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Q9UFB7

- ZBT47_HUMAN

UniProt

Q9UFB7 - ZBT47_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 47

Gene
ZBTB47, KIAA1190, ZNF651
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri436 – 45924C2H2-type 1Add
BLAST
Zinc fingeri463 – 48523C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri490 – 51324C2H2-type 3Add
BLAST
Zinc fingeri520 – 54223C2H2-type 4Add
BLAST
Zinc fingeri548 – 57023C2H2-type 5Add
BLAST
Zinc fingeri576 – 59823C2H2-type 6Add
BLAST
Zinc fingeri604 – 62623C2H2-type 7Add
BLAST
Zinc fingeri632 – 65423C2H2-type 8Add
BLAST
Zinc fingeri660 – 68728C2H2-type 9Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 47
Alternative name(s):
Zinc finger protein 651
Gene namesi
Name:ZBTB47
Synonyms:KIAA1190, ZNF651
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26955. ZBTB47.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Zinc finger and BTB domain-containing protein 47PRO_0000251896Add
BLAST

Proteomic databases

PaxDbiQ9UFB7.
PRIDEiQ9UFB7.

PTM databases

PhosphoSiteiQ9UFB7.

Expressioni

Gene expression databases

ArrayExpressiQ9UFB7.
BgeeiQ9UFB7.
CleanExiHS_ZBTB47.
GenevestigatoriQ9UFB7.

Interactioni

Protein-protein interaction databases

BioGridi124993. 1 interaction.
IntActiQ9UFB7. 1 interaction.
MINTiMINT-7555641.
STRINGi9606.ENSP00000411491.

Structurei

3D structure databases

ProteinModelPortaliQ9UFB7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8369BTBAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 354164Glu-richAdd
BLAST
Compositional biasi695 – 73945Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri436 – 45924C2H2-type 1Add
BLAST
Zinc fingeri463 – 48523C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri490 – 51324C2H2-type 3Add
BLAST
Zinc fingeri520 – 54223C2H2-type 4Add
BLAST
Zinc fingeri548 – 57023C2H2-type 5Add
BLAST
Zinc fingeri576 – 59823C2H2-type 6Add
BLAST
Zinc fingeri604 – 62623C2H2-type 7Add
BLAST
Zinc fingeri632 – 65423C2H2-type 8Add
BLAST
Zinc fingeri660 – 68728C2H2-type 9Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000155764.
HOVERGENiHBG018163.
KOiK10518.
OMAiHFACLMG.
OrthoDBiEOG7JQBN4.
PhylomeDBiQ9UFB7.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UFB7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK    50
QLQRVELSLE ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD 100
IAASCQELLD ARSLGPPGPG TVALAQPAAS CTPAAPPYYC DIKQEADTPG 150
LPKIYAREGP DPYSVRVEDG AGTAGGTVPA TIGPAQPFFK EEKEGGVEEA 200
GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL NNQTLHVSTG 250
PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR 300
EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG 350
EEGEAGGKQG PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG 400
GKRPKPPPGV ASASARGPPA TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY 450
LEKHMNVTHS RMQICDQCGK RFLLESELLL HRQTDCERNI QCVTCGKAFK 500
KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV AHTKDMPFTC 550
ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG 600
HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH 650
RRTHTGEKPY PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL 700
PPTQPQAHAL PLLPGLPQTL PPPPHLPPPP PLFPTTASPG GRMNANN 747
Length:747
Mass (Da):82,760
Last modified:April 16, 2014 - v3
Checksum:i8F816B6B7BD4DFDE
GO
Isoform 2 (identifier: Q9UFB7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-430: Missing.

Note: No experimental confirmation available.

Show »
Length:646
Mass (Da):72,115
Checksum:iD4EA35455F89ED13
GO

Sequence cautioni

The sequence AAH21855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB61386.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti385 – 3851A → T.
Corresponds to variant rs9878239 [ dbSNP | Ensembl ].
VAR_027715

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 430101Missing in isoform 2. VSP_054051Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601P → R in BAC86810. 1 Publication
Sequence conflicti272 – 2721L → P in BAC86810. 1 Publication
Sequence conflicti282 – 2821D → G in BAC86810. 1 Publication
Sequence conflicti301 – 3011Missing in BAC86810. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127065 mRNA. Translation: BAC86810.1.
AC006059 Genomic DNA. No translation available.
AL133062 mRNA. Translation: CAB61386.2. Different initiation.
BC021855 mRNA. Translation: AAH21855.1. Different initiation.
AB033016 mRNA. Translation: BAA86504.1.
CCDSiCCDS46805.2. [Q9UFB7-1]
PIRiT42663.
RefSeqiNP_660149.2. NM_145166.3. [Q9UFB7-1]
UniGeneiHs.409561.

Genome annotation databases

EnsembliENST00000232974; ENSP00000232974; ENSG00000114853.
ENST00000457842; ENSP00000411491; ENSG00000114853.
GeneIDi92999.
KEGGihsa:92999.

Polymorphism databases

DMDMi74761930.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127065 mRNA. Translation: BAC86810.1 .
AC006059 Genomic DNA. No translation available.
AL133062 mRNA. Translation: CAB61386.2 . Different initiation.
BC021855 mRNA. Translation: AAH21855.1 . Different initiation.
AB033016 mRNA. Translation: BAA86504.1 .
CCDSi CCDS46805.2. [Q9UFB7-1 ]
PIRi T42663.
RefSeqi NP_660149.2. NM_145166.3. [Q9UFB7-1 ]
UniGenei Hs.409561.

3D structure databases

ProteinModelPortali Q9UFB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124993. 1 interaction.
IntActi Q9UFB7. 1 interaction.
MINTi MINT-7555641.
STRINGi 9606.ENSP00000411491.

PTM databases

PhosphoSitei Q9UFB7.

Polymorphism databases

DMDMi 74761930.

Proteomic databases

PaxDbi Q9UFB7.
PRIDEi Q9UFB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000232974 ; ENSP00000232974 ; ENSG00000114853 .
ENST00000457842 ; ENSP00000411491 ; ENSG00000114853 .
GeneIDi 92999.
KEGGi hsa:92999.

Organism-specific databases

CTDi 92999.
GeneCardsi GC03P042674.
HGNCi HGNC:26955. ZBTB47.
neXtProti NX_Q9UFB7.
PharmGKBi PA162409466.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000155764.
HOVERGENi HBG018163.
KOi K10518.
OMAi HFACLMG.
OrthoDBi EOG7JQBN4.
PhylomeDBi Q9UFB7.
TreeFami TF332655.

Miscellaneous databases

GenomeRNAii 92999.
NextBioi 77939.
PROi Q9UFB7.

Gene expression databases

ArrayExpressi Q9UFB7.
Bgeei Q9UFB7.
CleanExi HS_ZBTB47.
Genevestigatori Q9UFB7.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-747 (ISOFORM 1).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-747 (ISOFORM 1).
    Tissue: Brain.
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-747 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZBT47_HUMAN
AccessioniPrimary (citable) accession number: Q9UFB7
Secondary accession number(s): H7BXD3
, Q6ZSY6, Q8WTY8, Q9ULN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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