Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UFF9

- CNOT8_HUMAN

UniProt

Q9UFF9 - CNOT8_HUMAN

Protein

CCR4-NOT transcription complex subunit 8

Gene

CNOT8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.4 Publications

    Catalytic activityi

    Exonucleolytic cleavage of poly(A) to 5'-AMP.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401Divalent metal cation 1; catalyticBy similarity
    Metal bindingi40 – 401Divalent metal cation 2; catalyticBy similarity
    Metal bindingi42 – 421Divalent metal cation 2; catalyticBy similarity
    Metal bindingi161 – 1611Divalent metal cation 1; catalyticBy similarity
    Metal bindingi230 – 2301Divalent metal cation 2; catalyticBy similarity

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro
    4. poly(A)-specific ribonuclease activity Source: UniProtKB
    5. protein binding Source: IntAct
    6. RNA binding Source: UniProtKB-KW
    7. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: UniProtKB
    2. gene expression Source: Reactome
    3. gene silencing by miRNA Source: UniProtKB
    4. mRNA metabolic process Source: Reactome
    5. negative regulation of cell proliferation Source: ProtInc
    6. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
    7. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
    8. positive regulation of cell proliferation Source: UniProtKB
    9. regulation of transcription, DNA-templated Source: UniProtKB
    10. regulation of translation Source: UniProtKB-KW
    11. RNA metabolic process Source: Reactome
    12. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease, Repressor

    Keywords - Biological processi

    RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

    Keywords - Ligandi

    Metal-binding, RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_20514. Deadenylation of mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCR4-NOT transcription complex subunit 8 (EC:3.1.13.4)
    Alternative name(s):
    CAF1-like protein
    Short name:
    CALIFp
    CAF2
    CCR4-associated factor 8
    Caf1b
    Gene namesi
    Name:CNOT8
    Synonyms:CALIF, POP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:9207. CNOT8.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. CCR4-NOT complex Source: UniProtKB
    2. cytosol Source: Reactome
    3. intracellular Source: LIFEdb
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi40 – 401D → A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated wit A-42. 1 Publication
    Mutagenesisi42 – 421E → A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated wit A-40. 1 Publication

    Organism-specific databases

    PharmGKBiPA26679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292CCR4-NOT transcription complex subunit 8PRO_0000212846Add
    BLAST

    Proteomic databases

    MaxQBiQ9UFF9.
    PaxDbiQ9UFF9.
    PRIDEiQ9UFF9.

    PTM databases

    PhosphoSiteiQ9UFF9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UFF9.
    BgeeiQ9UFF9.
    CleanExiHS_CNOT8.
    GenevestigatoriQ9UFF9.

    Organism-specific databases

    HPAiHPA051398.

    Interactioni

    Subunit structurei

    Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. In the complex interacts directly with CNOT1. Interacts with BTG1, BTG2 and TOB1.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BTG1P623244EBI-742299,EBI-742279
    BTG2P785432EBI-742299,EBI-1047576
    CNOT1A5YKK65EBI-742299,EBI-1222758
    CNOT2Q9NZN82EBI-742299,EBI-743033
    CNOT3O751753EBI-742299,EBI-743073
    CNOT6Q9ULM62EBI-742299,EBI-2104530

    Protein-protein interaction databases

    BioGridi114744. 13 interactions.
    DIPiDIP-29084N.
    IntActiQ9UFF9. 17 interactions.
    MINTiMINT-155732.
    STRINGi9606.ENSP00000285896.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UFF9.
    SMRiQ9UFF9. Positions 12-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CAF1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5228.
    HOGENOMiHOG000173077.
    HOVERGENiHBG051044.
    InParanoidiQ9UFF9.
    KOiK12581.
    OMAiHDFFQIL.
    OrthoDBiEOG74BJSP.
    PhylomeDBiQ9UFF9.
    TreeFamiTF314185.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR027212. Cnot8.
    IPR006941. RNase_CAF1.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PANTHERiPTHR10797:SF1. PTHR10797:SF1. 1 hit.
    PfamiPF04857. CAF1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UFF9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAALVENSQ VICEVWASNL EEEMRKIREI VLSYSYIAMD TEFPGVVVRP    50
    IGEFRSSIDY QYQLLRCNVD LLKIIQLGLT FTNEKGEYPS GINTWQFNFK 100
    FNLTEDMYSQ DSIDLLANSG LQFQKHEEEG IDTLHFAELL MTSGVVLCDN 150
    VKWLSFHSGY DFGYMVKLLT DSRLPEEEHE FFHILNLFFP SIYDVKYLMK 200
    SCKNLKGGLQ EVADQLDLQR IGRQHQAGSD SLLTGMAFFR MKELFFEDSI 250
    DDAKYCGRLY GLGTGVAQKQ NEDVDSAQEK MSILAIINNM QQ 292
    Length:292
    Mass (Da):33,540
    Last modified:May 1, 2000 - v1
    Checksum:i81027A966E51AFDB
    GO
    Isoform 2 (identifier: Q9UFF9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:186
    Mass (Da):21,239
    Checksum:i7704142451AE8485
    GO
    Isoform 3 (identifier: Q9UFF9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-158: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:238
    Mass (Da):27,415
    Checksum:i0EC415BBE87D19BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 1057FKFNLTE → CKLYLTV in AAP97157. 1 PublicationCurated
    Sequence conflicti152 – 1521K → R in BAB15119. 1 PublicationCurated
    Sequence conflicti182 – 1821F → L in AAD02685. (PubMed:10036195)Curated
    Sequence conflicti189 – 1891F → S in AAD02685. (PubMed:10036195)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321L → P.1 Publication
    Corresponds to variant rs1139980 [ dbSNP | Ensembl ].
    VAR_048751

