Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 5V1

Gene

OR5V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5V1
Alternative name(s):
Hs6M1-21
Olfactory receptor OR6-26
Gene namesi
Name:OR5V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13972. OR5V1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32129CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32570.

Polymorphism and mutation databases

BioMutaiOR5V1.
DMDMi14423825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 5V1PRO_0000150617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGF6.
PeptideAtlasiQ9UGF6.
PRIDEiQ9UGF6.

PTM databases

iPTMnetiQ9UGF6.
PhosphoSiteiQ9UGF6.

Expressioni

Gene expression databases

CleanExiHS_OR5V1.
GenevisibleiQ9UGF6. HS.

Organism-specific databases

HPAiHPA046707.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366356.

Structurei

3D structure databases

ProteinModelPortaliQ9UGF6.
SMRiQ9UGF6. Positions 41-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ2. Eukaryota.
ENOG410YFRI. LUCA.
GeneTreeiENSGT00840000129837.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF6.
KOiK04257.
OMAiPNELQFL.
OrthoDBiEOG71K63J.
PhylomeDBiQ9UGF6.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKNQTAIT EFIILGFSNL NELQFLLFTI FFLTYFCTLG GNILIILTTV
60 70 80 90 100
TDPHLHTPMY YFLGNLAFID ICYTTSNVPQ MMVHLLSKKK SISYVGCVVQ
110 120 130 140 150
LFAFVFFVGS ECLLLAAMAY DRYIAICNPL RYSVILSKVL CNQLAASCWA
160 170 180 190 200
AGFLNSVVHT VLTFCLPFCG NNQINYFFCD IPPLLILSCG NTSVNELALL
210 220 230 240 250
STGVFIGWTP FLCIVLSYIC IISTILRIQS SEGRRKAFST CASHLAIVFL
260 270 280 290 300
FYGSAIFTYV RPISTYSLKK DRLVSVLYSV VTPMLNPIIY TLRNKDIKEA
310 320
VKTIGSKWQP PISSLDSKLT Y
Length:321
Mass (Da):36,057
Last modified:May 1, 2000 - v1
Checksum:iAAC426FDCF58E375
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121C → R in CAD31042 (PubMed:12637542).Curated
Sequence conflicti116 – 1161A → T in CAD31042 (PubMed:12637542).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231L → W.2 Publications
Corresponds to variant rs6930033 [ dbSNP | Ensembl ].
VAR_053211
Natural varianti45 – 451I → M.1 Publication
Corresponds to variant rs9257770 [ dbSNP | Ensembl ].
VAR_053212
Natural varianti136 – 1361L → P Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064740

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459859 mRNA. Translation: CAD31042.1.
BX005133 Genomic DNA. Translation: CAM25847.1.
BX927232 Genomic DNA. Translation: CAQ08989.1.
AL096770 Genomic DNA. Translation: CAB65797.1.
AL732432 Genomic DNA. Translation: CAI17829.1.
AL662781 Genomic DNA. Translation: CAI18131.1.
CR759808 Genomic DNA. Translation: CAQ07996.1.
CH471081 Genomic DNA. Translation: EAX03189.1.
BC069149 mRNA. Translation: AAH69149.1.
BK004440 Genomic DNA. Translation: DAA04838.1.
CCDSiCCDS4657.1.
RefSeqiNP_110503.3. NM_030876.5.
XP_011513231.1. XM_011514929.1.
XP_011513232.1. XM_011514930.1.
XP_011513233.1. XM_011514931.1.
XP_011513234.1. XM_011514932.1.
XP_011545624.1. XM_011547322.1.
XP_011545625.1. XM_011547323.1.
XP_011545626.1. XM_011547324.1.
XP_011545627.1. XM_011547325.1.
XP_011546240.1. XM_011547938.1.
XP_011546241.1. XM_011547939.1.
XP_011546242.1. XM_011547940.1.
XP_011546243.1. XM_011547941.1.
XP_011546411.1. XM_011548109.1.
XP_011546412.1. XM_011548110.1.
XP_011546413.1. XM_011548111.1.
UniGeneiHs.666316.

