Q9UFC0 (LRWD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat and WD repeat-containing protein 1

Alternative name(s):
Centromere protein 33
Short name=CENP-33
Origin recognition complex-associated protein
Short name=ORC-associated protein
Short name=ORCA

Gene names

Name:	LRWD1
Synonyms:	CENP33, ORCA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Ref.12 Ref.13 Ref.14 Ref.18 Ref.19
Subunit structure	Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination. Ref.12 Ref.13 Ref.14 Ref.17 Ref.19
Subcellular location	Nucleus. Chromosome › centromere. Chromosome › telomere. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome By similarity. Note: Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3. Ref.13 Ref.14 Ref.17 Ref.18
Tissue specificity	Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). Ref.7
Developmental stage	Regulated in a cell-cycle dependent manner. Highest expression in G1 phase. Expression decreases during S phase, rises again during G2 and drops during mitosis (at protein level). In contrast to protein levels, transcript levels do not show any significant variation during different stages of the cell cycle (Ref.17). Ref.14 Ref.17
Domain	The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3. Ref.14 Ref.18 Ref.19
Post-translational modification	Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases. Ref.17
Sequence similarities	Belongs to the LRWD1 family. Contains 4 LRR (leucine-rich) repeats. Contains 5 WD repeats.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Nucleus Telomere
Domain	Leucine-rich repeat Repeat WD repeat
Molecular function	Chromatin regulator
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication initiation Traceable author statement Ref.14. Source: UniProtKB chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW chromatin organization Inferred from mutant phenotype Ref.14. Source: UniProtKB establishment of protein localization to chromatin Inferred from direct assay Ref.14. Source: UniProtKB
Cellular_component	centromeric heterochromatin Inferred from direct assay Ref.14. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear origin of replication recognition complex Inferred from direct assay Ref.14Ref.13. Source: UniProtKB telomeric heterochromatin Inferred from direct assay Ref.14. Source: UniProtKB
Molecular_function	chromatin binding Inferred from direct assay Ref.14Ref.13. Source: UniProtKB methyl-CpG binding Inferred from direct assay Ref.13. Source: UniProtKB methylated histone residue binding Inferred from direct assay Ref.13. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Leucine-rich repeat and WD repeat-containing protein 1		PRO_0000310994
Regions
	Repeat	22 – 43	22	LRR 1
	Repeat	48 – 69	22	LRR 2
	Repeat	70 – 91	22	LRR 3
	Repeat	92 – 113	22	LRR 4
	Repeat	390 – 430	41	WD 1
	Repeat	441 – 480	40	WD 2
	Repeat	495 – 534	40	WD 3
	Repeat	551 – 590	40	WD 4
	Repeat	615 – 647	33	WD 5
Amino acid modifications
	Modified residue	212	1	Phosphoserine Ref.6 Ref.11 Ref.15 Ref.16
	Modified residue	243	1	Phosphoserine Ref.9 Ref.11 Ref.15 Ref.16
	Modified residue	251	1	Phosphoserine Ref.9
	Modified residue	259	1	Phosphoserine Ref.8 Ref.9 Ref.11
Experimental info
	Sequence conflict	629	1	F → S in BAF83656. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UFC0 [UniParc]. Last modified October 25, 2004. Version 2. Checksum: 59C6ABF57A957D9F	FASTA	647	70,861
	10 20 30 40 50 60 MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE 70 80 90 100 110 120 TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR 130 140 150 160 170 180 KVNGKDASST YSQVENLNRE LTSRVTAHWE KFMATLGPEE EAEKAQADFV KSAVRDVRYG 190 200 210 220 230 240 PESLSEFTQW RVRMISEELV AASRTQVQKA NSPEKPPEAG AAHKPRARLA ALKRPDDVPL 250 260 270 280 290 300 SLSPSKRACA SPSAQVEGSP VAGSDGSQPA VKLEPLHFLQ CHSKNNSPQD LETQLWACAF 310 320 330 340 350 360 EPAWEEGATS QTVATCGGEA VCVIDCQTGI VLHKYKAPGE EFFSVAWTAL MVVTQAGHKK 370 380 390 400 410 420 RWSVLAAAGL RGLVRLLHVR AGFCCGVIRA HKKAIATLCF SPAHETHLFT ASYDKRIILW 430 440 450 460 470 480 DIGVPNQDYE FQASQLLTLD TTSIPLRLCP VASCPDARLL AGCEGGCCCW DVRLDQPQKR 490 500 510 520 530 540 RVCEVEFVFS EGSEASGRRV DGLAFVNEDI VASKGSGLGT ICLWSWRQTW GGRGSQSTVA 550 560 570 580 590 600 VVVLARLQWS STELAYFSLS ACPDKGIVLC GDEEGNVWLY DVSNILKQPP LLPAALQAPT 610 620 630 640 QILKWPQPWA LGQVVTKTMV NTVVANASFT YLTALTDSNI VAIWGRM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue." Lin Y.H., Lin Y.M., Teng Y.N., Hsieh T.Y., Lin Y.S., Kuo P.L. Fertil. Steril. 