Q9UG56 (PISD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:

PISD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Subunit structure	Heterodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family.
Sequence caution	The sequence CAB43678.2 differs from that shown. Reason: Erroneous translation.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UG56-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UG56-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MATSVGHRCL...IPPKLAGHWE → MMCQSEARQG...SRVGWRPVSR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Phosphatidylserine decarboxylase beta chain		PRO_0000029835
	Chain	378 – 409	32	Phosphatidylserine decarboxylase alpha chain		PRO_0000029836
Sites
	Site	377 – 378	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	378	1	Pyruvic acid (Ser) By similarity
Natural variations
	Alternative sequence	1 – 107	107	MATSV…AGHWE → MMCQSEARQGPELRAAKWLH FPQLALRRRLGQLSCMSRPA LKLRSWPLTVLYYLLPFGAL RPLSRVGWRPVSR in isoform 2.		VSP_007540

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 4. Checksum: 6A5148265369D9DF	FASTA	409	46,672
	10 20 30 40 50 60 MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART 70 80 90 100 110 120 MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS 130 140 150 160 170 180 RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV 190 200 210 220 230 240 CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK 250 260 270 280 290 300 NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC 310 320 330 340 350 360 HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN DFSFVTHTNR 370 380 390 400 EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL
	Isoform 2 [UniParc]. Checksum: 4ED283AD1944C3C9	FASTA	375	43,047
	10 20 30 40 50 60 MMCQSEARQG PELRAAKWLH FPQLALRRRL GQLSCMSRPA LKLRSWPLTV LYYLLPFGAL 70 80 90 100 110 120 RPLSRVGWRP VSRVALYKSV PTRLLSRAWG RLNQVELPHW LRRPVYSLYI WTFGVNMKEA 130 140 150 160 170 180 AVEDLHHYRN LSEFFRRKLK PQARPVCGLH SVISPSDGRI LNFGQVKNCE VEQVKGVTYS 190 200 210 220 230 240 LESFLGPRMC TEDLPFPPAA SCDSFKNQLV TREGNELYHC VIYLAPGDYH CFHSPTDWTV 250 260 270 280 290 300 SHRRHFPGSL MSVNPGMARW IKELFCHNER VVLTGDWKHG FFSLTAVGAT NVGSIRIYFD 310 320 330 340 350 360 RDLHTNSPRH SKGSYNDFSF VTHTNREGVP MRKGEHLGEF NLGSTIVLIF EAPKDFNFQL 370 KTGQKIRFGE ALGSL

References

[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Neuroblastoma and Rhabdomyosarcoma.
[6]	Yu W., Sarginson J., Gibbs R.A. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-409. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR456540 mRNA. Translation: CAG30426.1. AL050371 Transcribed RNA. Translation: CAB43678.2. Sequence problems. AL096768 Genomic DNA. Translation: CAB56394.1. AL096768, AL031255 Genomic DNA. Translation: CAI23032.1. AL031255, AL096768 Genomic DNA. Translation: CAI22447.1. CH471095 Genomic DNA. Translation: EAW59984.1. BC001482 mRNA. Translation: AAH01482.1. BC009315 mRNA. Translation: AAH09315.1. AF035304 mRNA. Translation: AAB88186.1.
IPI	IPI00003827. IPI00937891.
RefSeq	NP_055153.1. NM_014338.3.
UniGene	Hs.420559.
3D structure databases
ProteinModelPortal	Q9UG56.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UG56. 2 interactions.
STRING	Q9UG56.
PTM databases
PhosphoSite	Q9UG56.
Polymorphism databases
DMDM	311033492.
Proteomic databases
PRIDE	Q9UG56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336566; ENSP00000338695; ENSG00000241878.
GeneID	23761.
KEGG	hsa:23761.
UCSC	uc003alm.2. human.
Organism-specific databases
CTD	23761.
GeneCards	GC22M032014.
HGNC	HGNC:8999. PISD.
HPA	HPA031090. HPA031091.
MIM	612770. gene.
neXtProt	NX_Q9UG56.
PharmGKB	PA33333.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11415.
GeneTree	ENSGT00390000013484.
HOVERGEN	HBG039630.
OMA	MCQSEAR.
PhylomeDB	Q9UG56.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000100141-MONOMER.
Pathway_Interaction_DB	hnf3apathway. FOXA1 transcription factor network.
Gene expression databases
ArrayExpress	Q9UG56.
Bgee	Q9UG56.
CleanEx	HS_PISD.
Genevestigator	Q9UG56.
GermOnline	ENSG00000100141. Homo sapiens.
Family and domain databases
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
KO	K01613.
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00144. Phosphatidylserine.
NextBio	46711.
SOURCE	Search...

Entry information

Entry name

PISD_HUMAN

Accession

Primary (citable) accession number: Q9UG56
Secondary accession number(s): B1AKM7 , O43207, O95535, Q6IC28, Q96GQ2, Q9UGA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	November 2, 2010
Last modified:	January 25, 2012
This is version 92 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.