Q9UGF7 (O12D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 12D3

Alternative name(s):
Hs6M1-27
Olfactory receptor OR6-27

Gene names

Name:

OR12D3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Olfactory receptor 12D3		PRO_0000150729
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 97	24	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 215	20	Helical; Name=5; Potential
	Topological domain	216 – 236	21	Cytoplasmic Potential
	Transmembrane	237 – 257	21	Helical; Name=6; Potential
	Topological domain	258 – 270	13	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Name=7; Potential
	Topological domain	292 – 316	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	97	1	T → I. Ref.2 Corresponds to variant rs3749971 [ dbSNP | Ensembl ].		VAR_020383
	Natural variant	250	1	F → L in a breast cancer sample; somatic mutation. Ref.6		VAR_036209
	Natural variant	277	1	Y → H. Corresponds to variant rs9380122 [ dbSNP | Ensembl ].		VAR_053298

Sequences

	Sequence		Length	Mass (Da)
	Q9UGF7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 07FDCF869D8989B2	FASTA	316	35,791
	10 20 30 40 50 60 MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE PQLHSPMYFF 70 80 90 100 110 120 LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH FFHFLGSTEA ILLAIMAFDR 130 140 150 160 170 180 FVAICNPLRY TVIMNPQVCI LLAAAAWLIS FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK 190 200 210 220 230 240 PLLELACSDT LLNQWLLSIV TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC 250 260 270 280 290 300 ASHFMVVCLF YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL 310 KKIFGRKLFK DWQQHH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complex transcription and splicing of odorant receptor genes." Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., Beck S., Ziegler A. J. Biol. Chem. 278:19691-19701(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-97.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-250.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ459858 mRNA. Translation: CAD31041.1. AL096770 Genomic DNA. Translation: CAB65796.1. AL662781 Genomic DNA. Translation: CAI18132.1. BC069082 mRNA. Translation: AAH69082.1. BC069154 mRNA. Translation: AAH69154.1. BC103892 mRNA. Translation: AAI03893.1. BC106898 mRNA. No translation available. BK004439 Genomic DNA. Translation: DAA04837.1.
IPI	IPI00005290.
RefSeq	NP_112221.1. NM_030959.2.
UniGene	Hs.272280.
3D structure databases
ProteinModelPortal	Q9UGF7.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423826.
Proteomic databases
PaxDb	Q9UGF7.
PRIDE	Q9UGF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377143; ENSP00000366348; ENSG00000112462. ENST00000383556; ENSP00000373048; ENSG00000204692. ENST00000396806; ENSP00000380023; ENSG00000112462. ENST00000430148; ENSP00000393734; ENSG00000224487. ENST00000505384; ENSP00000421215; ENSG00000242022. ENST00000550681; ENSP00000449350; ENSG00000204692. ENST00000550913; ENSP00000447580; ENSG00000224487. ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneID	81797.
KEGG	hsa:81797.
UCSC	uc003nme.3. human.
Organism-specific databases
CTD	81797.
GeneCards	GC06M029346.
H-InvDB	HIX0166575. HIX0166829.
HGNC	HGNC:13963. OR12D3.
neXtProt	NX_Q9UGF7.
PharmGKB	PA32029.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303914.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
KO	K04257.
OMA	VTTMNEF.
OrthoDB	EOG43TZW2.
PhylomeDB	Q9UGF7.
Gene expression databases
ArrayExpress	Q9UGF7.
Bgee	Q9UGF7.
CleanEx	HS_OR12D3.
Genevestigator	Q9UGF7.
GermOnline	ENSG00000204692. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81797.
NextBio	72118.

Entry information

Entry name

O12D3_HUMAN

Accession

Primary (citable) accession number: Q9UGF7
Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.