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Q9UGF7 (O12D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 12D3
Alternative name(s):
Hs6M1-27
Olfactory receptor OR6-27
Gene names
Name:OR12D3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 12D3
PRO_0000150729

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9724Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21520Helical; Name=5; Potential
Topological domain216 – 23621Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 31625Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant971T → I. Ref.2
Corresponds to variant rs3749971 [ dbSNP | Ensembl ].
VAR_020383
Natural variant2501F → L in a breast cancer sample; somatic mutation. Ref.6
VAR_036209
Natural variant2771Y → H.
Corresponds to variant rs9380122 [ dbSNP | Ensembl ].
VAR_053298

Sequences

Sequence LengthMass (Da)Tools
Q9UGF7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 07FDCF869D8989B2

FASTA31635,791
        10         20         30         40         50         60 
MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE PQLHSPMYFF 

        70         80         90        100        110        120 
LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH FFHFLGSTEA ILLAIMAFDR 

       130        140        150        160        170        180 
FVAICNPLRY TVIMNPQVCI LLAAAAWLIS FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK 

       190        200        210        220        230        240 
PLLELACSDT LLNQWLLSIV TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC 

       250        260        270        280        290        300 
ASHFMVVCLF YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL 

       310 
KKIFGRKLFK DWQQHH 

« Hide

References

« Hide 'large scale' references
[1]"Complex transcription and splicing of odorant receptor genes."
Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D., Beck S., Ziegler A.
J. Biol. Chem. 278:19691-19701(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-97.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-250.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ459858 mRNA. Translation: CAD31041.1.
AL096770 Genomic DNA. Translation: CAB65796.1.
AL662781 Genomic DNA. Translation: CAI18132.1.
BC069082 mRNA. Translation: AAH69082.1.
BC069154 mRNA. Translation: AAH69154.1.
BC103892 mRNA. Translation: AAI03893.1.
BC106898 mRNA. No translation available.
BK004439 Genomic DNA. Translation: DAA04837.1.
RefSeqNP_112221.1. NM_030959.2.
UniGeneHs.272280.

3D structure databases

ProteinModelPortalQ9UGF7.
SMRQ9UGF7. Positions 25-305.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423826.

Proteomic databases

PaxDbQ9UGF7.
PRIDEQ9UGF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383556; ENSP00000373048; ENSG00000204692.
ENST00000396806; ENSP00000380023; ENSG00000112462.
ENST00000430148; ENSP00000393734; ENSG00000224487.
ENST00000505384; ENSP00000421215; ENSG00000242022.
ENST00000550681; ENSP00000449350; ENSG00000204692.
ENST00000550913; ENSP00000447580; ENSG00000224487.
ENST00000552446; ENSP00000447204; ENSG00000242022.
GeneID81797.
KEGGhsa:81797.
UCSCuc003nme.3. human.

Organism-specific databases

CTD81797.
GeneCardsGC06M029346.
GC06Mk29341.
GC06Ml29340.
GC06Mm29341.
H-InvDBHIX0166575.
HIX0166829.
HGNCHGNC:13963. OR12D3.
neXtProtNX_Q9UGF7.
PharmGKBPA32029.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303914.
HOGENOMHOG000041362.
HOVERGENHBG017625.
KOK04257.
OMAQMCILLA.
OrthoDBEOG7V766W.
PhylomeDBQ9UGF7.
TreeFamTF338273.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9UGF7.
BgeeQ9UGF7.
CleanExHS_OR12D3.
GenevestigatorQ9UGF7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR12D3.
GenomeRNAi81797.
NextBio72118.
PROQ9UGF7.

Entry information

Entry nameO12D3_HUMAN
AccessionPrimary (citable) accession number: Q9UGF7
Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries