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Protein

Solute carrier family 23 member 2

Gene

SLC23A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  • L-ascorbate:sodium symporter activity Source: Ensembl
  • L-ascorbic acid transporter activity Source: UniProtKB
  • nucleobase transmembrane transporter activity Source: ProtInc
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
  • sodium-dependent multivitamin transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • L-ascorbic acid metabolic process Source: UniProtKB
  • L-ascorbic acid transport Source: UniProtKB
  • molecular hydrogen transport Source: UniProtKB
  • nucleobase-containing compound metabolic process Source: ProtInc
  • nucleobase transport Source: ProtInc
  • response to oxidative stress Source: Ensembl
  • transepithelial L-ascorbic acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089057-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Nucleobase transporter-like 1 protein
Sodium-dependent vitamin C transporter 2
Short name:
hSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:SLC23A2
Synonyms:KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:10973. SLC23A2.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 218ExtracellularSequence analysisAdd BLAST36
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 266CytoplasmicSequence analysisAdd BLAST27
Transmembranei267 – 284HelicalSequence analysisAdd BLAST18
Topological domaini285 – 288ExtracellularSequence analysis4
Intramembranei289 – 302HelicalSequence analysisAdd BLAST14
Topological domaini303 – 309ExtracellularSequence analysis7
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 371CytoplasmicSequence analysisAdd BLAST41
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 417ExtracellularSequence analysisAdd BLAST25
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 461CytoplasmicSequence analysisAdd BLAST23
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 485ExtracellularSequence analysis3
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 516CytoplasmicSequence analysis10
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 547ExtracellularSequence analysis10
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 650CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: UniProtKB
  • cytoplasm Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9962.
OpenTargetsiENSG00000089057.
PharmGKBiPA35849.

Chemistry databases

ChEMBLiCHEMBL3271.

Polymorphism and mutation databases

BioMutaiSLC23A2.
DMDMi24212469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659781 – 650Solute carrier family 23 member 2Add BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineBy similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei81PhosphoserineCombined sources1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Modified residuei649PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UGH3.
PaxDbiQ9UGH3.
PeptideAtlasiQ9UGH3.
PRIDEiQ9UGH3.

PTM databases

iPTMnetiQ9UGH3.
PhosphoSitePlusiQ9UGH3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000089057.
CleanExiHS_SLC23A1.
HS_SLC23A2.
ExpressionAtlasiQ9UGH3. baseline and differential.
GenevisibleiQ9UGH3. HS.

Organism-specific databases

HPAiHPA052825.
HPA059314.

Interactioni

Protein-protein interaction databases

BioGridi115287. 4 interactors.
IntActiQ9UGH3. 1 interactor.
STRINGi9606.ENSP00000344322.

Structurei

3D structure databases

ProteinModelPortaliQ9UGH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9UGH3.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9UGH3.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GYDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT DVSVANGTAE
210 220 230 240 250
LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK YIGPLTITPT
260 270 280 290 300
VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK
310 320 330 340 350
KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD
360 370 380 390 400
ARQGVLLVAP WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA
410 420 430 440 450
CARLSCAPPP PIHAINRGIF VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI
460 470 480 490 500
TKVGSRRVIQ CGAALMLALG MIGKFSALFA SLPDPVLGAL FCTLFGMITA
510 520 530 540 550
VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV TGITGIDQVL
560 570 580 590 600
NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES
610 620 630 640 650
YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG
Length:650
Mass (Da):70,337
Last modified:May 1, 2000 - v1
Checksum:i28C9E190D9528D39
GO
Isoform 2 (identifier: Q9UGH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-275: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):58,177
Checksum:iB4CA6A0D1B57592A
GO

