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Protein

Olfactory receptor 14J1

Gene

OR14J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181243-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14J1
Alternative name(s):
Hs6M1-28
Olfactory receptor 5U1
Olfactory receptor OR6-25
Gene namesi
Name:OR14J1
Synonyms:OR5U1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13971. OR14J1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 321CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi442191.
OpenTargetsiENSG00000112459.
ENSG00000204695.
ENSG00000225291.
PharmGKBiPA162398444.

Polymorphism and mutation databases

BioMutaiOR14J1.
DMDMi14423824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506161 – 321Olfactory receptor 14J1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UGF5.
PRIDEiQ9UGF5.

Expressioni

Gene expression databases

BgeeiENSG00000204695.
CleanExiHS_OR14J1.
ExpressionAtlasiQ9UGF5. baseline and differential.
GenevisibleiQ9UGF5. HS.

Organism-specific databases

HPAiHPA045575.

Structurei

3D structure databases

ProteinModelPortaliQ9UGF5.
SMRiQ9UGF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9UGF5.
KOiK04257.
OMAiYISLGQC.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ9UGF5.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLTSMSGF LLMGFSDERK LQILHALVFL VTYLLALTGN LLIITIITVD
60 70 80 90 100
RRLHSPMYYF LKHLSLLDLC FISVTVPQSI ANSLMGNGYI SLVQCILQVF
110 120 130 140 150
FFIALASSEV AILTVMSYDR YAAICQPLHY ETIMDPRACR HAVIAVWIAG
160 170 180 190 200
GLSGLMHAAI NFSIPLCGKR VIHQFFCDVP QMLKLACSYE FINEIALAAF
210 220 230 240 250
TTSAAFICLI SIVLSYIRIF STVLRIPSAE GRTKVFSTCL PHLFVATFFL
260 270 280 290 300
SAAGFEFLRL PSDSSSTVDL VFSVFYTVIP PTLNPVIYSL RNDSMKAALR
310 320
KMLSKEELPQ RKMCLKAMFK L
Length:321
Mass (Da):35,892
Last modified:May 1, 2000 - v1
Checksum:i69B33B0A14F49772
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0342347M → T.1 PublicationCorresponds to variant rs9257694dbSNPEnsembl.1
Natural variantiVAR_034235278V → M.Corresponds to variant rs17404424dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096770 Genomic DNA. Translation: CAB65799.1.
AL662857 Genomic DNA. Translation: CAI17513.1.
AL662781 Genomic DNA. Translation: CAI18129.1.
BX005432 Genomic DNA. Translation: CAM26129.1.
CR753509 Genomic DNA. Translation: CAQ07321.1.
CR759808 Genomic DNA. Translation: CAQ07994.1.
CR936918 Genomic DNA. Translation: CAQ08487.1.
BX927232 Genomic DNA. Translation: CAQ08987.1.
BC136905 mRNA. Translation: AAI36906.1.
BK004441 Genomic DNA. Translation: DAA04839.1.
CCDSiCCDS34362.1.
RefSeqiNP_112208.1. NM_030946.1.
UniGeneiHs.632004.

Genome annotation databases

EnsembliENST00000230221; ENSP00000230221; ENSG00000112459.
ENST00000377160; ENSP00000366365; ENSG00000204695.
ENST00000420495; ENSP00000389802; ENSG00000236927.
ENST00000421489; ENSP00000403553; ENSG00000234195.
ENST00000434778; ENSP00000398851; ENSG00000225291.
ENST00000435798; ENSP00000400501; ENSG00000234100.
ENST00000451272; ENSP00000408647; ENSG00000237777.
GeneIDi442191.
KEGGihsa:442191.
UCSCiuc011dln.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096770 Genomic DNA. Translation: CAB65799.1.
AL662857 Genomic DNA. Translation: CAI17513.1.
AL662781 Genomic DNA. Translation: CAI18129.1.
BX005432 Genomic DNA. Translation: CAM26129.1.
CR753509 Genomic DNA. Translation: CAQ07321.1.
CR759808 Genomic DNA. Translation: CAQ07994.1.
CR936918 Genomic DNA. Translation: CAQ08487.1.
BX927232 Genomic DNA. Translation: CAQ08987.1.
BC136905 mRNA. Translation: AAI36906.1.
BK004441 Genomic DNA. Translation: DAA04839.1.
CCDSiCCDS34362.1.
RefSeqiNP_112208.1. NM_030946.1.
UniGeneiHs.632004.

3D structure databases

ProteinModelPortaliQ9UGF5.
SMRiQ9UGF5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR14J1.
DMDMi14423824.

Proteomic databases

PaxDbiQ9UGF5.
PRIDEiQ9UGF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230221; ENSP00000230221; ENSG00000112459.
ENST00000377160; ENSP00000366365; ENSG00000204695.
ENST00000420495; ENSP00000389802; ENSG00000236927.
ENST00000421489; ENSP00000403553; ENSG00000234195.
ENST00000434778; ENSP00000398851; ENSG00000225291.
ENST00000435798; ENSP00000400501; ENSG00000234100.
ENST00000451272; ENSP00000408647; ENSG00000237777.
GeneIDi442191.
KEGGihsa:442191.
UCSCiuc011dln.2. human.

Organism-specific databases

CTDi442191.
DisGeNETi442191.
GeneCardsiOR14J1.
HGNCiHGNC:13971. OR14J1.
HPAiHPA045575.
neXtProtiNX_Q9UGF5.
OpenTargetsiENSG00000112459.
ENSG00000204695.
ENSG00000225291.
PharmGKBiPA162398444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9UGF5.
KOiK04257.
OMAiYISLGQC.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ9UGF5.
TreeFamiTF352740.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181243-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5U1.
GenomeRNAii442191.
PROiQ9UGF5.

Gene expression databases

BgeeiENSG00000204695.
CleanExiHS_OR14J1.
ExpressionAtlasiQ9UGF5. baseline and differential.
GenevisibleiQ9UGF5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO14J1_HUMAN
AccessioniPrimary (citable) accession number: Q9UGF5
Secondary accession number(s): A2BEC2, B0V078, Q5ST27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.