Q9UFB7 (ZBT47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 47

Alternative name(s):
Zinc finger protein 651

Gene names

Name:	ZBTB47
Synonyms:	KIAA1190, ZNF651

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Zinc finger and BTB domain-containing protein 47		PRO_0000251896
Regions
	Zinc finger	60 – 83	24	C2H2-type 1
	Zinc finger	87 – 109	23	C2H2-type 2; degenerate
	Zinc finger	114 – 137	24	C2H2-type 3
	Zinc finger	144 – 166	23	C2H2-type 4
	Zinc finger	172 – 194	23	C2H2-type 5
	Zinc finger	200 – 222	23	C2H2-type 6
	Zinc finger	228 – 250	23	C2H2-type 7
	Zinc finger	256 – 278	23	C2H2-type 8
	Zinc finger	284 – 311	28	C2H2-type 9
	Compositional bias	319 – 363	45	Pro-rich
Natural variations
	Natural variant	9	1	A → T. Corresponds to variant rs9878239 [ dbSNP | Ensembl ].		VAR_027715

Sequences

	Sequence		Length	Mass (Da)
	Q9UFB7 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: B3ACFDFB8A2E0B21	FASTA	371	42,465
	10 20 30 40 50 60 MATRSRENAR RRGTPEPEEA GRRGGKRPKP PPGVASASAR GPPATDGLGA KVKLEEKQHH 70 80 90 100 110 120 PCQKCPRVFN NRWYLEKHMN VTHSRMQICD QCGKRFLLES ELLLHRQTDC ERNIQCVTCG 130 140 150 160 170 180 KAFKKLWSLH EHNKIVHGYA EKKFSCEICE KKFYTMAHVR KHMVAHTKDM PFTCETCGKS 190 200 210 220 230 240 FKRSMSLKVH SLQHSGEKPF RCENCNERFQ YKYQLRSHMS IHIGHKQFMC QWCGKDFNMK 250 260 270 280 290 300 QYFDEHMKTH TGEKPYICEI CGKSFTSRPN MKRHRRTHTG EKPYPCDVCG QRFRFSNMLK 310 320 330 340 350 360 AHKEKCFRVS HTLAGDGVPA APGLPPTQPQ AHALPLLPGL PQTLPPPPHL PPPPPLFPTT 370 ASPGGRMNAN N

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-371. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL133062 mRNA. Translation: CAB61386.2. BC021855 mRNA. Translation: AAH21855.1. AB033016 mRNA. Translation: BAA86504.1.
IPI	IPI00444845.
PIR	T42663.
RefSeq	NP_660149.2. NM_145166.3.
UniGene	Hs.409561.
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ProteinModelPortal	Q9UFB7.
SMR	Q9UFB7. Positions 50-118, 226-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UFB7.
PTM databases
PhosphoSite	Q9UFB7.
Polymorphism databases
DMDM	74761930.
Proteomic databases
PRIDE	Q9UFB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000457842; ENSP00000411491; ENSG00000114853.
GeneID	92999.
KEGG	hsa:92999.
UCSC	uc003clu.1. human.
Organism-specific databases
CTD	92999.
GeneCards	GC03P042674.
H-InvDB	HIX0200523.
HGNC	HGNC:26955. ZBTB47.
neXtProt	NX_Q9UFB7.
PharmGKB	PA162409466.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000037877.
HOVERGEN	HBG018163.
OMA	THNRMQI.
Gene expression databases
ArrayExpress	Q9UFB7.
Bgee	Q9UFB7.
CleanEx	HS_ZBTB47.
Genevestigator	Q9UFB7.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 6 hits.
KO	K10518.
Pfam	PF00096. zf-C2H2. 8 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 9 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 8 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	77939.

Entry information

Entry name

ZBT47_HUMAN

Accession

Primary (citable) accession number: Q9UFB7
Secondary accession number(s): Q8WTY8, Q9ULN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	February 15, 2005
Last modified:	December 14, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.