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Protein

Olfactory receptor 5V1

Gene

OR5V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112461-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5V1
Alternative name(s):
Hs6M1-21
Olfactory receptor OR6-26
Gene namesi
Name:OR5V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13972. OR5V1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 321CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81696.
OpenTargetsiENSG00000233046.
ENSG00000243441.
ENSG00000243729.
PharmGKBiPA32570.

Polymorphism and mutation databases

BioMutaiOR5V1.
DMDMi14423825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506171 – 321Olfactory receptor 5V1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGF6.
PeptideAtlasiQ9UGF6.
PRIDEiQ9UGF6.

PTM databases

iPTMnetiQ9UGF6.
PhosphoSitePlusiQ9UGF6.

Expressioni

Gene expression databases

CleanExiHS_OR5V1.
ExpressionAtlasiQ9UGF6. baseline and differential.
GenevisibleiQ9UGF6. HS.

Organism-specific databases

HPAiHPA046707.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366356.

Structurei

3D structure databases

ProteinModelPortaliQ9UGF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ2. Eukaryota.
ENOG410YFRI. LUCA.
GeneTreeiENSGT00840000129837.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF6.
KOiK04257.
OMAiPNELQFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9UGF6.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKNQTAIT EFIILGFSNL NELQFLLFTI FFLTYFCTLG GNILIILTTV
60 70 80 90 100
TDPHLHTPMY YFLGNLAFID ICYTTSNVPQ MMVHLLSKKK SISYVGCVVQ
110 120 130 140 150
LFAFVFFVGS ECLLLAAMAY DRYIAICNPL RYSVILSKVL CNQLAASCWA
160 170 180 190 200
AGFLNSVVHT VLTFCLPFCG NNQINYFFCD IPPLLILSCG NTSVNELALL
210 220 230 240 250
STGVFIGWTP FLCIVLSYIC IISTILRIQS SEGRRKAFST CASHLAIVFL
260 270 280 290 300
FYGSAIFTYV RPISTYSLKK DRLVSVLYSV VTPMLNPIIY TLRNKDIKEA
310 320
VKTIGSKWQP PISSLDSKLT Y
Length:321
Mass (Da):36,057
Last modified:May 1, 2000 - v1
Checksum:iAAC426FDCF58E375
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112C → R in CAD31042 (PubMed:12637542).Curated1
Sequence conflicti116A → T in CAD31042 (PubMed:12637542).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05321123L → W.2 PublicationsCorresponds to variant rs6930033dbSNPEnsembl.1
Natural variantiVAR_05321245I → M.1 PublicationCorresponds to variant rs9257770dbSNPEnsembl.1
Natural variantiVAR_064740136L → P Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459859 mRNA. Translation: CAD31042.1.
BX005133 Genomic DNA. Translation: CAM25847.1.
BX927232 Genomic DNA. Translation: CAQ08989.1.
AL096770 Genomic DNA. Translation: CAB65797.1.
AL732432 Genomic DNA. Translation: CAI17829.1.
AL662781 Genomic DNA. Translation: CAI18131.1.
CR759808 Genomic DNA. Translation: CAQ07996.1.
CH471081 Genomic DNA. Translation: EAX03189.1.
BC069149 mRNA. Translation: AAH69149.1.
BK004440 Genomic DNA. Translation: DAA04838.1.
CCDSiCCDS4657.1.
RefSeqiNP_110503.3. NM_030876.5.
XP_011513231.1. XM_011514929.2.
XP_011513232.1. XM_011514930.2.
UniGeneiHs.666316.

Genome annotation databases

EnsembliENST00000230223; ENSP00000230223; ENSG00000112461.
ENST00000377154; ENSP00000366359; ENSG00000243729.
ENST00000400698; ENSP00000383534; ENSG00000112461.
ENST00000418692; ENSP00000415545; ENSG00000227137.
ENST00000421859; ENSP00000412591; ENSG00000227137.
ENST00000441440; ENSP00000404163; ENSG00000233046.
ENST00000444009; ENSP00000407363; ENSG00000243441.
ENST00000446761; ENSP00000404109; ENSG00000233046.
ENST00000458372; ENSP00000404990; ENSG00000243441.
ENST00000543825; ENSP00000443309; ENSG00000243729.
ENST00000548546; ENSP00000449041; ENSG00000227137.
ENST00000549299; ENSP00000450230; ENSG00000233046.
ENST00000550240; ENSP00000446579; ENSG00000243441.
GeneIDi81696.
KEGGihsa:81696.
UCSCiuc011dlo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459859 mRNA. Translation: CAD31042.1.
BX005133 Genomic DNA. Translation: CAM25847.1.
BX927232 Genomic DNA. Translation: CAQ08989.1.
AL096770 Genomic DNA. Translation: CAB65797.1.
AL732432 Genomic DNA. Translation: CAI17829.1.
AL662781 Genomic DNA. Translation: CAI18131.1.
CR759808 Genomic DNA. Translation: CAQ07996.1.
CH471081 Genomic DNA. Translation: EAX03189.1.
BC069149 mRNA. Translation: AAH69149.1.
BK004440 Genomic DNA. Translation: DAA04838.1.
CCDSiCCDS4657.1.
RefSeqiNP_110503.3. NM_030876.5.
XP_011513231.1. XM_011514929.2.
XP_011513232.1. XM_011514930.2.
UniGeneiHs.666316.

3D structure databases

ProteinModelPortaliQ9UGF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366356.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UGF6.
PhosphoSitePlusiQ9UGF6.

Polymorphism and mutation databases

BioMutaiOR5V1.
DMDMi14423825.

Proteomic databases

PaxDbiQ9UGF6.
PeptideAtlasiQ9UGF6.
PRIDEiQ9UGF6.

Protocols and materials databases

DNASUi81696.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230223; ENSP00000230223; ENSG00000112461.
ENST00000377154; ENSP00000366359; ENSG00000243729.
ENST00000400698; ENSP00000383534; ENSG00000112461.
ENST00000418692; ENSP00000415545; ENSG00000227137.
ENST00000421859; ENSP00000412591; ENSG00000227137.
ENST00000441440; ENSP00000404163; ENSG00000233046.
ENST00000444009; ENSP00000407363; ENSG00000243441.
ENST00000446761; ENSP00000404109; ENSG00000233046.
ENST00000458372; ENSP00000404990; ENSG00000243441.
ENST00000543825; ENSP00000443309; ENSG00000243729.
ENST00000548546; ENSP00000449041; ENSG00000227137.
ENST00000549299; ENSP00000450230; ENSG00000233046.
ENST00000550240; ENSP00000446579; ENSG00000243441.
GeneIDi81696.
KEGGihsa:81696.
UCSCiuc011dlo.2. human.

Organism-specific databases

CTDi81696.
DisGeNETi81696.
GeneCardsiOR5V1.
HGNCiHGNC:13972. OR5V1.
HPAiHPA046707.
neXtProtiNX_Q9UGF6.
OpenTargetsiENSG00000233046.
ENSG00000243441.
ENSG00000243729.
PharmGKBiPA32570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ2. Eukaryota.
ENOG410YFRI. LUCA.
GeneTreeiENSGT00840000129837.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF6.
KOiK04257.
OMAiPNELQFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9UGF6.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112461-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5V1.
GenomeRNAii81696.
PROiQ9UGF6.

Gene expression databases

CleanExiHS_OR5V1.
ExpressionAtlasiQ9UGF6. baseline and differential.
GenevisibleiQ9UGF6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5V1_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF6
Secondary accession number(s): A2BDZ0
, B0S860, Q5SQI9, Q6NTB5, Q8IVL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.