FBXL17

Functionⁱ

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: F-box/LRR-repeat protein 17 Alternative name(s): F-box and leucine-rich repeat protein 17 F-box only protein 13
Gene namesⁱ	Name:FBXL17 Synonyms:FBL17, FBX13, FBXO13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13615. FBXL17.

HGNCⁱ

HGNC:13615. FBXL17.

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64839.
Open Targets More...OpenTargetsⁱ	ENSG00000145743.
PharmGKBⁱ	PA134920563.

Polymorphism and mutation databases

BioMutaⁱ	FBXL17.
DMDMⁱ	229462981.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119865	1 – 701	F-box/LRR-repeat protein 17Add BLAST		701

Proteomic databases

EPDⁱ	Q9UF56.
PaxDbⁱ	Q9UF56.
PeptideAtlas More...PeptideAtlasⁱ	Q9UF56.
PRIDEⁱ	Q9UF56.

PTM databases

iPTMnetⁱ	Q9UF56.
PhosphoSitePlusⁱ	Q9UF56.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000145743.
CleanExⁱ	HS_FBXL17.
ExpressionAtlasⁱ	Q9UF56. baseline and differential.
Genevisibleⁱ	Q9UF56. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036410. HPA036411.

HPAⁱ

HPA036410.
HPA036411.

Interactionⁱ

Subunit structureⁱ

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridⁱ	122315. 24 interactors.
IntActⁱ	Q9UF56. 1 interactor.
STRINGⁱ	9606.ENSP00000437464.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UF56.
SMRⁱ	Q9UF56.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	318 – 365	F-boxPROSITE-ProRule annotationAdd BLAST		48

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	25 – 28	Poly-Arg	4
Compositional biasⁱ	29 – 86	Pro-richAdd BLAST	58
Compositional biasⁱ	90 – 151	Ala-richAdd BLAST	62
Compositional biasⁱ	216 – 236	Gly-richAdd BLAST	21

Phylogenomic databases

eggNOGⁱ	KOG1947. Eukaryota. ENOG410XQ54. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119059.
HOGENOMⁱ	HOG000169154.
HOVERGENⁱ	HBG107935.
InParanoidⁱ	Q9UF56.
KEGG Orthology (KO) More...KOⁱ	K10283.
OMAⁱ	VCFLHIS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDW.
PhylomeDBⁱ	Q9UF56.
TreeFamⁱ	TF332421.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR001810. F-box_dom. IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR006553. Leu-rich_rpt_Cys-con_subtyp.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12937. F-box-like. 1 hit. PF13516. LRR_6. 1 hit.
SMARTⁱ	View protein in SMART SM00256. FBOX. 1 hit. SM00367. LRR_CC. 11 hits.
SUPFAMⁱ	SSF81383. SSF81383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50181. FBOX. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9UF56-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS 
        60         70         80         90        100
RDCFFRGPCM LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL 
       110        120        130        140        150
ARRYAALAAE DCAAAARRFL LSSAAAAAAA AASASSPASC CKELGLAAAA 
       160        170        180        190        200
AWEQQGRSLF LASLGPVRFL GPPAAVQLFR GPTPSPAELP TPPEMVCKRK 
       210        220        230        240        250
GAGVPACTPC KQPRCGGGGC GGGGGGGGGG GPAGGGASPP RPPDAGCCQA 
       260        270        280        290        300
PEQPPQPLCP PPSSPTSEGA PTEAGGDAVR AGGTAPLSAQ QQHECGDADC 
       310        320        330        340        350
RESPENPCDC HREPPPETPD INQLPPSILL KIFSNLSLDE RCLSASLVCK 
       360        370        380        390        400
YWRDLCLDFQ FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSMS 
       410        420        430        440        450
DNGVCVLAFK CPGLLRYTAY RCKQLSDTSI IAVASHCPLL QKVHVGNQDK 
       460        470        480        490        500
LTDEGLKQLG SKCRELKDIH FGQCYKISDE GMIVIAKGCL KLQRIYMQEN 
       510        520        530        540        550
KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR NLSSLDLRHI 
       560        570        580        590        600
TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV 
       610        620        630        640        650
SCKITDYALI AIGRYSMTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL 
       660        670        680        690        700
MRCDKVNEVT VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAS 

S

Length:701

Mass (Da):75,695

Last modified:May 5, 2009 - v3

Checksum:ⁱ87B7792A9357C94C

GO

Isoform 2 (identifier: Q9UF56-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-398: Missing.

