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Protein

Phosphoinositide phospholipase C

Gene

DKFZp434N101

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:DKFZp434N101Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ9UFY1.
PaxDbiQ9UFY1.
PRIDEiQ9UFY1.

Expressioni

Gene expression databases

GenevisibleiQ9UFY1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000244007.

Structurei

3D structure databases

ProteinModelPortaliQ9UFY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 13661SH3InterPro annotationAdd
BLAST
Domaini180 – 21637PHInterPro annotationAdd
BLAST
Domaini238 – 355118PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini360 – 462103C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains PI-PLC X-box domain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
HOVERGENiHBG053611.
KOiK01116.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028380. PLC-gamma1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF52. PTHR10336:SF52. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00149. PLCYc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF51695. SSF51695. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UFY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RVQQEGQTVM LGNSEFDSLV DLISYYEKHP LYRKMKLRYP INEEALEKIG
60 70 80 90 100
TAEPDYGALY EGRNPGFYVE ANPMPTFKCA VKALFDYKAQ REDELTFTKS
110 120 130 140 150
AIIQNVEKQE GGWWRGDYGG KKQLWFPSNY VEEMVNPVAL EPEREHLDEN
160 170 180 190 200
SPLGDLLRGV LDVPACQIAI RPEGKNNRLF VFSISMASVA HWSLDVAADS
210 220 230 240 250
QEELQDWVKK IREVAQTADA RLTEGKIMER RKKIALELSE LVVYCRPVPF
260 270 280 290 300
DEEKIGTERA CYRDMSSFPE TKAEKYVNKA KGKKFLQYNR LQLSRIYPKG
310 320 330 340 350
QRLDSSNYDP LPMWICGSQL VALNFQTPDK PMQMNQALFM TGRHCGYVLQ
360 370 380 390 400
PSTMRDEAFD PFDKSSLRGL EPCAISIEVL GARHLPKNGR GIVCPFVEIE
410 420 430 440 450
VAGAEYDSTK QKTEFVVDNG LNPVWPAKPF HFQISNPEFA FLRFVVYEED
460 470 480 490 500
MFSDQNFLAQ ATFPVKGLKT GYRAVPLKNN YSEDLELASL LIKIDIFPAK
510 520 530 540 550
QENGDLSPFS GTSLRERGSD ASGQLFHGRA REGSFESRYQ QPFEDFRISQ
560 570 580 590 600
EHLADHFDSR ERSKDTLPFC PGPQEGLGSM ETTASSCTPA SLESSRCCAP
610 620
CRMPRTGFFG SSPLWRPSGS RSLKPGFQQ
Length:629
Mass (Da):71,370
Last modified:May 1, 2000 - v1
Checksum:i0DC47D69895BD95F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110247 mRNA. Translation: CAB53696.1.
PIRiT14776.
RefSeqiNP_002651.2. NM_002660.2.
UniGeneiHs.268177.

Genome annotation databases

GeneIDi5335.
KEGGihsa:5335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110247 mRNA. Translation: CAB53696.1.
PIRiT14776.
RefSeqiNP_002651.2. NM_002660.2.
UniGeneiHs.268177.

3D structure databases

ProteinModelPortaliQ9UFY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000244007.

Proteomic databases

MaxQBiQ9UFY1.
PaxDbiQ9UFY1.
PRIDEiQ9UFY1.

Protocols and materials databases

DNASUi5335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5335.
KEGGihsa:5335.

Organism-specific databases

CTDi5335.

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
HOVERGENiHBG053611.
KOiK01116.

Miscellaneous databases

GenomeRNAii5335.

Gene expression databases

GenevisibleiQ9UFY1. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028380. PLC-gamma1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF52. PTHR10336:SF52. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00149. PLCYc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF51695. SSF51695. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ9UFY1_HUMAN
AccessioniPrimary (citable) accession number: Q9UFY1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.