ID   DNJ5B_HUMAN             Reviewed;         199 AA.
AC   Q9UF47; Q969Y8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2002, sequence version 2.
DT   25-JAN-2012, entry version 81.
DE   RecName: Full=DnaJ homolog subfamily C member 5B;
DE   AltName: Full=Cysteine string protein beta;
DE            Short=CSP-beta;
GN   Name=DNAJC5B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tobaben S., Stahl B.;
RT   "Novel isoforms of the cysteine string protein.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, AND
RP   PALMITOYLATION.
RX   PubMed=17034881; DOI=10.1016/j.bbamcr.2006.08.054;
RA   Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.;
RT   "Cysteine-string protein isoform beta (Cspbeta) is targeted to the
RT   trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells.";
RL   Biochim. Biophys. Acta 1773:109-119(2007).
CC   -!- SUBUNIT: Interacts with the chaperone complex consisting of HSC70
CC       and SGTA.
CC   -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Note=May be
CC       associated with the trans-Golgi network (PubMed:17034881).
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- PTM: Palmitoylated. Palmitoylation is not required for membrane
CC       association.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AF368276; AAK60571.1; -; mRNA.
DR   EMBL; BC016742; AAH16742.1; -; mRNA.
DR   EMBL; AL133660; CAB63773.2; -; mRNA.
DR   IPI; IPI00647830; -.
DR   PIR; T43470; T43470.
DR   RefSeq; NP_149096.2; NM_033105.4.
DR   UniGene; Hs.491885; -.
DR   ProteinModelPortal; Q9UF47; -.
DR   SMR; Q9UF47; 9-104.
DR   STRING; Q9UF47; -.
DR   DMDM; 20141445; -.
DR   PRIDE; Q9UF47; -.
DR   Ensembl; ENST00000276570; ENSP00000276570; ENSG00000147570.
DR   GeneID; 85479; -.
DR   KEGG; hsa:85479; -.
DR   UCSC; uc003xvs.1; human.
DR   CTD; 85479; -.
DR   GeneCards; GC08P066984; -.
DR   H-InvDB; HIX0007550; -.
DR   HGNC; HGNC:24138; DNAJC5B.
DR   MIM; 613945; gene.
DR   neXtProt; NX_Q9UF47; -.
DR   PharmGKB; PA134962894; -.
DR   eggNOG; prNOG07520; -.
DR   GeneTree; ENSGT00600000084291; -.
DR   HOGENOM; HBG713019; -.
DR   HOVERGEN; HBG005414; -.
DR   InParanoid; Q9UF47; -.
DR   OMA; DENVNTY; -.
DR   OrthoDB; EOG4NZTVC; -.
DR   PhylomeDB; Q9UF47; -.
DR   NextBio; 76144; -.
DR   ArrayExpress; Q9UF47; -.
DR   Bgee; Q9UF47; -.
DR   CleanEx; HS_DNAJC5B; -.
DR   Genevestigator; Q9UF47; -.
DR   GermOnline; ENSG00000147570; Homo sapiens.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09525; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Complete proteome; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome.
FT   CHAIN         1    199       DnaJ homolog subfamily C member 5B.
FT                                /FTId=PRO_0000071055.
FT   DOMAIN       19     84       J.
FT   COMPBIAS    123    140       Cys-rich.
FT   COMPBIAS    126    137       Poly-Cys.
FT   CONFLICT     41     44       KLAL -> LENP (in Ref. 3; CAB63773).
SQ   SEQUENCE   199 AA;  22496 MW;  4FDBF489D16B6EC0 CRC64;
     MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK
     FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL
     TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN
     ANEKTQLIKE GSRSYCTDS
//