Sequence cautioni

The sequence BAA13244 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30P → R in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti141I → T in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti167A → T in AAC78806 (PubMed:9804989).Curated1
Sequence conflicti182L → S in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti215I → V in AAD11783 (PubMed:10395795).Curated1
Sequence conflicti314F → L in CAC83100 (PubMed:11396616).Curated1
Sequence conflicti418 – 424GIFVEGL → YVPEKTS (PubMed:15489334).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056485162 – 275Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA. Translation: AAC78806.1.
AJ269478 mRNA. Translation: CAB58120.1.
AF164142 mRNA. Translation: AAF80493.1.
AF092511 mRNA. Translation: AAD11783.1.
AJ292318 mRNA. Translation: CAC83100.1.
AY380556 mRNA. Translation: AAQ79775.1.
D87075 mRNA. Translation: BAA13244.2. Different initiation.
AK296304 mRNA. Translation: BAG59003.1.
AL109841 Genomic DNA. No translation available.
AL121890 Genomic DNA. No translation available.
AL389886 Genomic DNA. Translation: CAC16126.1.
BC013112 mRNA. Translation: AAH13112.1.
CCDSiCCDS13085.1. [Q9UGH3-1]
PIRiJC7095.
RefSeqiNP_005107.4. NM_005116.5. [Q9UGH3-1]
NP_976072.1. NM_203327.1. [Q9UGH3-1]
XP_011527716.1. XM_011529414.2. [Q9UGH3-1]
XP_011527717.1. XM_011529415.2. [Q9UGH3-1]
XP_011527718.1. XM_011529416.2. [Q9UGH3-1]
XP_011527719.1. XM_011529417.2. [Q9UGH3-1]
XP_016883660.1. XM_017028171.1. [Q9UGH3-1]
XP_016883661.1. XM_017028172.1. [Q9UGH3-1]
XP_016883662.1. XM_017028173.1. [Q9UGH3-1]
XP_016883663.1. XM_017028174.1. [Q9UGH3-1]
XP_016883665.1. XM_017028176.1. [Q9UGH3-2]
XP_016883666.1. XM_017028177.1. [Q9UGH3-2]
UniGeneiHs.516866.

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057. [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057. [Q9UGH3-1]
GeneIDi9962.
KEGGihsa:9962.
UCSCiuc002wlg.1. human. [Q9UGH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058319 mRNA. Translation: AAC78806.1.
AJ269478 mRNA. Translation: CAB58120.1.
AF164142 mRNA. Translation: AAF80493.1.
AF092511 mRNA. Translation: AAD11783.1.
AJ292318 mRNA. Translation: CAC83100.1.
AY380556 mRNA. Translation: AAQ79775.1.
D87075 mRNA. Translation: BAA13244.2. Different initiation.
AK296304 mRNA. Translation: BAG59003.1.
AL109841 Genomic DNA. No translation available.
AL121890 Genomic DNA. No translation available.
AL389886 Genomic DNA. Translation: CAC16126.1.
BC013112 mRNA. Translation: AAH13112.1.
CCDSiCCDS13085.1. [Q9UGH3-1]
PIRiJC7095.
RefSeqiNP_005107.4. NM_005116.5. [Q9UGH3-1]
NP_976072.1. NM_203327.1. [Q9UGH3-1]
XP_011527716.1. XM_011529414.2. [Q9UGH3-1]
XP_011527717.1. XM_011529415.2. [Q9UGH3-1]
XP_011527718.1. XM_011529416.2. [Q9UGH3-1]
XP_011527719.1. XM_011529417.2. [Q9UGH3-1]
XP_016883660.1. XM_017028171.1. [Q9UGH3-1]
XP_016883661.1. XM_017028172.1. [Q9UGH3-1]
XP_016883662.1. XM_017028173.1. [Q9UGH3-1]
XP_016883663.1. XM_017028174.1. [Q9UGH3-1]
XP_016883665.1. XM_017028176.1. [Q9UGH3-2]
XP_016883666.1. XM_017028177.1. [Q9UGH3-2]
UniGeneiHs.516866.

3D structure databases

ProteinModelPortaliQ9UGH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115287. 4 interactors.
IntActiQ9UGH3. 1 interactor.
STRINGi9606.ENSP00000344322.

Chemistry databases

ChEMBLiCHEMBL3271.

Protein family/group databases

TCDBi2.A.40.6.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

iPTMnetiQ9UGH3.
PhosphoSitePlusiQ9UGH3.

Polymorphism and mutation databases

BioMutaiSLC23A2.
DMDMi24212469.

Proteomic databases

EPDiQ9UGH3.
PaxDbiQ9UGH3.
PeptideAtlasiQ9UGH3.
PRIDEiQ9UGH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338244; ENSP00000344322; ENSG00000089057. [Q9UGH3-1]
ENST00000379333; ENSP00000368637; ENSG00000089057. [Q9UGH3-1]
GeneIDi9962.
KEGGihsa:9962.
UCSCiuc002wlg.1. human. [Q9UGH3-1]

Organism-specific databases

CTDi9962.
DisGeNETi9962.
GeneCardsiSLC23A2.
HGNCiHGNC:10973. SLC23A2.
HPAiHPA052825.
HPA059314.
MIMi603791. gene.
neXtProtiNX_Q9UGH3.
OpenTargetsiENSG00000089057.
PharmGKBiPA35849.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9UGH3.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9UGH3.
TreeFamiTF313272.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089057-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

ChiTaRSiSLC23A2. human.
GeneWikiiSLC23A2.
GenomeRNAii9962.
PROiQ9UGH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089057.
CleanExiHS_SLC23A1.
HS_SLC23A2.
ExpressionAtlasiQ9UGH3. baseline and differential.
GenevisibleiQ9UGH3. HS.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGH3
Secondary accession number(s): B4DJZ1
, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.