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Q9UGC6

- RGS17_HUMAN

UniProt

Q9UGC6 - RGS17_HUMAN

Protein

Regulator of G-protein signaling 17

Gene

RGS17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19333. G alpha (z) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 17
    Short name:
    RGS17
    Gene namesi
    Name:RGS17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14088. RGS17.

    Subcellular locationi

    Membrane; Lipid-anchor. Nucleus. Cytoplasm
    Note: Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Regulator of G-protein signaling 17PRO_0000204224Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei137 – 1371PhosphotyrosineBy similarity

    Post-translational modificationi

    Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity.By similarity
    N- and O-glycosylated in synapsomal membranes.By similarity
    Serine phosphorylated in synapsomal membranes.By similarity
    Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9UGC6.
    PRIDEiQ9UGC6.

    PTM databases

    PhosphoSiteiQ9UGC6.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.1 Publication

    Gene expression databases

    BgeeiQ9UGC6.
    CleanExiHS_RGS17.
    GenevestigatoriQ9UGC6.

    Organism-specific databases

    HPAiHPA022276.

    Interactioni

    Protein-protein interaction databases

    BioGridi117744. 7 interactions.
    DIPiDIP-59095N.
    IntActiQ9UGC6. 3 interactions.
    STRINGi9606.ENSP00000206262.

    Structurei

    Secondary structure

    1
    210
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi75 – 806
    Helixi85 – 895
    Helixi92 – 10413
    Helixi108 – 12215
    Helixi126 – 14015
    Helixi153 – 1619
    Turni168 – 1714
    Helixi172 – 18413
    Helixi187 – 1904
    Helixi194 – 20310

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZV4X-ray2.40X72-206[»]
    ProteinModelPortaliQ9UGC6.
    SMRiQ9UGC6. Positions 69-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UGC6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 200117RGSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 4013Poly-CysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258376.
    HOGENOMiHOG000233513.
    HOVERGENiHBG013233.
    InParanoidiQ9UGC6.
    KOiK16449.
    OMAiQQSQNEE.
    OrthoDBiEOG7SN8DQ.
    PhylomeDBiQ9UGC6.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UGC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE    50
    NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE 100
    FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS 150
    LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV 200
    ESTAGSSSES 210
    Length:210
    Mass (Da):24,359
    Last modified:August 14, 2001 - v2
    Checksum:i0AFA22A43BF5E481
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF202257 mRNA. Translation: AAF08978.3.
    BT006997 mRNA. Translation: AAP35643.1.
    AL080276 Genomic DNA. Translation: CAI18900.1.
    BC013117 mRNA. Translation: AAH13117.1.
    AF493938 mRNA. Translation: AAM12652.1.
    CCDSiCCDS5244.1.
    RefSeqiNP_036551.3. NM_012419.4.
    UniGeneiHs.166313.

    Genome annotation databases

    EnsembliENST00000206262; ENSP00000206262; ENSG00000091844.
    ENST00000367225; ENSP00000356194; ENSG00000091844.
    GeneIDi26575.
    KEGGihsa:26575.
    UCSCiuc003qpm.3. human.

    Polymorphism databases

    DMDMi15214238.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF202257 mRNA. Translation: AAF08978.3 .
    BT006997 mRNA. Translation: AAP35643.1 .
    AL080276 Genomic DNA. Translation: CAI18900.1 .
    BC013117 mRNA. Translation: AAH13117.1 .
    AF493938 mRNA. Translation: AAM12652.1 .
    CCDSi CCDS5244.1.
    RefSeqi NP_036551.3. NM_012419.4.
    UniGenei Hs.166313.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZV4 X-ray 2.40 X 72-206 [» ]
    ProteinModelPortali Q9UGC6.
    SMRi Q9UGC6. Positions 69-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117744. 7 interactions.
    DIPi DIP-59095N.
    IntActi Q9UGC6. 3 interactions.
    STRINGi 9606.ENSP00000206262.

    PTM databases

    PhosphoSitei Q9UGC6.

    Polymorphism databases

    DMDMi 15214238.

    Proteomic databases

    PaxDbi Q9UGC6.
    PRIDEi Q9UGC6.

    Protocols and materials databases

    DNASUi 26575.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206262 ; ENSP00000206262 ; ENSG00000091844 .
    ENST00000367225 ; ENSP00000356194 ; ENSG00000091844 .
    GeneIDi 26575.
    KEGGi hsa:26575.
    UCSCi uc003qpm.3. human.

    Organism-specific databases

    CTDi 26575.
    GeneCardsi GC06M153331.
    HGNCi HGNC:14088. RGS17.
    HPAi HPA022276.
    MIMi 607191. gene.
    neXtProti NX_Q9UGC6.
    PharmGKBi PA34368.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258376.
    HOGENOMi HOG000233513.
    HOVERGENi HBG013233.
    InParanoidi Q9UGC6.
    KOi K16449.
    OMAi QQSQNEE.
    OrthoDBi EOG7SN8DQ.
    PhylomeDBi Q9UGC6.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_19333. G alpha (z) signalling events.

    Miscellaneous databases

    ChiTaRSi RGS17. human.
    EvolutionaryTracei Q9UGC6.
    GeneWikii RGS17.
    GenomeRNAii 26575.
    NextBioi 48914.
    PROi Q9UGC6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UGC6.
    CleanExi HS_RGS17.
    Genevestigatori Q9UGC6.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ghahremani M.H., Daigle M., Albert P.R.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-210.
      Tissue: Brain.
    6. "RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling."
      Mao H., Zhao Q., Daigle M., Ghahremani M.H., Chidiac P., Albert P.R.
      J. Biol. Chem. 279:26314-26322(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRGS17_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGC6
    Secondary accession number(s): Q5TF49, Q8TD61, Q9UJS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3