Genome annotation databases

EnsembliENST00000230223; ENSP00000230223; ENSG00000112461.
ENST00000377154; ENSP00000366359; ENSG00000243729.
ENST00000400698; ENSP00000383534; ENSG00000112461.
ENST00000418692; ENSP00000415545; ENSG00000227137.
ENST00000421859; ENSP00000412591; ENSG00000227137.
ENST00000441440; ENSP00000404163; ENSG00000233046.
ENST00000444009; ENSP00000407363; ENSG00000243441.
ENST00000446761; ENSP00000404109; ENSG00000233046.
ENST00000458372; ENSP00000404990; ENSG00000243441.
ENST00000543825; ENSP00000443309; ENSG00000243729.
ENST00000548546; ENSP00000449041; ENSG00000227137.
ENST00000549299; ENSP00000450230; ENSG00000233046.
ENST00000550240; ENSP00000446579; ENSG00000243441.
GeneIDi81696.
KEGGihsa:81696.
UCSCiuc011dlo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459859 mRNA. Translation: CAD31042.1.
BX005133 Genomic DNA. Translation: CAM25847.1.
BX927232 Genomic DNA. Translation: CAQ08989.1.
AL096770 Genomic DNA. Translation: CAB65797.1.
AL732432 Genomic DNA. Translation: CAI17829.1.
AL662781 Genomic DNA. Translation: CAI18131.1.
CR759808 Genomic DNA. Translation: CAQ07996.1.
CH471081 Genomic DNA. Translation: EAX03189.1.
BC069149 mRNA. Translation: AAH69149.1.
BK004440 Genomic DNA. Translation: DAA04838.1.
CCDSiCCDS4657.1.
RefSeqiNP_110503.3. NM_030876.5.
XP_011513231.1. XM_011514929.1.
XP_011513232.1. XM_011514930.1.
XP_011513233.1. XM_011514931.1.
XP_011513234.1. XM_011514932.1.
XP_011545624.1. XM_011547322.1.
XP_011545625.1. XM_011547323.1.
XP_011545626.1. XM_011547324.1.
XP_011545627.1. XM_011547325.1.
XP_011546240.1. XM_011547938.1.
XP_011546241.1. XM_011547939.1.
XP_011546242.1. XM_011547940.1.
XP_011546243.1. XM_011547941.1.
XP_011546411.1. XM_011548109.1.
XP_011546412.1. XM_011548110.1.
XP_011546413.1. XM_011548111.1.
UniGeneiHs.666316.

3D structure databases

ProteinModelPortaliQ9UGF6.
SMRiQ9UGF6. Positions 41-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366356.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UGF6.
PhosphoSiteiQ9UGF6.

Polymorphism and mutation databases

BioMutaiOR5V1.
DMDMi14423825.

Proteomic databases

PaxDbiQ9UGF6.
PeptideAtlasiQ9UGF6.
PRIDEiQ9UGF6.

Protocols and materials databases

DNASUi81696.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230223; ENSP00000230223; ENSG00000112461.
ENST00000377154; ENSP00000366359; ENSG00000243729.
ENST00000400698; ENSP00000383534; ENSG00000112461.
ENST00000418692; ENSP00000415545; ENSG00000227137.
ENST00000421859; ENSP00000412591; ENSG00000227137.
ENST00000441440; ENSP00000404163; ENSG00000233046.
ENST00000444009; ENSP00000407363; ENSG00000243441.
ENST00000446761; ENSP00000404109; ENSG00000233046.
ENST00000458372; ENSP00000404990; ENSG00000243441.
ENST00000543825; ENSP00000443309; ENSG00000243729.
ENST00000548546; ENSP00000449041; ENSG00000227137.
ENST00000549299; ENSP00000450230; ENSG00000233046.
ENST00000550240; ENSP00000446579; ENSG00000243441.
GeneIDi81696.
KEGGihsa:81696.
UCSCiuc011dlo.2. human.

Organism-specific databases

CTDi81696.
GeneCardsiOR5V1.
HGNCiHGNC:13972. OR5V1.
HPAiHPA046707.
neXtProtiNX_Q9UGF6.
PharmGKBiPA32570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ2. Eukaryota.
ENOG410YFRI. LUCA.
GeneTreeiENSGT00840000129837.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9UGF6.
KOiK04257.
OMAiPNELQFL.
OrthoDBiEOG71K63J.
PhylomeDBiQ9UGF6.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5V1.
GenomeRNAii81696.
PROiQ9UGF6.

Gene expression databases

CleanExiHS_OR5V1.
GenevisibleiQ9UGF6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TRP-23 AND MET-45.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-23.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. Cited for: VARIANT PRO-136.

Entry informationi

Entry nameiOR5V1_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF6
Secondary accession number(s): A2BDZ0
, B0S860, Q5SQI9, Q6NTB5, Q8IVL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.