UniProtKB - Q9UF56 (FXL17_HUMAN)
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Protein
F-box/LRR-repeat protein 17
Gene
FBXL17
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
SIGNORi | Q9UF56. |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/LRR-repeat protein 17Alternative name(s): F-box and leucine-rich repeat protein 17 F-box only protein 13 |
Gene namesi | Name:FBXL17 Synonyms:FBL17, FBX13, FBXO13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145743.15. |
HGNCi | HGNC:13615. FBXL17. |
MIMi | 609083. gene. |
neXtProti | NX_Q9UF56. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 64839. |
OpenTargetsi | ENSG00000145743. |
PharmGKBi | PA134920563. |
Polymorphism and mutation databases
BioMutai | FBXL17. |
DMDMi | 229462981. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119865 | 1 – 701 | F-box/LRR-repeat protein 17Add BLAST | 701 |
Proteomic databases
PaxDbi | Q9UF56. |
PeptideAtlasi | Q9UF56. |
PRIDEi | Q9UF56. |
PTM databases
iPTMneti | Q9UF56. |
PhosphoSitePlusi | Q9UF56. |
Expressioni
Gene expression databases
Bgeei | ENSG00000145743. |
CleanExi | HS_FBXL17. |
ExpressionAtlasi | Q9UF56. baseline and differential. |
Genevisiblei | Q9UF56. HS. |
Organism-specific databases
HPAi | HPA036410. HPA036411. |
Interactioni
Subunit structurei
Interacts with SKP1 and CUL1.By similarity
Protein-protein interaction databases
BioGridi | 122315. 25 interactors. |
IntActi | Q9UF56. 1 interactor. |
STRINGi | 9606.ENSP00000437464. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 318 – 365 | F-boxPROSITE-ProRule annotationAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 28 | Poly-Arg | 4 | |
Compositional biasi | 29 – 86 | Pro-richAdd BLAST | 58 | |
Compositional biasi | 90 – 151 | Ala-richAdd BLAST | 62 | |
Compositional biasi | 216 – 236 | Gly-richAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG1947. Eukaryota. ENOG410XQ54. LUCA. |
GeneTreei | ENSGT00760000119059. |
HOGENOMi | HOG000169154. |
HOVERGENi | HBG107935. |
InParanoidi | Q9UF56. |
KOi | K10283. |
OMAi | VCFLHIS. |
OrthoDBi | EOG091G0KDW. |
PhylomeDBi | Q9UF56. |
TreeFami | TF332421. |
Family and domain databases
Gene3Di | 3.80.10.10. 2 hits. |
InterProi | View protein in InterPro IPR036047. F-box-like_dom_sf. IPR001810. F-box_dom. IPR001611. Leu-rich_rpt. IPR006553. Leu-rich_rpt_Cys-con_subtyp. IPR032675. LRR_dom_sf. |
Pfami | View protein in Pfam PF12937. F-box-like. 1 hit. PF13516. LRR_6. 1 hit. |
SMARTi | View protein in SMART SM00256. FBOX. 1 hit. SM00367. LRR_CC. 11 hits. |
SUPFAMi | SSF81383. SSF81383. 1 hit. |
PROSITEi | View protein in PROSITE PS50181. FBOX. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UF56-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS
60 70 80 90 100
RDCFFRGPCM LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL
110 120 130 140 150
ARRYAALAAE DCAAAARRFL LSSAAAAAAA AASASSPASC CKELGLAAAA
160 170 180 190 200
AWEQQGRSLF LASLGPVRFL GPPAAVQLFR GPTPSPAELP TPPEMVCKRK
210 220 230 240 250
GAGVPACTPC KQPRCGGGGC GGGGGGGGGG GPAGGGASPP RPPDAGCCQA
260 270 280 290 300
PEQPPQPLCP PPSSPTSEGA PTEAGGDAVR AGGTAPLSAQ QQHECGDADC
310 320 330 340 350
RESPENPCDC HREPPPETPD INQLPPSILL KIFSNLSLDE RCLSASLVCK
360 370 380 390 400
YWRDLCLDFQ FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSMS
410 420 430 440 450
DNGVCVLAFK CPGLLRYTAY RCKQLSDTSI IAVASHCPLL QKVHVGNQDK
460 470 480 490 500
LTDEGLKQLG SKCRELKDIH FGQCYKISDE GMIVIAKGCL KLQRIYMQEN
510 520 530 540 550
KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR NLSSLDLRHI
560 570 580 590 600
TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
610 620 630 640 650
SCKITDYALI AIGRYSMTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL
660 670 680 690 700
MRCDKVNEVT VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAS
S
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037034 | 1 – 398 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 398 | |
Alternative sequenceiVSP_009476 | 657 – 701 | NEVTV…SAASS → RVDYQVVCFLHISIVNSLMS YPLSFSISTPVYYILYIHFI CIYAIIAMHCLPAFVN in isoform 3. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126722 mRNA. Translation: BAC86658.1. AL133602 mRNA. Translation: CAB63737.2. AC008462 Genomic DNA. No translation available. AC011419 Genomic DNA. No translation available. CH471086 Genomic DNA. Translation: EAW49061.1. BC126144 mRNA. Translation: AAI26145.1. BC126146 mRNA. Translation: AAI26147.1. |
CCDSi | CCDS54886.1. [Q9UF56-1] |
PIRi | T43444. |
RefSeqi | NP_001156787.2. NM_001163315.2. [Q9UF56-1] |
UniGenei | Hs.657225. |
Genome annotation databases
Ensembli | ENST00000359660; ENSP00000352683; ENSG00000145743. [Q9UF56-3] ENST00000496714; ENSP00000418111; ENSG00000145743. [Q9UF56-2] ENST00000542267; ENSP00000437464; ENSG00000145743. [Q9UF56-1] |
GeneIDi | 64839. |
KEGGi | hsa:64839. |
UCSCi | uc003kon.5. human. [Q9UF56-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | FXL17_HUMAN | |
Accessioni | Q9UF56Primary (citable) accession number: Q9UF56 Secondary accession number(s): A1A4E3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 28, 2018 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |