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Protein

ATP-binding cassette sub-family F member 2

Gene

ABCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi430 – 437ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

  • transport Source: ProtInc

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 2
Alternative name(s):
Iron-inhibited ABC transporter 2
Gene namesi
Name:ABCF2
ORF Names:HUSSY-18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000033050.7.
HGNCiHGNC:71. ABCF2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10061.
OpenTargetsiENSG00000033050.
PharmGKBiPA24406.

Polymorphism and mutation databases

DMDMi12643306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933231 – 623ATP-binding cassette sub-family F member 2Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphothreonineCombined sources1
Modified residuei304N6-acetyllysineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UG63.
PaxDbiQ9UG63.
PeptideAtlasiQ9UG63.
PRIDEiQ9UG63.

PTM databases

iPTMnetiQ9UG63.
PhosphoSitePlusiQ9UG63.

Miscellaneous databases

PMAP-CutDBiQ9UG63.

Expressioni

Gene expression databases

BgeeiENSG00000033050.
CleanExiHS_ABCF2.
ExpressionAtlasiQ9UG63. baseline and differential.
GenevisibleiQ9UG63. HS.

Organism-specific databases

HPAiCAB020682.
HPA020091.
HPA021815.
HPA030388.

Interactioni

Protein-protein interaction databases

BioGridi115372. 54 interactors.
CORUMiQ9UG63.
IntActiQ9UG63. 20 interactors.
MINTiMINT-3079728.
STRINGi9606.ENSP00000222388.

Structurei

3D structure databases

ProteinModelPortaliQ9UG63.
SMRiQ9UG63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 325ABC transporter 1PROSITE-ProRule annotationAdd BLAST240
Domaini396 – 613ABC transporter 2PROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089910.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ9UG63.
KOiK06185.
OMAiSALQCVM.
PhylomeDBiQ9UG63.
TreeFamiTF105208.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UG63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET
60 70 80 90 100
TEVDLLTKEL EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL
110 120 130 140 150
LSDTKLELNS GRRYGLIGLN GIGKSMLLSA IGKREVPIPE HIDIYHLTRE
160 170 180 190 200
MPPSDKTPLH CVMEVDTERA MLEKEAERLA HEDAECEKLM ELYERLEELD
210 220 230 240 250
ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA RALFIRPFML
260 270 280 290 300
LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN
310 320 330 340 350
KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA
360 370 380 390 400
KLARQAQSKE KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN
410 420 430 440 450
VSFKYTKDGP CIYNNLEFGI DLDTRVALVG PNGAGKSTLL KLLTGELLPT
460 470 480 490 500
DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL EYMMKCYPEI KEKEEMRKII
510 520 530 540 550
GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL DEPTNHLDIE
560 570 580 590 600
TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA
610 620
YKEHLKSKLV DEEPQLTKRT HNV
Length:623
Mass (Da):71,290
Last modified:January 24, 2001 - v2
Checksum:i702A968BCF8061AE
GO
Isoform 2 (identifier: Q9UG63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VCTLTLASLPRP

Show »
Length:634
Mass (Da):72,444
Checksum:iFCB0633F0D9BA0DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39V → A in AAG13902 (PubMed:10944468).Curated1
Sequence conflicti39V → A in AAG13903 (PubMed:10944468).Curated1
Sequence conflicti74T → A in CAA06290 (PubMed:11124703).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054715623V → VCTLTLASLPRP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261091 mRNA. Translation: AAG13902.1.
AF261092 mRNA. Translation: AAG13903.1.
BT007451 mRNA. Translation: AAP36119.1.
AL050291 mRNA. Translation: CAB43392.1.
AC021097 Genomic DNA. Translation: AAS00378.1.
AC021097 Genomic DNA. Translation: AAS00379.1.
CH471173 Genomic DNA. Translation: EAW54014.1.
CH471173 Genomic DNA. Translation: EAW54016.1.
CH471173 Genomic DNA. Translation: EAW54017.1.
BC001661 mRNA. Translation: AAH01661.1.
AJ005016 mRNA. Translation: CAA06290.1.
CCDSiCCDS5922.1. [Q9UG63-2]
CCDS5923.1. [Q9UG63-1]
PIRiT08810.
RefSeqiNP_005683.2. NM_005692.4. [Q9UG63-2]
NP_009120.1. NM_007189.2. [Q9UG63-1]
XP_016867128.1. XM_017011639.1. [Q9UG63-1]
XP_016867129.1. XM_017011640.1. [Q9UG63-1]
UniGeneiHs.654958.

Genome annotation databases

EnsembliENST00000222388; ENSP00000222388; ENSG00000033050. [Q9UG63-2]
ENST00000287844; ENSP00000287844; ENSG00000033050. [Q9UG63-1]
GeneIDi10061.
KEGGihsa:10061.
UCSCiuc003wjo.3. human. [Q9UG63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABCF2_HUMAN
AccessioniPrimary (citable) accession number: Q9UG63
Secondary accession number(s): O60864
, Q75MJ0, Q75MJ1, Q96TE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 27, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families