LRWD1

Functionⁱ

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.5 Publications

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20932478
- 21029866
methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21029866
methyl-CpG binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21029866

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20932478
covalent chromatin modification Source: UniProtKB-KW
DNA replication initiation
Source: UniProtKB
Traceable author statementⁱ
- 20932478
establishment of protein localization to chromatin
Source: UniProtKB
Inferred from direct assayⁱ
- 20932478

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	DNA replication

Enzyme and pathway databases

SignaLinkⁱ	Q9UFC0.

SignaLinkⁱ

Q9UFC0.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat and WD repeat-containing protein 1 Alternative name(s): Centromere protein 33 Short name: CENP-33 Origin recognition complex-associated protein Short name: ORC-associated protein Short name: ORCA
Gene namesⁱ	Name:LRWD1 Synonyms:CENP-331 Publication, ORCA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161036.10.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21769. LRWD1.
MIMⁱ	615167. gene.
neXtProtⁱ	NX_Q9UFC0.

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus, Telomere

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	222229.
Open Targets More...OpenTargetsⁱ	ENSG00000161036.
PharmGKBⁱ	PA162394694.

Polymorphism and mutation databases

BioMutaⁱ	LRWD1.
DMDMⁱ	74761931.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000310994	1 – 647	Leucine-rich repeat and WD repeat-containing protein 1Add BLAST		647

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	212	PhosphoserineCombined sources	1
Modified residueⁱ	243	PhosphoserineCombined sources	1
Modified residueⁱ	251	PhosphoserineCombined sources	1
Modified residueⁱ	259	PhosphoserineCombined sources	1
Modified residueⁱ	264	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UFC0.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UFC0.
PaxDbⁱ	Q9UFC0.
PeptideAtlas More...PeptideAtlasⁱ	Q9UFC0.
PRIDEⁱ	Q9UFC0.

PTM databases

iPTMnetⁱ	Q9UFC0.
PhosphoSitePlusⁱ	Q9UFC0.

Expressionⁱ

Tissue specificityⁱ

Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).1 Publication

Developmental stageⁱ

Regulated in a cell-cycle dependent manner. Highest expression in G1 phase. Expression decreases during S phase, rises again during G2 and drops during mitosis (at protein level). In contrast to protein levels, transcript levels do not show any significant variation during different stages of the cell cycle (PubMed:22935713).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000161036.
CleanExⁱ	HS_LRWD1.
ExpressionAtlasⁱ	Q9UFC0. baseline and differential.
Genevisibleⁱ	Q9UFC0. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021320. HPA029916.

HPAⁱ

HPA021320.
HPA029916.

Interactionⁱ

Subunit structureⁱ

Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.5 Publications

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21029866

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128790. 49 interactors.
IntActⁱ	Q9UFC0. 28 interactors.
Molecular INTeraction database More...MINTⁱ	Q9UFC0.
STRINGⁱ	9606.ENSP00000292616.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UFC0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	22 – 43	LRR 1Add BLAST	22
Repeatⁱ	48 – 69	LRR 2Add BLAST	22
Repeatⁱ	70 – 91	LRR 3Add BLAST	22
Repeatⁱ	92 – 113	LRR 4Add BLAST	22
Repeatⁱ	282 – 335	WD 1Add BLAST	54
Repeatⁱ	341 – 379	WD 2Add BLAST	39
Repeatⁱ	383 – 422	WD 3Add BLAST	40
Repeatⁱ	426 – 472	WD 4Add BLAST	47
Repeatⁱ	484 – 526	WD 5Add BLAST	43
Repeatⁱ	542 – 582	WD 6Add BLAST	41
Repeatⁱ	598 – 646	WD 7Add BLAST	49

