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Q9UGH3

- S23A2_HUMAN

UniProt

Q9UGH3 - S23A2_HUMAN

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Protein

Solute carrier family 23 member 2

Gene

SLC23A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  1. L-ascorbate:sodium symporter activity Source: Ensembl
  2. L-ascorbic acid transporter activity Source: UniProtKB
  3. nucleobase transmembrane transporter activity Source: ProtInc
  4. sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
  5. sodium-dependent multivitamin transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. L-ascorbic acid metabolic process Source: UniProtKB
  2. L-ascorbic acid transport Source: UniProtKB
  3. molecular hydrogen transport Source: UniProtKB
  4. nucleobase-containing compound metabolic process Source: ProtInc
  5. nucleobase transport Source: ProtInc
  6. response to oxidative stress Source: Ensembl
  7. small molecule metabolic process Source: Reactome
  8. transepithelial L-ascorbic acid transport Source: UniProtKB
  9. vitamin metabolic process Source: Reactome
  10. vitamin transmembrane transport Source: GOC
  11. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Nucleobase transporter-like 1 protein
Sodium-dependent vitamin C transporter 2
Short name:
hSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:SLC23A2
Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:10973. SLC23A2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini9 – 110102CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 1398ExtracellularSequence Analysis
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 1611CytoplasmicSequence Analysis
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 21836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 26627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei267 – 28418HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 2884ExtracellularSequence Analysis
Intramembranei289 – 30214HelicalSequence AnalysisAdd
BLAST
Topological domaini303 – 3097ExtracellularSequence Analysis
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Topological domaini331 – 37141CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Topological domaini393 – 41725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Topological domaini439 – 46123CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 4853ExtracellularSequence Analysis
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Topological domaini507 – 51610CytoplasmicSequence Analysis
Transmembranei517 – 53721HelicalSequence AnalysisAdd
BLAST
Topological domaini538 – 54710ExtracellularSequence Analysis
Transmembranei548 – 56821HelicalSequence AnalysisAdd
BLAST
Topological domaini569 – 65082CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basal plasma membrane Source: Ensembl
  3. basolateral plasma membrane Source: UniProtKB
  4. cytoplasm Source: Ensembl
  5. integral component of membrane Source: UniProtKB
  6. integral component of plasma membrane Source: ProtInc
  7. membrane Source: ProtInc
  8. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 650650Solute carrier family 23 member 2PRO_0000165978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei79 – 791PhosphothreonineBy similarity
Modified residuei81 – 811Phosphoserine1 Publication
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Modified residuei649 – 6491PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UGH3.
PaxDbiQ9UGH3.
PRIDEiQ9UGH3.

PTM databases

PhosphoSiteiQ9UGH3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9UGH3.
CleanExiHS_SLC23A1.
HS_SLC23A2.
ExpressionAtlasiQ9UGH3. baseline and differential.
GenevestigatoriQ9UGH3.

Organism-specific databases

HPAiHPA052825.

Interactioni

Protein-protein interaction databases

BioGridi115287. 5 interactions.
IntActiQ9UGH3. 1 interaction.
STRINGi9606.ENSP00000344322.

Structurei

3D structure databases

ProteinModelPortaliQ9UGH3.
SMRiQ9UGH3. Positions 93-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
GeneTreeiENSGT00390000015686.
HOVERGENiHBG056256.
InParanoidiQ9UGH3.
KOiK14611.
OMAiKHPTFFT.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9UGH3.
TreeFamiTF313272.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UGH3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE
210 220 230 240 250
LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT
260 270 280 290 300
VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK
310 320 330 340 350
KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD
360 370 380 390 400
ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA
410 420 430 440 450
CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI
460 470 480 490 500
TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA
510 520 530 540 550
VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL
560 570 580 590 600
NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES
610 620 630 640 650
YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG
Length:650
Mass (Da):70,337
Last modified:May 1, 2000 - v1
Checksum:i28C9E190D9528D39
GO
Isoform 2 (identifier: Q9UGH3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-275: Missing.

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):58,177
Checksum:iB4CA6A0D1B57592A
GO

Sequence cautioni

The sequence BAA13244.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301P → R in AAD11783. (PubMed:10395795)Curated
Sequence conflicti141 – 1411I → T in AAD11783. (PubMed:10395795)Curated
Sequence conflicti167 – 1671A → T in AAC78806. (PubMed:9804989)Curated
Sequence conflicti182 – 1821L → S in AAD11783. (PubMed:10395795)Curated
Sequence conflicti215 – 2151I → V in AAD11783. (PubMed:10395795)Curated
Sequence conflicti314 – 3141F → L in CAC83100. (PubMed:11396616)Curated
Sequence conflicti418 – 4247GIFVEGL → YVPEKTS(PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 275114Missing in isoform 2. 1 PublicationVSP_056485Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA. Translation: AAC78806.1.
AJ269478 mRNA. Translation: CAB58120.1.
AF164142 mRNA. Translation: AAF80493.1.
AF092511 mRNA. Translation: AAD11783.1.
AJ292318 mRNA. Translation: CAC83100.1.
AY380556 mRNA. Translation: AAQ79775.1.
D87075 mRNA. Translation: BAA13244.2. Different initiation.
AK296304 mRNA. Translation: BAG59003.1.
AL109841 Genomic DNA. No translation available.
AL121890 Genomic DNA. No translation available.
AL389886 Genomic DNA. Translation: CAC16126.1.
BC013112 mRNA. Translation: AAH13112.1.
CCDSiCCDS13085.1. [Q9UGH3-1]
PIRiJC7095.
RefSeqiNP_005107.4. NM_005116.5. [Q9UGH3-1]
NP_976072.1. NM_203327.1. [Q9UGH3-1]
UniGeneiHs.516866.

