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Q9UG63

- ABCF2_HUMAN

UniProt

Q9UG63 - ABCF2_HUMAN

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Protein

ATP-binding cassette sub-family F member 2

Gene
ABCF2, HUSSY-18
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1258ATP 1 By similarity
Nucleotide bindingi430 – 4378ATP 2 By similarity

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: ProtInc
  3. transporter activity Source: ProtInc

GO - Biological processi

  1. transport Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 2
Alternative name(s):
Iron-inhibited ABC transporter 2
Gene namesi
Name:ABCF2
ORF Names:HUSSY-18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:71. ABCF2.

Subcellular locationi

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: ProtInc
  2. mitochondrial envelope Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623ATP-binding cassette sub-family F member 2PRO_0000093323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UG63.
PaxDbiQ9UG63.
PRIDEiQ9UG63.

PTM databases

PhosphoSiteiQ9UG63.

Miscellaneous databases

PMAP-CutDBQ9UG63.

Expressioni

Gene expression databases

ArrayExpressiQ9UG63.
BgeeiQ9UG63.
CleanExiHS_ABCF2.
GenevestigatoriQ9UG63.

Organism-specific databases

HPAiCAB020682.
HPA020091.
HPA021815.
HPA030388.

Interactioni

Protein-protein interaction databases

BioGridi115372. 11 interactions.
IntActiQ9UG63. 3 interactions.
MINTiMINT-3079728.
STRINGi9606.ENSP00000222388.

Structurei

3D structure databases

ProteinModelPortaliQ9UG63.
SMRiQ9UG63. Positions 98-609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 325240ABC transporter 1Add
BLAST
Domaini396 – 613218ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0488.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ9UG63.
KOiK06185.
OrthoDBiEOG7RJPQW.
PhylomeDBiQ9UG63.
TreeFamiTF105208.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UG63-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET    50
TEVDLLTKEL EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL 100
LSDTKLELNS GRRYGLIGLN GIGKSMLLSA IGKREVPIPE HIDIYHLTRE 150
MPPSDKTPLH CVMEVDTERA MLEKEAERLA HEDAECEKLM ELYERLEELD 200
ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA RALFIRPFML 250
LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN 300
KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA 350
KLARQAQSKE KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN 400
VSFKYTKDGP CIYNNLEFGI DLDTRVALVG PNGAGKSTLL KLLTGELLPT 450
DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL EYMMKCYPEI KEKEEMRKII 500
GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL DEPTNHLDIE 550
TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA 600
YKEHLKSKLV DEEPQLTKRT HNV 623
Length:623
Mass (Da):71,290
Last modified:January 24, 2001 - v2
Checksum:i702A968BCF8061AE
GO
Isoform 2 (identifier: Q9UG63-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VCTLTLASLPRP

Show »
Length:634
Mass (Da):72,444
Checksum:iFCB0633F0D9BA0DC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei623 – 6231V → VCTLTLASLPRP in isoform 2. VSP_054715

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391V → A in AAG13902. 1 Publication
Sequence conflicti39 – 391V → A in AAG13903. 1 Publication
Sequence conflicti74 – 741T → A in CAA06290. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261091 mRNA. Translation: AAG13902.1.
AF261092 mRNA. Translation: AAG13903.1.
BT007451 mRNA. Translation: AAP36119.1.
AL050291 mRNA. Translation: CAB43392.1.
AC021097 Genomic DNA. Translation: AAS00378.1.
AC021097 Genomic DNA. Translation: AAS00379.1.
CH471173 Genomic DNA. Translation: EAW54014.1.
CH471173 Genomic DNA. Translation: EAW54016.1.
CH471173 Genomic DNA. Translation: EAW54017.1.
BC001661 mRNA. Translation: AAH01661.1.
AJ005016 mRNA. Translation: CAA06290.1.
CCDSiCCDS5922.1. [Q9UG63-2]
CCDS5923.1. [Q9UG63-1]
PIRiT08810.
RefSeqiNP_005683.2. NM_005692.4. [Q9UG63-2]
NP_009120.1. NM_007189.2. [Q9UG63-1]
XP_005249988.1. XM_005249931.2. [Q9UG63-2]
XP_006715887.1. XM_006715824.1. [Q9UG63-2]
UniGeneiHs.654958.

