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Reviewed, UniProtKB/Swiss-Prot Q9UF47 (DNJ5B_HUMAN)

Last modified March 2, 2010. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily C member 5B
Alternative name(s):
Beta cysteine string protein
Short name=Beta-CSP
Gene names
Name:DNAJC5B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subcellular location

Membrane; Lipid-anchor By similarity.

Tissue specificity

Testis specific.

Post-translational modification

Palmitoylated By similarity.

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
   Cellular componentMembrane
   Molecular functionChaperone
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199DnaJ homolog subfamily C member 5B
PRO_0000071055

Regions

Domain19 – 8466J
Compositional bias123 – 14018Cys-rich
Compositional bias126 – 13712Poly-Cys

Experimental info

Sequence conflict41 – 444KLAL → LENP in CAB63773. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9UF47-1 [UniParc].

Last modified April 3, 2002. Version 2.
Checksum: 4FDBF489D16B6EC0

FASTA19922,496
        10         20         30         40         50         60 
MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK 

        70         80         90        100        110        120 
FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL 

       130        140        150        160        170        180 
TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN 

       190 
ANEKTQLIKE GSRSYCTDS 

« Hide

References

« Hide 'large scale' references
[1]"Novel isoforms of the cysteine string protein."
Tobaben S., Stahl B.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF368276 mRNA. Translation: AAK60571.1.
BC016742 mRNA. Translation: AAH16742.1.
AL133660 mRNA. Translation: CAB63773.2.
IPIIPI00647830.
PIRT43470.
RefSeqNP_149096.2.
UniGeneHs.491885

3D structure databases

SMRQ9UF47. Positions 9-104.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9UF47.

Proteomic databases

PRIDEQ9UF47.

Genome annotation databases

EnsemblENST00000276570; ENSP00000276570; ENSG00000147570; Homo sapiens. [Genome view]
GeneID85479.
KEGGhsa:85479.
UCSCuc003xvs.1. human.

Organism-specific databases

CTD85479.
GeneCardsGC08P067096.
HGNCHGNC:24138. DNAJC5B.
PharmGKBPA134962894.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07520.
HOGENOMHBG713019.
HOVERGENHBG005414.
InParanoidQ9UF47.
OMADENVNTY.
OrthoDBEOG9N0716.
PhylomeDBQ9UF47.

Gene expression databases

ArrayExpressQ9UF47.
BgeeQ9UF47.
CleanExHS_DNAJC5B.
GenevestigatorQ9UF47.
GermOnlineENSG00000147570. Homo sapiens.

Family and domain databases

InterProIPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHERPTHR11821. Hsp40/DnaJ_Rel. 1 hit.
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. DNAJPROTEIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. DnaJ_N. 1 hit.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio76144.

Entry information

Entry nameDNJ5B_HUMAN
AccessionPrimary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: March 2, 2010
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents