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Protein

Ephrin type-A receptor 6

Gene

EPHA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei663 – 6631ATPPROSITE-ProRule annotation
Active sitei798 – 7981Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi637 – 6459ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ephrin receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: Reactome
  2. ephrin receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_264068. EPH-Ephrin signaling.
REACT_264198. EPH-ephrin mediated repulsion of cells.
REACT_264548. EPHA-mediated growth cone collapse.
SignaLinkiQ9UF33.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 6 (EC:2.7.10.1)
Alternative name(s):
EPH homology kinase 2
Short name:
EHK-2
EPH-like kinase 12
Short name:
EK12
Gene namesi
Name:EPHA6
Synonyms:EHK2, HEK12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19296. EPHA6.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 550528ExtracellularSequence AnalysisAdd
BLAST
Transmembranei551 – 57121HelicalSequence AnalysisAdd
BLAST
Topological domaini572 – 1036465CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
  2. nucleoplasm Source: HPA
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 10361014Ephrin type-A receptor 6PRO_0000235684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Modified residuei606 – 6061Phosphotyrosine; by autocatalysisSequence Analysis
Modified residuei612 – 6121Phosphotyrosine; by autocatalysisSequence Analysis
Modified residuei831 – 8311Phosphotyrosine; by autocatalysisSequence Analysis
Modified residuei978 – 9781Phosphotyrosine; by autocatalysisSequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UF33.
PRIDEiQ9UF33.

PTM databases

PhosphoSiteiQ9UF33.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiQ9UF33.
CleanExiHS_EPHA6.
ExpressionAtlasiQ9UF33. baseline and differential.
GenevestigatoriQ9UF33.

Organism-specific databases

HPAiHPA007397.
HPA058047.

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Protein-protein interaction databases

BioGridi130049. 2 interactions.
STRINGi9606.ENSP00000374323.

Structurei

3D structure databases

ProteinModelPortaliQ9UF33.
SMRiQ9UF33. Positions 32-329, 618-938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 212179Eph LBDPROSITE-ProRule annotationAdd
BLAST
Domaini331 – 441111Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini442 – 53796Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini631 – 944314Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini961 – 102565SAMPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1034 – 10363PDZ-bindingSequence Analysis

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233858.
HOVERGENiHBG062180.
InParanoidiQ9UF33.
KOiK05107.
OrthoDBiEOG7VTDM6.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UF33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNNQVVLLDT TTVLGELGWK
60 70 80 90 100
TYPLNGWDAI TEMDEHNRPI HTYQVCNVME PNQNNWLRTN WISRDAAQKI
110 120 130 140 150
YVEMKFTLRD CNSIPWVLGT CKETFNLFYM ESDESHGIKF KPNQYTKIDT
160 170 180 190 200
IAADESFTQM DLGDRILKLN TEIREVGPIE RKGFYLAFQD IGACIALVSV
210 220 230 240 250
RVFYKKCPFT VRNLAMFPDT IPRVDSSSLV EVRGSCVKSA EERDTPKLYC
260 270 280 290 300
GADGDWLVPL GRCICSTGYE EIEGSCHACR PGFYKAFAGN TKCSKCPPHS
310 320 330 340 350
LTYMEATSVC QCEKGYFRAE KDPPSMACTR PPSAPRNVVF NINETALILE
360 370 380 390 400
WSPPSDTGGR KDLTYSVICK KCGLDTSQCE DCGGGLRFIP RHTGLINNSV
410 420 430 440 450
IVLDFVSHVN YTFEIEAMNG VSELSFSPKP FTAITVTTDQ DAPSLIGVVR
460 470 480 490 500
KDWASQNSIA LSWQAPAFSN GAILDYEIKY YEKEHEQLTY SSTRSKAPSV
510 520 530 540 550
IITGLKPATK YVFHIRVRTA TGYSGYSQKF EFETGDETSD MAAEQGQILV
560 570 580 590 600
IATAAVGGFT LLVILTLFFL ITGRCQWYIK AKMKSEEKRR NHLQNGHLRF
610 620 630 640 650
PGIKTYIDPD TYEDPSLAVH EFAKEIDPSR IRIERVIGAG EFGEVCSGRL
660 670 680 690 700
KTPGKREIPV AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP NIIRLEGVVT
710 720 730 740 750
KRSFPAIGVE AFCPSFLRAG FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV
760 770 780 790 800
VEYMENGSLD SFLRKHDGHF TVIQLVGMLR GIASGMKYLS DMGYVHRDLA
810 820 830 840 850
ARNILVNSNL VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI RWTAPEAIAY
860 870 880 890 900
RKFSSASDAW SYGIVMWEVM SYGERPYWEM SNQDVILSIE EGYRLPAPMG
910 920 930 940 950
CPASLHQLML HCWQKERNHR PKFTDIVSFL DKLIRNPSAL HTLVEDILVM
960 970 980 990 1000
PESPGEVPEY PLFVTVGDWL DSIKMGQYKN NFVAAGFTTF DLISRMSIDD
1010 1020 1030
IRRIGVILIG HQRRIVSSIQ TLRLHMMHIQ EKGFHV
Length:1,036
Mass (Da):116,379
Last modified:May 14, 2014 - v3
Checksum:i53402C6DCD7CD32C
GO
Isoform 2 (identifier: Q9UF33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-514: Missing.
     515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
     835-848: GGKIPIRWTAPEAI → DLFQTLTLNLCYSA
     849-1036: Missing.

Show »
Length:334
Mass (Da):37,274
Checksum:iDF89BC8423AC1A60
GO
Isoform 3 (identifier: Q9UF33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-514: Missing.
     515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
     835-912: GGKIPIRWTA...ASLHQLMLHC → RPTNHNKEQS...TLTLNLCYSA
     913-1036: Missing.

