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Protein

UPF0449 protein C19orf25

Gene

C19orf25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0449 protein C19orf25
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26711. C19orf25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878893.

Polymorphism and mutation databases

BioMutaiC19orf25.
DMDMi74735005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118UPF0449 protein C19orf25PRO_0000252420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UFG5.
MaxQBiQ9UFG5.
PaxDbiQ9UFG5.
PRIDEiQ9UFG5.

PTM databases

iPTMnetiQ9UFG5.
PhosphoSiteiQ9UFG5.

Expressioni

Gene expression databases

BgeeiQ9UFG5.
CleanExiHS_C19orf25.
ExpressionAtlasiQ9UFG5. baseline and differential.
GenevisibleiQ9UFG5. HS.

Organism-specific databases

HPAiHPA050270.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BAIAP2Q9UQB83EBI-741214,EBI-525456
CCDC85BQ158342EBI-741214,EBI-739674
EPS8Q129293EBI-741214,EBI-375576
SATQ6ICU93EBI-741214,EBI-10178867

Protein-protein interaction databases

BioGridi127131. 28 interactions.
IntActiQ9UFG5. 10 interactions.
STRINGi9606.ENSP00000397394.

Structurei

3D structure databases

ProteinModelPortaliQ9UFG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili81 – 10929Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0449 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J2WJ. Eukaryota.
ENOG410XTXT. LUCA.
GeneTreeiENSGT00390000007991.
HOGENOMiHOG000111986.
HOVERGENiHBG061066.
InParanoidiQ9UFG5.
PhylomeDBiQ9UFG5.
TreeFamiTF330719.

Family and domain databases

InterProiIPR028227. UPF0449.
[Graphical view]
PfamiPF15136. UPF0449. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UFG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKAKKRVL LPTRPAPPTV EQILEDVRGA PAEDPVFTIL APEDPPVPFR
60 70 80 90 100
MMEDAEAPGE QLYQQSRAYV AANQRLQQAG NVLRQRCELL QRAGEDLERE
110
VAQMKQAALP AAEAASSG
Length:118
Mass (Da):12,878
Last modified:September 13, 2004 - v2
Checksum:iFF3F96AA35398C63
GO
Isoform 2 (identifier: Q9UFG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-118: LRQRCELLQR...LPAAEAASSG → PRLPPQADLS...PTQLAPSCVT

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):17,215
Checksum:iF115744350BA63CF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei83 – 11836LRQRC…AASSG → PRLPPQADLSGPAGLGSAQG GLHPGFPWGSVGPRLAFTGS QPTWVLTQAPLLMLGLRFIR RLIHAELVGPTQLAPSCVT in isoform 2. 1 PublicationVSP_020961Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093985 mRNA. Translation: BAC04262.1.
AK075267 mRNA. Translation: BAG52098.1.
AL122089 mRNA. Translation: CAB59260.2.
BC018441 mRNA. Translation: AAH18441.1.
CCDSiCCDS45898.1. [Q9UFG5-1]
PIRiT34521.
RefSeqiNP_689695.2. NM_152482.2. [Q9UFG5-1]
XP_005259563.1. XM_005259506.2. [Q9UFG5-1]
XP_006722716.1. XM_006722653.2. [Q9UFG5-1]
UniGeneiHs.532840.
Hs.700773.

Genome annotation databases

EnsembliENST00000436106; ENSP00000397394; ENSG00000119559. [Q9UFG5-1]
ENST00000585675; ENSP00000468688; ENSG00000119559. [Q9UFG5-1]
ENST00000586564; ENSP00000466372; ENSG00000119559. [Q9UFG5-1]
ENST00000592872; ENSP00000467861; ENSG00000119559. [Q9UFG5-1]
GeneIDi148223.
KEGGihsa:148223.
UCSCiuc010dsk.4. human. [Q9UFG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093985 mRNA. Translation: BAC04262.1.
AK075267 mRNA. Translation: BAG52098.1.
AL122089 mRNA. Translation: CAB59260.2.
BC018441 mRNA. Translation: AAH18441.1.
CCDSiCCDS45898.1. [Q9UFG5-1]
PIRiT34521.
RefSeqiNP_689695.2. NM_152482.2. [Q9UFG5-1]
XP_005259563.1. XM_005259506.2. [Q9UFG5-1]
XP_006722716.1. XM_006722653.2. [Q9UFG5-1]
UniGeneiHs.532840.
Hs.700773.

3D structure databases

ProteinModelPortaliQ9UFG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127131. 28 interactions.
IntActiQ9UFG5. 10 interactions.
STRINGi9606.ENSP00000397394.

PTM databases

iPTMnetiQ9UFG5.
PhosphoSiteiQ9UFG5.

Polymorphism and mutation databases

BioMutaiC19orf25.
DMDMi74735005.

Proteomic databases

EPDiQ9UFG5.
MaxQBiQ9UFG5.
PaxDbiQ9UFG5.
PRIDEiQ9UFG5.

Protocols and materials databases

DNASUi148223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436106; ENSP00000397394; ENSG00000119559. [Q9UFG5-1]
ENST00000585675; ENSP00000468688; ENSG00000119559. [Q9UFG5-1]
ENST00000586564; ENSP00000466372; ENSG00000119559. [Q9UFG5-1]
ENST00000592872; ENSP00000467861; ENSG00000119559. [Q9UFG5-1]
GeneIDi148223.
KEGGihsa:148223.
UCSCiuc010dsk.4. human. [Q9UFG5-1]

Organism-specific databases

CTDi148223.
GeneCardsiC19orf25.
H-InvDBHIX0014588.
HGNCiHGNC:26711. C19orf25.
HPAiHPA050270.
neXtProtiNX_Q9UFG5.
PharmGKBiPA134878893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2WJ. Eukaryota.
ENOG410XTXT. LUCA.
GeneTreeiENSGT00390000007991.
HOGENOMiHOG000111986.
HOVERGENiHBG061066.
InParanoidiQ9UFG5.
PhylomeDBiQ9UFG5.
TreeFamiTF330719.

Miscellaneous databases

ChiTaRSiC19orf25. human.
GeneWikiiC19orf25.
GenomeRNAii148223.
PROiQ9UFG5.

Gene expression databases

BgeeiQ9UFG5.
CleanExiHS_C19orf25.
ExpressionAtlasiQ9UFG5. baseline and differential.
GenevisibleiQ9UFG5. HS.

Family and domain databases

InterProiIPR028227. UPF0449.
[Graphical view]
PfamiPF15136. UPF0449. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.

Entry informationi

Entry nameiCS025_HUMAN
AccessioniPrimary (citable) accession number: Q9UFG5
Secondary accession number(s): B3KQN6, Q8N9R7, Q8WV94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.