtKB
  4. cytoplasm Source: Ensembl
  5. integral component of membrane Source: UniProtKB
  6. integral component of plasma membrane Source: ProtInc
  7. membrane Source: ProtInc
  8. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 650650Solute carrier family 23 member 2
PRO_0000165978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine By similarity
Modified residuei78 – 781Phosphoserine By similarity
Modified residuei79 – 791Phosphothreonine By similarity
Modified residuei81 – 811Phosphoserine1 Publication
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Modified residuei649 – 6491Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated Inferred.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UGH3.
PaxDbiQ9UGH3.
PRIDEiQ9UGH3.

PTM databases

PhosphoSiteiQ9UGH3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9UGH3.
BgeeiQ9UGH3.
CleanExiHS_SLC23A1.
HS_SLC23A2.
GenevestigatoriQ9UGH3.

Organism-specific databases

HPAiHPA052825.

Interactioni

Protein-protein interaction databases

BioGridi115287. 4 interactions.
IntActiQ9UGH3. 1 interaction.
STRINGi9606.ENSP00000344322.

Structurei

3D structure databases

ProteinModelPortaliQ9UGH3.
SMRiQ9UGH3. Positions 90-573.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
HOVERGENiHBG056256.
InParanoidiQ9UGH3.
KOiK14611.
OMAiKHPTFFT.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9UGH3.
TreeFamiTF313272.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGH3-1 [UniParc]FASTAAdd to Basket

« Hide

MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD    50
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY 100
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI 150
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE 200
LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT 250
VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK 300
KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD 350
ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA 400
CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI 450
TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA 500
VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL 550
NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES 600
YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG 650
Length:650
Mass (Da):70,337
Last modified:May 1, 2000 - v1
Checksum:i28C9E190D9528D39
GO

Sequence cautioni

The sequence BAA13244.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301P → R in AAD11783. 1 Publication
Sequence conflicti141 – 1411I → T in AAD11783. 1 Publication
Sequence conflicti167 – 1671A → T in AAC78806. 1 Publication
Sequence conflicti182 – 1821L → S in AAD11783. 1 Publication
Sequence conflicti215 – 2151I → V in AAD11783. 1 Publication
Sequence conflicti314 – 3141F → L in CAC83100. 1 Publication
Sequence conflicti418 – 4247GIFVEGL → YVPEKTS1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF058319 mRNA. Translation: AAC78806.1.
AJ269478 mRNA. Translation: CAB58120.1.
AF164142 mRNA. Translation: AAF80493.1.
AF092511 mRNA. Translation: AAD11783.1.
AJ292318 mRNA. Translation: CAC83100.1.
AY380556 mRNA. Translation: AAQ79775.1.
D87075 mRNA. Translation: BAA13244.2. Different initiation.
AL389886 Genomic DNA. Translation: CAC16126.1.
BC013112 mRNA. Translation: AAH13112.1.
CCDSiCCDS13085.1.
PIRiJC7095.
RefSeqiNP_005107.4. NM_005116.5.
NP_976072.1. NM_203327.1.
UniGeneiHs.516866.

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057.
ENST00000379333; ENSP00000368637; ENSG00000089057.
GeneIDi9962.
KEGGihsa:9962.
UCSCiuc002wlg.1. human.

Polymorphism databases

DMDMi24212469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF058319 mRNA. Translation: AAC78806.1 .
AJ269478 mRNA. Translation: CAB58120.1 .
AF164142 mRNA. Translation: AAF80493.1 .
AF092511 mRNA. Translation: AAD11783.1 .
AJ292318 mRNA. Translation: CAC83100.1 .
AY380556 mRNA. Translation: AAQ79775.1 .
D87075 mRNA. Translation: BAA13244.2 . Different initiation.
AL389886 Genomic DNA. Translation: CAC16126.1 .
BC013112 mRNA. Translation: AAH13112.1 .
CCDSi CCDS13085.1.
PIRi JC7095.
RefSeqi NP_005107.4. NM_005116.5.
NP_976072.1. NM_203327.1.
UniGenei Hs.516866.

3D structure databases

ProteinModelPortali Q9UGH3.
SMRi Q9UGH3. Positions 90-573.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115287. 4 interactions.
IntActi Q9UGH3. 1 interaction.
STRINGi 9606.ENSP00000344322.

Chemistry

ChEMBLi CHEMBL3271.
GuidetoPHARMACOLOGYi 1042.

Protein family/group databases

TCDBi 2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

PhosphoSitei Q9UGH3.

Polymorphism databases

DMDMi 24212469.

Proteomic databases

MaxQBi Q9UGH3.
PaxDbi Q9UGH3.
PRIDEi Q9UGH3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338244 ; ENSP00000344322 ; ENSG00000089057 .
ENST00000379333 ; ENSP00000368637 ; ENSG00000089057 .
GeneIDi 9962.
KEGGi hsa:9962.
UCSCi uc002wlg.1. human.

Organism-specific databases

CTDi 9962.
GeneCardsi GC20M004781.
HGNCi HGNC:10973. SLC23A2.
HPAi HPA052825.
MIMi 603791. gene.
neXtProti NX_Q9UGH3.
PharmGKBi PA35849.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2233.
HOVERGENi HBG056256.
InParanoidi Q9UGH3.
KOi K14611.
OMAi KHPTFFT.
OrthoDBi EOG7R56RZ.
PhylomeDBi Q9UGH3.
TreeFami TF313272.

Enzyme and pathway databases

Reactomei REACT_11202. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

ChiTaRSi SLC23A2. human.
GeneWikii SLC23A2.
GenomeRNAii 9962.
NextBioi 37592.
PROi Q9UGH3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UGH3.
Bgeei Q9UGH3.
CleanExi HS_SLC23A1.
HS_SLC23A2.
Genevestigatori Q9UGH3.

Family and domain databases

InterProi IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view ]
PANTHERi PTHR11119. PTHR11119. 1 hit.
Pfami PF00860. Xan_ur_permease. 1 hit.
[Graphical view ]
PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters."
    Faaland C.A., Race J.E., Ricken G., Warner F.J., Williams W.J., Holtzman E.J.
    Biochim. Biophys. Acta 1442:353-360(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function."
    Rajan D.P., Huang W., Dutta B., Devoe L.D., Leibach F.H., Ganapathy V., Prasad P.D.
    Biochem. Biophys. Res. Commun. 262:762-768(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Choriocarcinoma.
  3. "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2."
    Daruwala R.C., Song J., Koh W.S., Rumsey S.C., Levine M.
    FEBS Lett. 460:480-484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals."
    Hogue D.L., Ling V.
    Genomics 59:18-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary carcinoma.
  5. "Vitamin C transport systems of mammalian cells."
    Liang W.J., Johnson D., Jarvis S.M.
    Mol. Membr. Biol. 18:87-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  6. "SVCT2 in ciliated human tracheal epithelial cultures."
    Schwarzer C., Borcanski G., Widdicombe J., Fischer H., Illek B.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.
  7. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  9. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-424.
    Tissue: Skin.
  11. "Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting."
    Velho A.M., Jarvis S.M.
    Exp. Cell Res. 315:2312-2321(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiS23A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGH3
Secondary accession number(s): Q8WWR4
, Q92512, Q96D54, Q9UNU1, Q9UP85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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