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Q9UF33

- EPHA6_HUMAN

UniProt

Q9UF33 - EPHA6_HUMAN

Protein

Ephrin type-A receptor 6

Gene

EPHA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (14 May 2014)
      Previous versions | rss
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    Functioni

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei663 – 6631ATPPROSITE-ProRule annotation
    Active sitei798 – 7981Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi637 – 6459ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ephrin receptor activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9UF33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin type-A receptor 6 (EC:2.7.10.1)
    Alternative name(s):
    EPH homology kinase 2
    Short name:
    EHK-2
    EPH-like kinase 12
    Short name:
    EK12
    Gene namesi
    Name:EPHA6
    Synonyms:EHK2, HEK12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19296. EPHA6.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10361014Ephrin type-A receptor 6PRO_0000235684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Modified residuei606 – 6061Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei612 – 6121Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei831 – 8311Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei978 – 9781Phosphotyrosine; by autocatalysisSequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9UF33.
    PRIDEiQ9UF33.

    PTM databases

    PhosphoSiteiQ9UF33.

    Expressioni

    Tissue specificityi

    Expressed in brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9UF33.
    BgeeiQ9UF33.
    CleanExiHS_EPHA6.
    GenevestigatoriQ9UF33.

    Organism-specific databases

    HPAiHPA007397.
    HPA058047.

    Interactioni

    Subunit structurei

    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses By similarity.By similarity

    Protein-protein interaction databases

    BioGridi130049. 1 interaction.
    STRINGi9606.ENSP00000374323.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UF33.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 550528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini572 – 1036465CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei551 – 57121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 212179Eph LBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 441111Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini442 – 53796Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini631 – 944314Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini961 – 102565SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1034 – 10363PDZ-bindingSequence Analysis

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233858.
    HOVERGENiHBG062180.
    InParanoidiQ9UF33.
    KOiK05107.
    OrthoDBiEOG7VTDM6.
    PhylomeDBiQ9UF33.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 2 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 2 hits.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UF33-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNNQVVLLDT TTVLGELGWK     50
    TYPLNGWDAI TEMDEHNRPI HTYQVCNVME PNQNNWLRTN WISRDAAQKI 100
    YVEMKFTLRD CNSIPWVLGT CKETFNLFYM ESDESHGIKF KPNQYTKIDT 150
    IAADESFTQM DLGDRILKLN TEIREVGPIE RKGFYLAFQD IGACIALVSV 200
    RVFYKKCPFT VRNLAMFPDT IPRVDSSSLV EVRGSCVKSA EERDTPKLYC 250
    GADGDWLVPL GRCICSTGYE EIEGSCHACR PGFYKAFAGN TKCSKCPPHS 300
    LTYMEATSVC QCEKGYFRAE KDPPSMACTR PPSAPRNVVF NINETALILE 350
    WSPPSDTGGR KDLTYSVICK KCGLDTSQCE DCGGGLRFIP RHTGLINNSV 400
    IVLDFVSHVN YTFEIEAMNG VSELSFSPKP FTAITVTTDQ DAPSLIGVVR 450
    KDWASQNSIA LSWQAPAFSN GAILDYEIKY YEKEHEQLTY SSTRSKAPSV 500
    IITGLKPATK YVFHIRVRTA TGYSGYSQKF EFETGDETSD MAAEQGQILV 550
    IATAAVGGFT LLVILTLFFL ITGRCQWYIK AKMKSEEKRR NHLQNGHLRF 600
    PGIKTYIDPD TYEDPSLAVH EFAKEIDPSR IRIERVIGAG EFGEVCSGRL 650
    KTPGKREIPV AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP NIIRLEGVVT 700
    KRSFPAIGVE AFCPSFLRAG FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV 750
    VEYMENGSLD SFLRKHDGHF TVIQLVGMLR GIASGMKYLS DMGYVHRDLA 800
    ARNILVNSNL VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI RWTAPEAIAY 850
    RKFSSASDAW SYGIVMWEVM SYGERPYWEM SNQDVILSIE EGYRLPAPMG 900
    CPASLHQLML HCWQKERNHR PKFTDIVSFL DKLIRNPSAL HTLVEDILVM 950
    PESPGEVPEY PLFVTVGDWL DSIKMGQYKN NFVAAGFTTF DLISRMSIDD 1000
    IRRIGVILIG HQRRIVSSIQ TLRLHMMHIQ EKGFHV 1036
    Length:1,036
    Mass (Da):116,379
    Last modified:May 14, 2014 - v3
    Checksum:i53402C6DCD7CD32C
    GO
    Isoform 2 (identifier: Q9UF33-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-514: Missing.
         515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
         835-848: GGKIPIRWTAPEAI → DLFQTLTLNLCYSA
         849-1036: Missing.

    Show »
    Length:334
    Mass (Da):37,274
    Checksum:iDF89BC8423AC1A60
    GO
    Isoform 3 (identifier: Q9UF33-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-514: Missing.
         515-538: IRVRTATGYSGYSQKFEFETGDET → MKDSPFQVTKLYWLNEKWDFIASA
         835-912: GGKIPIRWTA...ASLHQLMLHC → RPTNHNKEQS...TLTLNLCYSA
         913-1036: Missing.

