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Protein

Olfactory receptor 12D3

Gene

OR12D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112462-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D3
Alternative name(s):
Hs6M1-27
Olfactory receptor OR6-27
Gene namesi
Name:OR12D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13963. OR12D3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 316CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81797.
OpenTargetsiENSG00000112462.
ENSG00000204692.
ENSG00000224487.
ENSG00000242022.
PharmGKBiPA32029.

Polymorphism and mutation databases

BioMutaiOR12D3.
DMDMi14423826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507291 – 316Olfactory receptor 12D3Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGF7.
PeptideAtlasiQ9UGF7.
PRIDEiQ9UGF7.

Expressioni

Gene expression databases

BgeeiENSG00000112462.
CleanExiHS_OR12D3.
ExpressionAtlasiQ9UGF7. baseline.
GenevisibleiQ9UGF7. HS.

Organism-specific databases

HPAiCAB025163.

Structurei

3D structure databases

ProteinModelPortaliQ9UGF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH3D. Eukaryota.
ENOG410YBP5. LUCA.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF7.
KOiK04257.
OMAiQMCILLA.
OrthoDBiEOG091G0CKO.
PhylomeDBiQ9UGF7.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE
60 70 80 90 100
PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH
110 120 130 140 150
FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS
160 170 180 190 200
FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV
210 220 230 240 250
TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF
260 270 280 290 300
YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL
310
KKIFGRKLFK DWQQHH
Length:316
Mass (Da):35,791
Last modified:May 1, 2000 - v1
Checksum:i07FDCF869D8989B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02038397T → I.1 PublicationCorresponds to variant rs3749971dbSNPEnsembl.1
Natural variantiVAR_036209250F → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs545611345dbSNPEnsembl.1
Natural variantiVAR_053298277Y → H.Corresponds to variant rs9380122dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA. Translation: CAD31041.1.
AL096770 Genomic DNA. Translation: CAB65796.1.
AL662781 Genomic DNA. Translation: CAI18132.1.
BC069082 mRNA. Translation: AAH69082.1.
BC069154 mRNA. Translation: AAH69154.1.
BC103892 mRNA. Translation: AAI03893.1.
BC106898 mRNA. No translation available.
BK004439 Genomic DNA. Translation: DAA04837.1.
CCDSiCCDS4658.1.
RefSeqiNP_112221.1. NM_030959.2.
UniGeneiHs.272280.

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692.
ENST00000396806; ENSP00000380023; ENSG00000112462.
ENST00000430148; ENSP00000393734; ENSG00000224487.
ENST00000505384; ENSP00000421215; ENSG00000242022.
ENST00000550681; ENSP00000449350; ENSG00000204692.
ENST00000550913; ENSP00000447580; ENSG00000224487.
ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneIDi81797.
KEGGihsa:81797.
UCSCiuc003nme.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA. Translation: CAD31041.1.
AL096770 Genomic DNA. Translation: CAB65796.1.
AL662781 Genomic DNA. Translation: CAI18132.1.
BC069082 mRNA. Translation: AAH69082.1.
BC069154 mRNA. Translation: AAH69154.1.
BC103892 mRNA. Translation: AAI03893.1.
BC106898 mRNA. No translation available.
BK004439 Genomic DNA. Translation: DAA04837.1.
CCDSiCCDS4658.1.
RefSeqiNP_112221.1. NM_030959.2.
UniGeneiHs.272280.

3D structure databases

ProteinModelPortaliQ9UGF7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR12D3.
DMDMi14423826.

Proteomic databases

PaxDbiQ9UGF7.
PeptideAtlasiQ9UGF7.
PRIDEiQ9UGF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692.
ENST00000396806; ENSP00000380023; ENSG00000112462.
ENST00000430148; ENSP00000393734; ENSG00000224487.
ENST00000505384; ENSP00000421215; ENSG00000242022.
ENST00000550681; ENSP00000449350; ENSG00000204692.
ENST00000550913; ENSP00000447580; ENSG00000224487.
ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneIDi81797.
KEGGihsa:81797.
UCSCiuc003nme.3. human.

Organism-specific databases

CTDi81797.
DisGeNETi81797.
GeneCardsiOR12D3.
H-InvDBHIX0166575.
HIX0166829.
HGNCiHGNC:13963. OR12D3.
HPAiCAB025163.
neXtProtiNX_Q9UGF7.
OpenTargetsiENSG00000112462.
ENSG00000204692.
ENSG00000224487.
ENSG00000242022.
PharmGKBiPA32029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3D. Eukaryota.
ENOG410YBP5. LUCA.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF7.
KOiK04257.
OMAiQMCILLA.
OrthoDBiEOG091G0CKO.
PhylomeDBiQ9UGF7.
TreeFamiTF338273.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112462-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR12D3.
GenomeRNAii81797.
PROiQ9UGF7.

Gene expression databases

BgeeiENSG00000112462.
CleanExiHS_OR12D3.
ExpressionAtlasiQ9UGF7. baseline.
GenevisibleiQ9UGF7. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO12D3_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF7
Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.