Domainⁱ

The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.3 Publications

Sequence similaritiesⁱ

Belongs to the LRWD1 family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008446.
HOGENOMⁱ	HOG000113393.
HOVERGENⁱ	HBG076949.
InParanoidⁱ	Q9UFC0.
OMAⁱ	RRVCEVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I17.
PhylomeDBⁱ	Q9UFC0.
TreeFamⁱ	TF329554.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit. 3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12799. LRR_4. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 1 hit. SM00320. WD40. 3 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 3 hits. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UFC0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ 
        60         70         80         90        100
ELDLSNNHLE TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG 
       110        120        130        140        150
NPFLTVNDNL KVSFLLPTLR KVNGKDASST YSQVENLNRE LTSRVTAHWE 
       160        170        180        190        200
KFMATLGPEE EAEKAQADFV KSAVRDVRYG PESLSEFTQW RVRMISEELV 
       210        220        230        240        250
AASRTQVQKA NSPEKPPEAG AAHKPRARLA ALKRPDDVPL SLSPSKRACA 
       260        270        280        290        300
SPSAQVEGSP VAGSDGSQPA VKLEPLHFLQ CHSKNNSPQD LETQLWACAF 
       310        320        330        340        350
EPAWEEGATS QTVATCGGEA VCVIDCQTGI VLHKYKAPGE EFFSVAWTAL 
       360        370        380        390        400
MVVTQAGHKK RWSVLAAAGL RGLVRLLHVR AGFCCGVIRA HKKAIATLCF 
       410        420        430        440        450
SPAHETHLFT ASYDKRIILW DIGVPNQDYE FQASQLLTLD TTSIPLRLCP 
       460        470        480        490        500
VASCPDARLL AGCEGGCCCW DVRLDQPQKR RVCEVEFVFS EGSEASGRRV 
       510        520        530        540        550
DGLAFVNEDI VASKGSGLGT ICLWSWRQTW GGRGSQSTVA VVVLARLQWS 
       560        570        580        590        600
STELAYFSLS ACPDKGIVLC GDEEGNVWLY DVSNILKQPP LLPAALQAPT 
       610        620        630        640 
QILKWPQPWA LGQVVTKTMV NTVVANASFT YLTALTDSNI VAIWGRM

Length:647

Mass (Da):70,861

Last modified:October 25, 2004 - v2

Checksum:ⁱ59C6ABF57A957D9F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	629	F → S in BAF83656 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290967 mRNA. Translation: BAF83656.1. AK313771 mRNA. Translation: BAG36509.1. AL133057 mRNA. Translation: CAB61382.2. AC093668 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50250.1. BC009436 mRNA. Translation: AAH09436.1. BC018769 mRNA. Translation: AAH18769.1. BC030547 mRNA. Translation: AAH30547.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34715.1.
PIRⁱ	T42659.
NCBI Reference Sequences More...RefSeqⁱ	NP_001304650.1. NM_001317721.1. NP_690852.1. NM_152892.2.
UniGeneⁱ	Hs.274135.

Genome annotation databases

Ensemblⁱ	ENST00000292616; ENSP00000292616; ENSG00000161036.
GeneIDⁱ	222229.
KEGGⁱ	hsa:222229.
UCSC genome browser More...UCSCⁱ	uc003uzn.4. human.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9UFC0	A0A140VJD0 UPI00024CCEE8 F8WDB4 UPI00024CF704	Homo sapiens (Human)	647	UniRef100_Q9UFC0	Cluster: Leucine-rich repeat and WD repeat-containing protein 1	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9UFC0	A0A140VJD0 UPI00024CCEE8 F8WDB4 UPI00024CF704 A0A2I2ZIR4 H2QV59 A0A2J8PWB7 F7HKM2 F7GYC7 UPI000732A2B3 +20	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	647	UniRef90_Q9UFC0	Cluster: Leucine-rich repeat and WD repeat-containing protein 1	31

