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Protein

ATP-binding cassette sub-family F member 2

Gene

ABCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi430 – 437ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: ProtInc
  • transporter activity Source: ProtInc

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 2
Alternative name(s):
Iron-inhibited ABC transporter 2
Gene namesi
Name:ABCF2
ORF Names:HUSSY-18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000033050.7
HGNCiHGNC:71 ABCF2
MIMi612510 gene
neXtProtiNX_Q9UG63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10061
OpenTargetsiENSG00000033050
PharmGKBiPA24406

Polymorphism and mutation databases

DMDMi12643306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933231 – 623ATP-binding cassette sub-family F member 2Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphothreonineCombined sources1
Modified residuei304N6-acetyllysineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UG63
PaxDbiQ9UG63
PeptideAtlasiQ9UG63
PRIDEiQ9UG63

PTM databases

iPTMnetiQ9UG63
PhosphoSitePlusiQ9UG63

Miscellaneous databases

PMAP-CutDBiQ9UG63

Expressioni

Gene expression databases

BgeeiENSG00000033050
CleanExiHS_ABCF2
ExpressionAtlasiQ9UG63 baseline and differential
GenevisibleiQ9UG63 HS

Organism-specific databases

HPAiCAB020682
HPA020091
HPA021815
HPA030388

Interactioni

Protein-protein interaction databases

BioGridi115372, 56 interactors
CORUMiQ9UG63
IntActiQ9UG63, 20 interactors
MINTiQ9UG63
STRINGi9606.ENSP00000222388

Structurei

3D structure databases

ProteinModelPortaliQ9UG63
SMRiQ9UG63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 325ABC transporter 1PROSITE-ProRule annotationAdd BLAST240
Domaini396 – 613ABC transporter 2PROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927 Eukaryota
COG0488 LUCA
GeneTreeiENSGT00630000089910
HOGENOMiHOG000271637
HOVERGENiHBG050440
InParanoidiQ9UG63
KOiK06185
OMAiSALQCVM
PhylomeDBiQ9UG63
TreeFamiTF105208

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UG63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET
60 70 80 90 100
TEVDLLTKEL EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL
110 120 130 140 150
LSDTKLELNS GRRYGLIGLN GIGKSMLLSA IGKREVPIPE HIDIYHLTRE
160 170 180 190 200
MPPSDKTPLH CVMEVDTERA MLEKEAERLA HEDAECEKLM ELYERLEELD
210 220 230 240 250
ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA RALFIRPFML
260 270 280 290 300
LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN
310 320 330 340 350
KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA
360 370 380 390 400
KLARQAQSKE KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN
410 420 430 440 450
VSFKYTKDGP CIYNNLEFGI DLDTRVALVG PNGAGKSTLL KLLTGELLPT
460 470 480 490 500
DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL EYMMKCYPEI KEKEEMRKII
510 520 530 540 550
GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL DEPTNHLDIE
560 570 580 590 600
TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA
610 620
YKEHLKSKLV DEEPQLTKRT HNV
Length:623
Mass (Da):71,290
Last modified:January 24, 2001 - v2
Checksum:i702A968BCF8061AE
GO
Isoform 2 (identifier: Q9UG63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VCTLTLASLPRP

Show »
Length:634
Mass (Da):72,444
Checksum:iFCB0633F0D9BA0DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39V → A in AAG13902 (PubMed:10944468).Curated1
Sequence conflicti39V → A in AAG13903 (PubMed:10944468).Curated1
Sequence conflicti74T → A in CAA06290 (PubMed:11124703).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054715623V → VCTLTLASLPRP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261091 mRNA Translation: AAG13902.1
AF261092 mRNA Translation: AAG13903.1
BT007451 mRNA Translation: AAP36119.1
AL050291 mRNA Translation: CAB43392.1
AC021097 Genomic DNA Translation: AAS00378.1
AC021097 Genomic DNA Translation: AAS00379.1
CH471173 Genomic DNA Translation: EAW54014.1
CH471173 Genomic DNA Translation: EAW54016.1
CH471173 Genomic DNA Translation: EAW54017.1
BC001661 mRNA Translation: AAH01661.1
AJ005016 mRNA Translation: CAA06290.1
CCDSiCCDS5922.1 [Q9UG63-2]
CCDS5923.1 [Q9UG63-1]
PIRiT08810
RefSeqiNP_005683.2, NM_005692.4 [Q9UG63-2]
NP_009120.1, NM_007189.2 [Q9UG63-1]
XP_016867128.1, XM_017011639.1 [Q9UG63-1]
XP_016867129.1, XM_017011640.1 [Q9UG63-1]
UniGeneiHs.654958

Genome annotation databases

EnsembliENST00000222388; ENSP00000222388; ENSG00000033050 [Q9UG63-2]
ENST00000287844; ENSP00000287844; ENSG00000033050 [Q9UG63-1]
GeneIDi10061
KEGGihsa:10061
UCSCiuc003wjo.3 human [Q9UG63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABCF2_HUMAN
AccessioniPrimary (citable) accession number: Q9UG63
Secondary accession number(s): O60864
, Q75MJ0, Q75MJ1, Q96TE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: March 28, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health