Q9UG63 (ABCF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family F member 2

Alternative name(s):
Iron-inhibited ABC transporter 2

Gene names

Name:	ABCF2
ORF Names:	HUSSY-18

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Contains 2 ABC transporter domains.
Caution	Lacks transmembrane domains and is probably not involved in transport.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	ATP-binding cassette (ABC) transporter complex Traceable author statement PubMed 9878413. Source: ProtInc mitochondrial envelope Traceable author statement PubMed 9878413. Source: ProtInc
Molecular_function	ATP binding Traceable author statement PubMed 9878413. Source: ProtInc ATPase activity Inferred from electronic annotation. Source: InterPro transporter activity Traceable author statement PubMed 9878413. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	ATP-binding cassette sub-family F member 2		PRO_0000093323
Regions
	Domain	86 – 325	240	ABC transporter 1
	Domain	396 – 613	218	ABC transporter 2
	Nucleotide binding	118 – 125	8	ATP 1 By similarity
	Nucleotide binding	430 – 437	8	ATP 2 By similarity
Amino acid modifications
	Modified residue	304	1	N6-acetyllysine Ref.8
Experimental info
	Sequence conflict	39	1	V → A in AAG13902. Ref.1
	Sequence conflict	39	1	V → A in AAG13903. Ref.1
	Sequence conflict	74	1	T → A in CAA06290. Ref.7
	Sequence conflict	623	1	V → VCTLTLASLPRP in CAB43392. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UG63 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 702A968BCF8061AE	FASTA	623	71,290
	10 20 30 40 50 60 MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL 70 80 90 100 110 120 EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN 130 140 150 160 170 180 GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA 190 200 210 220 230 240 HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA 250 260 270 280 290 300 RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN 310 320 330 340 350 360 KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE 370 380 390 400 410 420 KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI 430 440 450 460 470 480 DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL 490 500 510 520 530 540 EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL 550 560 570 580 590 600 DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA 610 620 YKEHLKSKLV DEEPQLTKRT HNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs." Ye Z., Connor J.R. Biochem. Biophys. Res. Commun. 275:223-227(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[7]	"Characterization of 16 novel human genes showing high similarity to yeast sequences." Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G. Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-623. Tissue: Lung.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF261091 mRNA. Translation: AAG13902.1. AF261092 mRNA. Translation: AAG13903.1. BT007451 mRNA. Translation: AAP36119.1. AL050291 mRNA. Translation: CAB43392.1. AC021097 Genomic DNA. Translation: AAS00379.1. CH471173 Genomic DNA. Translation: EAW54014.1. CH471173 Genomic DNA. Translation: EAW54017.1. BC001661 mRNA. Translation: AAH01661.1. AJ005016 mRNA. Translation: CAA06290.1.
IPI	IPI00005045.
PIR	T08810.
RefSeq	NP_005683.2. NM_005692.3. NP_009120.1. NM_007189.1.
UniGene	Hs.654958.
3D structure databases
ProteinModelPortal	Q9UG63.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UG63. 3 interactions.
STRING	9606.ENSP00000222388.
PTM databases
PhosphoSite	Q9UG63.
Polymorphism databases
DMDM	12643306.
Proteomic databases
PaxDb	Q9UG63.
PRIDE	Q9UG63.
Protocols and materials databases
DNASU	10061.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287844; ENSP00000287844; ENSG00000033050.
GeneID	10061.
KEGG	hsa:10061.
UCSC	uc003wjp.3. human.
Organism-specific databases
CTD	10061.
GeneCards	GC07M150904.
HGNC	HGNC:71. ABCF2.
HPA	CAB020682. HPA020091. HPA021815. HPA030388.
MIM	612510. gene.
neXtProt	NX_Q9UG63.
PharmGKB	PA24406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0488.
HOGENOM	HOG000271637.
HOVERGEN	HBG050440.
InParanoid	Q9UG63.
KO	K06185.
OrthoDB	EOG4T1HM5.
Gene expression databases
ArrayExpress	Q9UG63.
Bgee	Q9UG63.
CleanEx	HS_ABCF2.
Genevestigator	Q9UG63.
GermOnline	ENSG00000033050. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABCF2. human.
GenomeRNAi	10061.
NextBio	38023.
PMAP-CutDB	Q9UG63.
SOURCE	Search...

Entry information

Entry name

ABCF2_HUMAN

Accession

Primary (citable) accession number: Q9UG63
Secondary accession number(s): O60864, Q75MJ0, Q96TE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.