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Q9UGC6

- RGS17_HUMAN

UniProt

Q9UGC6 - RGS17_HUMAN

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Protein

Regulator of G-protein signaling 17

Gene
RGS17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins By similarity.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19333. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 17
Short name:
RGS17
Gene namesi
Name:RGS17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14088. RGS17.

Subcellular locationi

Membrane; Lipid-anchor. Nucleus. Cytoplasm
Note: Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Regulator of G-protein signaling 17PRO_0000204224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371Phosphotyrosine By similarity

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity.
N- and O-glycosylated in synapsomal membranes By similarity.
Serine phosphorylated in synapsomal membranes By similarity.
Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits By similarity.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9UGC6.
PRIDEiQ9UGC6.

PTM databases

PhosphoSiteiQ9UGC6.

Expressioni

Tissue specificityi

Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.1 Publication

Gene expression databases

BgeeiQ9UGC6.
CleanExiHS_RGS17.
GenevestigatoriQ9UGC6.

Organism-specific databases

HPAiHPA022276.

Interactioni

Protein-protein interaction databases

BioGridi117744. 7 interactions.
DIPiDIP-59095N.
IntActiQ9UGC6. 3 interactions.
STRINGi9606.ENSP00000206262.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi75 – 806
Helixi85 – 895
Helixi92 – 10413
Helixi108 – 12215
Helixi126 – 14015
Helixi153 – 1619
Turni168 – 1714
Helixi172 – 18413
Helixi187 – 1904
Helixi194 – 20310

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZV4X-ray2.40X72-206[»]
ProteinModelPortaliQ9UGC6.
SMRiQ9UGC6. Positions 69-204.

Miscellaneous databases

EvolutionaryTraceiQ9UGC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 200117RGSAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 4013Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG258376.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ9UGC6.
KOiK16449.
OMAiQQSQNEE.
OrthoDBiEOG7SN8DQ.
PhylomeDBiQ9UGC6.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGC6-1 [UniParc]FASTAAdd to Basket

« Hide

MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE    50
NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE 100
FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS 150
LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV 200
ESTAGSSSES 210
Length:210
Mass (Da):24,359
Last modified:August 14, 2001 - v2
Checksum:i0AFA22A43BF5E481
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF202257 mRNA. Translation: AAF08978.3.
BT006997 mRNA. Translation: AAP35643.1.
AL080276 Genomic DNA. Translation: CAI18900.1.
BC013117 mRNA. Translation: AAH13117.1.
AF493938 mRNA. Translation: AAM12652.1.
CCDSiCCDS5244.1.
RefSeqiNP_036551.3. NM_012419.4.
UniGeneiHs.166313.

Genome annotation databases

EnsembliENST00000206262; ENSP00000206262; ENSG00000091844.
ENST00000367225; ENSP00000356194; ENSG00000091844.
GeneIDi26575.
KEGGihsa:26575.
UCSCiuc003qpm.3. human.

Polymorphism databases

DMDMi15214238.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF202257 mRNA. Translation: AAF08978.3 .
BT006997 mRNA. Translation: AAP35643.1 .
AL080276 Genomic DNA. Translation: CAI18900.1 .
BC013117 mRNA. Translation: AAH13117.1 .
AF493938 mRNA. Translation: AAM12652.1 .
CCDSi CCDS5244.1.
RefSeqi NP_036551.3. NM_012419.4.
UniGenei Hs.166313.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZV4 X-ray 2.40 X 72-206 [» ]
ProteinModelPortali Q9UGC6.
SMRi Q9UGC6. Positions 69-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117744. 7 interactions.
DIPi DIP-59095N.
IntActi Q9UGC6. 3 interactions.
STRINGi 9606.ENSP00000206262.

PTM databases

PhosphoSitei Q9UGC6.

Polymorphism databases

DMDMi 15214238.

Proteomic databases

PaxDbi Q9UGC6.
PRIDEi Q9UGC6.

Protocols and materials databases

DNASUi 26575.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000206262 ; ENSP00000206262 ; ENSG00000091844 .
ENST00000367225 ; ENSP00000356194 ; ENSG00000091844 .
GeneIDi 26575.
KEGGi hsa:26575.
UCSCi uc003qpm.3. human.

Organism-specific databases

CTDi 26575.
GeneCardsi GC06M153331.
HGNCi HGNC:14088. RGS17.
HPAi HPA022276.
MIMi 607191. gene.
neXtProti NX_Q9UGC6.
PharmGKBi PA34368.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258376.
HOGENOMi HOG000233513.
HOVERGENi HBG013233.
InParanoidi Q9UGC6.
KOi K16449.
OMAi QQSQNEE.
OrthoDBi EOG7SN8DQ.
PhylomeDBi Q9UGC6.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_19333. G alpha (z) signalling events.

Miscellaneous databases

ChiTaRSi RGS17. human.
EvolutionaryTracei Q9UGC6.
GeneWikii RGS17.
GenomeRNAii 26575.
NextBioi 48914.
PROi Q9UGC6.
SOURCEi Search...

Gene expression databases

Bgeei Q9UGC6.
CleanExi HS_RGS17.
Genevestigatori Q9UGC6.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ghahremani M.H., Daigle M., Albert P.R.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-210.
    Tissue: Brain.
  6. "RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling."
    Mao H., Zhao Q., Daigle M., Ghahremani M.H., Chidiac P., Albert P.R.
    J. Biol. Chem. 279:26314-26322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRGS17_HUMAN
AccessioniPrimary (citable) accession number: Q9UGC6
Secondary accession number(s): Q5TF49, Q8TD61, Q9UJS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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