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9UFC0	A0A140VJD0 UPI00024CCEE8 F8WDB4 UPI00024CF704 A0A2I2ZIR4 A0A2K5LNI2 A0A2K6LSZ3 A0A2K6RAS6 F7HKM2 UPI000C297B48 +158	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Callithrix jacchus (White-tufted-ear marmoset) Piliocolobus tephrosceles (Ugandan red Colobus) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca mulatta (Rhesus macaque) Cebus capucinus imitator And more	647	UniRef50_Q9UFC0	Cluster: Leucine-rich repeat and WD repeat-containing protein 1	169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290967 mRNA. Translation: BAF83656.1. AK313771 mRNA. Translation: BAG36509.1. AL133057 mRNA. Translation: CAB61382.2. AC093668 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50250.1. BC009436 mRNA. Translation: AAH09436.1. BC018769 mRNA. Translation: AAH18769.1. BC030547 mRNA. Translation: AAH30547.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34715.1.
PIRⁱ	T42659.
NCBI Reference Sequences More...RefSeqⁱ	NP_001304650.1. NM_001317721.1. NP_690852.1. NM_152892.2.
UniGeneⁱ	Hs.274135.

3D structure databases

ProteinModelPortalⁱ	Q9UFC0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128790. 49 interactors.
IntActⁱ	Q9UFC0. 28 interactors.
Molecular INTeraction database More...MINTⁱ	Q9UFC0.
STRINGⁱ	9606.ENSP00000292616.

PTM databases

iPTMnetⁱ	Q9UFC0.
PhosphoSitePlusⁱ	Q9UFC0.

Polymorphism and mutation databases

BioMutaⁱ	LRWD1.
DMDMⁱ	74761931.

Proteomic databases

EPDⁱ	Q9UFC0.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UFC0.
PaxDbⁱ	Q9UFC0.
PeptideAtlas More...PeptideAtlasⁱ	Q9UFC0.
PRIDEⁱ	Q9UFC0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000292616; ENSP00000292616; ENSG00000161036.
GeneIDⁱ	222229.
KEGGⁱ	hsa:222229.
UCSC genome browser More...UCSCⁱ	uc003uzn.4. human.

Organism-specific databases

CTDⁱ	222229.
DisGeNET More...DisGeNETⁱ	222229.
EuPathDBⁱ	HostDB:ENSG00000161036.10.
GeneCardsⁱ	LRWD1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21769. LRWD1.
Human Protein Atlas More...HPAⁱ	HPA021320. HPA029916.
MIMⁱ	615167. gene.
neXtProtⁱ	NX_Q9UFC0.
Open Targets More...OpenTargetsⁱ	ENSG00000161036.
PharmGKBⁱ	PA162394694.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619. Eukaryota. COG4886. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008446.
HOGENOMⁱ	HOG000113393.
HOVERGENⁱ	HBG076949.
InParanoidⁱ	Q9UFC0.
OMAⁱ	RRVCEVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I17.
PhylomeDBⁱ	Q9UFC0.
TreeFamⁱ	TF329554.

Enzyme and pathway databases

SignaLinkⁱ	Q9UFC0.

SignaLinkⁱ

Q9UFC0.

Miscellaneous databases

ChiTaRSⁱ	LRWD1. human.
GenomeRNAiⁱ	222229.
Protein Ontology More...PROⁱ	PR:Q9UFC0.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161036.
CleanExⁱ	HS_LRWD1.
ExpressionAtlasⁱ	Q9UFC0. baseline and differential.
Genevisibleⁱ	Q9UFC0. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit. 3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR032675. LRR_dom_sf. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR036322. WD40_repeat_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12799. LRR_4. 1 hit.
SMARTⁱ	View protein in SMART SM00369. LRR_TYP. 1 hit. SM00320. WD40. 3 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51450. LRR. 3 hits. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRWD1_HUMAN
Accessionⁱ	Q9UFC0Primary (citable) accession number: Q9UFC0 Secondary accession number(s): A8K4K2 , B2R9G2, Q8N0T9, Q8WV43, Q96GJ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	October 25, 2004
	Last modified:	February 28, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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Help

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UniProtKB - Q9UFC0 (LRWD1_HUMAN)

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Leucine-rich repeat and WD repeat-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

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Cytoskeleton

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