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Q9UGH3

- S23A2_HUMAN

UniProt

Q9UGH3 - S23A2_HUMAN

Protein

Solute carrier family 23 member 2

Gene

SLC23A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

    GO - Molecular functioni

    1. L-ascorbate:sodium symporter activity Source: Ensembl
    2. L-ascorbic acid transporter activity Source: UniProtKB
    3. nucleobase transmembrane transporter activity Source: ProtInc
    4. sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
    5. sodium-dependent multivitamin transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. L-ascorbic acid metabolic process Source: UniProtKB
    2. L-ascorbic acid transport Source: UniProtKB
    3. molecular hydrogen transport Source: UniProtKB
    4. nucleobase-containing compound metabolic process Source: ProtInc
    5. nucleobase transport Source: ProtInc
    6. response to oxidative stress Source: Ensembl
    7. small molecule metabolic process Source: Reactome
    8. transepithelial L-ascorbic acid transport Source: UniProtKB
    9. vitamin metabolic process Source: Reactome
    10. vitamin transmembrane transport Source: GOC
    11. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.

    Protein family/group databases

    TCDBi2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 23 member 2
    Alternative name(s):
    Na(+)/L-ascorbic acid transporter 2
    Nucleobase transporter-like 1 protein
    Sodium-dependent vitamin C transporter 2
    Short name:
    hSVCT2
    Yolk sac permease-like molecule 2
    Gene namesi
    Name:SLC23A2
    Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:10973. SLC23A2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basal plasma membrane Source: Ensembl
    3. basolateral plasma membrane Source: UniProtKB
    4. cytoplasm Source: Ensembl
    5. integral component of membrane Source: UniProtKB
    6. integral component of plasma membrane Source: ProtInc
    7. membrane Source: ProtInc
    8. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35849.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 650650Solute carrier family 23 member 2PRO_0000165978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701PhosphoserineBy similarity
    Modified residuei78 – 781PhosphoserineBy similarity
    Modified residuei79 – 791PhosphothreonineBy similarity
    Modified residuei81 – 811Phosphoserine1 Publication
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Modified residuei649 – 6491PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UGH3.
    PaxDbiQ9UGH3.
    PRIDEiQ9UGH3.

    PTM databases

    PhosphoSiteiQ9UGH3.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9UGH3.
    BgeeiQ9UGH3.
    CleanExiHS_SLC23A1.
    HS_SLC23A2.
    GenevestigatoriQ9UGH3.

    Organism-specific databases

    HPAiHPA052825.

    Interactioni

    Protein-protein interaction databases

    BioGridi115287. 4 interactions.
    IntActiQ9UGH3. 1 interaction.
    STRINGi9606.ENSP00000344322.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UGH3.
    SMRiQ9UGH3. Positions 90-573.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini9 – 110102CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 1398ExtracellularSequence Analysis
    Topological domaini161 – 1611CytoplasmicSequence Analysis
    Topological domaini183 – 21836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 26627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2884ExtracellularSequence Analysis
    Topological domaini303 – 3097ExtracellularSequence Analysis
    Topological domaini331 – 37141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini439 – 46123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini483 – 4853ExtracellularSequence Analysis
    Topological domaini507 – 51610CytoplasmicSequence Analysis
    Topological domaini538 – 54710ExtracellularSequence Analysis
    Topological domaini569 – 65082CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei289 – 30214HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei517 – 53721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei548 – 56821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2233.
    HOVERGENiHBG056256.
    InParanoidiQ9UGH3.
    KOiK14611.
    OMAiKHPTFFT.
    OrthoDBiEOG7R56RZ.
    PhylomeDBiQ9UGH3.
    TreeFamiTF313272.

    Family and domain databases

    InterProiIPR006042. Xan_ur_permease.
    IPR006043. Xant/urac/vitC.
    [Graphical view]
    PANTHERiPTHR11119. PTHR11119. 1 hit.
    PfamiPF00860. Xan_ur_permease. 1 hit.
    [Graphical view]
    PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UGH3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD    50
    NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY 100
    LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI 150
    TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE 200
    LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT 250
    VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK 300
    KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD 350
    ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA 400
    CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI 450
    TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA 500
    VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL 550
    NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES 600
    YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG 650
    Length:650
    Mass (Da):70,337
    Last modified:May 1, 2000 - v1
    Checksum:i28C9E190D9528D39
    GO
    Isoform 2 (identifier: Q9UGH3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         162-275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):58,177
    Checksum:iB4CA6A0D1B57592A
    GO

    Sequence cautioni

    The sequence BAA13244.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301P → R in AAD11783. (PubMed:10395795)Curated
    Sequence conflicti141 – 1411I → T in AAD11783. (PubMed:10395795)Curated
    Sequence conflicti167 – 1671A → T in AAC78806. (PubMed:9804989)Curated
    Sequence conflicti182 – 1821L → S in AAD11783. (PubMed:10395795)Curated
    Sequence conflicti215 – 2151I → V in AAD11783. (PubMed:10395795)Curated
    Sequence conflicti314 – 3141F → L in CAC83100. (PubMed:11396616)Curated
    Sequence conflicti418 – 4247GIFVEGL → YVPEKTS(PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei162 – 275114Missing in isoform 2. 1 PublicationVSP_056485Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058319 mRNA. Translation: AAC78806.1.
    AJ269478 mRNA. Translation: CAB58120.1.
    AF164142 mRNA. Translation: AAF80493.1.
    AF092511 mRNA. Translation: AAD11783.1.
    AJ292318 mRNA. Translation: CAC83100.1.
    AY380556 mRNA. Translation: AAQ79775.1.
    D87075 mRNA. Translation: BAA13244.2. Different initiation.
    AK296304 mRNA. Translation: BAG59003.1.
    AL109841 Genomic DNA. No translation available.
    AL121890 Genomic DNA. No translation available.
    AL389886 Genomic DNA. Translation: CAC16126.1.
    BC013112 mRNA. Translation: AAH13112.1.
    CCDSiCCDS13085.1.
    PIRiJC7095.
    RefSeqiNP_005107.4. NM_005116.5.
    NP_976072.1. NM_203327.1.
    UniGeneiHs.516866.

