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Q9UG56

- PISD_HUMAN

UniProt

Q9UG56 - PISD_HUMAN

Protein

Phosphatidylserine decarboxylase proenzyme

Gene

PISD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

    Cofactori

    Pyruvoyl group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei377 – 3782Cleavage (non-hydrolytic)By similarity

    GO - Molecular functioni

    1. phosphatidylserine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. phosphatidylethanolamine biosynthetic process Source: Reactome
    3. phospholipid metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01985-MONOMER.
    ReactomeiREACT_120919. Synthesis of PE.
    UniPathwayiUPA00558; UER00616.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylserine decarboxylase proenzyme (EC:4.1.1.65)
    Cleaved into the following 2 chains:
    Gene namesi
    Name:PISD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:8999. PISD.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33333.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Phosphatidylserine decarboxylase beta chainPRO_0000029835Add
    BLAST
    Chaini378 – 40932Phosphatidylserine decarboxylase alpha chainPRO_0000029836Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei378 – 3781Pyruvic acid (Ser)By similarity

    Keywords - PTMi

    Zymogen

    Proteomic databases

    MaxQBiQ9UG56.
    PaxDbiQ9UG56.
    PRIDEiQ9UG56.

    PTM databases

    PhosphoSiteiQ9UG56.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UG56.
    BgeeiQ9UG56.
    CleanExiHS_PISD.
    GenevestigatoriQ9UG56.

    Organism-specific databases

    HPAiHPA031090.
    HPA031091.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Protein-protein interaction databases

    BioGridi117262. 5 interactions.
    IntActiQ9UG56. 2 interactions.
    STRINGi9606.ENSP00000266095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UG56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0688.
    HOVERGENiHBG039630.
    KOiK01613.
    OMAiTWEYPTV.
    OrthoDBiEOG76T9RH.
    PhylomeDBiQ9UG56.
    TreeFamiTF313148.

    Family and domain databases

    InterProiIPR003817. PS_Dcarbxylase.
    IPR005221. PS_decarb.
    [Graphical view]
    PANTHERiPTHR10067. PTHR10067. 1 hit.
    PfamiPF02666. PS_Dcarbxylase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00163. PS_decarb. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UG56-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA    50
    RKIHTAPART MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP 100
    KLAGHWEVAL YKSVPTRLLS RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN 150
    MKEAAVEDLH HYRNLSEFFR RKLKPQARPV CGLHSVISPS DGRILNFGQV 200
    KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK NQLVTREGNE 250
    LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC 300
    HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN 350
    DFSFVTHTNR EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI 400
    RFGEALGSL 409
    Length:409
    Mass (Da):46,672
    Last modified:November 2, 2010 - v4
    Checksum:i6A5148265369D9DF
    GO
    Isoform 2 (identifier: Q9UG56-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: MATSVGHRCL...IPPKLAGHWE → MMCQSEARQG...SRVGWRPVSR

    Note: No experimental confirmation available.

    Show »
    Length:375
    Mass (Da):43,047
    Checksum:i4ED283AD1944C3C9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 107107MATSV…AGHWE → MMCQSEARQGPELRAAKWLH FPQLALRRRLGQLSCMSRPA LKLRSWPLTVLYYLLPFGAL RPLSRVGWRPVSR in isoform 2. 1 PublicationVSP_007540Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456540 mRNA. Translation: CAG30426.1.
    AL050371 Transcribed RNA. Translation: CAB43678.2. Sequence problems.
    AL096768 Genomic DNA. Translation: CAB56394.1.
    AL096768, AL031255 Genomic DNA. Translation: CAI23032.1.
    AL031255, AL096768 Genomic DNA. Translation: CAI22447.1.
    CH471095 Genomic DNA. Translation: EAW59984.1.
    BC001482 mRNA. Translation: AAH01482.1.
    BC009315 mRNA. Translation: AAH09315.1.
    AF035304 mRNA. Translation: AAB88186.1.
    CCDSiCCDS13899.1. [Q9UG56-2]
    RefSeqiNP_055153.1. NM_014338.3. [Q9UG56-2]
    XP_005261512.1. XM_005261455.1. [Q9UG56-3]
    XP_005261513.1. XM_005261456.1. [Q9UG56-2]
    XP_005261514.1. XM_005261457.2. [Q9UG56-2]
    XP_005261515.1. XM_005261458.1. [Q9UG56-2]
    XP_005261516.1. XM_005261459.1. [Q9UG56-2]
    XP_005261517.1. XM_005261460.2. [Q9UG56-2]
    XP_005261518.1. XM_005261461.2. [Q9UG56-2]
    XP_006724263.1. XM_006724200.1. [Q9UG56-2]
    XP_006724264.1. XM_006724201.1. [Q9UG56-2]
    XP_006724265.1. XM_006724202.1. [Q9UG56-2]
    UniGeneiHs.420559.
    Hs.732339.

