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Protein

Protein NipSnap homolog 3A

Gene

NIPSNAP3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NipSnap homolog 3A
Short name:
NipSnap3A
Alternative name(s):
Protein NipSnap homolog 4
Short name:
NipSnap4
Target for Salmonella secreted protein C
Short name:
TassC
Gene namesi
Name:NIPSNAP3A
Synonyms:NIPSNAP4
ORF Names:HSPC299
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23619. NIPSNAP3A.

Subcellular locationi

  • Cytoplasmcytosol 1 Publication

  • Note: May be part of some vesicular structure distinct from lysosomal vesicles.

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954501.

Polymorphism and mutation databases

BioMutaiNIPSNAP3A.
DMDMi18203499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Protein NipSnap homolog 3APRO_0000221152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481N6-acetyllysineCombined sources
Modified residuei166 – 1661N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UFN0.
MaxQBiQ9UFN0.
PaxDbiQ9UFN0.
PeptideAtlasiQ9UFN0.
PRIDEiQ9UFN0.

2D gel databases

OGPiQ9UFN0.
UCD-2DPAGEQ9UFN0.

PTM databases

iPTMnetiQ9UFN0.
PhosphoSiteiQ9UFN0.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.1 Publication

Gene expression databases

BgeeiQ9UFN0.
CleanExiHS_NIPSNAP3A.
GenevisibleiQ9UFN0. HS.

Organism-specific databases

HPAiHPA042491.
HPA047909.
HPA047925.
HPA049256.

Interactioni

Subunit structurei

Interacts with the Salmonella typhimurium virulence protein spiC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-716291,EBI-739624
TP63Q9H3D42EBI-716291,EBI-2337775

Protein-protein interaction databases

BioGridi117432. 26 interactions.
IntActiQ9UFN0. 12 interactions.
MINTiMINT-1385104.
STRINGi9606.ENSP00000363899.

Structurei

3D structure databases

ProteinModelPortaliQ9UFN0.
SMRiQ9UFN0. Positions 35-128, 180-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NipSnap family.Curated

Phylogenomic databases

eggNOGiKOG2883. Eukaryota.
ENOG410XSWP. LUCA.
GeneTreeiENSGT00730000111003.
HOGENOMiHOG000007437.
HOVERGENiHBG052660.
InParanoidiQ9UFN0.
OMAiFHAEYGV.
OrthoDBiEOG776SQT.
PhylomeDBiQ9UFN0.
TreeFamiTF314501.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UFN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLRSALTR ALASRTLAPQ MCSSFATGPR QYDGIFYEFR SYYLKPSKMN
60 70 80 90 100
EFLENFEKNA HLRTAHSELV GYWSVEFGGR MNTVFHIWKY DNFAHRTEVR
110 120 130 140 150
KALAKDKEWQ EQFLIPNLAL IDKQESEITY LVPWCKLEKP PKEGVYELAT
160 170 180 190 200
FQMKPGGPAL WGDAFKRAVH AHVNLGYTKL VGVFHTEYGA LNRVHVLWWN
210 220 230 240
ESADSRAAGR HKSHEDPRVV AAVRESVNYL VSQQNMLLIP TSFSPLK
Length:247
Mass (Da):28,467
Last modified:September 26, 2001 - v2
Checksum:iDA668E2AD42BA1AA
GO

Sequence cautioni

The sequence AAF28977.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081E → G in AAF28977 (Ref. 3) Curated
Sequence conflicti118 – 1181L → S in AAF28977 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001R → Q.1 Publication
Corresponds to variant rs2274870 [ dbSNP | Ensembl ].
VAR_020442

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024015 mRNA. Translation: BAB14777.1.
AL117557 mRNA. Translation: CAB55992.2.
AF161417 mRNA. Translation: AAF28977.1. Different initiation.
AL359846 Genomic DNA. Translation: CAH73580.1.
CH471105 Genomic DNA. Translation: EAW58990.1.
BC005935 mRNA. Translation: AAH05935.1.
CCDSiCCDS6760.1.
RefSeqiNP_056284.1. NM_015469.1.
UniGeneiHs.530275.

Genome annotation databases

EnsembliENST00000374767; ENSP00000363899; ENSG00000136783.
GeneIDi25934.
KEGGihsa:25934.
UCSCiuc004bch.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024015 mRNA. Translation: BAB14777.1.
AL117557 mRNA. Translation: CAB55992.2.
AF161417 mRNA. Translation: AAF28977.1. Different initiation.
AL359846 Genomic DNA. Translation: CAH73580.1.
CH471105 Genomic DNA. Translation: EAW58990.1.
BC005935 mRNA. Translation: AAH05935.1.
CCDSiCCDS6760.1.
RefSeqiNP_056284.1. NM_015469.1.
UniGeneiHs.530275.

3D structure databases

ProteinModelPortaliQ9UFN0.
SMRiQ9UFN0. Positions 35-128, 180-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117432. 26 interactions.
IntActiQ9UFN0. 12 interactions.
MINTiMINT-1385104.
STRINGi9606.ENSP00000363899.

PTM databases

iPTMnetiQ9UFN0.
PhosphoSiteiQ9UFN0.

Polymorphism and mutation databases

BioMutaiNIPSNAP3A.
DMDMi18203499.

2D gel databases

OGPiQ9UFN0.
UCD-2DPAGEQ9UFN0.

Proteomic databases

EPDiQ9UFN0.
MaxQBiQ9UFN0.
PaxDbiQ9UFN0.
PeptideAtlasiQ9UFN0.
PRIDEiQ9UFN0.

Protocols and materials databases

DNASUi25934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374767; ENSP00000363899; ENSG00000136783.
GeneIDi25934.
KEGGihsa:25934.
UCSCiuc004bch.1. human.

Organism-specific databases

CTDi25934.
GeneCardsiNIPSNAP3A.
HGNCiHGNC:23619. NIPSNAP3A.
HPAiHPA042491.
HPA047909.
HPA047925.
HPA049256.
MIMi608871. gene.
neXtProtiNX_Q9UFN0.
PharmGKBiPA134954501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2883. Eukaryota.
ENOG410XSWP. LUCA.
GeneTreeiENSGT00730000111003.
HOGENOMiHOG000007437.
HOVERGENiHBG052660.
InParanoidiQ9UFN0.
OMAiFHAEYGV.
OrthoDBiEOG776SQT.
PhylomeDBiQ9UFN0.
TreeFamiTF314501.

Miscellaneous databases

GenomeRNAii25934.
NextBioi47484.
PROiQ9UFN0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UFN0.
CleanExiHS_NIPSNAP3A.
GenevisibleiQ9UFN0. HS.

Family and domain databases

InterProiIPR011008. Dimeric_a/b-barrel.
IPR012577. NIPSNAP.
[Graphical view]
PfamiPF07978. NIPSNAP. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-100.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  7. "Identification of a NIPSNAP homologue as host cell target for Salmonella virulence protein SpiC."
    Lee A.H., Zareei M.P., Daefler S.
    Cell. Microbiol. 4:739-750(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SALMONELLA SPIC.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48 AND LYS-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNPS3A_HUMAN
AccessioniPrimary (citable) accession number: Q9UFN0
Secondary accession number(s): A6NM55
, Q5VX32, Q9BRV7, Q9H843, Q9P083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: March 16, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.