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Protein

Probable proline dehydrogenase 2

Gene

PRODH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Converts proline to delta-1-pyrroline-5-carboxylate.Curated

Catalytic activityi

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.

Cofactori

FADBy similarity

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable proline dehydrogenase 2 (PRODH2), Proline dehydrogenase 1, mitochondrial (PRODH)
  2. Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Proline metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-34410.
UniPathwayiUPA00261; UER00373.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline dehydrogenase 2 (EC:1.5.5.2)
Alternative name(s):
Kidney and liver proline oxidase 1
Short name:
HsPOX1
Probable proline oxidase 2
Gene namesi
Name:PRODH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17325. PRODH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

MalaCardsiPRODH2.
PharmGKBiPA33802.

Polymorphism and mutation databases

BioMutaiPRODH2.
DMDMi74720632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Probable proline dehydrogenase 2PRO_0000308623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UF12.
PaxDbiQ9UF12.
PRIDEiQ9UF12.

PTM databases

iPTMnetiQ9UF12.

Expressioni

Gene expression databases

BgeeiQ9UF12.
CleanExiHS_PRODH2.
ExpressionAtlasiQ9UF12. baseline and differential.
GenevisibleiQ9UF12. HS.

Organism-specific databases

HPAiHPA051287.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301175.

Structurei

3D structure databases

ProteinModelPortaliQ9UF12.
SMRiQ9UF12. Positions 376-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
GeneTreeiENSGT00390000006265.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ9UF12.
KOiK11394.
OMAiTGNILMQ.
PhylomeDBiQ9UF12.
TreeFamiTF313544.

Family and domain databases

Gene3Di3.20.20.220. 2 hits.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UF12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP
60 70 80 90 100
GLGKGQLVNL LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF
110 120 130 140 150
DGGAFHLKGT GELTRALLVL RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA
160 170 180 190 200
FLRASVYGQF VAGETAEEVK GCVQQLRTLS LRPLLAVPTE EEPDSAAKSG
210 220 230 240 250
EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL TSTRLCKELA
260 270 280 290 300
SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV
310 320 330 340 350
AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ
360 370 380 390 400
ACLKDTFERL GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT
410 420 430 440 450
QPDYEATSQS YSRCLELMLT HVARHGPMCH LMVASHNEES VRQATKRMWE
460 470 480 490 500
LGIPLDGTVC FGQLLGMCDH VSLALGQAGY VVYKSIPYGS LEEVIPYLIR
510 520 530
RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH
Length:536
Mass (Da):58,871
Last modified:May 1, 2000 - v1
Checksum:i81EB2F4B21E39E09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911P → R.
Corresponds to variant rs3848666 [ dbSNP | Ensembl ].
VAR_036852
Natural varianti525 – 5251R → Q.
Corresponds to variant rs3761097 [ dbSNP | Ensembl ].
VAR_036853

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80018 mRNA. Translation: AAF21465.1.
CCDSiCCDS12478.1.
RefSeqiNP_067055.1. NM_021232.1.
UniGeneiHs.515366.

Genome annotation databases

EnsembliENST00000301175; ENSP00000301175; ENSG00000250799.
GeneIDi58510.
KEGGihsa:58510.
UCSCiuc002obx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80018 mRNA. Translation: AAF21465.1.
CCDSiCCDS12478.1.
RefSeqiNP_067055.1. NM_021232.1.
UniGeneiHs.515366.

3D structure databases

ProteinModelPortaliQ9UF12.
SMRiQ9UF12. Positions 376-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301175.

PTM databases

iPTMnetiQ9UF12.

Polymorphism and mutation databases

BioMutaiPRODH2.
DMDMi74720632.

Proteomic databases

MaxQBiQ9UF12.
PaxDbiQ9UF12.
PRIDEiQ9UF12.

Protocols and materials databases

DNASUi58510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301175; ENSP00000301175; ENSG00000250799.
GeneIDi58510.
KEGGihsa:58510.
UCSCiuc002obx.1. human.

Organism-specific databases

CTDi58510.
GeneCardsiPRODH2.
HGNCiHGNC:17325. PRODH2.
HPAiHPA051287.
MalaCardsiPRODH2.
MIMi616377. gene.
neXtProtiNX_Q9UF12.
PharmGKBiPA33802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0186. Eukaryota.
COG0506. LUCA.
GeneTreeiENSGT00390000006265.
HOGENOMiHOG000233406.
HOVERGENiHBG108294.
InParanoidiQ9UF12.
KOiK11394.
OMAiTGNILMQ.
PhylomeDBiQ9UF12.
TreeFamiTF313544.

Enzyme and pathway databases

UniPathwayiUPA00261; UER00373.
BioCyciMetaCyc:MONOMER66-34410.

Miscellaneous databases

GenomeRNAii58510.
PROiQ9UF12.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UF12.
CleanExiHS_PRODH2.
ExpressionAtlasiQ9UF12. baseline and differential.
GenevisibleiQ9UF12. HS.

Family and domain databases

Gene3Di3.20.20.220. 2 hits.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR002872. Proline_DH_dom.
IPR015659. Proline_oxidase.
[Graphical view]
PANTHERiPTHR13914. PTHR13914. 1 hit.
PfamiPF01619. Pro_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Lin W.-W., Hu C.A., Valle D.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPROD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UF12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.