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Protein

Phosphoinositide phospholipase C

Gene

DKFZp434N101

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:DKFZp434N101Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiQ9UFY1
PeptideAtlasiQ9UFY1
PRIDEiQ9UFY1

Expressioni

Gene expression databases

GenevisibleiQ9UFY1 HS

Structurei

3D structure databases

ProteinModelPortaliQ9UFY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 136SH3InterPro annotationAdd BLAST61
Domaini180 – 216PHInterPro annotationAdd BLAST37
Domaini238 – 355PI-PLC Y-boxInterPro annotationAdd BLAST118
Domaini360 – 462C2InterPro annotationAdd BLAST103

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
HOVERGENiHBG053611

Family and domain databases

CDDicd11970 SH3_PLCgamma1, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR028380 PLC-gamma1
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR035724 PLCgamma1_SH3
IPR001711 PLipase_C_Pinositol-sp_Y
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF52 PTHR10336:SF52, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00149 PLCYc, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9UFY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RVQQEGQTVM LGNSEFDSLV DLISYYEKHP LYRKMKLRYP INEEALEKIG
60 70 80 90 100
TAEPDYGALY EGRNPGFYVE ANPMPTFKCA VKALFDYKAQ REDELTFTKS
110 120 130 140 150
AIIQNVEKQE GGWWRGDYGG KKQLWFPSNY VEEMVNPVAL EPEREHLDEN
160 170 180 190 200
SPLGDLLRGV LDVPACQIAI RPEGKNNRLF VFSISMASVA HWSLDVAADS
210 220 230 240 250
QEELQDWVKK IREVAQTADA RLTEGKIMER RKKIALELSE LVVYCRPVPF
260 270 280 290 300
DEEKIGTERA CYRDMSSFPE TKAEKYVNKA KGKKFLQYNR LQLSRIYPKG
310 320 330 340 350
QRLDSSNYDP LPMWICGSQL VALNFQTPDK PMQMNQALFM TGRHCGYVLQ
360 370 380 390 400
PSTMRDEAFD PFDKSSLRGL EPCAISIEVL GARHLPKNGR GIVCPFVEIE
410 420 430 440 450
VAGAEYDSTK QKTEFVVDNG LNPVWPAKPF HFQISNPEFA FLRFVVYEED
460 470 480 490 500
MFSDQNFLAQ ATFPVKGLKT GYRAVPLKNN YSEDLELASL LIKIDIFPAK
510 520 530 540 550
QENGDLSPFS GTSLRERGSD ASGQLFHGRA REGSFESRYQ QPFEDFRISQ
560 570 580 590 600
EHLADHFDSR ERSKDTLPFC PGPQEGLGSM ETTASSCTPA SLESSRCCAP
610 620
CRMPRTGFFG SSPLWRPSGS RSLKPGFQQ
Length:629
Mass (Da):71,370
Last modified:May 1, 2000 - v1
Checksum:i0DC47D69895BD95F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110247 mRNA Translation: CAB53696.1
PIRiT14776
RefSeqiNP_002651.2, NM_002660.2
UniGeneiHs.268177

Genome annotation databases

GeneIDi5335

Similar proteinsi

Entry informationi

Entry nameiQ9UFY1_HUMAN
AccessioniPrimary (citable) accession number: Q9UFY1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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