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Q9UG56 (PISD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme

EC=4.1.1.65
Gene names
Name:PISD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactor

Pyruvoyl group By similarity.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Subunit structure

Heterodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family.

Sequence caution

The sequence CAB43678.2 differs from that shown. Reason: Erroneous translation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UG56-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UG56-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MATSVGHRCL...IPPKLAGHWE → MMCQSEARQG...SRVGWRPVSR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Phosphatidylserine decarboxylase beta chain
PRO_0000029835
Chain378 – 40932Phosphatidylserine decarboxylase alpha chain
PRO_0000029836

Sites

Site377 – 3782Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue3781Pyruvic acid (Ser) By similarity

Natural variations

Alternative sequence1 – 107107MATSV…AGHWE → MMCQSEARQGPELRAAKWLH FPQLALRRRLGQLSCMSRPA LKLRSWPLTVLYYLLPFGAL RPLSRVGWRPVSR in isoform 2.
VSP_007540

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 4.
Checksum: 6A5148265369D9DF

FASTA40946,672
        10         20         30         40         50         60 
MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART 

        70         80         90        100        110        120 
MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS 

       130        140        150        160        170        180 
RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV 

       190        200        210        220        230        240 
CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK 

       250        260        270        280        290        300 
NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC 

       310        320        330        340        350        360 
HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN DFSFVTHTNR 

       370        380        390        400 
EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL 

« Hide

Isoform 2 [UniParc].

Checksum: 4ED283AD1944C3C9
Show »

FASTA37543,047

References

[1]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Neuroblastoma and Rhabdomyosarcoma.
[6]Yu W., Sarginson J., Gibbs R.A.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-409.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR456540 mRNA. Translation: CAG30426.1.
AL050371 Transcribed RNA. Translation: CAB43678.2. Sequence problems.
AL096768 Genomic DNA. Translation: CAB56394.1.
AL096768, AL031255 Genomic DNA. Translation: CAI23032.1.
AL031255, AL096768 Genomic DNA. Translation: CAI22447.1.
CH471095 Genomic DNA. Translation: EAW59984.1.
BC001482 mRNA. Translation: AAH01482.1.
BC009315 mRNA. Translation: AAH09315.1.
AF035304 mRNA. Translation: AAB88186.1.
CCDSCCDS13899.1. [Q9UG56-2]
RefSeqNP_055153.1. NM_014338.3. [Q9UG56-2]
XP_005261512.1. XM_005261455.1. [Q9UG56-3]
XP_005261513.1. XM_005261456.1. [Q9UG56-2]
XP_005261514.1. XM_005261457.2. [Q9UG56-2]
XP_005261515.1. XM_005261458.1. [Q9UG56-2]
XP_005261516.1. XM_005261459.1. [Q9UG56-2]
XP_005261517.1. XM_005261460.2. [Q9UG56-2]
XP_005261518.1. XM_005261461.2. [Q9UG56-2]
XP_006724263.1. XM_006724200.1. [Q9UG56-2]
XP_006724264.1. XM_006724201.1. [Q9UG56-2]
XP_006724265.1. XM_006724202.1. [Q9UG56-2]
UniGeneHs.420559.
Hs.732339.

3D structure databases

ProteinModelPortalQ9UG56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117262. 4 interactions.
IntActQ9UG56. 2 interactions.
STRING9606.ENSP00000266095.

Chemistry

DrugBankDB00144. Phosphatidylserine.

PTM databases

PhosphoSiteQ9UG56.

Polymorphism databases

DMDM311033492.

Proteomic databases

MaxQBQ9UG56.
PaxDbQ9UG56.
PRIDEQ9UG56.

Protocols and materials databases

DNASU23761.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266095; ENSP00000266095; ENSG00000241878. [Q9UG56-2]
ENST00000336566; ENSP00000338695; ENSG00000241878.
ENST00000382151; ENSP00000371586; ENSG00000241878. [Q9UG56-2]
ENST00000439502; ENSP00000391739; ENSG00000241878. [Q9UG56-3]
GeneID23761.
KEGGhsa:23761.
UCSCuc003alk.2. human. [Q9UG56-2]
uc003alm.4. human. [Q9UG56-3]

Organism-specific databases

CTD23761.
GeneCardsGC22M032014.
HGNCHGNC:8999. PISD.
HPAHPA031090.
HPA031091.
MIM612770. gene.
neXtProtNX_Q9UG56.
PharmGKBPA33333.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0688.
HOVERGENHBG039630.
KOK01613.
OMATWEYPTV.
OrthoDBEOG76T9RH.
PhylomeDBQ9UG56.
TreeFamTF313148.

Enzyme and pathway databases

BioCycMetaCyc:HS01985-MONOMER.
ReactomeREACT_111217. Metabolism.
UniPathwayUPA00558; UER00616.

Gene expression databases

ArrayExpressQ9UG56.
BgeeQ9UG56.
CleanExHS_PISD.
GenevestigatorQ9UG56.

Family and domain databases

InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
PANTHERPTHR10067. PTHR10067. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPISD. human.
GeneWikiPISD_(gene).
GenomeRNAi23761.
NextBio46711.
PROQ9UG56.
SOURCESearch...

Entry information

Entry namePISD_HUMAN
AccessionPrimary (citable) accession number: Q9UG56
Secondary accession number(s): B1AKM7 expand/collapse secondary AC list , O43207, O95535, Q6IC28, Q96GQ2, Q9UGA9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM