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Protein

F-box/LRR-repeat protein 17

Gene

FBXL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 17
Alternative name(s):
F-box and leucine-rich repeat protein 17
F-box only protein 13
Gene namesi
Name:FBXL17
Synonyms:FBL17, FBX13, FBXO13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13615. FBXL17.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920563.

Polymorphism and mutation databases

BioMutaiFBXL17.
DMDMi229462981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 701701F-box/LRR-repeat protein 17PRO_0000119865Add
BLAST

Proteomic databases

MaxQBiQ9UF56.
PaxDbiQ9UF56.
PRIDEiQ9UF56.

PTM databases

iPTMnetiQ9UF56.
PhosphoSiteiQ9UF56.

Expressioni

Gene expression databases

BgeeiQ9UF56.
CleanExiHS_FBXL17.
ExpressionAtlasiQ9UF56. baseline and differential.
GenevisibleiQ9UF56. HS.

Organism-specific databases

HPAiHPA036410.
HPA036411.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi122315. 15 interactions.
STRINGi9606.ENSP00000437464.

Structurei

3D structure databases

ProteinModelPortaliQ9UF56.
SMRiQ9UF56. Positions 322-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini318 – 36548F-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 284Poly-Arg
Compositional biasi29 – 8658Pro-richAdd
BLAST
Compositional biasi90 – 15162Ala-richAdd
BLAST
Compositional biasi216 – 23621Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000169154.
HOVERGENiHBG107935.
InParanoidiQ9UF56.
KOiK10283.
OMAiIAMHCLP.
OrthoDBiEOG7DNNW7.
PhylomeDBiQ9UF56.
TreeFamiTF332421.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UF56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS
60 70 80 90 100
RDCFFRGPCM LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL
110 120 130 140 150
ARRYAALAAE DCAAAARRFL LSSAAAAAAA AASASSPASC CKELGLAAAA
160 170 180 190 200
AWEQQGRSLF LASLGPVRFL GPPAAVQLFR GPTPSPAELP TPPEMVCKRK
210 220 230 240 250
GAGVPACTPC KQPRCGGGGC GGGGGGGGGG GPAGGGASPP RPPDAGCCQA
260 270 280 290 300
PEQPPQPLCP PPSSPTSEGA PTEAGGDAVR AGGTAPLSAQ QQHECGDADC
310 320 330 340 350
RESPENPCDC HREPPPETPD INQLPPSILL KIFSNLSLDE RCLSASLVCK
360 370 380 390 400
YWRDLCLDFQ FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSMS
410 420 430 440 450
DNGVCVLAFK CPGLLRYTAY RCKQLSDTSI IAVASHCPLL QKVHVGNQDK
460 470 480 490 500
LTDEGLKQLG SKCRELKDIH FGQCYKISDE GMIVIAKGCL KLQRIYMQEN
510 520 530 540 550
KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR NLSSLDLRHI
560 570 580 590 600
TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
610 620 630 640 650
SCKITDYALI AIGRYSMTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL
660 670 680 690 700
MRCDKVNEVT VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAS

S
Length:701
Mass (Da):75,695
Last modified:May 5, 2009 - v3
Checksum:i87B7792A9357C94C
GO
Isoform 2 (identifier: Q9UF56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):34,107
Checksum:iA39FAE2C64AB2FA0
GO
Isoform 3 (identifier: Q9UF56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.
     657-701: NEVTVEQLVQ...WTPNMSAASS → RVDYQVVCFL...AMHCLPAFVN

Note: No experimental confirmation available.
Show »
Length:314
Mass (Da):35,451
Checksum:iAB679086097882AD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 398398Missing in isoform 2 and isoform 3. 3 PublicationsVSP_037034Add
BLAST
Alternative sequencei657 – 70145NEVTV…SAASS → RVDYQVVCFLHISIVNSLMS YPLSFSISTPVYYILYIHFI CIYAIIAMHCLPAFVN in isoform 3. 1 PublicationVSP_009476Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126722 mRNA. Translation: BAC86658.1.
AL133602 mRNA. Translation: CAB63737.2.
AC008462 Genomic DNA. No translation available.
AC011419 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49061.1.
BC126144 mRNA. Translation: AAI26145.1.
BC126146 mRNA. Translation: AAI26147.1.
CCDSiCCDS54886.1. [Q9UF56-1]
PIRiT43444.
RefSeqiNP_001156787.2. NM_001163315.2. [Q9UF56-1]
UniGeneiHs.657225.

Genome annotation databases

EnsembliENST00000359660; ENSP00000352683; ENSG00000145743. [Q9UF56-3]
ENST00000496714; ENSP00000418111; ENSG00000145743. [Q9UF56-2]
ENST00000542267; ENSP00000437464; ENSG00000145743. [Q9UF56-1]
GeneIDi64839.
KEGGihsa:64839.
UCSCiuc003kon.5. human. [Q9UF56-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126722 mRNA. Translation: BAC86658.1.
AL133602 mRNA. Translation: CAB63737.2.
AC008462 Genomic DNA. No translation available.
AC011419 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49061.1.
BC126144 mRNA. Translation: AAI26145.1.
BC126146 mRNA. Translation: AAI26147.1.
CCDSiCCDS54886.1. [Q9UF56-1]
PIRiT43444.
RefSeqiNP_001156787.2. NM_001163315.2. [Q9UF56-1]
UniGeneiHs.657225.

3D structure databases

ProteinModelPortaliQ9UF56.
SMRiQ9UF56. Positions 322-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122315. 15 interactions.
STRINGi9606.ENSP00000437464.

PTM databases

iPTMnetiQ9UF56.
PhosphoSiteiQ9UF56.

Polymorphism and mutation databases

BioMutaiFBXL17.
DMDMi229462981.

Proteomic databases

MaxQBiQ9UF56.
PaxDbiQ9UF56.
PRIDEiQ9UF56.

Protocols and materials databases

DNASUi64839.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359660; ENSP00000352683; ENSG00000145743. [Q9UF56-3]
ENST00000496714; ENSP00000418111; ENSG00000145743. [Q9UF56-2]
ENST00000542267; ENSP00000437464; ENSG00000145743. [Q9UF56-1]
GeneIDi64839.
KEGGihsa:64839.
UCSCiuc003kon.5. human. [Q9UF56-1]

Organism-specific databases

CTDi64839.
GeneCardsiFBXL17.
HGNCiHGNC:13615. FBXL17.
HPAiHPA036410.
HPA036411.
MIMi609083. gene.
neXtProtiNX_Q9UF56.
PharmGKBiPA134920563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000169154.
HOVERGENiHBG107935.
InParanoidiQ9UF56.
KOiK10283.
OMAiIAMHCLP.
OrthoDBiEOG7DNNW7.
PhylomeDBiQ9UF56.
TreeFamiTF332421.

Miscellaneous databases

ChiTaRSiFBXL17. human.
GenomeRNAii64839.
PROiQ9UF56.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UF56.
CleanExiHS_FBXL17.
ExpressionAtlasiQ9UF56. baseline and differential.
GenevisibleiQ9UF56. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiFXL17_HUMAN
AccessioniPrimary (citable) accession number: Q9UF56
Secondary accession number(s): A1A4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.