86:1650-1658(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-251 AND SER-259, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212; SER-243 AND SER-259, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers." Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M. Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE ORC COMPLEX, FUNCTION.
[13]	"Nucleosome-interacting proteins regulated by DNA and histone methylation." Bartke T., Vermeulen M., Xhemalce B., Robson S.C., Mann M., Kouzarides T. Cell 143:470-484(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE ORC COMPLEX, FUNCTION.
[14]	"A WD-repeat protein stabilizes ORC binding to chromatin." Shen Z., Sathyan K.M., Geng Y., Zheng R., Chakraborty A., Freeman B., Wang F., Prasanth K.V., Prasanth S.G. Mol. Cell 40:99-111(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN WD REPEATS, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE ORC COMPLEX, DEVELOPMENTAL STAGE.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND SER-243, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND SER-243, MASS SPECTROMETRY.
[17]	"Orc2 protects ORCA from ubiquitin-mediated degradation." Shen Z., Prasanth S.G. Cell Cycle 11:3578-3589(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ORC2; CUL4A AND DDB1, SUBCELLULAR LOCATION, UBIQUITINATION, DEVELOPMENTAL STAGE.
[18]	"Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing." Chan K.M., Zhang Z. J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, BINDING TO HISTONE H3 AND H4 TRIMETHYLATION MARKS, SUBCELLULAR LOCATION, DOMAIN.
[19]	"Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation." Shen Z., Chakraborty A., Jain A., Giri S., Ha T., Prasanth K.V., Prasanth S.G. Mol. Cell. Biol. 32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CDT1; GMNN; ORC1 AND ORC2, STOICHIOMETRY OF THE COMPLEX, DOMAIN.
[20]	"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK290967 mRNA. Translation: BAF83656.1. AK313771 mRNA. Translation: BAG36509.1. AL133057 mRNA. Translation: CAB61382.2. AC093668 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50250.1. BC009436 mRNA. Translation: AAH09436.1. BC018769 mRNA. Translation: AAH18769.1. BC030547 mRNA. Translation: AAH30547.1.
IPI	IPI00069309.
PIR	T42659.
RefSeq	NP_690852.1. NM_152892.1.
UniGene	Hs.274135.
3D structure databases
ProteinModelPortal	Q9UFC0.
SMR	Q9UFC0. Positions 24-104, 557-583.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UFC0. 3 interactions.
MINT	MINT-7944578.
STRING	9606.ENSP00000292616.
PTM databases
PhosphoSite	Q9UFC0.
Polymorphism databases
DMDM	74761931.
Proteomic databases
PaxDb	Q9UFC0.
PeptideAtlas	Q9UFC0.
PRIDE	Q9UFC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292616; ENSP00000292616; ENSG00000161036.
GeneID	222229.
KEGG	hsa:222229.
UCSC	uc003uzn.3. human.
Organism-specific databases
CTD	222229.
GeneCards	GC07P102105.
HGNC	HGNC:21769. LRWD1.
HPA	HPA021320. HPA029916.
MIM	615167. gene.
neXtProt	NX_Q9UFC0.
PharmGKB	PA162394694.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304996.
HOGENOM	HOG000113393.
HOVERGEN	HBG076949.
InParanoid	Q9UFC0.
OMA	LSEFTQW.
OrthoDB	EOG7W9RT7.
Enzyme and pathway databases
SignaLink	Q9UFC0.
Gene expression databases
ArrayExpress	Q9UFC0.
Bgee	Q9UFC0.
CleanEx	HS_LRWD1.
Genevestigator	Q9UFC0.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 1 hit. SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. SSF50978. 1 hit.
PROSITE	PS51450. LRR. 3 hits. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	222229.
NextBio	91575.
PRO	Q9UFC0.
SOURCE	Search...

Entry information

Entry name

LRWD1_HUMAN

Accession

Primary (citable) accession number: Q9UFC0
Secondary accession number(s): A8K4K2 , B2R9G2, Q8N0T9, Q8WV43, Q96GJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	October 25, 2004
Last modified:	November 13, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.