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Q9UG56

- PISD_HUMAN

UniProt

Q9UG56 - PISD_HUMAN

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Protein

Phosphatidylserine decarboxylase proenzyme

Gene
PISD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactori

Pyruvoyl group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Cleavage (non-hydrolytic) By similarity

GO - Molecular functioni

  1. phosphatidylserine decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. phosphatidylethanolamine biosynthetic process Source: Reactome
  3. phospholipid metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciMetaCyc:HS01985-MONOMER.
ReactomeiREACT_120919. Synthesis of PE.
UniPathwayiUPA00558; UER00616.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine decarboxylase proenzyme (EC:4.1.1.65)
Cleaved into the following 2 chains:
Gene namesi
Name:PISD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:8999. PISD.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Phosphatidylserine decarboxylase beta chainPRO_0000029835Add
BLAST
Chaini378 – 40932Phosphatidylserine decarboxylase alpha chainPRO_0000029836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei378 – 3781Pyruvic acid (Ser) By similarity

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiQ9UG56.
PaxDbiQ9UG56.
PRIDEiQ9UG56.

PTM databases

PhosphoSiteiQ9UG56.

Expressioni

Gene expression databases

ArrayExpressiQ9UG56.
BgeeiQ9UG56.
CleanExiHS_PISD.
GenevestigatoriQ9UG56.

Organism-specific databases

HPAiHPA031090.
HPA031091.

Interactioni

Subunit structurei

Heterodimer By similarity.

Protein-protein interaction databases

BioGridi117262. 5 interactions.
IntActiQ9UG56. 2 interactions.
STRINGi9606.ENSP00000266095.

Structurei

3D structure databases

ProteinModelPortaliQ9UG56.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0688.
HOVERGENiHBG039630.
KOiK01613.
OMAiTWEYPTV.
OrthoDBiEOG76T9RH.
PhylomeDBiQ9UG56.
TreeFamiTF313148.

Family and domain databases

InterProiIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
PANTHERiPTHR10067. PTHR10067. 1 hit.
PfamiPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00163. PS_decarb. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UG56-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA    50
RKIHTAPART MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP 100
KLAGHWEVAL YKSVPTRLLS RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN 150
MKEAAVEDLH HYRNLSEFFR RKLKPQARPV CGLHSVISPS DGRILNFGQV 200
KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK NQLVTREGNE 250
LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC 300
HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN 350
DFSFVTHTNR EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI 400
RFGEALGSL 409
Length:409
Mass (Da):46,672
Last modified:November 2, 2010 - v4
Checksum:i6A5148265369D9DF
GO
Isoform 2 (identifier: Q9UG56-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MATSVGHRCL...IPPKLAGHWE → MMCQSEARQG...SRVGWRPVSR

Note: No experimental confirmation available.

Show »
Length:375
Mass (Da):43,047
Checksum:i4ED283AD1944C3C9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107MATSV…AGHWE → MMCQSEARQGPELRAAKWLH FPQLALRRRLGQLSCMSRPA LKLRSWPLTVLYYLLPFGAL RPLSRVGWRPVSR in isoform 2. VSP_007540Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456540 mRNA. Translation: CAG30426.1.
AL050371 Transcribed RNA. Translation: CAB43678.2. Sequence problems.
AL096768 Genomic DNA. Translation: CAB56394.1.
AL096768, AL031255 Genomic DNA. Translation: CAI23032.1.
AL031255, AL096768 Genomic DNA. Translation: CAI22447.1.
CH471095 Genomic DNA. Translation: EAW59984.1.
BC001482 mRNA. Translation: AAH01482.1.
BC009315 mRNA. Translation: AAH09315.1.
AF035304 mRNA. Translation: AAB88186.1.
CCDSiCCDS13899.1. [Q9UG56-2]
RefSeqiNP_055153.1. NM_014338.3. [Q9UG56-2]
XP_005261512.1. XM_005261455.1. [Q9UG56-3]
XP_005261513.1. XM_005261456.1. [Q9UG56-2]
XP_005261514.1. XM_005261457.2. [Q9UG56-2]
XP_005261515.1. XM_005261458.1. [Q9UG56-2]
XP_005261516.1. XM_005261459.1. [Q9UG56-2]
XP_005261517.1. XM_005261460.2. [Q9UG56-2]
XP_005261518.1. XM_005261461.2. [Q9UG56-2]
XP_006724263.1. XM_006724200.1. [Q9UG56-2]
XP_006724264.1. XM_006724201.1. [Q9UG56-2]
XP_006724265.1. XM_006724202.1. [Q9UG56-2]
UniGeneiHs.420559.
Hs.732339.

