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Q9UFB7

- ZBT47_HUMAN

UniProt

Q9UFB7 - ZBT47_HUMAN

Protein

Zinc finger and BTB domain-containing protein 47

Gene

ZBTB47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (16 Apr 2014)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri436 – 45924C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri576 – 59823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri604 – 62623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri632 – 65423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri660 – 68728C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 47
    Alternative name(s):
    Zinc finger protein 651
    Gene namesi
    Name:ZBTB47
    Synonyms:KIAA1190, ZNF651
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:26955. ZBTB47.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409466.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747Zinc finger and BTB domain-containing protein 47PRO_0000251896Add
    BLAST

    Proteomic databases

    PaxDbiQ9UFB7.
    PRIDEiQ9UFB7.

    PTM databases

    PhosphoSiteiQ9UFB7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UFB7.
    BgeeiQ9UFB7.
    CleanExiHS_ZBTB47.
    GenevestigatoriQ9UFB7.

    Interactioni

    Protein-protein interaction databases

    BioGridi124993. 1 interaction.
    IntActiQ9UFB7. 1 interaction.
    MINTiMINT-7555641.
    STRINGi9606.ENSP00000411491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UFB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 8369BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi191 – 354164Glu-richAdd
    BLAST
    Compositional biasi695 – 73945Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri436 – 45924C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri576 – 59823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri604 – 62623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri632 – 65423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri660 – 68728C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000155764.
    HOVERGENiHBG018163.
    KOiK10518.
    OMAiHFACLMG.
    OrthoDBiEOG7JQBN4.
    PhylomeDBiQ9UFB7.
    TreeFamiTF332655.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UFB7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK    50
    QLQRVELSLE ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD 100
    IAASCQELLD ARSLGPPGPG TVALAQPAAS CTPAAPPYYC DIKQEADTPG 150
    LPKIYAREGP DPYSVRVEDG AGTAGGTVPA TIGPAQPFFK EEKEGGVEEA 200
    GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL NNQTLHVSTG 250
    PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR 300
    EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG 350
    EEGEAGGKQG PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG 400
    GKRPKPPPGV ASASARGPPA TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY 450
    LEKHMNVTHS RMQICDQCGK RFLLESELLL HRQTDCERNI QCVTCGKAFK 500
    KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV AHTKDMPFTC 550
    ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG 600
    HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH 650
    RRTHTGEKPY PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL 700
    PPTQPQAHAL PLLPGLPQTL PPPPHLPPPP PLFPTTASPG GRMNANN 747
    Length:747
    Mass (Da):82,760
    Last modified:April 16, 2014 - v3
    Checksum:i8F816B6B7BD4DFDE
    GO
    Isoform 2 (identifier: Q9UFB7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         330-430: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:646
    Mass (Da):72,115
    Checksum:iD4EA35455F89ED13
    GO

    Sequence cautioni

    The sequence AAH21855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAB61386.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601P → R in BAC86810. (PubMed:14702039)Curated
    Sequence conflicti272 – 2721L → P in BAC86810. (PubMed:14702039)Curated
    Sequence conflicti282 – 2821D → G in BAC86810. (PubMed:14702039)Curated
    Sequence conflicti301 – 3011Missing in BAC86810. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti385 – 3851A → T.
    Corresponds to variant rs9878239 [ dbSNP | Ensembl ].
    VAR_027715

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei330 – 430101Missing in isoform 2. 1 PublicationVSP_054051Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127065 mRNA. Translation: BAC86810.1.
    AC006059 Genomic DNA. No translation available.
    AL133062 mRNA. Translation: CAB61386.2. Different initiation.
    BC021855 mRNA. Translation: AAH21855.1. Different initiation.
    AB033016 mRNA. Translation: BAA86504.1.
    CCDSiCCDS46805.2. [Q9UFB7-1]
    PIRiT42663.
    RefSeqiNP_660149.2. NM_145166.3. [Q9UFB7-1]
    UniGeneiHs.409561.

    Genome annotation databases

    EnsembliENST00000232974; ENSP00000232974; ENSG00000114853. [Q9UFB7-1]
    GeneIDi92999.
    KEGGihsa:92999.

    Polymorphism databases

    DMDMi74761930.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127065 mRNA. Translation: BAC86810.1 .
    AC006059 Genomic DNA. No translation available.
    AL133062 mRNA. Translation: CAB61386.2 . Different initiation.
    BC021855 mRNA. Translation: AAH21855.1 . Different initiation.
    AB033016 mRNA. Translation: BAA86504.1 .
    CCDSi CCDS46805.2. [Q9UFB7-1 ]
    PIRi T42663.
    RefSeqi NP_660149.2. NM_145166.3. [Q9UFB7-1 ]
    UniGenei Hs.409561.

    3D structure databases

    ProteinModelPortali Q9UFB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124993. 1 interaction.
    IntActi Q9UFB7. 1 interaction.
    MINTi MINT-7555641.
    STRINGi 9606.ENSP00000411491.

    PTM databases

    PhosphoSitei Q9UFB7.

    Polymorphism databases

    DMDMi 74761930.

    Proteomic databases

    PaxDbi Q9UFB7.
    PRIDEi Q9UFB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000232974 ; ENSP00000232974 ; ENSG00000114853 . [Q9UFB7-1 ]
    GeneIDi 92999.
    KEGGi hsa:92999.

    Organism-specific databases

    CTDi 92999.
    GeneCardsi GC03P042674.
    HGNCi HGNC:26955. ZBTB47.
    neXtProti NX_Q9UFB7.
    PharmGKBi PA162409466.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000155764.
    HOVERGENi HBG018163.
    KOi K10518.
    OMAi HFACLMG.
    OrthoDBi EOG7JQBN4.
    PhylomeDBi Q9UFB7.
    TreeFami TF332655.

    Miscellaneous databases

    GenomeRNAii 92999.
    NextBioi 77939.
    PROi Q9UFB7.

    Gene expression databases

    ArrayExpressi Q9UFB7.
    Bgeei Q9UFB7.
    CleanExi HS_ZBTB47.
    Genevestigatori Q9UFB7.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-747 (ISOFORM 1).
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-747 (ISOFORM 1).
      Tissue: Brain.
    5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-747 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiZBT47_HUMAN
    AccessioniPrimary (citable) accession number: Q9UFB7
    Secondary accession number(s): H7BXD3
    , Q6ZSY6, Q8WTY8, Q9ULN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3