Q9UF12 (PROD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable proline dehydrogenase 2
EC=1.5.99.8

Alternative name(s):
Kidney and liver proline oxidase 1
Short name=HsPOX1
Probable proline oxidase 2

Gene names

Name:

PRODH2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate Probable.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Coding sequence diversity	Polymorphism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro proline catabolic process to glutamate Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: Compara
Molecular_function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	Probable proline dehydrogenase 2		PRO_0000308623
Natural variations
	Natural variant	91	1	P → R. Corresponds to variant rs3848666 [ dbSNP | Ensembl ].		VAR_036852
	Natural variant	525	1	R → Q. Corresponds to variant rs3761097 [ dbSNP | Ensembl ].		VAR_036853

Sequences

	Sequence		Length	Mass (Da)
	Q9UF12 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 81EB2F4B21E39E09	FASTA	536	58,871
	10 20 30 40 50 60 MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP GLGKGQLVNL 70 80 90 100 110 120 LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF DGGAFHLKGT GELTRALLVL 130 140 150 160 170 180 RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA FLRASVYGQF VAGETAEEVK GCVQQLRTLS 190 200 210 220 230 240 LRPLLAVPTE EEPDSAAKSG EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL 250 260 270 280 290 300 TSTRLCKELA SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV 310 320 330 340 350 360 AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ ACLKDTFERL 370 380 390 400 410 420 GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT QPDYEATSQS YSRCLELMLT 430 440 450 460 470 480 HVARHGPMCH LMVASHNEES VRQATKRMWE LGIPLDGTVC FGQLLGMCDH VSLALGQAGY 490 500 510 520 530 VVYKSIPYGS LEEVIPYLIR RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH

References

[1]	Lin W.-W., Hu C.A., Valle D. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U80018 mRNA. Translation: AAF21465.1.
IPI	IPI00009704.
RefSeq	NP_067055.1. NM_021232.1.
UniGene	Hs.515366.
3D structure databases
ProteinModelPortal	Q9UF12.
ModBase	Search...
Polymorphism databases
DMDM	74720632.
Proteomic databases
PRIDE	Q9UF12.
Protocols and materials databases
DNASU	58510.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301175; ENSP00000301175; ENSG00000250799.
GeneID	58510.
KEGG	hsa:58510.
UCSC	uc002obx.1. human.
Organism-specific databases
CTD	58510.
GeneCards	GC19M036292.
HGNC	HGNC:17325. PRODH2.
HPA	HPA051287.
neXtProt	NX_Q9UF12.
PharmGKB	PA33802.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000233406.
HOVERGEN	HBG108294.
InParanoid	Q9UF12.
KO	K11394.
OMA	RGAYMDK.
OrthoDB	EOG4BK541.
Enzyme and pathway databases
UniPathway	UPA00261; UER00373.
Gene expression databases
Bgee	Q9UF12.
CleanEx	HS_PRODH2.
Genevestigator	Q9UF12.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
PANTHER	PTHR13914. PTHR13914. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	58510.
NextBio	65037.

Entry information

Entry name

PROD2_HUMAN

Accession

Primary (citable) accession number: Q9UF12

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.