    Show »
    Length:398
    Mass (Da):44,466
    Checksum:i6A414ED81CCC5C47
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti704 – 7041F → S.1 Publication
    VAR_042149
    Natural varianti711 – 7111A → V.
    Corresponds to variant rs4857276 [ dbSNP | Ensembl ].
    VAR_055991

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 514514Missing in isoform 2 and isoform 3. 1 PublicationVSP_018473Add
    BLAST
    Alternative sequencei515 – 53824IRVRT…TGDET → MKDSPFQVTKLYWLNEKWDF IASA in isoform 2 and isoform 3. 1 PublicationVSP_018474Add
    BLAST
    Alternative sequencei835 – 91278GGKIP…LMLHC → RPTNHNKEQSELVKEDGLES LCEQCESSSGYGTGLVLMWK RNRRAMGASGQTRKQCDKRD NPPTDLFQTLTLNLCYSA in isoform 3. CuratedVSP_054716Add
    BLAST
    Alternative sequencei835 – 84814GGKIP…APEAI → DLFQTLTLNLCYSA in isoform 2. 1 PublicationVSP_018475Add
    BLAST
    Alternative sequencei849 – 1036188Missing in isoform 2. 1 PublicationVSP_018476Add
    BLAST
    Alternative sequencei913 – 1036124Missing in isoform 3. CuratedVSP_054717Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133666 mRNA. Translation: CAB63775.1.
    AC109782 Genomic DNA. No translation available.
    AC108714 Genomic DNA. No translation available.
    AC110717 Genomic DNA. No translation available.
    AC134730 Genomic DNA. No translation available.
    AC135369 Genomic DNA. No translation available.
    AC119745 Genomic DNA. No translation available.
    AC107482 Genomic DNA. No translation available.
    AC117470 Genomic DNA. No translation available.
    AC130510 Genomic DNA. No translation available.
    AC117439 Genomic DNA. No translation available.
    CCDSiCCDS54616.1. [Q9UF33-2]
    CCDS63697.1. [Q9UF33-3]
    PIRiT43450.
    RefSeqiNP_001265229.1. NM_001278300.1. [Q9UF33-3]
    NP_775926.1. NM_173655.3. [Q9UF33-2]
    UniGeneiHs.653244.

    Genome annotation databases

    EnsembliENST00000502694; ENSP00000423950; ENSG00000080224. [Q9UF33-2]
    ENST00000514100; ENSP00000421711; ENSG00000080224. [Q9UF33-3]
    GeneIDi285220.
    KEGGihsa:285220.
    UCSCiuc010how.1. human. [Q9UF33-1]

    Polymorphism databases

    DMDMi97048747.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133666 mRNA. Translation: CAB63775.1 .
    AC109782 Genomic DNA. No translation available.
    AC108714 Genomic DNA. No translation available.
    AC110717 Genomic DNA. No translation available.
    AC134730 Genomic DNA. No translation available.
    AC135369 Genomic DNA. No translation available.
    AC119745 Genomic DNA. No translation available.
    AC107482 Genomic DNA. No translation available.
    AC117470 Genomic DNA. No translation available.
    AC130510 Genomic DNA. No translation available.
    AC117439 Genomic DNA. No translation available.
    CCDSi CCDS54616.1. [Q9UF33-2 ]
    CCDS63697.1. [Q9UF33-3 ]
    PIRi T43450.
    RefSeqi NP_001265229.1. NM_001278300.1. [Q9UF33-3 ]
    NP_775926.1. NM_173655.3. [Q9UF33-2 ]
    UniGenei Hs.653244.

    3D structure databases

    ProteinModelPortali Q9UF33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130049. 1 interaction.
    STRINGi 9606.ENSP00000374323.

    Chemistry

    BindingDBi Q9UF33.
    ChEMBLi CHEMBL2363043.
    GuidetoPHARMACOLOGYi 1826.

    PTM databases

    PhosphoSitei Q9UF33.

    Polymorphism databases

    DMDMi 97048747.

    Proteomic databases

    PaxDbi Q9UF33.
    PRIDEi Q9UF33.

    Protocols and materials databases

    DNASUi 285220.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000502694 ; ENSP00000423950 ; ENSG00000080224 . [Q9UF33-2 ]
    ENST00000514100 ; ENSP00000421711 ; ENSG00000080224 . [Q9UF33-3 ]
    GeneIDi 285220.
    KEGGi hsa:285220.
    UCSCi uc010how.1. human. [Q9UF33-1 ]

    Organism-specific databases

    CTDi 285220.
    GeneCardsi GC03P096533.
    HGNCi HGNC:19296. EPHA6.
    HPAi HPA007397.
    HPA058047.
    MIMi 600066. gene.
    neXtProti NX_Q9UF33.
    PharmGKBi PA134866684.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233858.
    HOVERGENi HBG062180.
    InParanoidi Q9UF33.
    KOi K05107.
    OrthoDBi EOG7VTDM6.
    PhylomeDBi Q9UF33.

    Enzyme and pathway databases

    SignaLinki Q9UF33.

    Miscellaneous databases

    GeneWikii EPHA6.
    GenomeRNAii 285220.
    NextBioi 35493297.
    PROi Q9UF33.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UF33.
    Bgeei Q9UF33.
    CleanExi HS_EPHA6.
    Genevestigatori Q9UF33.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 2 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 2 hits.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers."
      Hafner C., Schmitz G., Meyer S., Bataille F., Hau P., Langmann T., Dietmaier W., Landthaler M., Vogt T.
      Clin. Chem. 50:490-499(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-704.

    Entry informationi

    Entry nameiEPHA6_HUMAN
    AccessioniPrimary (citable) accession number: Q9UF33
    Secondary accession number(s): D6RAL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3