Q9UGC6 (RGS17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 17
Short name=RGS17

Gene names

Name:

RGS17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins By similarity. Ref.6
Subcellular location	Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation By similarity.
Tissue specificity	Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. Ref.6
Post-translational modification	Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity. N- and O-glycosylated in synapsomal membranes By similarity. Serine phosphorylated in synapsomal membranes By similarity. Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Molecular function	Signal transduction inhibitor
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 210

210

Regulator of G-protein signaling 17

PRO_0000204224

Regions

Domain

84 – 200

117

RGS

Compositional bias

28 – 40

13

Poly-Cys

Amino acid modifications

Modified residue

137

1

Phosphotyrosine By similarity

Secondary structure

1

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210

Helix Strand Turn

Details...

Helix

75 – 80

6

Helix

85 – 89

5

Helix

92 – 104

13

Helix

108 – 122

15

Helix

126 – 140

15

Helix

153 – 161

9

Turn

168 – 171

4

Helix

172 – 184

13

Helix

187 – 190

4

Helix

194 – 203

10

Sequences

	Sequence		Length	Mass (Da)
	Q9UGC6 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: 0AFA22A43BF5E481	FASTA	210	24,359
	10 20 30 40 50 60 MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK 70 80 90 100 110 120 MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL 130 140 150 160 170 180 KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT 190 200 210 LMHRDSFPRF LNSQIYKSFV ESTAGSSSES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ghahremani M.H., Daigle M., Albert P.R. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-210. Tissue: Brain.
[6]	"RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling." Mao H., Zhao Q., Daigle M., Ghahremani M.H., Chidiac P., Albert P.R. J. Biol. Chem. 279:26314-26322(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF202257 mRNA. Translation: AAF08978.3.
BT006997 mRNA. Translation: AAP35643.1.
AL080276 Genomic DNA. Translation: CAI18900.1.
BC013117 mRNA. Translation: AAH13117.1.
AF493938 mRNA. Translation: AAM12652.1.

IPI

IPI00005250.

RefSeq

NP_036551.3. NM_012419.4.

UniGene

Hs.166313.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZV4	X-ray	2.40	X	72-206	[»]

ProteinModelPortal

Q9UGC6.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59095N.

IntAct

Q9UGC6. 3 interactions.

STRING

9606.ENSP00000206262.

PTM databases

PhosphoSite

Q9UGC6.

Polymorphism databases

DMDM

15214238.

Proteomic databases

PaxDb

Q9UGC6.

PRIDE

Q9UGC6.

Protocols and materials databases

DNASU

26575.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000206262; ENSP00000206262; ENSG00000091844.
ENST00000367225; ENSP00000356194; ENSG00000091844.

GeneID

26575.

KEGG

hsa:26575.

UCSC

uc003qpm.3. human.

Organism-specific databases

CTD

26575.

GeneCards

GC06M153331.

HGNC

HGNC:14088. RGS17.

HPA

HPA022276.

MIM

607191. gene.

neXtProt

NX_Q9UGC6.

PharmGKB

PA34368.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG258376.

HOGENOM

HOG000233513.

HOVERGEN

HBG013233.

InParanoid

Q9UGC6.

KO

K16449.

OMA

QQSQNEE.

OrthoDB

EOG418BPC.

PhylomeDB

Q9UGC6.

Gene expression databases

Bgee

Q9UGC6.

CleanEx

HS_RGS17.

Genevestigator

Q9UGC6.

GermOnline

ENSG00000091844. Homo sapiens.

Family and domain databases

Gene3D

1.10.196.10. 1 hit.

InterPro

IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
[Graphical view]

Pfam

PF00615. RGS. 1 hit.
[Graphical view]

PRINTS

PR01301. RGSPROTEIN.

SMART

SM00315. RGS. 1 hit.
[Graphical view]

SUPFAM

SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RGS17. human.

EvolutionaryTrace

Q9UGC6.

GenomeRNAi

26575.

NextBio

48914.

SOURCE

Search...

Entry information

Entry name

RGS17_HUMAN

Accession

Primary (citable) accession number: Q9UGC6
Secondary accession number(s): Q5TF49, Q8TD61, Q9UJS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	August 14, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.