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Protein

Protein NipSnap homolog 3A

Gene

NIPSNAP3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136783-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NipSnap homolog 3A
Short name:
NipSnap3A
Alternative name(s):
Protein NipSnap homolog 4
Short name:
NipSnap4
Target for Salmonella secreted protein C
Short name:
TassC
Gene namesi
Name:NIPSNAP3A
Synonyms:NIPSNAP4
ORF Names:HSPC299
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23619. NIPSNAP3A.

Subcellular locationi

  • Cytoplasmcytosol 1 Publication

  • Note: May be part of some vesicular structure distinct from lysosomal vesicles.

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • mitochondrion Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136783.
PharmGKBiPA134954501.

Polymorphism and mutation databases

BioMutaiNIPSNAP3A.
DMDMi18203499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211521 – 247Protein NipSnap homolog 3AAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-acetyllysineCombined sources1
Modified residuei166N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UFN0.
MaxQBiQ9UFN0.
PaxDbiQ9UFN0.
PeptideAtlasiQ9UFN0.
PRIDEiQ9UFN0.

2D gel databases

OGPiQ9UFN0.
UCD-2DPAGEQ9UFN0.

PTM databases

iPTMnetiQ9UFN0.
PhosphoSitePlusiQ9UFN0.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.1 Publication

Gene expression databases

BgeeiENSG00000136783.
CleanExiHS_NIPSNAP3A.
GenevisibleiQ9UFN0. HS.

Organism-specific databases

HPAiHPA042491.
HPA047909.
HPA047925.
HPA049256.

Interactioni

Subunit structurei

Interacts with the Salmonella typhimurium virulence protein spiC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-716291,EBI-739624
TP63Q9H3D42EBI-716291,EBI-2337775

Protein-protein interaction databases

BioGridi117432. 26 interactors.
IntActiQ9UFN0. 12 interactors.
MINTiMINT-1385104.
STRINGi9606.ENSP00000363899.

Structurei

3D structure databases

ProteinModelPortaliQ9UFN0.
SMRiQ9UFN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NipSnap family.Curated

Phylogenomic databases

eggNOGiKOG2883. Eukaryota.
ENOG410XSWP. LUCA.
GeneTreeiENSGT00730000111003.
HOGENOMiHOG000007437.
HOVERGENiHBG052660.
InParanoidiQ9UFN0.
OMAiHAEYGVL.
OrthoDBiEOG091G0MXA.
PhylomeDBiQ9UFN0.
TreeFamiTF314501.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UFN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLRSALTR ALASRTLAPQ MCSSFATGPR QYDGIFYEFR SYYLKPSKMN
60 70 80 90 100
EFLENFEKNA HLRTAHSELV GYWSVEFGGR MNTVFHIWKY DNFAHRTEVR
110 120 130 140 150
KALAKDKEWQ EQFLIPNLAL IDKQESEITY LVPWCKLEKP PKEGVYELAT
160 170 180 190 200
FQMKPGGPAL WGDAFKRAVH AHVNLGYTKL VGVFHTEYGA LNRVHVLWWN
210 220 230 240
ESADSRAAGR HKSHEDPRVV AAVRESVNYL VSQQNMLLIP TSFSPLK
Length:247
Mass (Da):28,467
Last modified:September 26, 2001 - v2
Checksum:iDA668E2AD42BA1AA
GO

Sequence cautioni

The sequence AAF28977 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108E → G in AAF28977 (Ref. 3) Curated1
Sequence conflicti118L → S in AAF28977 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020442100R → Q.1 PublicationCorresponds to variant rs2274870dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024015 mRNA. Translation: BAB14777.1.
AL117557 mRNA. Translation: CAB55992.2.
AF161417 mRNA. Translation: AAF28977.1. Different initiation.
AL359846 Genomic DNA. Translation: CAH73580.1.
CH471105 Genomic DNA. Translation: EAW58990.1.
BC005935 mRNA. Translation: AAH05935.1.
CCDSiCCDS6760.1.
RefSeqiNP_001316499.1. NM_001329570.1.
NP_056284.1. NM_015469.2.
UniGeneiHs.530275.

Genome annotation databases

EnsembliENST00000374767; ENSP00000363899; ENSG00000136783.
GeneIDi25934.
KEGGihsa:25934.
UCSCiuc004bch.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024015 mRNA. Translation: BAB14777.1.
AL117557 mRNA. Translation: CAB55992.2.
AF161417 mRNA. Translation: AAF28977.1. Different initiation.
AL359846 Genomic DNA. Translation: CAH73580.1.
CH471105 Genomic DNA. Translation: EAW58990.1.
BC005935 mRNA. Translation: AAH05935.1.
CCDSiCCDS6760.1.
RefSeqiNP_001316499.1. NM_001329570.1.
NP_056284.1. NM_015469.2.
UniGeneiHs.530275.

3D structure databases

ProteinModelPortaliQ9UFN0.
SMRiQ9UFN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117432. 26 interactors.
IntActiQ9UFN0. 12 interactors.
MINTiMINT-1385104.
STRINGi9606.ENSP00000363899.

PTM databases

iPTMnetiQ9UFN0.
PhosphoSitePlusiQ9UFN0.

Polymorphism and mutation databases

BioMutaiNIPSNAP3A.
DMDMi18203499.

2D gel databases

OGPiQ9UFN0.
UCD-2DPAGEQ9UFN0.

Proteomic databases

EPDiQ9UFN0.
MaxQBiQ9UFN0.
PaxDbiQ9UFN0.
PeptideAtlasiQ9UFN0.
PRIDEiQ9UFN0.

Protocols and materials databases

DNASUi25934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374767; ENSP00000363899; ENSG00000136783.
GeneIDi25934.
KEGGihsa:25934.
UCSCiuc004bch.1. human.

Organism-specific databases

CTDi25934.
GeneCardsiNIPSNAP3A.
HGNCiHGNC:23619. NIPSNAP3A.
HPAiHPA042491.
HPA047909.
HPA047925.
HPA049256.
MIMi608871. gene.
neXtProtiNX_Q9UFN0.
OpenTargetsiENSG00000136783.
PharmGKBiPA134954501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2883. Eukaryota.
ENOG410XSWP. LUCA.
GeneTreeiENSGT00730000111003.
HOGENOMiHOG000007437.
HOVERGENiHBG052660.
InParanoidiQ9UFN0.
OMAiHAEYGVL.
OrthoDBiEOG091G0MXA.
PhylomeDBiQ9UFN0.
TreeFamiTF314501.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136783-MONOMER.

Miscellaneous databases

GenomeRNAii25934.
PROiQ9UFN0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136783.
CleanExiHS_NIPSNAP3A.
GenevisibleiQ9UFN0. HS.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNPS3A_HUMAN
AccessioniPrimary (citable) accession number: Q9UFN0
Secondary accession number(s): A6NM55
, Q5VX32, Q9BRV7, Q9H843, Q9P083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.