Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UG01

- IF172_HUMAN

UniProt

Q9UG01 - IF172_HUMAN

Protein

Intraflagellar transport protein 172 homolog

Gene

IFT172

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway By similarity.By similarity

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. determination of left/right symmetry Source: Ensembl
    3. dorsal/ventral pattern formation Source: Ensembl
    4. neural tube formation Source: Ensembl
    5. protein processing Source: Ensembl
    6. smoothened signaling pathway Source: Ensembl
    7. spinal cord motor neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intraflagellar transport protein 172 homolog
    Gene namesi
    Name:IFT172
    Synonyms:KIAA1179
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30391. IFT172.

    Subcellular locationi

    Cell projectioncilium 1 Publication
    Note: Localized to the axoneme and around the base of the cilium.

    GO - Cellular componenti

    1. axoneme Source: RefGenome
    2. ciliary basal body Source: RefGenome
    3. cilium Source: UniProtKB
    4. intraciliary transport particle B Source: RefGenome

    Keywords - Cellular componenti

    Cell projection, Cilium

    Pathology & Biotechi

    Involvement in diseasei

    Short-rib thoracic dysplasia 10 with or without polydactyly (SRTD10) [MIM:615630]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti296 – 2961R → W in SRTD10. 1 Publication
    VAR_070956
    Natural varianti411 – 4111I → N in SRTD10. 1 Publication
    VAR_070957
    Natural varianti464 – 4652Missing in SRTD10.
    VAR_070958
    Natural varianti1536 – 15361L → P in SRTD10. 1 Publication
    VAR_070959
    Natural varianti1544 – 15441R → C in SRTD10. 1 Publication
    VAR_070960
    Natural varianti1727 – 17271C → R in SRTD10. 1 Publication
    VAR_070961

    Keywords - Diseasei

    Ciliopathy, Disease mutation

    Organism-specific databases

    MIMi615630. phenotype.
    Orphaneti474. Jeune syndrome.
    140969. Saldino-Mainzer syndrome.
    PharmGKBiPA142671666.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17491749Intraflagellar transport protein 172 homologPRO_0000328941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Cross-linki4 – 4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1)

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ9UG01.
    PaxDbiQ9UG01.
    PRIDEiQ9UG01.

    PTM databases

    PhosphoSiteiQ9UG01.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UG01.
    BgeeiQ9UG01.
    CleanExiHS_IFT172.
    GenevestigatoriQ9UG01.

    Organism-specific databases

    HPAiHPA044893.

    Interactioni

    Subunit structurei

    Interacts with IFT88. Interacts with RABL2/RABL2A; binds preferentially to GDP-bound RABL2.By similarity

    Protein-protein interaction databases

    BioGridi117589. 5 interactions.
    IntActiQ9UG01. 6 interactions.
    STRINGi9606.ENSP00000260570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UG01.
    SMRiQ9UG01. Positions 236-312, 1107-1168, 1202-1250, 1276-1303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati14 – 5340WD 1Add
    BLAST
    Repeati64 – 10340WD 2Add
    BLAST
    Repeati110 – 14839WD 3Add
    BLAST
    Repeati150 – 19142WD 4Add
    BLAST
    Repeati195 – 23339WD 5Add
    BLAST
    Repeati238 – 27841WD 6Add
    BLAST
    Repeati284 – 32340WD 7Add
    BLAST
    Repeati483 – 52038WD 8Add
    BLAST
    Repeati521 – 55939WD 9Add
    BLAST
    Repeati593 – 62432TPR 1Add
    BLAST
    Repeati692 – 72534TPR 2Add
    BLAST
    Repeati809 – 84234TPR 3Add
    BLAST
    Repeati854 – 88734TPR 4Add
    BLAST
    Repeati912 – 94534TPR 5Add
    BLAST
    Repeati947 – 97024TPR 6Add
    BLAST
    Repeati971 – 100434TPR 7Add
    BLAST
    Repeati1042 – 107534TPR 8Add
    BLAST
    Repeati1142 – 117534TPR 9Add
    BLAST
    Repeati1276 – 130934TPR 10Add
    BLAST
    Repeati1345 – 137834TPR 11Add
    BLAST
    Repeati1411 – 144535TPR 12Add
    BLAST
    Repeati1447 – 147731TPR 13Add
    BLAST
    Repeati1574 – 160734TPR 14Add
    BLAST