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        10         20         30         40         50
MSDNGVCVLA FKCPGLLRYT AYRCKQLSDT SIIAVASHCP LLQKVHVGNQ 
        60         70         80         90        100
DKLTDEGLKQ LGSKCRELKD IHFGQCYKIS DEGMIVIAKG CLKLQRIYMQ 
       110        120        130        140        150
ENKLVTDQSV KAFAEHCPEL QYVGFMGCSV TSKGVIHLTK LRNLSSLDLR 
       160        170        180        190        200
HITELDNETV MEIVKRCKNL SSLNLCLNWI INDRCVEVIA KEGQNLKELY 
       210        220        230        240        250
LVSCKITDYA LIAIGRYSMT IETVDVGWCK EITDQGATLI AQSSKSLRYL 
       260        270        280        290        300
GLMRCDKVNE VTVEQLVQQY PHITFSTVLQ DCKRTLERAY QMGWTPNMSA 

ASS

Note: No experimental confirmation available.

Show »

Length:303

Mass (Da):34,107

Checksum:ⁱA39FAE2C64AB2FA0

GO

Isoform 3 (identifier: Q9UF56-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-398: Missing.
657-701: NEVTVEQLVQ...WTPNMSAASS → RVDYQVVCFL...AMHCLPAFVN

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        10         20         30         40         50
MSDNGVCVLA FKCPGLLRYT AYRCKQLSDT SIIAVASHCP LLQKVHVGNQ 
        60         70         80         90        100
DKLTDEGLKQ LGSKCRELKD IHFGQCYKIS DEGMIVIAKG CLKLQRIYMQ 
       110        120        130        140        150
ENKLVTDQSV KAFAEHCPEL QYVGFMGCSV TSKGVIHLTK LRNLSSLDLR 
       160        170        180        190        200
HITELDNETV MEIVKRCKNL SSLNLCLNWI INDRCVEVIA KEGQNLKELY 
       210        220        230        240        250
LVSCKITDYA LIAIGRYSMT IETVDVGWCK EITDQGATLI AQSSKSLRYL 
       260        270        280        290        300
GLMRCDKVRV DYQVVCFLHI SIVNSLMSYP LSFSISTPVY YILYIHFICI 
       310 
YAIIAMHCLP AFVN

Note: No experimental confirmation available.

Show »

Length:314

Mass (Da):35,451

Checksum:ⁱAB679086097882AD

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037034	1 – 398	Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST		398
Alternative sequenceⁱVSP_009476	657 – 701	NEVTV…SAASS → RVDYQVVCFLHISIVNSLMS YPLSFSISTPVYYILYIHFI CIYAIIAMHCLPAFVN in isoform 3. 1 PublicationAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126722 mRNA. Translation: BAC86658.1. AL133602 mRNA. Translation: CAB63737.2. AC008462 Genomic DNA. No translation available. AC011419 Genomic DNA. No translation available. CH471086 Genomic DNA. Translation: EAW49061.1. BC126144 mRNA. Translation: AAI26145.1. BC126146 mRNA. Translation: AAI26147.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS54886.1. [Q9UF56-1]
PIRⁱ	T43444.
NCBI Reference Sequences More...RefSeqⁱ	NP_001156787.2. NM_001163315.2. [Q9UF56-1]
UniGeneⁱ	Hs.657225.