Show »
Length:398
Mass (Da):44,466
Checksum:i6A414ED81CCC5C47
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti704 – 7041F → S.1 Publication
VAR_042149
Natural varianti711 – 7111A → V.
Corresponds to variant rs4857276 [ dbSNP | Ensembl ].
VAR_055991

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 514514Missing in isoform 2 and isoform 3. 1 PublicationVSP_018473Add
BLAST
Alternative sequencei515 – 53824IRVRT…TGDET → MKDSPFQVTKLYWLNEKWDF IASA in isoform 2 and isoform 3. 1 PublicationVSP_018474Add
BLAST
Alternative sequencei835 – 91278GGKIP…LMLHC → RPTNHNKEQSELVKEDGLES LCEQCESSSGYGTGLVLMWK RNRRAMGASGQTRKQCDKRD NPPTDLFQTLTLNLCYSA in isoform 3. CuratedVSP_054716Add
BLAST
Alternative sequencei835 – 84814GGKIP…APEAI → DLFQTLTLNLCYSA in isoform 2. 1 PublicationVSP_018475Add
BLAST
Alternative sequencei849 – 1036188Missing in isoform 2. 1 PublicationVSP_018476Add
BLAST
Alternative sequencei913 – 1036124Missing in isoform 3. CuratedVSP_054717Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133666 mRNA. Translation: CAB63775.1.
AC109782 Genomic DNA. No translation available.
AC108714 Genomic DNA. No translation available.
AC110717 Genomic DNA. No translation available.
AC134730 Genomic DNA. No translation available.
AC135369 Genomic DNA. No translation available.
AC119745 Genomic DNA. No translation available.
AC107482 Genomic DNA. No translation available.
AC117470 Genomic DNA. No translation available.
AC130510 Genomic DNA. No translation available.
AC117439 Genomic DNA. No translation available.
CCDSiCCDS54616.1. [Q9UF33-2]
CCDS63697.1. [Q9UF33-3]
PIRiT43450.
RefSeqiNP_001265229.1. NM_001278300.1. [Q9UF33-3]
NP_775926.1. NM_173655.3. [Q9UF33-2]
UniGeneiHs.653244.

Genome annotation databases

EnsembliENST00000502694; ENSP00000423950; ENSG00000080224. [Q9UF33-2]
ENST00000514100; ENSP00000421711; ENSG00000080224. [Q9UF33-3]
GeneIDi285220.
KEGGihsa:285220.
UCSCiuc010how.1. human. [Q9UF33-1]

Polymorphism databases

DMDMi97048747.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133666 mRNA. Translation: CAB63775.1.
AC109782 Genomic DNA. No translation available.
AC108714 Genomic DNA. No translation available.
AC110717 Genomic DNA. No translation available.
AC134730 Genomic DNA. No translation available.
AC135369 Genomic DNA. No translation available.
AC119745 Genomic DNA. No translation available.
AC107482 Genomic DNA. No translation available.
AC117470 Genomic DNA. No translation available.
AC130510 Genomic DNA. No translation available.
AC117439 Genomic DNA. No translation available.
CCDSiCCDS54616.1. [Q9UF33-2]
CCDS63697.1. [Q9UF33-3]
PIRiT43450.
RefSeqiNP_001265229.1. NM_001278300.1. [Q9UF33-3]
NP_775926.1. NM_173655.3. [Q9UF33-2]
UniGeneiHs.653244.

3D structure databases

ProteinModelPortaliQ9UF33.
SMRiQ9UF33. Positions 32-329, 618-938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130049. 2 interactions.
STRINGi9606.ENSP00000374323.

Chemistry

BindingDBiQ9UF33.
ChEMBLiCHEMBL4526.
GuidetoPHARMACOLOGYi1826.

PTM databases

PhosphoSiteiQ9UF33.

Polymorphism databases

DMDMi97048747.

Proteomic databases

PaxDbiQ9UF33.
PRIDEiQ9UF33.

Protocols and materials databases

DNASUi285220.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502694; ENSP00000423950; ENSG00000080224. [Q9UF33-2]
ENST00000514100; ENSP00000421711; ENSG00000080224. [Q9UF33-3]
GeneIDi285220.
KEGGihsa:285220.
UCSCiuc010how.1. human. [Q9UF33-1]

Organism-specific databases

CTDi285220.
GeneCardsiGC03P096533.
HGNCiHGNC:19296. EPHA6.
HPAiHPA007397.
HPA058047.
MIMi600066. gene.
neXtProtiNX_Q9UF33.
PharmGKBiPA134866684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233858.
HOVERGENiHBG062180.
InParanoidiQ9UF33.
KOiK05107.
OrthoDBiEOG7VTDM6.

Enzyme and pathway databases

ReactomeiREACT_264068. EPH-Ephrin signaling.
REACT_264198. EPH-ephrin mediated repulsion of cells.
REACT_264548. EPHA-mediated growth cone collapse.
SignaLinkiQ9UF33.

Miscellaneous databases

ChiTaRSiEPHA6. human.
GeneWikiiEPHA6.
GenomeRNAii285220.
NextBioi35493297.
PROiQ9UF33.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UF33.
CleanExiHS_EPHA6.
ExpressionAtlasiQ9UF33. baseline and differential.
GenevestigatoriQ9UF33.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers."
    Hafner C., Schmitz G., Meyer S., Bataille F., Hau P., Langmann T., Dietmaier W., Landthaler M., Vogt T.
    Clin. Chem. 50:490-499(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-704.

Entry informationi

Entry nameiEPHA6_HUMAN
AccessioniPrimary (citable) accession number: Q9UF33
Secondary accession number(s): D6RAL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 14, 2014
Last modified: April 1, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.