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Q9UFF9 (CNOT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCR4-NOT transcription complex subunit 8
Alternative name(s):
CAF1-like protein
Short name=CALIFp
CAF2
CCR4-associated factor 8
Gene names
Name:CNOT8
Synonyms:CALIF, POP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Ref.9

Subunit structure

Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds BTG2.

Subcellular location

Cytoplasm. Nucleus Ref.9.

Sequence similarities

Belongs to the CAF1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CNOT3O751752EBI-742299,EBI-743073

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292CCR4-NOT transcription complex subunit 8
PRO_0000212846

Natural variations

Natural variant321L → P. Ref.1
Corresponds to variant rs1139980 [ dbSNP | Ensembl ].
VAR_048751

Experimental info

Sequence conflict99 – 1057FKFNLTE → CKLYLTV in AAP97157. Ref.3
Sequence conflict1521K → R in BAB15119. Ref.5
Sequence conflict1821F → L in AAD02685. Ref.1
Sequence conflict1891F → S in AAD02685. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UFF9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 81027A966E51AFDB

FASTA29233,540
        10         20         30         40         50         60 
MPAALVENSQ VICEVWASNL EEEMRKIREI VLSYSYIAMD TEFPGVVVRP IGEFRSSIDY 

        70         80         90        100        110        120 
QYQLLRCNVD LLKIIQLGLT FTNEKGEYPS GINTWQFNFK FNLTEDMYSQ DSIDLLANSG 

       130        140        150        160        170        180 
LQFQKHEEEG IDTLHFAELL MTSGVVLCDN VKWLSFHSGY DFGYMVKLLT DSRLPEEEHE 

       190        200        210        220        230        240 
FFHILNLFFP SIYDVKYLMK SCKNLKGGLQ EVADQLDLQR IGRQHQAGSD SLLTGMAFFR 

       250        260        270        280        290 
MKELFFEDSI DDAKYCGRLY GLGTGVAQKQ NEDVDSAQEK MSILAIINNM QQ 

« Hide

References

« Hide 'large scale' references
[1]"The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome."
Fidler C., Wainscoat J.S., Boultwood J.
Genomics 56:134-136(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-32.
[2]"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and characterization of a new human cDNA homologous to murine mCAF1 mRNA."
Jiang C.L., Yu L., Ding J.B., Ge H.P., He H., Zhao S.Y.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Tongue.
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[9]"BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms."
Morel A.-P., Sentis S., Bianchin C., Le Romancer M., Jonard L., Rostan M.-C., Rimokh R., Corbo L.
J. Cell Sci. 116:2929-2936(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BTG2.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053318 mRNA. Translation: AAD02685.1.
AF180476 mRNA. Translation: AAF29830.1.
AF087844 mRNA. Translation: AAP97157.1.
AL122045 mRNA. Translation: CAB59181.1.
AK025358 mRNA. Translation: BAB15119.1.
AK314317 mRNA. Translation: BAG36965.1.
BT006857 mRNA. Translation: AAP35503.1.
CH471062 Genomic DNA. Translation: EAW61625.1.
CH471062 Genomic DNA. Translation: EAW61626.1.
CH471062 Genomic DNA. Translation: EAW61627.1.
CH471062 Genomic DNA. Translation: EAW61628.1.
BC017366 mRNA. Translation: AAH17366.1.
IPIIPI00295501.
PIRT34529.
T52257.
RefSeqNP_004770.4. NM_004779.4.
UniGeneHs.26703.

3D structure databases

ProteinModelPortalQ9UFF9.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29084N.
IntActQ9UFF9. 6 interactions.
MINTMINT-155732.
STRING9606.ENSP00000285896.

PTM databases

PhosphoSiteQ9UFF9.

Polymorphism databases

DMDM15213949.

Proteomic databases

PaxDbQ9UFF9.
PRIDEQ9UFF9.

Protocols and materials databases

DNASU9337.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000285896; ENSP00000285896; ENSG00000155508.
ENST00000403027; ENSP00000384747; ENSG00000155508.
ENST00000517876; ENSP00000430493; ENSG00000155508.
GeneID9337.
KEGGhsa:9337.
UCSCuc003lvu.3. human.

Organism-specific databases

CTD9337.
GeneCardsGC05P154218.
HGNCHGNC:9207. CNOT8.
HPAHPA051398.
MIM603731. gene.
neXtProtNX_Q9UFF9.
PharmGKBPA26679.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5228.
HOGENOMHOG000173077.
HOVERGENHBG051044.
InParanoidQ9UFF9.
KOK12581.
OMAQPQNGLS.
OrthoDBEOG4MKNGS.
PhylomeDBQ9UFF9.

Enzyme and pathway databases

ReactomeREACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9UFF9.
BgeeQ9UFF9.
CleanExHS_CNOT8.
GenevestigatorQ9UFF9.
GermOnlineENSG00000155508. Homo sapiens.

Family and domain databases

InterProIPR027212. Cnot8.
IPR006941. RNase_CAF1.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERPTHR10797:SF1. PTHR10797:SF1. 1 hit.
PfamPF04857. CAF1. 1 hit.
[Graphical view]
SUPFAMSSF53098. RNaseH_fold. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCNOT8. human.
GenomeRNAi9337.
NextBio34971.
SOURCESearch...

Entry information

Entry nameCNOT8_HUMAN
AccessionPrimary (citable) accession number: Q9UFF9
Secondary accession number(s): B2RAR8 expand/collapse secondary AC list , D3DQI8, O95709, Q7Z521, Q9H6Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families