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Protein

Zinc finger and BTB domain-containing protein 47

Gene

ZBTB47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri436 – 45924C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68728C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 47
Alternative name(s):
Zinc finger protein 651
Gene namesi
Name:ZBTB47
Synonyms:KIAA1190, ZNF651
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26955. ZBTB47.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Zinc finger and BTB domain-containing protein 47PRO_0000251896Add
BLAST

Proteomic databases

PaxDbiQ9UFB7.
PRIDEiQ9UFB7.

PTM databases

PhosphoSiteiQ9UFB7.

Expressioni

Gene expression databases

BgeeiQ9UFB7.
CleanExiHS_ZBTB47.
ExpressionAtlasiQ9UFB7. baseline and differential.
GenevestigatoriQ9UFB7.

Interactioni

Protein-protein interaction databases

BioGridi124993. 1 interaction.
IntActiQ9UFB7. 1 interaction.
MINTiMINT-7555641.
STRINGi9606.ENSP00000411491.

Structurei

3D structure databases

ProteinModelPortaliQ9UFB7.
SMRiQ9UFB7. Positions 4-110, 436-679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8369BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 354164Glu-richAdd
BLAST
Compositional biasi695 – 73945Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri436 – 45924C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68728C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000155764.
HOVERGENiHBG018163.
InParanoidiQ9UFB7.
KOiK10518.
OMAiHFACLMG.
OrthoDBiEOG7JQBN4.
PhylomeDBiQ9UFB7.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UFB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK
60 70 80 90 100
QLQRVELSLE ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD
110 120 130 140 150
IAASCQELLD ARSLGPPGPG TVALAQPAAS CTPAAPPYYC DIKQEADTPG
160 170 180 190 200
LPKIYAREGP DPYSVRVEDG AGTAGGTVPA TIGPAQPFFK EEKEGGVEEA
210 220 230 240 250
GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL NNQTLHVSTG
260 270 280 290 300
PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR
310 320 330 340 350
EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG
360 370 380 390 400
EEGEAGGKQG PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG
410 420 430 440 450
GKRPKPPPGV ASASARGPPA TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY
460 470 480 490 500
LEKHMNVTHS RMQICDQCGK RFLLESELLL HRQTDCERNI QCVTCGKAFK
510 520 530 540 550
KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV AHTKDMPFTC
560 570 580 590 600
ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG
610 620 630 640 650
HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH
660 670 680 690 700
RRTHTGEKPY PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL
710 720 730 740
PPTQPQAHAL PLLPGLPQTL PPPPHLPPPP PLFPTTASPG GRMNANN
Length:747
Mass (Da):82,760
Last modified:April 16, 2014 - v3
Checksum:i8F816B6B7BD4DFDE
GO
Isoform 2 (identifier: Q9UFB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-430: Missing.

Note: No experimental confirmation available.

Show »
Length:646
Mass (Da):72,115
Checksum:iD4EA35455F89ED13
GO

Sequence cautioni

The sequence AAH21855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB61386.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601P → R in BAC86810 (PubMed:14702039).Curated
Sequence conflicti272 – 2721L → P in BAC86810 (PubMed:14702039).Curated
Sequence conflicti282 – 2821D → G in BAC86810 (PubMed:14702039).Curated
Sequence conflicti301 – 3011Missing in BAC86810 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti385 – 3851A → T.
Corresponds to variant rs9878239 [ dbSNP | Ensembl ].
VAR_027715

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 430101Missing in isoform 2. 1 PublicationVSP_054051Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127065 mRNA. Translation: BAC86810.1.
AC006059 Genomic DNA. No translation available.
AL133062 mRNA. Translation: CAB61386.2. Different initiation.
BC021855 mRNA. Translation: AAH21855.1. Different initiation.
AB033016 mRNA. Translation: BAA86504.1.
CCDSiCCDS46805.2. [Q9UFB7-1]
PIRiT42663.
RefSeqiNP_660149.2. NM_145166.3. [Q9UFB7-1]
UniGeneiHs.409561.

Genome annotation databases

EnsembliENST00000232974; ENSP00000232974; ENSG00000114853. [Q9UFB7-1]
GeneIDi92999.
KEGGihsa:92999.

Polymorphism databases

DMDMi74761930.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127065 mRNA. Translation: BAC86810.1.
AC006059 Genomic DNA. No translation available.
AL133062 mRNA. Translation: CAB61386.2. Different initiation.
BC021855 mRNA. Translation: AAH21855.1. Different initiation.
AB033016 mRNA. Translation: BAA86504.1.
CCDSiCCDS46805.2. [Q9UFB7-1]
PIRiT42663.
RefSeqiNP_660149.2. NM_145166.3. [Q9UFB7-1]
UniGeneiHs.409561.

3D structure databases

ProteinModelPortaliQ9UFB7.
SMRiQ9UFB7. Positions 4-110, 436-679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124993. 1 interaction.
IntActiQ9UFB7. 1 interaction.
MINTiMINT-7555641.
STRINGi9606.ENSP00000411491.

PTM databases

PhosphoSiteiQ9UFB7.

Polymorphism databases

DMDMi74761930.

Proteomic databases

PaxDbiQ9UFB7.
PRIDEiQ9UFB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232974; ENSP00000232974; ENSG00000114853. [Q9UFB7-1]
GeneIDi92999.
KEGGihsa:92999.

Organism-specific databases

CTDi92999.
GeneCardsiGC03P042695.
HGNCiHGNC:26955. ZBTB47.
neXtProtiNX_Q9UFB7.
PharmGKBiPA162409466.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000155764.
HOVERGENiHBG018163.
InParanoidiQ9UFB7.
KOiK10518.
OMAiHFACLMG.
OrthoDBiEOG7JQBN4.
PhylomeDBiQ9UFB7.
TreeFamiTF332655.

Miscellaneous databases

GenomeRNAii92999.
NextBioi77939.
PROiQ9UFB7.

Gene expression databases

BgeeiQ9UFB7.
CleanExiHS_ZBTB47.
ExpressionAtlasiQ9UFB7. baseline and differential.
GenevestigatoriQ9UFB7.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-747 (ISOFORM 1).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-747 (ISOFORM 1).
    Tissue: Brain.
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-747 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZBT47_HUMAN
AccessioniPrimary (citable) accession number: Q9UFB7
Secondary accession number(s): H7BXD3
, Q6ZSY6, Q8WTY8, Q9ULN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: April 16, 2014
Last modified: January 7, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.