    Genome annotation databases

    EnsembliENST00000338244; ENSP00000344322; ENSG00000089057.
    ENST00000379333; ENSP00000368637; ENSG00000089057.
    ENST00000424750; ENSP00000406601; ENSG00000089057.
    GeneIDi9962.
    KEGGihsa:9962.
    UCSCiuc002wlg.1. human.

    Polymorphism databases

    DMDMi24212469.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058319 mRNA. Translation: AAC78806.1 .
    AJ269478 mRNA. Translation: CAB58120.1 .
    AF164142 mRNA. Translation: AAF80493.1 .
    AF092511 mRNA. Translation: AAD11783.1 .
    AJ292318 mRNA. Translation: CAC83100.1 .
    AY380556 mRNA. Translation: AAQ79775.1 .
    D87075 mRNA. Translation: BAA13244.2 . Different initiation.
    AK296304 mRNA. Translation: BAG59003.1 .
    AL109841 Genomic DNA. No translation available.
    AL121890 Genomic DNA. No translation available.
    AL389886 Genomic DNA. Translation: CAC16126.1 .
    BC013112 mRNA. Translation: AAH13112.1 .
    CCDSi CCDS13085.1.
    PIRi JC7095.
    RefSeqi NP_005107.4. NM_005116.5.
    NP_976072.1. NM_203327.1.
    UniGenei Hs.516866.

    3D structure databases

    ProteinModelPortali Q9UGH3.
    SMRi Q9UGH3. Positions 90-573.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115287. 4 interactions.
    IntActi Q9UGH3. 1 interaction.
    STRINGi 9606.ENSP00000344322.

    Chemistry

    ChEMBLi CHEMBL3271.
    GuidetoPHARMACOLOGYi 1042.

    Protein family/group databases

    TCDBi 2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

    PTM databases

    PhosphoSitei Q9UGH3.

    Polymorphism databases

    DMDMi 24212469.

    Proteomic databases

    MaxQBi Q9UGH3.
    PaxDbi Q9UGH3.
    PRIDEi Q9UGH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338244 ; ENSP00000344322 ; ENSG00000089057 .
    ENST00000379333 ; ENSP00000368637 ; ENSG00000089057 .
    ENST00000424750 ; ENSP00000406601 ; ENSG00000089057 .
    GeneIDi 9962.
    KEGGi hsa:9962.
    UCSCi uc002wlg.1. human.

    Organism-specific databases

    CTDi 9962.
    GeneCardsi GC20M004781.
    HGNCi HGNC:10973. SLC23A2.
    HPAi HPA052825.
    MIMi 603791. gene.
    neXtProti NX_Q9UGH3.
    PharmGKBi PA35849.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2233.
    HOVERGENi HBG056256.
    InParanoidi Q9UGH3.
    KOi K14611.
    OMAi KHPTFFT.
    OrthoDBi EOG7R56RZ.
    PhylomeDBi Q9UGH3.
    TreeFami TF313272.

    Enzyme and pathway databases

    Reactomei REACT_11202. Vitamin C (ascorbate) metabolism.

    Miscellaneous databases

    ChiTaRSi SLC23A2. human.
    GeneWikii SLC23A2.
    GenomeRNAii 9962.
    NextBioi 37592.
    PROi Q9UGH3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UGH3.
    Bgeei Q9UGH3.
    CleanExi HS_SLC23A1.
    HS_SLC23A2.
    Genevestigatori Q9UGH3.

    Family and domain databases

    InterProi IPR006042. Xan_ur_permease.
    IPR006043. Xant/urac/vitC.
    [Graphical view ]
    PANTHERi PTHR11119. PTHR11119. 1 hit.
    Pfami PF00860. Xan_ur_permease. 1 hit.
    [Graphical view ]
    PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters."
      Faaland C.A., Race J.E., Ricken G., Warner F.J., Williams W.J., Holtzman E.J.
      Biochim. Biophys. Acta 1442:353-360(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function."
      Rajan D.P., Huang W., Dutta B., Devoe L.D., Leibach F.H., Ganapathy V., Prasad P.D.
      Biochem. Biophys. Res. Commun. 262:762-768(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Choriocarcinoma.
    3. "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2."
      Daruwala R.C., Song J., Koh W.S., Rumsey S.C., Levine M.
      FEBS Lett. 460:480-484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals."
      Hogue D.L., Ling V.
      Genomics 59:18-23(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary carcinoma.
    5. "Vitamin C transport systems of mammalian cells."
      Liang W.J., Johnson D., Jarvis S.M.
      Mol. Membr. Biol. 18:87-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "SVCT2 in ciliated human tracheal epithelial cultures."
      Schwarzer C., Borcanski G., Widdicombe J., Fischer H., Illek B.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Trachea.
    7. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thalamus.
    10. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-424 (ISOFORM 1).
      Tissue: Skin.
    12. "Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting."
      Velho A.M., Jarvis S.M.
      Exp. Cell Res. 315:2312-2321(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiS23A2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGH3
    Secondary accession number(s): B4DJZ1
    , Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3