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Q9UF47 (DNJ5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily C member 5B
Alternative name(s):
Cysteine string protein beta
Short name=CSP-beta
Gene names
Name:DNAJC5B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with the chaperone complex consisting of HSC70 and SGTA. Ref.4

Subcellular location

Membrane; Lipid-anchor. Note: May be associated with the trans-Golgi network (Ref.4). Ref.4

Tissue specificity

Testis specific.

Post-translational modification

Palmitoylated. Palmitoylation is not required for membrane association. Ref.4

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
   Cellular componentMembrane
   Molecular functionChaperone
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199DnaJ homolog subfamily C member 5B
PRO_0000071055

Regions

Domain19 – 8466J
Compositional bias123 – 14018Cys-rich
Compositional bias126 – 13712Poly-Cys

Experimental info

Sequence conflict41 – 444KLAL → LENP in CAB63773. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9UF47 [UniParc].

Last modified April 3, 2002. Version 2.
Checksum: 4FDBF489D16B6EC0

FASTA19922,496
        10         20         30         40         50         60 
MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK 

        70         80         90        100        110        120 
FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL 

       130        140        150        160        170        180 
TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN 

       190 
ANEKTQLIKE GSRSYCTDS 

« Hide

References

« Hide 'large scale' references
[1]"Novel isoforms of the cysteine string protein."
Tobaben S., Stahl B.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44.
Tissue: Testis.
[4]"Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
Biochim. Biophys. Acta 1773:109-119(2007) [PubMed: 17034881] [Abstract]
Cited for: INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, PALMITOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF368276 mRNA. Translation: AAK60571.1.
BC016742 mRNA. Translation: AAH16742.1.
AL133660 mRNA. Translation: CAB63773.2.
IPIIPI00647830.
PIRT43470.
RefSeqNP_149096.2. NM_033105.4.
UniGeneHs.491885.

3D structure databases

ProteinModelPortalQ9UF47.
SMRQ9UF47. Positions 9-104.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9UF47.

Polymorphism databases

DMDM20141445.

Proteomic databases

PRIDEQ9UF47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276570; ENSP00000276570; ENSG00000147570.
GeneID85479.
KEGGhsa:85479.
UCSCuc003xvs.1. human.

Organism-specific databases

CTD85479.
GeneCardsGC08P066984.
H-InvDBHIX0007550.
HGNCHGNC:24138. DNAJC5B.
MIM613945. gene.
neXtProtNX_Q9UF47.
PharmGKBPA134962894.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07520.
GeneTreeENSGT00600000084291.
HOGENOMHBG713019.
HOVERGENHBG005414.
InParanoidQ9UF47.
OMADENVNTY.
OrthoDBEOG4NZTVC.
PhylomeDBQ9UF47.

Gene expression databases

ArrayExpressQ9UF47.
BgeeQ9UF47.
CleanExHS_DNAJC5B.
GenevestigatorQ9UF47.
GermOnlineENSG00000147570. Homo sapiens.

Family and domain databases

InterProIPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR003095. Hsp_DnaJ.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
KOK09525.
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. DnaJ_N. 1 hit.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio76144.
SOURCESearch...

Entry information

Entry nameDNJ5B_HUMAN
AccessionPrimary (citable) accession number: Q9UF47
Secondary accession number(s): Q969Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families