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057. [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057. [Q9UGH3-1]
GeneIDi9962.
KEGGihsa:9962.
UCSCiuc002wlg.1. human. [Q9UGH3-1]

Polymorphism databases

DMDMi24212469.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA. Translation: AAC78806.1 .
AJ269478 mRNA. Translation: CAB58120.1 .
AF164142 mRNA. Translation: AAF80493.1 .
AF092511 mRNA. Translation: AAD11783.1 .
AJ292318 mRNA. Translation: CAC83100.1 .
AY380556 mRNA. Translation: AAQ79775.1 .
D87075 mRNA. Translation: BAA13244.2 . Different initiation.
AK296304 mRNA. Translation: BAG59003.1 .
AL109841 Genomic DNA. No translation available.
AL121890 Genomic DNA. No translation available.
AL389886 Genomic DNA. Translation: CAC16126.1 .
BC013112 mRNA. Translation: AAH13112.1 .
CCDSi CCDS13085.1. [Q9UGH3-1 ]
PIRi JC7095.
RefSeqi NP_005107.4. NM_005116.5. [Q9UGH3-1 ]
NP_976072.1. NM_203327.1. [Q9UGH3-1 ]
UniGenei Hs.516866.

3D structure databases

ProteinModelPortali Q9UGH3.
SMRi Q9UGH3. Positions 93-528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115287. 5 interactions.
IntActi Q9UGH3. 1 interaction.
STRINGi 9606.ENSP00000344322.

Chemistry

ChEMBLi CHEMBL3271.
GuidetoPHARMACOLOGYi 1042.

Protein family/group databases

TCDBi 2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

PhosphoSitei Q9UGH3.

Polymorphism databases

DMDMi 24212469.

Proteomic databases

MaxQBi Q9UGH3.
PaxDbi Q9UGH3.
PRIDEi Q9UGH3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338244 ; ENSP00000344322 ; ENSG00000089057 . [Q9UGH3-1 ]
ENST00000379333 ; ENSP00000368637 ; ENSG00000089057 . [Q9UGH3-1 ]
GeneIDi 9962.
KEGGi hsa:9962.
UCSCi uc002wlg.1. human. [Q9UGH3-1 ]

Organism-specific databases

CTDi 9962.
GeneCardsi GC20M004781.
HGNCi HGNC:10973. SLC23A2.
HPAi HPA052825.
MIMi 603791. gene.
neXtProti NX_Q9UGH3.
PharmGKBi PA35849.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2233.
GeneTreei ENSGT00390000015686.
HOVERGENi HBG056256.
InParanoidi Q9UGH3.
KOi K14611.
OMAi KHPTFFT.
OrthoDBi EOG7R56RZ.
PhylomeDBi Q9UGH3.
TreeFami TF313272.

Enzyme and pathway databases

Reactomei REACT_11202. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

ChiTaRSi SLC23A2. human.
GeneWikii SLC23A2.
GenomeRNAii 9962.
NextBioi 35472656.
PROi Q9UGH3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UGH3.
CleanExi HS_SLC23A1.
HS_SLC23A2.
ExpressionAtlasi Q9UGH3. baseline and differential.
Genevestigatori Q9UGH3.

Family and domain databases

InterProi IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view ]
PANTHERi PTHR11119. PTHR11119. 1 hit.
Pfami PF00860. Xan_ur_permease. 1 hit.
[Graphical view ]
PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters."
    Faaland C.A., Race J.E., Ricken G., Warner F.J., Williams W.J., Holtzman E.J.
    Biochim. Biophys. Acta 1442:353-360(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function."
    Rajan D.P., Huang W., Dutta B., Devoe L.D., Leibach F.H., Ganapathy V., Prasad P.D.
    Biochem. Biophys. Res. Commun. 262:762-768(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Choriocarcinoma.
  3. "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2."
    Daruwala R.C., Song J., Koh W.S., Rumsey S.C., Levine M.
    FEBS Lett. 460:480-484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals."
    Hogue D.L., Ling V.
    Genomics 59:18-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary carcinoma.
  5. "Vitamin C transport systems of mammalian cells."
    Liang W.J., Johnson D., Jarvis S.M.
    Mol. Membr. Biol. 18:87-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "SVCT2 in ciliated human tracheal epithelial cultures."
    Schwarzer C., Borcanski G., Widdicombe J., Fischer H., Illek B.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Trachea.
  7. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  10. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-424 (ISOFORM 1).
    Tissue: Skin.
  12. "Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting."
    Velho A.M., Jarvis S.M.
    Exp. Cell Res. 315:2312-2321(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiS23A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGH3
Secondary accession number(s): B4DJZ1
, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

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