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Protein

DnaJ homolog subfamily C member 5B

Gene

DNAJC5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5B
Alternative name(s):
Cysteine string protein beta
Short name:
CSP-beta
Gene namesi
Name:DNAJC5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24138. DNAJC5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962894.

Polymorphism and mutation databases

BioMutaiDNAJC5B.
DMDMi20141445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199DnaJ homolog subfamily C member 5BPRO_0000071055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity

Post-translational modificationi

Palmitoylated. Palmitoylation is not required for membrane association.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9UF47.
PeptideAtlasiQ9UF47.
PRIDEiQ9UF47.

PTM databases

iPTMnetiQ9UF47.
PhosphoSiteiQ9UF47.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000147570.
CleanExiHS_DNAJC5B.
ExpressionAtlasiQ9UF47. baseline and differential.
GenevisibleiQ9UF47. HS.

Interactioni

Subunit structurei

Interacts with the chaperone complex consisting of HSC70 and SGTA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-10320535,EBI-717422

Protein-protein interaction databases

BioGridi124554. 1 interaction.
IntActiQ9UF47. 1 interaction.
STRINGi9606.ENSP00000276570.

Structurei

3D structure databases

ProteinModelPortaliQ9UF47.
SMRiQ9UF47. Positions 9-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 8466JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 14018Cys-richAdd
BLAST
Compositional biasi126 – 13712Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiQ9UF47.
KOiK09525.
OMAiSWWAKTL.
OrthoDBiEOG091G0QJP.
PhylomeDBiQ9UF47.
TreeFamiTF105164.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UF47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK
60 70 80 90 100
NPDDPAATEK FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN
110 120 130 140 150
TYFMLSSWWA KALFVIVGLL TGCYFCCCLC CCCNCCCGHC RPESSVPEED
160 170 180 190
FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN ANEKTQLIKE GSRSYCTDS
Length:199
Mass (Da):22,496
Last modified:April 3, 2002 - v2
Checksum:i4FDBF489D16B6EC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 444KLAL → LENP in CAB63773 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368276 mRNA. Translation: AAK60571.1.
BC016742 mRNA. Translation: AAH16742.1.
AL133660 mRNA. Translation: CAB63773.2.
CCDSiCCDS6183.1.
PIRiT43470.
RefSeqiNP_149096.2. NM_033105.4.
XP_011515920.1. XM_011517618.2.
UniGeneiHs.491885.

Genome annotation databases

EnsembliENST00000276570; ENSP00000276570; ENSG00000147570.
GeneIDi85479.
KEGGihsa:85479.
UCSCiuc003xvs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368276 mRNA. Translation: AAK60571.1.
BC016742 mRNA. Translation: AAH16742.1.
AL133660 mRNA. Translation: CAB63773.2.
CCDSiCCDS6183.1.
PIRiT43470.
RefSeqiNP_149096.2. NM_033105.4.
XP_011515920.1. XM_011517618.2.
UniGeneiHs.491885.

3D structure databases

ProteinModelPortaliQ9UF47.
SMRiQ9UF47. Positions 9-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124554. 1 interaction.
IntActiQ9UF47. 1 interaction.
STRINGi9606.ENSP00000276570.

PTM databases

iPTMnetiQ9UF47.
PhosphoSiteiQ9UF47.

Polymorphism and mutation databases

BioMutaiDNAJC5B.
DMDMi20141445.

Proteomic databases

PaxDbiQ9UF47.
PeptideAtlasiQ9UF47.
PRIDEiQ9UF47.

Protocols and materials databases

DNASUi85479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276570; ENSP00000276570; ENSG00000147570.
GeneIDi85479.
KEGGihsa:85479.
UCSCiuc003xvs.2. human.

Organism-specific databases

CTDi85479.
GeneCardsiDNAJC5B.
HGNCiHGNC:24138. DNAJC5B.
MIMi613945. gene.
neXtProtiNX_Q9UF47.
PharmGKBiPA134962894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiQ9UF47.
KOiK09525.
OMAiSWWAKTL.
OrthoDBiEOG091G0QJP.
PhylomeDBiQ9UF47.
TreeFamiTF105164.

Miscellaneous databases

ChiTaRSiDNAJC5B. human.
GenomeRNAii85479.
PROiQ9UF47.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147570.
CleanExiHS_DNAJC5B.
ExpressionAtlasiQ9UF47. baseline and differential.
GenevisibleiQ9UF47. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJ5B_HUMAN
AccessioniPrimary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.