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Protein

Olfactory receptor 12D3

Gene

OR12D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D3
Alternative name(s):
Hs6M1-27
Olfactory receptor OR6-27
Gene namesi
Name:OR12D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:13963. OR12D3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21520Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31625CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 12D3PRO_0000150729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGF7.
PRIDEiQ9UGF7.

Expressioni

Gene expression databases

BgeeiQ9UGF7.
CleanExiHS_OR12D3.
ExpressionAtlasiQ9UGF7. differential.
GenevestigatoriQ9UGF7.

Structurei

3D structure databases

ProteinModelPortaliQ9UGF7.
SMRiQ9UGF7. Positions 25-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303914.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF7.
KOiK04257.
OMAiWITSIFN.
OrthoDBiEOG7V766W.
PhylomeDBiQ9UGF7.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE
60 70 80 90 100
PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH
110 120 130 140 150
FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS
160 170 180 190 200
FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV
210 220 230 240 250
TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF
260 270 280 290 300
YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL
310
KKIFGRKLFK DWQQHH
Length:316
Mass (Da):35,791
Last modified:May 1, 2000 - v1
Checksum:i07FDCF869D8989B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971T → I.1 Publication
Corresponds to variant rs3749971 [ dbSNP | Ensembl ].
VAR_020383
Natural varianti250 – 2501F → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036209
Natural varianti277 – 2771Y → H.
Corresponds to variant rs9380122 [ dbSNP | Ensembl ].
VAR_053298

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA. Translation: CAD31041.1.
AL096770 Genomic DNA. Translation: CAB65796.1.
AL662781 Genomic DNA. Translation: CAI18132.1.
BC069082 mRNA. Translation: AAH69082.1.
BC069154 mRNA. Translation: AAH69154.1.
BC103892 mRNA. Translation: AAI03893.1.
BC106898 mRNA. No translation available.
BK004439 Genomic DNA. Translation: DAA04837.1.
CCDSiCCDS4658.1.
RefSeqiNP_112221.1. NM_030959.2.
UniGeneiHs.272280.

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692.
ENST00000396806; ENSP00000380023; ENSG00000112462.
ENST00000430148; ENSP00000393734; ENSG00000224487.
ENST00000505384; ENSP00000421215; ENSG00000242022.
ENST00000550681; ENSP00000449350; ENSG00000204692.
ENST00000550913; ENSP00000447580; ENSG00000224487.
ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneIDi81797.
KEGGihsa:81797.
UCSCiuc003nme.3. human.

Polymorphism databases

DMDMi14423826.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459858 mRNA. Translation: CAD31041.1.
AL096770 Genomic DNA. Translation: CAB65796.1.
AL662781 Genomic DNA. Translation: CAI18132.1.
BC069082 mRNA. Translation: AAH69082.1.
BC069154 mRNA. Translation: AAH69154.1.
BC103892 mRNA. Translation: AAI03893.1.
BC106898 mRNA. No translation available.
BK004439 Genomic DNA. Translation: DAA04837.1.
CCDSiCCDS4658.1.
RefSeqiNP_112221.1. NM_030959.2.
UniGeneiHs.272280.

3D structure databases

ProteinModelPortaliQ9UGF7.
SMRiQ9UGF7. Positions 25-303.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi14423826.

Proteomic databases

PaxDbiQ9UGF7.
PRIDEiQ9UGF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383556; ENSP00000373048; ENSG00000204692.
ENST00000396806; ENSP00000380023; ENSG00000112462.
ENST00000430148; ENSP00000393734; ENSG00000224487.
ENST00000505384; ENSP00000421215; ENSG00000242022.
ENST00000550681; ENSP00000449350; ENSG00000204692.
ENST00000550913; ENSP00000447580; ENSG00000224487.
ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneIDi81797.
KEGGihsa:81797.
UCSCiuc003nme.3. human.

Organism-specific databases

CTDi81797.
GeneCardsiGC06M029346.
GC06Mk29341.
GC06Ml29340.
GC06Mm29341.
H-InvDBHIX0166575.
HIX0166829.
HGNCiHGNC:13963. OR12D3.
neXtProtiNX_Q9UGF7.
PharmGKBiPA32029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303914.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF7.
KOiK04257.
OMAiWITSIFN.
OrthoDBiEOG7V766W.
PhylomeDBiQ9UGF7.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR12D3.
GenomeRNAii81797.
NextBioi72118.
PROiQ9UGF7.

Gene expression databases

BgeeiQ9UGF7.
CleanExiHS_OR12D3.
ExpressionAtlasiQ9UGF7. differential.
GenevestigatoriQ9UGF7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-97.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-250.

Entry informationi

Entry nameiO12D3_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF7
Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.