Genome annotation databases

EnsembliENST00000266095; ENSP00000266095; ENSG00000241878. [Q9UG56-2]
ENST00000336566; ENSP00000338695; ENSG00000241878.
ENST00000382151; ENSP00000371586; ENSG00000241878. [Q9UG56-2]
ENST00000439502; ENSP00000391739; ENSG00000241878. [Q9UG56-3]
GeneIDi23761.
KEGGihsa:23761.
UCSCiuc003alk.2. human. [Q9UG56-2]
uc003alm.4. human. [Q9UG56-3]

Polymorphism databases

DMDMi311033492.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456540 mRNA. Translation: CAG30426.1 .
AL050371 Transcribed RNA. Translation: CAB43678.2 . Sequence problems.
AL096768 Genomic DNA. Translation: CAB56394.1 .
AL096768 , AL031255 Genomic DNA. Translation: CAI23032.1 .
AL031255 , AL096768 Genomic DNA. Translation: CAI22447.1 .
CH471095 Genomic DNA. Translation: EAW59984.1 .
BC001482 mRNA. Translation: AAH01482.1 .
BC009315 mRNA. Translation: AAH09315.1 .
AF035304 mRNA. Translation: AAB88186.1 .
CCDSi CCDS13899.1. [Q9UG56-2 ]
RefSeqi NP_055153.1. NM_014338.3. [Q9UG56-2 ]
XP_005261512.1. XM_005261455.1. [Q9UG56-3 ]
XP_005261513.1. XM_005261456.1. [Q9UG56-2 ]
XP_005261514.1. XM_005261457.2. [Q9UG56-2 ]
XP_005261515.1. XM_005261458.1. [Q9UG56-2 ]
XP_005261516.1. XM_005261459.1. [Q9UG56-2 ]
XP_005261517.1. XM_005261460.2. [Q9UG56-2 ]
XP_005261518.1. XM_005261461.2. [Q9UG56-2 ]
XP_006724263.1. XM_006724200.1. [Q9UG56-2 ]
XP_006724264.1. XM_006724201.1. [Q9UG56-2 ]
XP_006724265.1. XM_006724202.1. [Q9UG56-2 ]
UniGenei Hs.420559.
Hs.732339.

3D structure databases

ProteinModelPortali Q9UG56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117262. 5 interactions.
IntActi Q9UG56. 2 interactions.
STRINGi 9606.ENSP00000266095.

Chemistry

DrugBanki DB00144. Phosphatidylserine.

PTM databases

PhosphoSitei Q9UG56.

Polymorphism databases

DMDMi 311033492.

Proteomic databases

MaxQBi Q9UG56.
PaxDbi Q9UG56.
PRIDEi Q9UG56.

Protocols and materials databases

DNASUi 23761.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266095 ; ENSP00000266095 ; ENSG00000241878 . [Q9UG56-2 ]
ENST00000336566 ; ENSP00000338695 ; ENSG00000241878 .
ENST00000382151 ; ENSP00000371586 ; ENSG00000241878 . [Q9UG56-2 ]
ENST00000439502 ; ENSP00000391739 ; ENSG00000241878 . [Q9UG56-3 ]
GeneIDi 23761.
KEGGi hsa:23761.
UCSCi uc003alk.2. human. [Q9UG56-2 ]
uc003alm.4. human. [Q9UG56-3 ]

Organism-specific databases

CTDi 23761.
GeneCardsi GC22M032014.
HGNCi HGNC:8999. PISD.
HPAi HPA031090.
HPA031091.
MIMi 612770. gene.
neXtProti NX_Q9UG56.
PharmGKBi PA33333.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0688.
HOVERGENi HBG039630.
KOi K01613.
OMAi TWEYPTV.
OrthoDBi EOG76T9RH.
PhylomeDBi Q9UG56.
TreeFami TF313148.

Enzyme and pathway databases

UniPathwayi UPA00558 ; UER00616 .
BioCyci MetaCyc:HS01985-MONOMER.
Reactomei REACT_120919. Synthesis of PE.

Miscellaneous databases

ChiTaRSi PISD. human.
GeneWikii PISD_(gene).
GenomeRNAii 23761.
NextBioi 46711.
PROi Q9UG56.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UG56.
Bgeei Q9UG56.
CleanExi HS_PISD.
Genevestigatori Q9UG56.

Family and domain databases

InterProi IPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view ]
PANTHERi PTHR10067. PTHR10067. 1 hit.
Pfami PF02666. PS_Dcarbxylase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00163. PS_decarb. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Neuroblastoma and Rhabdomyosarcoma.
  6. Yu W., Sarginson J., Gibbs R.A.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-409.
    Tissue: Brain.

Entry informationi

Entry nameiPISD_HUMAN
AccessioniPrimary (citable) accession number: Q9UG56
Secondary accession number(s): B1AKM7
, O43207, O95535, Q6IC28, Q96GQ2, Q9UGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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