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 106106Missing in isoform 2. 1 PublicationVSP_055527Add
    BLAST
    Alternative sequencei105 – 15854Missing in isoform 3. 1 PublicationVSP_055528Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053318 mRNA. Translation: AAD02685.1.
    AF180476 mRNA. Translation: AAF29830.1.
    AF087844 mRNA. Translation: AAP97157.1.
    AL122045 mRNA. Translation: CAB59181.1.
    BT006857 mRNA. Translation: AAP35503.1.
    AK025358 mRNA. Translation: BAB15119.1.
    AK315864 mRNA. Translation: BAF98755.1.
    AK297381 mRNA. Translation: BAH12567.1.
    AK303775 mRNA. Translation: BAH14047.1.
    AK314317 mRNA. Translation: BAG36965.1.
    AK316221 mRNA. Translation: BAH14592.1.
    AK316269 mRNA. Translation: BAH14640.1.
    AC112169 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61625.1.
    CH471062 Genomic DNA. Translation: EAW61626.1.
    CH471062 Genomic DNA. Translation: EAW61627.1.
    CH471062 Genomic DNA. Translation: EAW61628.1.
    BC017366 mRNA. Translation: AAH17366.1.
    CCDSiCCDS4329.1.
    PIRiT34529.
    T52257.
    RefSeqiNP_004770.4. NM_004779.4.
    XP_005268583.1. XM_005268526.2.
    UniGeneiHs.26703.

    Genome annotation databases

    EnsembliENST00000285896; ENSP00000285896; ENSG00000155508. [Q9UFF9-1]
    ENST00000403027; ENSP00000384747; ENSG00000155508. [Q9UFF9-1]
    ENST00000517876; ENSP00000430493; ENSG00000155508. [Q9UFF9-1]
    ENST00000519404; ENSP00000430833; ENSG00000155508. [Q9UFF9-3]
    ENST00000520671; ENSP00000428305; ENSG00000155508. [Q9UFF9-2]
    ENST00000521450; ENSP00000431034; ENSG00000155508. [Q9UFF9-2]
    ENST00000521583; ENSP00000429882; ENSG00000155508. [Q9UFF9-2]
    ENST00000523698; ENSP00000428565; ENSG00000155508. [Q9UFF9-2]
    GeneIDi9337.
    KEGGihsa:9337.
    UCSCiuc003lvu.3. human.

    Polymorphism databases

    DMDMi15213949.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053318 mRNA. Translation: AAD02685.1 .
    AF180476 mRNA. Translation: AAF29830.1 .
    AF087844 mRNA. Translation: AAP97157.1 .
    AL122045 mRNA. Translation: CAB59181.1 .
    BT006857 mRNA. Translation: AAP35503.1 .
    AK025358 mRNA. Translation: BAB15119.1 .
    AK315864 mRNA. Translation: BAF98755.1 .
    AK297381 mRNA. Translation: BAH12567.1 .
    AK303775 mRNA. Translation: BAH14047.1 .
    AK314317 mRNA. Translation: BAG36965.1 .
    AK316221 mRNA. Translation: BAH14592.1 .
    AK316269 mRNA. Translation: BAH14640.1 .
    AC112169 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61625.1 .
    CH471062 Genomic DNA. Translation: EAW61626.1 .
    CH471062 Genomic DNA. Translation: EAW61627.1 .
    CH471062 Genomic DNA. Translation: EAW61628.1 .
    BC017366 mRNA. Translation: AAH17366.1 .
    CCDSi CCDS4329.1.
    PIRi T34529.
    T52257.
    RefSeqi NP_004770.4. NM_004779.4.
    XP_005268583.1. XM_005268526.2.
    UniGenei Hs.26703.

