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Q9UGF7

- O12D3_HUMAN

UniProt

Q9UGF7 - O12D3_HUMAN

Protein

Olfactory receptor 12D3

Gene

OR12D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 12D3
    Alternative name(s):
    Hs6M1-27
    Olfactory receptor OR6-27
    Gene namesi
    Name:OR12D3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13963. OR12D3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32029.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 12D3PRO_0000150729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UGF7.
    PRIDEiQ9UGF7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UGF7.
    BgeeiQ9UGF7.
    CleanExiHS_OR12D3.
    GenevestigatoriQ9UGF7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UGF7.
    SMRiQ9UGF7. Positions 25-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31625CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21520Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303914.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiQMCILLA.
    OrthoDBiEOG7V766W.
    PhylomeDBiQ9UGF7.
    TreeFamiTF338273.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UGF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE    50
    PQLHSPMYFF LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH 100
    FFHFLGSTEA ILLAIMAFDR FVAICNPLRY TVIMNPQVCI LLAAAAWLIS 150
    FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK PLLELACSDT LLNQWLLSIV 200
    TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC ASHFMVVCLF 250
    YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL 300
    KKIFGRKLFK DWQQHH 316
    Length:316
    Mass (Da):35,791
    Last modified:May 1, 2000 - v1
    Checksum:i07FDCF869D8989B2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971T → I.1 Publication
    Corresponds to variant rs3749971 [ dbSNP | Ensembl ].
    VAR_020383
    Natural varianti250 – 2501F → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036209
    Natural varianti277 – 2771Y → H.
    Corresponds to variant rs9380122 [ dbSNP | Ensembl ].
    VAR_053298

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459858 mRNA. Translation: CAD31041.1.
    AL096770 Genomic DNA. Translation: CAB65796.1.
    AL662781 Genomic DNA. Translation: CAI18132.1.
    BC069082 mRNA. Translation: AAH69082.1.
    BC069154 mRNA. Translation: AAH69154.1.
    BC103892 mRNA. Translation: AAI03893.1.
    BC106898 mRNA. No translation available.
    BK004439 Genomic DNA. Translation: DAA04837.1.
    CCDSiCCDS4658.1.
    RefSeqiNP_112221.1. NM_030959.2.
    UniGeneiHs.272280.

    Genome annotation databases

    EnsembliENST00000383556; ENSP00000373048; ENSG00000204692.
    ENST00000396806; ENSP00000380023; ENSG00000112462.
    ENST00000430148; ENSP00000393734; ENSG00000224487.
    ENST00000505384; ENSP00000421215; ENSG00000242022.
    ENST00000550681; ENSP00000449350; ENSG00000204692.
    ENST00000550913; ENSP00000447580; ENSG00000224487.
    ENST00000552446; ENSP00000447204; ENSG00000242022.
    GeneIDi81797.
    KEGGihsa:81797.
    UCSCiuc003nme.3. human.

    Polymorphism databases

    DMDMi14423826.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459858 mRNA. Translation: CAD31041.1 .
    AL096770 Genomic DNA. Translation: CAB65796.1 .
    AL662781 Genomic DNA. Translation: CAI18132.1 .
    BC069082 mRNA. Translation: AAH69082.1 .
    BC069154 mRNA. Translation: AAH69154.1 .
    BC103892 mRNA. Translation: AAI03893.1 .
    BC106898 mRNA. No translation available.
    BK004439 Genomic DNA. Translation: DAA04837.1 .
    CCDSi CCDS4658.1.
    RefSeqi NP_112221.1. NM_030959.2.
    UniGenei Hs.272280.

    3D structure databases

    ProteinModelPortali Q9UGF7.
    SMRi Q9UGF7. Positions 25-303.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423826.

    Proteomic databases

    PaxDbi Q9UGF7.
    PRIDEi Q9UGF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383556 ; ENSP00000373048 ; ENSG00000204692 .
    ENST00000396806 ; ENSP00000380023 ; ENSG00000112462 .
    ENST00000430148 ; ENSP00000393734 ; ENSG00000224487 .
    ENST00000505384 ; ENSP00000421215 ; ENSG00000242022 .
    ENST00000550681 ; ENSP00000449350 ; ENSG00000204692 .
    ENST00000550913 ; ENSP00000447580 ; ENSG00000224487 .
    ENST00000552446 ; ENSP00000447204 ; ENSG00000242022 .
    GeneIDi 81797.
    KEGGi hsa:81797.
    UCSCi uc003nme.3. human.

    Organism-specific databases

    CTDi 81797.
    GeneCardsi GC06M029346.
    GC06Mk29341.
    GC06Ml29340.
    GC06Mm29341.
    H-InvDB HIX0166575.
    HIX0166829.
    HGNCi HGNC:13963. OR12D3.
    neXtProti NX_Q9UGF7.
    PharmGKBi PA32029.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303914.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi QMCILLA.
    OrthoDBi EOG7V766W.
    PhylomeDBi Q9UGF7.
    TreeFami TF338273.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR12D3.
    GenomeRNAii 81797.
    NextBioi 72118.
    PROi Q9UGF7.

    Gene expression databases

    ArrayExpressi Q9UGF7.
    Bgeei Q9UGF7.
    CleanExi HS_OR12D3.
    Genevestigatori Q9UGF7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-97.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-250.

    Entry informationi

    Entry nameiO12D3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGF7
    Secondary accession number(s): A2BDZ1, Q5SQI8, Q6IF23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3