    Genome annotation databases

    EnsembliENST00000266095; ENSP00000266095; ENSG00000241878. [Q9UG56-2]
    ENST00000382151; ENSP00000371586; ENSG00000241878. [Q9UG56-2]
    ENST00000439502; ENSP00000391739; ENSG00000241878. [Q9UG56-3]
    GeneIDi23761.
    KEGGihsa:23761.
    UCSCiuc003alk.2. human. [Q9UG56-2]
    uc003alm.4. human. [Q9UG56-3]

    Polymorphism databases

    DMDMi311033492.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR456540 mRNA. Translation: CAG30426.1 .
    AL050371 Transcribed RNA. Translation: CAB43678.2 . Sequence problems.
    AL096768 Genomic DNA. Translation: CAB56394.1 .
    AL096768 , AL031255 Genomic DNA. Translation: CAI23032.1 .
    AL031255 , AL096768 Genomic DNA. Translation: CAI22447.1 .
    CH471095 Genomic DNA. Translation: EAW59984.1 .
    BC001482 mRNA. Translation: AAH01482.1 .
    BC009315 mRNA. Translation: AAH09315.1 .
    AF035304 mRNA. Translation: AAB88186.1 .
    CCDSi CCDS13899.1. [Q9UG56-2 ]
    RefSeqi NP_055153.1. NM_014338.3. [Q9UG56-2 ]
    XP_005261512.1. XM_005261455.1. [Q9UG56-3 ]
    XP_005261513.1. XM_005261456.1. [Q9UG56-2 ]
    XP_005261514.1. XM_005261457.2. [Q9UG56-2 ]
    XP_005261515.1. XM_005261458.1. [Q9UG56-2 ]
    XP_005261516.1. XM_005261459.1. [Q9UG56-2 ]
    XP_005261517.1. XM_005261460.2. [Q9UG56-2 ]
    XP_005261518.1. XM_005261461.2. [Q9UG56-2 ]
    XP_006724263.1. XM_006724200.1. [Q9UG56-2 ]
    XP_006724264.1. XM_006724201.1. [Q9UG56-2 ]
    XP_006724265.1. XM_006724202.1. [Q9UG56-2 ]
    UniGenei Hs.420559.
    Hs.732339.

    3D structure databases

    ProteinModelPortali Q9UG56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117262. 5 interactions.
    IntActi Q9UG56. 2 interactions.
    STRINGi 9606.ENSP00000266095.

    Chemistry

    DrugBanki DB00144. Phosphatidylserine.

    PTM databases

    PhosphoSitei Q9UG56.

    Polymorphism databases

    DMDMi 311033492.

    Proteomic databases

    MaxQBi Q9UG56.
    PaxDbi Q9UG56.
    PRIDEi Q9UG56.

    Protocols and materials databases

    DNASUi 23761.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266095 ; ENSP00000266095 ; ENSG00000241878 . [Q9UG56-2 ]
    ENST00000382151 ; ENSP00000371586 ; ENSG00000241878 . [Q9UG56-2 ]
    ENST00000439502 ; ENSP00000391739 ; ENSG00000241878 . [Q9UG56-3 ]
    GeneIDi 23761.
    KEGGi hsa:23761.
    UCSCi uc003alk.2. human. [Q9UG56-2 ]
    uc003alm.4. human. [Q9UG56-3 ]

    Organism-specific databases

    CTDi 23761.
    GeneCardsi GC22M032014.
    HGNCi HGNC:8999. PISD.
    HPAi HPA031090.
    HPA031091.
    MIMi 612770. gene.
    neXtProti NX_Q9UG56.
    PharmGKBi PA33333.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0688.
    HOVERGENi HBG039630.
    KOi K01613.
    OMAi TWEYPTV.
    OrthoDBi EOG76T9RH.
    PhylomeDBi Q9UG56.
    TreeFami TF313148.

    Enzyme and pathway databases

    UniPathwayi UPA00558 ; UER00616 .
    BioCyci MetaCyc:HS01985-MONOMER.
    Reactomei REACT_120919. Synthesis of PE.

    Miscellaneous databases

    ChiTaRSi PISD. human.
    GeneWikii PISD_(gene).
    GenomeRNAii 23761.
    NextBioi 46711.
    PROi Q9UG56.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UG56.
    Bgeei Q9UG56.
    CleanExi HS_PISD.
    Genevestigatori Q9UG56.

    Family and domain databases

    InterProi IPR003817. PS_Dcarbxylase.
    IPR005221. PS_decarb.
    [Graphical view ]
    PANTHERi PTHR10067. PTHR10067. 1 hit.
    Pfami PF02666. PS_Dcarbxylase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00163. PS_decarb. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Neuroblastoma and Rhabdomyosarcoma.
    6. Yu W., Sarginson J., Gibbs R.A.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-409.
      Tissue: Brain.

    Entry informationi

    Entry nameiPISD_HUMAN
    AccessioniPrimary (citable) accession number: Q9UG56
    Secondary accession number(s): B1AKM7
    , O43207, O95535, Q6IC28, Q96GQ2, Q9UGA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3