Q9UG63 (ABCF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family F member 2

Alternative name(s):
Iron-inhibited ABC transporter 2

Gene names

Name:	ABCF2
ORF Names:	HUSSY-18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Contains 2 ABC transporter domains.
Caution	Lacks transmembrane domains and is probably not involved in transport.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	ATP-binding cassette (ABC) transporter complex Traceable author statement. Source: ProtInc mitochondrial envelope Traceable author statement. Source: ProtInc
Molecular function	ATP binding Traceable author statement. Source: ProtInc ATPase activity Inferred from electronic annotation. Source: InterPro transporter activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	ATP-binding cassette sub-family F member 2		PRO_0000093323
Regions
	Domain	86 – 325	240	ABC transporter 1
	Domain	396 – 613	218	ABC transporter 2
	Nucleotide binding	118 – 125	8	ATP 1 By similarity
	Nucleotide binding	430 – 437	8	ATP 2 By similarity
Amino acid modifications
	Modified residue	304	1	N6-acetyllysine Ref.6
	Modified residue	349	1	Phosphoserine Ref.5
Experimental info
	Sequence conflict	39	1	V → A in AAG13902. Ref.1
	Sequence conflict	39	1	V → A in AAG13903. Ref.1
	Sequence conflict	74	1	T → A in CAA06290. Ref.4
	Sequence conflict	623	1	V → VCTLTLASLPRP in CAB43392. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UG63 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 702A968BCF8061AE	FASTA	623	71,290
	10 20 30 40 50 60 MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL 70 80 90 100 110 120 EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN 130 140 150 160 170 180 GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA 190 200 210 220 230 240 HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA 250 260 270 280 290 300 RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN 310 320 330 340 350 360 KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE 370 380 390 400 410 420 KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI 430 440 450 460 470 480 DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL 490 500 510 520 530 540 EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL 550 560 570 580 590 600 DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA 610 620 YKEHLKSKLV DEEPQLTKRT HNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs." Ye Z., Connor J.R. Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed: 10944468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Characterization of 16 novel human genes showing high similarity to yeast sequences." Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G. Yeast 18:69-80(2001) [PubMed: 11124703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-623. Tissue: Lung.
[5]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304, MASS SPECTROMETRY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF261091 mRNA. Translation: AAG13902.1. AF261092 mRNA. Translation: AAG13903.1. AL050291 mRNA. Translation: CAB43392.1. BC001661 mRNA. Translation: AAH01661.1. AJ005016 mRNA. Translation: CAA06290.1.
IPI	IPI00005045.
PIR	T08810.
RefSeq	NP_005683.2. NM_005692.3. NP_009120.1. NM_007189.1.
UniGene	Hs.654958.
3D structure databases
ProteinModelPortal	Q9UG63.
SMR	Q9UG63. Positions 85-311, 394-600.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UG63. 1 interaction.
STRING	Q9UG63.
PTM databases
PhosphoSite	Q9UG63.
Polymorphism databases
DMDM	12643306.
Proteomic databases
PRIDE	Q9UG63.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222388; ENSP00000222388; ENSG00000033050. ENST00000287844; ENSP00000287844; ENSG00000033050.
GeneID	10061.
KEGG	hsa:10061.
UCSC	uc003wjp.1. human.
Organism-specific databases
CTD	10061.
GeneCards	GC07M150904.
H-InvDB	HIX0007228.
HGNC	HGNC:71. ABCF2.
HPA	CAB020682. HPA020091. HPA021815. HPA030388.
MIM	612510. gene.
neXtProt	NX_Q9UG63.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17507.
GeneTree	ENSGT00550000075014.
HOVERGEN	HBG050440.
InParanoid	Q9UG63.
OrthoDB	EOG4T1HM5.
PhylomeDB	Q9UG63.
Gene expression databases
ArrayExpress	Q9UG63.
Bgee	Q9UG63.
CleanEx	HS_ABCF2.
Genevestigator	Q9UG63.
GermOnline	ENSG00000033050. Homo sapiens.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K06185.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	38023.
PMAP-CutDB	Q9UG63.
SOURCE	Search...

Entry information

Entry name

ABCF2_HUMAN

Accession

Primary (citable) accession number: Q9UG63
Secondary accession number(s): O60864, Q96TE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	January 25, 2012
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.