Genome annotation databases

EnsembliENST00000222388; ENSP00000222388; ENSG00000033050.
ENST00000287844; ENSP00000287844; ENSG00000033050.
GeneIDi10061.
KEGGihsa:10061.
UCSCiuc003wjo.1. human.
uc003wjp.3. human. [Q9UG63-1]

Polymorphism databases

DMDMi12643306.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261091 mRNA. Translation: AAG13902.1 .
AF261092 mRNA. Translation: AAG13903.1 .
BT007451 mRNA. Translation: AAP36119.1 .
AL050291 mRNA. Translation: CAB43392.1 .
AC021097 Genomic DNA. Translation: AAS00378.1 .
AC021097 Genomic DNA. Translation: AAS00379.1 .
CH471173 Genomic DNA. Translation: EAW54014.1 .
CH471173 Genomic DNA. Translation: EAW54016.1 .
CH471173 Genomic DNA. Translation: EAW54017.1 .
BC001661 mRNA. Translation: AAH01661.1 .
AJ005016 mRNA. Translation: CAA06290.1 .
CCDSi CCDS5922.1. [Q9UG63-2 ]
CCDS5923.1. [Q9UG63-1 ]
PIRi T08810.
RefSeqi NP_005683.2. NM_005692.4. [Q9UG63-2 ]
NP_009120.1. NM_007189.2. [Q9UG63-1 ]
XP_005249988.1. XM_005249931.2. [Q9UG63-2 ]
XP_006715887.1. XM_006715824.1. [Q9UG63-2 ]
UniGenei Hs.654958.

3D structure databases

ProteinModelPortali Q9UG63.
SMRi Q9UG63. Positions 98-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115372. 11 interactions.
IntActi Q9UG63. 3 interactions.
MINTi MINT-3079728.
STRINGi 9606.ENSP00000222388.

PTM databases

PhosphoSitei Q9UG63.

Polymorphism databases

DMDMi 12643306.

Proteomic databases

MaxQBi Q9UG63.
PaxDbi Q9UG63.
PRIDEi Q9UG63.

Protocols and materials databases

DNASUi 10061.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222388 ; ENSP00000222388 ; ENSG00000033050 .
ENST00000287844 ; ENSP00000287844 ; ENSG00000033050 .
GeneIDi 10061.
KEGGi hsa:10061.
UCSCi uc003wjo.1. human.
uc003wjp.3. human. [Q9UG63-1 ]

Organism-specific databases

CTDi 10061.
GeneCardsi GC07M150904.
HGNCi HGNC:71. ABCF2.
HPAi CAB020682.
HPA020091.
HPA021815.
HPA030388.
MIMi 612510. gene.
neXtProti NX_Q9UG63.
PharmGKBi PA24406.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0488.
HOGENOMi HOG000271637.
HOVERGENi HBG050440.
InParanoidi Q9UG63.
KOi K06185.
OrthoDBi EOG7RJPQW.
PhylomeDBi Q9UG63.
TreeFami TF105208.

Miscellaneous databases

ChiTaRSi ABCF2. human.
GeneWikii ABCF2.
GenomeRNAii 10061.
NextBioi 38023.
PMAP-CutDB Q9UG63.
PROi Q9UG63.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UG63.
Bgeei Q9UG63.
CleanExi HS_ABCF2.
Genevestigatori Q9UG63.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs."
    Ye Z., Connor J.R.
    Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  7. "Characterization of 16 novel human genes showing high similarity to yeast sequences."
    Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G.
    Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-623.
    Tissue: Lung.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABCF2_HUMAN
AccessioniPrimary (citable) accession number: Q9UG63
Secondary accession number(s): O60864
, Q75MJ0, Q75MJ1, Q96TE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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