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Protein

Zinc finger and BTB domain-containing protein 47

Gene

ZBTB47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri436 – 459C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 513C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 687C2H2-type 9PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9UFB7.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 47
Alternative name(s):
Zinc finger protein 651
Gene namesi
Name:ZBTB47
Synonyms:KIAA1190, ZNF651
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114853.13.
HGNCiHGNC:26955. ZBTB47.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114853.
PharmGKBiPA162409466.

Polymorphism and mutation databases

DMDMi74761930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002518961 – 747Zinc finger and BTB domain-containing protein 47Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UFB7.
PaxDbiQ9UFB7.
PeptideAtlasiQ9UFB7.
PRIDEiQ9UFB7.

PTM databases

iPTMnetiQ9UFB7.
PhosphoSitePlusiQ9UFB7.

Expressioni

Gene expression databases

BgeeiENSG00000114853.
CleanExiHS_ZBTB47.
ExpressionAtlasiQ9UFB7. baseline and differential.
GenevisibleiQ9UFB7. HS.

Organism-specific databases

HPAiHPA074057.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DVL3Q929974EBI-7781767,EBI-739789

Protein-protein interaction databases

BioGridi124993. 3 interactors.
IntActiQ9UFB7. 13 interactors.
MINTiMINT-7555641.
STRINGi9606.ENSP00000232974.

Structurei

3D structure databases

ProteinModelPortaliQ9UFB7.
SMRiQ9UFB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 83BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 354Glu-richAdd BLAST164
Compositional biasi695 – 739Pro-richAdd BLAST45

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri436 – 459C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 513C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 687C2H2-type 9PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000155764.
HOVERGENiHBG018163.
InParanoidiQ9UFB7.
KOiK10518.
OMAiHFACLMG.
OrthoDBiEOG091G055W.
PhylomeDBiQ9UFB7.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UFB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK
60 70 80 90 100
QLQRVELSLE ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD
110 120 130 140 150
IAASCQELLD ARSLGPPGPG TVALAQPAAS CTPAAPPYYC DIKQEADTPG
160 170 180 190 200
LPKIYAREGP DPYSVRVEDG AGTAGGTVPA TIGPAQPFFK EEKEGGVEEA
210 220 230 240 250
GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL NNQTLHVSTG
260 270 280 290 300
PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR
310 320 330 340 350
EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG
360 370 380 390 400
EEGEAGGKQG PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG
410 420 430 440 450
GKRPKPPPGV ASASARGPPA TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY
460 470 480 490 500
LEKHMNVTHS RMQICDQCGK RFLLESELLL HRQTDCERNI QCVTCGKAFK
510 520 530 540 550
KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV AHTKDMPFTC
560 570 580 590 600
ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG
610 620 630 640 650
HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH
660 670 680 690 700
RRTHTGEKPY PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL
710 720 730 740
PPTQPQAHAL PLLPGLPQTL PPPPHLPPPP PLFPTTASPG GRMNANN
Length:747
Mass (Da):82,760
Last modified:April 16, 2014 - v3
Checksum:i8F816B6B7BD4DFDE
GO
Isoform 2 (identifier: Q9UFB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-430: Missing.

Note: No experimental confirmation available.
Show »
Length:646
Mass (Da):72,115
Checksum:iD4EA35455F89ED13
GO

Sequence cautioni

The sequence AAH21855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB61386 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160P → R in BAC86810 (PubMed:14702039).Curated1
Sequence conflicti272L → P in BAC86810 (PubMed:14702039).Curated1
Sequence conflicti282D → G in BAC86810 (PubMed:14702039).Curated1
Sequence conflicti301Missing in BAC86810 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027715385A → T. Corresponds to variant dbSNP:rs9878239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054051330 – 430Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127065 mRNA. Translation: BAC86810.1.
AC006059 Genomic DNA. No translation available.
AL133062 mRNA. Translation: CAB61386.2. Different initiation.
BC021855 mRNA. Translation: AAH21855.1. Different initiation.
AB033016 mRNA. Translation: BAA86504.1.
CCDSiCCDS46805.2. [Q9UFB7-1]
PIRiT42663.
RefSeqiNP_660149.2. NM_145166.3. [Q9UFB7-1]
UniGeneiHs.409561.

Genome annotation databases

EnsembliENST00000232974; ENSP00000232974; ENSG00000114853. [Q9UFB7-1]
GeneIDi92999.
KEGGihsa:92999.
UCSCiuc003clu.3. human. [Q9UFB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT47_HUMAN
AccessioniPrimary (citable) accession number: Q9UFB7
Secondary accession number(s): H7BXD3
, Q6ZSY6, Q8WTY8, Q9ULN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: April 16, 2014
Last modified: November 22, 2017
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families