    3D structure databases

    ProteinModelPortali Q9UFF9.
    SMRi Q9UFF9. Positions 12-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114744. 13 interactions.
    DIPi DIP-29084N.
    IntActi Q9UFF9. 17 interactions.
    MINTi MINT-155732.
    STRINGi 9606.ENSP00000285896.

    PTM databases

    PhosphoSitei Q9UFF9.

    Polymorphism databases

    DMDMi 15213949.

    Proteomic databases

    MaxQBi Q9UFF9.
    PaxDbi Q9UFF9.
    PRIDEi Q9UFF9.

    Protocols and materials databases

    DNASUi 9337.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285896 ; ENSP00000285896 ; ENSG00000155508 . [Q9UFF9-1 ]
    ENST00000403027 ; ENSP00000384747 ; ENSG00000155508 . [Q9UFF9-1 ]
    ENST00000517876 ; ENSP00000430493 ; ENSG00000155508 . [Q9UFF9-1 ]
    ENST00000519404 ; ENSP00000430833 ; ENSG00000155508 . [Q9UFF9-3 ]
    ENST00000520671 ; ENSP00000428305 ; ENSG00000155508 . [Q9UFF9-2 ]
    ENST00000521450 ; ENSP00000431034 ; ENSG00000155508 . [Q9UFF9-2 ]
    ENST00000521583 ; ENSP00000429882 ; ENSG00000155508 . [Q9UFF9-2 ]
    ENST00000523698 ; ENSP00000428565 ; ENSG00000155508 . [Q9UFF9-2 ]
    GeneIDi 9337.
    KEGGi hsa:9337.
    UCSCi uc003lvu.3. human.

    Organism-specific databases

    CTDi 9337.
    GeneCardsi GC05P154218.
    HGNCi HGNC:9207. CNOT8.
    HPAi HPA051398.
    MIMi 603731. gene.
    neXtProti NX_Q9UFF9.
    PharmGKBi PA26679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5228.
    HOGENOMi HOG000173077.
    HOVERGENi HBG051044.
    InParanoidi Q9UFF9.
    KOi K12581.
    OMAi HDFFQIL.
    OrthoDBi EOG74BJSP.
    PhylomeDBi Q9UFF9.
    TreeFami TF314185.

    Enzyme and pathway databases

    Reactomei REACT_20514. Deadenylation of mRNA.

    Miscellaneous databases

    ChiTaRSi CNOT8. human.
    GeneWikii CNOT8.
    GenomeRNAii 9337.
    NextBioi 34971.
    PROi Q9UFF9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UFF9.
    Bgeei Q9UFF9.
    CleanExi HS_CNOT8.
    Genevestigatori Q9UFF9.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR027212. Cnot8.
    IPR006941. RNase_CAF1.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    PANTHERi PTHR10797:SF1. PTHR10797:SF1. 1 hit.
    Pfami PF04857. CAF1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome."
      Fidler C., Wainscoat J.S., Boultwood J.
      Genomics 56:134-136(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-32.
    2. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
      Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
      Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CNOT1 AND CNOT3.
    3. "Cloning and characterization of a new human cDNA homologous to murine mCAF1 mRNA."
      Jiang C.L., Yu L., Ding J.B., Ge H.P., He H., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain, Colon, Liver and Tongue.
    7. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    10. "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."
      Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P., Corbo L.
      J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BTG1 AND BTG2.
    11. "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms."
      Morel A.-P., Sentis S., Bianchin C., Le Romancer M., Jonard L., Rostan M.-C., Rimokh R., Corbo L.
      J. Cell Sci. 116:2929-2936(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BTG2.
    12. "Conservation of the deadenylase activity of proteins of the Caf1 family in human."
      Bianchin C., Mauxion F., Sentis S., Seraphin B., Corbo L.
      RNA 11:487-494(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY.
    13. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
    14. "The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation."
      Aslam A., Mittal S., Koch F., Andrau J.C., Winkler G.S.
      Mol. Biol. Cell 20:3840-3850(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "CCR4-NOT deadenylates mRNA associated with complexes in human cells."
      Piao X., Zhang X., Wu L., Belasco J.G.
      Mol. Cell. Biol. 30:1486-1494(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ASP-40 AND GLU-42.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex."
      Doidge R., Mittal S., Aslam A., Winkler G.S.
      PLoS ONE 7:E51331-E51331(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TOB1 AND BTG2.

    Entry informationi

    Entry nameiCNOT8_HUMAN
    AccessioniPrimary (citable) accession number: Q9UFF9
    Secondary accession number(s): B0AZS3
    , B2RAR8, B7Z8R1, D3DQI8, O95709, Q7Z521, Q9H6Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3