Probable proline dehydrogenase 2 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9UF12 (PROD2_HUMAN)

Last modified November 3, 2009. Version 46. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Probable proline dehydrogenase 2
    EC=1.5.99.8
Alternative name(s):
    Probable proline oxidase 2
    Kidney and liver proline oxidase 1
      Short name=HsPOX1

Gene names

Name:

PRODH2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate Probable.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline oxidase family.

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Ontologies

Keywords
Biological process	Proline metabolism
Coding sequence diversity	Polymorphism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 536

536

Probable proline dehydrogenase 2

PRO_0000308623

Natural variations

Natural variant

P → R: dbSNP rs3848666.

VAR_036852

Natural variant

525

R → Q: dbSNP rs3761097.

VAR_036853

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9UF12-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 81EB2F4B21E39E09
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FASTA

536

58,871

        10         20         30         40         50         60 
MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP GLGKGQLVNL 

        70         80         90        100        110        120 
LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF DGGAFHLKGT GELTRALLVL 

       130        140        150        160        170        180 
RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA FLRASVYGQF VAGETAEEVK GCVQQLRTLS 

       190        200        210        220        230        240 
LRPLLAVPTE EEPDSAAKSG EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL 

       250        260        270        280        290        300 
TSTRLCKELA SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV 

       310        320        330        340        350        360 
AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ ACLKDTFERL 

       370        380        390        400        410        420 
GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT QPDYEATSQS YSRCLELMLT 

       430        440        450        460        470        480 
HVARHGPMCH LMVASHNEES VRQATKRMWE LGIPLDGTVC FGQLLGMCDH VSLALGQAGY 

       490        500        510        520        530 
VVYKSIPYGS LEEVIPYLIR RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH

« Hide

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References

[1]	Lin W.-W., Hu C.A., Valle D. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U80018 mRNA. Translation: AAF21465.1.
IPI	IPI00009704.
RefSeq	NP_067055.1.
UniGene	Hs.515366
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9UF12.
Genome annotation databases
Ensembl	ENST00000301175; ENSP00000301175; ENSG00000161270; Homo sapiens. [Genome view] ENST00000353632; ENSP00000343634; ENSG00000161270; Homo sapiens. [Genome view] ENST00000378910; ENSP00000368190; ENSG00000161270; Homo sapiens. [Genome view] ENST00000443172; ENSP00000407329; ENSG00000161270; Homo sapiens. [Genome view]
GeneID	58510.
KEGG	hsa:58510.
UCSC	uc002obx.1. human.
Organism-specific databases
CTD	58510.
GeneCards	GC19M040982.
HGNC	HGNC:17325. PRODH2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UF12.
OMA	EAMDSGQ.
Enzyme and pathway databases
BRENDA	1.5.99.8. 247.
Gene expression databases
ArrayExpress	Q9UF12.
Bgee	Q9UF12.
CleanEx	HS_PRODH2.
Genevestigator	Q9UF12.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	65037.

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Entry information

Entry name

PROD2_HUMAN

Accession

Primary (citable) accession number: Q9UF12

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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