Q9UF47 (DNJ5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 5B

Alternative name(s):
Cysteine string protein beta
Short name=CSP-beta

Gene names

Name:

DNAJC5B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with the chaperone complex consisting of HSC70 and SGTA. Ref.4
Subcellular location	Membrane; Lipid-anchor. Note: May be associated with the trans-Golgi network (Ref.4). Ref.4
Tissue specificity	Testis specific.
Post-translational modification	Palmitoylated. Palmitoylation is not required for membrane association. Ref.4
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Membrane
Molecular function	Chaperone
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	DnaJ homolog subfamily C member 5B		PRO_0000071055
Regions
	Domain	19 – 84	66	J
	Compositional bias	123 – 140	18	Cys-rich
	Compositional bias	126 – 137	12	Poly-Cys
Experimental info
	Sequence conflict	41 – 44	4	KLAL → LENP in CAB63773. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UF47 [UniParc]. Last modified April 3, 2002. Version 2. Checksum: 4FDBF489D16B6EC0	FASTA	199	22,496
	10 20 30 40 50 60 MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK 70 80 90 100 110 120 FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL 130 140 150 160 170 180 TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN 190 ANEKTQLIKE GSRSYCTDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel isoforms of the cysteine string protein." Tobaben S., Stahl B. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44. Tissue: Testis.
[4]	"Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells." Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J. Biochim. Biophys. Acta 1773:109-119(2007) [PubMed: 17034881] [Abstract] Cited for: INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, PALMITOYLATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF368276 mRNA. Translation: AAK60571.1. BC016742 mRNA. Translation: AAH16742.1. AL133660 mRNA. Translation: CAB63773.2.
IPI	IPI00647830.
PIR	T43470.
RefSeq	NP_149096.2. NM_033105.4.
UniGene	Hs.491885.
3D structure databases
ProteinModelPortal	Q9UF47.
SMR	Q9UF47. Positions 9-104.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UF47.
Polymorphism databases
DMDM	20141445.
Proteomic databases
PRIDE	Q9UF47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276570; ENSP00000276570; ENSG00000147570.
GeneID	85479.
KEGG	hsa:85479.
UCSC	uc003xvs.1. human.
Organism-specific databases
CTD	85479.
GeneCards	GC08P066984.
H-InvDB	HIX0007550.
HGNC	HGNC:24138. DNAJC5B.
MIM	613945. gene.
neXtProt	NX_Q9UF47.
PharmGKB	PA134962894.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07520.
GeneTree	ENSGT00600000084291.
HOGENOM	HBG713019.
HOVERGEN	HBG005414.
InParanoid	Q9UF47.
OMA	DENVNTY.
OrthoDB	EOG4NZTVC.
PhylomeDB	Q9UF47.
Gene expression databases
ArrayExpress	Q9UF47.
Bgee	Q9UF47.
CleanEx	HS_DNAJC5B.
Genevestigator	Q9UF47.
GermOnline	ENSG00000147570. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR003095. Hsp_DnaJ. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
KO	K09525.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
PRINTS	PR00625. JDOMAIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76144.
SOURCE	Search...

Entry information

Entry name

DNJ5B_HUMAN

Accession

Primary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	April 3, 2002
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.