    Sequence similaritiesi

    Belongs to the IFT172 family.Curated
    Contains 14 TPR repeats.Curated
    Contains 9 WD repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG289811.
    HOGENOMiHOG000259226.
    HOVERGENiHBG098449.
    InParanoidiQ9UG01.
    OMAiKLRLHLY.
    OrthoDBiEOG7FJGZM.
    PhylomeDBiQ9UG01.
    TreeFamiTF312901.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF50978. SSF50978. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UG01-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR     50
    DKFSTKPADM KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG 100
    DKKVICNKFI QTSAVTCLQW PAEYIIVFGL AEGKVRLANT KTNKSSTIYG 150
    TESYVVSLTT NCSGKGILSG HADGTIVRYF FDDEGSGESQ GKLVNHPCPP 200
    YALAWATNSI VAAGCDRKIV AYGKEGHMLQ TFDYSRDPQE REFTTAVSSP 250
    GGQSVVLGSY DRLRVFNWIP RRSIWEEAKP KEITNLYTIT ALAWKRDGSR 300
    LCVGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK 350
    SHYGYEVEEV KILGKERYLV AHTSETLLLG DLNTNRLSEI AWQGSGGNEK 400
    YFFENENVCM IFNAGELTLV EYGNNDTLGS VRTEFMNPHL ISVRINERCQ 450
    RGTEDNKKLA YLIDIKTIAI VDLIGGYNIG TVSHESRVDW LELNETGHKL 500
    LFRDRKLRLH LYDIESCSKT MILNFCSYMQ WVPGSDVLVA QNRNSLCVWY 550
    NIEAPERVTM FTIRGDVIGL ERGGGKTEVM VMEGVTTVAY TLDEGLIEFG 600
    TAIDDGNYIR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHIAERCFSA 650
    LGQVAKARFL HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM 700
    IFLEQNAVEE AMGMYQELHR WDECIAVAEA KGHPALEKLR RSYYQWLMDT 750
    QQEERAGELQ ESQGDGLAAI SLYLKAGLPA KAARLVLTRE ELLANTELVE 800
    HITAALIKGE LYERAGDLFE KIHNPQKALE CYRKGNAFMK AVELARLAFP 850
    VEVVKLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI 900
    YILDLQDRNT ASKYYPLVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ 950
    AGRWEQAHKL AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVQEP 1000
    DLAITMYKKH KLYDDMIRLV GKHHPDLLSD THLHLGKELE AEGRLQEAEY 1050
    HYLEAQEWKA TVNMYRASGL WEEAYRVART QGGANAHKHV AYLWAKSLGG 1100
    EAAVRLLNKL GLLEAAVDHA ADNCSFEFAF ELSRLALKHK TPEVHLKYAM 1150
    FLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA 1200
    EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK 1250
    DYVPSQLEAL QEEYEREATK KGARGVEGFV EQARHWEQAG EYSRAVDCYL 1300
    KVRDSGNSGL AEKCWMKAAE LSIKFLPPQR NMEVVLAVGP QLIGIGKHSA 1350
    AAELYLNLDL VKEAIDAFIE GEEWNKAKRV AKELDPRYED YVDQHYKEFL 1400
    KNQGKVDSLV GVDVIAALDL YVEQGQWDKC IETATKQNYK ILHKYVALYA 1450
    THLIREGSSA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNCAEAY 1500
    HSWADLRDVL FNLCENLVKS SEANSPAHEE FKTMLLIAHY YATRSAAQSV 1550
    KQLETVAARL SVSLLRHTQL LPVDKAFYEA GIAAKAVGWD NMAFIFLNRF 1600
    LDLTDAIEEG TLDGLDHSDF QDTDIPFEVP LPAKQHVPEA EREEVRDWVL 1650
    TVSMDQRLEQ VLPRDERGAY EASLVAASTG VRALPCLITG YPILRNKIEF 1700
    KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG LPSTSFSFQ 1749
    Length:1,749
    Mass (Da):197,576
    Last modified:April 8, 2008 - v2
    Checksum:i78AA83802D79E3CE
    GO
    Isoform 2 (identifier: Q9UG01-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1514-1525: CENLVKSSEANS → AVLSPSSSVKTW
         1526-1749: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,525
    Mass (Da):172,438
    Checksum:i0F5C5D89B95F6B0F
    GO
    Isoform 3 (identifier: Q9UG01-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         509-532: LHLYDIESCSKTMILNFCSYMQWV → VRRATKALGIGWPTEGVRQAATRD
         533-1749: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:532
    Mass (Da):59,659
    Checksum:i73321ACEDA74FF52
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1475 – 14751P → L in CAB55914. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti296 – 2961R → W in SRTD10. 1 Publication
    VAR_070956
    Natural varianti411 – 4111I → N in SRTD10. 1 Publication
    VAR_070957
    Natural varianti464 – 4652Missing in SRTD10.
    VAR_070958
    Natural varianti953 – 9531R → H.
    Corresponds to variant rs704793 [ dbSNP | Ensembl ].
    VAR_042581
    Natural varianti1536 – 15361L → P in SRTD10. 1 Publication
    VAR_070959
    Natural varianti1544 – 15441R → C in SRTD10. 1 Publication
    VAR_070960
    Natural varianti1727 – 17271C → R in SRTD10. 1 Publication
    VAR_070961