Genome annotation databases

Ensemblⁱ	ENST00000359660; ENSP00000352683; ENSG00000145743. [Q9UF56-3] ENST00000496714; ENSP00000418111; ENSG00000145743. [Q9UF56-2] ENST00000542267; ENSP00000437464; ENSG00000145743. [Q9UF56-1]
GeneIDⁱ	64839.
KEGGⁱ	hsa:64839.
UCSC genome browser More...UCSCⁱ	uc003kon.5. human. [Q9UF56-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126722 mRNA. Translation: BAC86658.1. AL133602 mRNA. Translation: CAB63737.2. AC008462 Genomic DNA. No translation available. AC011419 Genomic DNA. No translation available. CH471086 Genomic DNA. Translation: EAW49061.1. BC126144 mRNA. Translation: AAI26145.1. BC126146 mRNA. Translation: AAI26147.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS54886.1. [Q9UF56-1]
PIRⁱ	T43444.
NCBI Reference Sequences More...RefSeqⁱ	NP_001156787.2. NM_001163315.2. [Q9UF56-1]
UniGeneⁱ	Hs.657225.

3D structure databases

ProteinModelPortalⁱ	Q9UF56.
SMRⁱ	Q9UF56.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122315. 24 interactors.
IntActⁱ	Q9UF56. 1 interactor.
STRINGⁱ	9606.ENSP00000437464.

PTM databases

iPTMnetⁱ	Q9UF56.
PhosphoSitePlusⁱ	Q9UF56.

Polymorphism and mutation databases

BioMutaⁱ	FBXL17.
DMDMⁱ	229462981.

Proteomic databases

EPDⁱ	Q9UF56.
PaxDbⁱ	Q9UF56.
PeptideAtlas More...PeptideAtlasⁱ	Q9UF56.
PRIDEⁱ	Q9UF56.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64839.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359660; ENSP00000352683; ENSG00000145743. [Q9UF56-3] ENST00000496714; ENSP00000418111; ENSG00000145743. [Q9UF56-2] ENST00000542267; ENSP00000437464; ENSG00000145743. [Q9UF56-1]
GeneIDⁱ	64839.
KEGGⁱ	hsa:64839.
UCSC genome browser More...UCSCⁱ	uc003kon.5. human. [Q9UF56-1]

Organism-specific databases

CTDⁱ	64839.
DisGeNET More...DisGeNETⁱ	64839.
GeneCardsⁱ	FBXL17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13615. FBXL17.
Human Protein Atlas More...HPAⁱ	HPA036410. HPA036411.
MIMⁱ	609083. gene.
neXtProtⁱ	NX_Q9UF56.
Open Targets More...OpenTargetsⁱ	ENSG00000145743.
PharmGKBⁱ	PA134920563.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1947. Eukaryota. ENOG410XQ54. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119059.
HOGENOMⁱ	HOG000169154.
HOVERGENⁱ	HBG107935.
InParanoidⁱ	Q9UF56.
KEGG Orthology (KO) More...KOⁱ	K10283.
OMAⁱ	VCFLHIS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDW.
PhylomeDBⁱ	Q9UF56.
TreeFamⁱ	TF332421.

Miscellaneous databases

ChiTaRSⁱ	FBXL17. human.
GenomeRNAiⁱ	64839.
Protein Ontology More...PROⁱ	PR:Q9UF56.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145743.
CleanExⁱ	HS_FBXL17.
ExpressionAtlasⁱ	Q9UF56. baseline and differential.
Genevisibleⁱ	Q9UF56. HS.

Family and domain databases

Gene3Dⁱ	3.80.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR001810. F-box_dom. IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR006553. Leu-rich_rpt_Cys-con_subtyp.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12937. F-box-like. 1 hit. PF13516. LRR_6. 1 hit.
SMARTⁱ	View protein in SMART SM00256. FBOX. 1 hit. SM00367. LRR_CC. 11 hits.
SUPFAMⁱ	SSF81383. SSF81383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50181. FBOX. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FXL17_HUMAN
Accessionⁱ	Q9UF56Primary (citable) accession number: Q9UF56 Secondary accession number(s): A1A4E3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
	Last sequence update:	May 5, 2009
	Last modified:	June 7, 2017
	This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UF56 (FXL17_HUMAN)

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F-box/LRR-repeat protein 17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (3)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