Reviewed, UniProtKB/Swiss-Prot Q9UF47 (DNJ5B_HUMAN)

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 5B

Alternative name(s):
Beta cysteine string protein
Short name=Beta-CSP

Gene names

Name:

DNAJC5B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Lipid-anchor By similarity.
Tissue specificity	Testis specific.
Post-translational modification	Palmitoylated By similarity.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Membrane
Molecular function	Chaperone
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	DnaJ homolog subfamily C member 5B		PRO_0000071055
Regions
	Domain	19 – 84	66	J
	Compositional bias	123 – 140	18	Cys-rich
	Compositional bias	126 – 137	12	Poly-Cys
Experimental info
	Sequence conflict	41 – 44	4	KLAL → LENP in CAB63773. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UF47-1 [UniParc]. Last modified April 3, 2002. Version 2. Checksum: 4FDBF489D16B6EC0	FASTA	199	22,496
	10 20 30 40 50 60 MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK 70 80 90 100 110 120 FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL 130 140 150 160 170 180 TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN 190 ANEKTQLIKE GSRSYCTDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel isoforms of the cysteine string protein." Tobaben S., Stahl B. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF368276 mRNA. Translation: AAK60571.1. BC016742 mRNA. Translation: AAH16742.1. AL133660 mRNA. Translation: CAB63773.2.
IPI	IPI00647830.
PIR	T43470.
RefSeq	NP_149096.2.
UniGene	Hs.491885
3D structure databases
SMR	Q9UF47. Positions 9-104.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UF47.
Proteomic databases
PRIDE	Q9UF47.
Genome annotation databases
Ensembl	ENST00000276570; ENSP00000276570; ENSG00000147570; Homo sapiens. [Genome view]
GeneID	85479.
KEGG	hsa:85479.
UCSC	uc003xvs.1. human.
Organism-specific databases
CTD	85479.
GeneCards	GC08P067096.
HGNC	HGNC:24138. DNAJC5B.
PharmGKB	PA134962894.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07520.
HOGENOM	HBG713019.
HOVERGEN	HBG005414.
InParanoid	Q9UF47.
OMA	DENVNTY.
OrthoDB	EOG9N0716.
PhylomeDB	Q9UF47.
Gene expression databases
ArrayExpress	Q9UF47.
Bgee	Q9UF47.
CleanEx	HS_DNAJC5B.
Genevestigator	Q9UF47.
GermOnline	ENSG00000147570. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
PRINTS	PR00625. DNAJPROTEIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	76144.

Entry information

Entry name

DNJ5B_HUMAN

Accession

Primary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	April 3, 2002
Last modified:	March 2, 2010
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.