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei509 – 53224LHLYD…YMQWV → VRRATKALGIGWPTEGVRQA ATRD in isoform 3. 1 PublicationVSP_054428Add
    BLAST
    Alternative sequencei533 – 17491217Missing in isoform 3. 1 PublicationVSP_054429Add
    BLAST
    Alternative sequencei1514 – 152512CENLV…SEANS → AVLSPSSSVKTW in isoform 2. 1 PublicationVSP_032848Add
    BLAST
    Alternative sequencei1526 – 1749224Missing in isoform 2. 1 PublicationVSP_032849Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC074117 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00573.1.
    BC008024 mRNA. Translation: AAH08024.1.
    BC047294 mRNA. Translation: AAH47294.1.
    BC137126 mRNA. Translation: AAI37127.1.
    BC142675 mRNA. Translation: AAI42676.1.
    BC142729 mRNA. Translation: AAI42730.1.
    AL110218 mRNA. Translation: CAB53678.1.
    AL117421 mRNA. Translation: CAB55914.2.
    AB033005 mRNA. Translation: BAA86493.1.
    CCDSiCCDS1755.1. [Q9UG01-1]
    PIRiT14758.
    T17224.
    RefSeqiNP_056477.1. NM_015662.2. [Q9UG01-1]
    UniGeneiHs.127401.

    Genome annotation databases

    EnsembliENST00000260570; ENSP00000260570; ENSG00000138002. [Q9UG01-1]
    ENST00000359466; ENSP00000352443; ENSG00000138002. [Q9UG01-3]
    GeneIDi26160.
    KEGGihsa:26160.
    UCSCiuc002rku.3. human. [Q9UG01-1]

    Polymorphism databases

    DMDMi182662418.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC074117 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00573.1 .
    BC008024 mRNA. Translation: AAH08024.1 .
    BC047294 mRNA. Translation: AAH47294.1 .
    BC137126 mRNA. Translation: AAI37127.1 .
    BC142675 mRNA. Translation: AAI42676.1 .
    BC142729 mRNA. Translation: AAI42730.1 .
    AL110218 mRNA. Translation: CAB53678.1 .
    AL117421 mRNA. Translation: CAB55914.2 .
    AB033005 mRNA. Translation: BAA86493.1 .
    CCDSi CCDS1755.1. [Q9UG01-1 ]
    PIRi T14758.
    T17224.
    RefSeqi NP_056477.1. NM_015662.2. [Q9UG01-1 ]
    UniGenei Hs.127401.

    3D structure databases

    ProteinModelPortali Q9UG01.
    SMRi Q9UG01. Positions 236-312, 1107-1168, 1202-1250, 1276-1303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117589. 5 interactions.
    IntActi Q9UG01. 6 interactions.
    STRINGi 9606.ENSP00000260570.

    PTM databases

    PhosphoSitei Q9UG01.

    Polymorphism databases

    DMDMi 182662418.

    Proteomic databases

    MaxQBi Q9UG01.
    PaxDbi Q9UG01.
    PRIDEi Q9UG01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260570 ; ENSP00000260570 ; ENSG00000138002 . [Q9UG01-1 ]
    ENST00000359466 ; ENSP00000352443 ; ENSG00000138002 . [Q9UG01-3 ]
    GeneIDi 26160.
    KEGGi hsa:26160.
    UCSCi uc002rku.3. human. [Q9UG01-1 ]

    Organism-specific databases

    CTDi 26160.
    GeneCardsi GC02M027667.
    H-InvDB HIX0001924.
    HIX0119024.
    HGNCi HGNC:30391. IFT172.
    HPAi HPA044893.
    MIMi 607386. gene.
    615630. phenotype.
    neXtProti NX_Q9UG01.
    Orphaneti 474. Jeune syndrome.
    140969. Saldino-Mainzer syndrome.
    PharmGKBi PA142671666.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289811.
    HOGENOMi HOG000259226.
    HOVERGENi HBG098449.
    InParanoidi Q9UG01.
    OMAi KLRLHLY.
    OrthoDBi EOG7FJGZM.
    PhylomeDBi Q9UG01.
    TreeFami TF312901.

    Miscellaneous databases

    ChiTaRSi IFT172. human.
    GenomeRNAii 26160.
    NextBioi 35462254.
    PROi Q9UG01.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UG01.
    Bgeei Q9UG01.
    CleanExi HS_IFT172.
    Genevestigatori Q9UG01.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-1749 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1203-1737 (ISOFORM 2).
      Tissue: Testis.
    5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 660-1749 (ISOFORM 1).
      Tissue: Brain.
    6. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
      Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A., Eriksson J.E., Sistonen L.
      J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION AT LYS-4, ACETYLATION AT MET-1.
      Tissue: Cervix carcinoma.
    7. Cited for: SUBCELLULAR LOCATION, VARIANTS SRTD10 TRP-296; ASN-411; 464-ASP-ILE-465 DEL; PRO-1536; CYS-1544 AND ARG-1727.

    Entry informationi

    Entry nameiIF172_HUMAN
    AccessioniPrimary (citable) accession number: Q9UG01
    Secondary accession number(s): A5PKZ0
    , B2RNU5, Q86X44, Q96HW4, Q9UFJ9, Q9ULP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3