SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UF11

- PKHB1_HUMAN

UniProt

Q9UF11 - PKHB1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pleckstrin homology domain-containing family B member 1
Gene
PLEKHB1, EVT1, KPL1, PHR1, PHRET1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for proper localization of retinogeniculate projections but not for eye-specific segregation By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. signal transducer activity Source: ProtInc

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. phototransduction Source: UniProtKB
  3. regulation of cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family B member 1
Short name:
PH domain-containing family B member 1
Alternative name(s):
Evectin-1
PH domain-containing protein in retina 1
Short name:
PHRET1
Pleckstrin homology domain retinal protein 1
Gene namesi
Name:PLEKHB1
Synonyms:EVT1, KPL1, PHR1, PHRET1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19079. PLEKHB1.

Subcellular locationi

Membrane. Cytoplasm By similarity
Note: Localizes to the apical juxta-nuclear Golgi region of the cytoplasm By similarity. Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Pleckstrin homology domain-containing family B member 1
PRO_0000053886Add
BLAST

Proteomic databases

MaxQBiQ9UF11.
PaxDbiQ9UF11.
PRIDEiQ9UF11.

PTM databases

PhosphoSiteiQ9UF11.

Expressioni

Tissue specificityi

Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested.1 Publication

Gene expression databases

ArrayExpressiQ9UF11.
BgeeiQ9UF11.
CleanExiHS_PLEKHB1.
GenevestigatoriQ9UF11.

Interactioni

Subunit structurei

Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A By similarity. Binds transducins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH54EBI-9089825,EBI-524753

Protein-protein interaction databases

BioGridi121807. 1 interaction.
IntActiQ9UF11. 2 interactions.
STRINGi9606.ENSP00000346127.

Structurei

3D structure databases

ProteinModelPortaliQ9UF11.
SMRiQ9UF11. Positions 21-138.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 128108PH
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG44470.
HOVERGENiHBG060487.
InParanoidiQ9UF11.
OMAiAWKTALM.
OrthoDBiEOG7CZK73.
PhylomeDBiQ9UF11.
TreeFamiTF331787.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UF11-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPAAPVPPD SALESPFEEM ALVRGGWLWR QSSILRRWKR NWFALWLDGT    50
LGYYHDETAQ DEEDRVLIHF NVRDIKIGPE CHDVQPPEGR SRDGLLTVNL 100
REGGRLHLCA ETKDDALAWK TALLEANSTP APAGATVPPR SRRVCSKVRC 150
VTRSWSPCKV ERRIWVRVYS PYQDYYEVVP PNAHEATYVR SYYGPPYAGP 200
GVTHVIVRED PCYSAGAPLA MGMLAGAATG AALGSLMWSP CWF 243
Length:243
Mass (Da):27,186
Last modified:May 1, 2000 - v1
Checksum:i8F60531721CF76CA
GO
Isoform 2 (identifier: Q9UF11-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-165: Missing.

Show »
Length:208
Mass (Da):23,207
Checksum:iC11C12BF6E6FE4F0
GO
Isoform 3 (identifier: Q9UF11-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:224
Mass (Da):25,233
Checksum:iCE38AF6D0DE093D1
GO
Isoform 4 (identifier: Q9UF11-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.
     131-165: Missing.

Show »
Length:189
Mass (Da):21,254
Checksum:i6A25AE30F80F7E07
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919Missing in isoform 3 and isoform 4.
VSP_009779Add
BLAST
Alternative sequencei131 – 16535Missing in isoform 2 and isoform 4.
VSP_009780Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89715 mRNA. Translation: AAF16675.1.
AF093249 mRNA. Translation: AAF16684.1.
AF101054 mRNA. Translation: AAF18572.1.
AF100612 mRNA. Translation: AAF18932.1.
AF081583 mRNA. Translation: AAF21786.1.
AK289620 mRNA. Translation: BAF82309.1.
AK289909 mRNA. Translation: BAF82598.1.
AK290109 mRNA. Translation: BAF82798.1.
AK301299 mRNA. Translation: BAH13452.1.
AK314748 mRNA. Translation: BAG37288.1.
CH471076 Genomic DNA. Translation: EAW74900.1.
CH471076 Genomic DNA. Translation: EAW74903.1.
CH471076 Genomic DNA. Translation: EAW74904.1.
BC008075 mRNA. Translation: AAH08075.1.
CCDSiCCDS44672.1. [Q9UF11-1]
CCDS44673.1. [Q9UF11-2]
CCDS44674.1. [Q9UF11-3]
CCDS44675.1. [Q9UF11-4]
RefSeqiNP_001123505.1. NM_001130033.1. [Q9UF11-2]
NP_001123506.1. NM_001130034.1. [Q9UF11-3]
NP_001123507.1. NM_001130035.1. [Q9UF11-4]
NP_001123508.1. NM_001130036.1. [Q9UF11-4]
NP_067023.1. NM_021200.2. [Q9UF11-1]
UniGeneiHs.445489.

Genome annotation databases

EnsembliENST00000227214; ENSP00000227214; ENSG00000021300. [Q9UF11-4]
ENST00000354190; ENSP00000346127; ENSG00000021300. [Q9UF11-1]
ENST00000398492; ENSP00000381505; ENSG00000021300. [Q9UF11-2]
ENST00000398494; ENSP00000381507; ENSG00000021300. [Q9UF11-3]
ENST00000535129; ENSP00000442616; ENSG00000021300. [Q9UF11-4]
GeneIDi58473.
KEGGihsa:58473.
UCSCiuc001oua.3. human. [Q9UF11-1]
uc001oub.3. human. [Q9UF11-2]
uc001oud.3. human. [Q9UF11-4]

Polymorphism databases

DMDMi48474683.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89715 mRNA. Translation: AAF16675.1 .
AF093249 mRNA. Translation: AAF16684.1 .
AF101054 mRNA. Translation: AAF18572.1 .
AF100612 mRNA. Translation: AAF18932.1 .
AF081583 mRNA. Translation: AAF21786.1 .
AK289620 mRNA. Translation: BAF82309.1 .
AK289909 mRNA. Translation: BAF82598.1 .
AK290109 mRNA. Translation: BAF82798.1 .
AK301299 mRNA. Translation: BAH13452.1 .
AK314748 mRNA. Translation: BAG37288.1 .
CH471076 Genomic DNA. Translation: EAW74900.1 .
CH471076 Genomic DNA. Translation: EAW74903.1 .
CH471076 Genomic DNA. Translation: EAW74904.1 .
BC008075 mRNA. Translation: AAH08075.1 .
CCDSi CCDS44672.1. [Q9UF11-1 ]
CCDS44673.1. [Q9UF11-2 ]
CCDS44674.1. [Q9UF11-3 ]
CCDS44675.1. [Q9UF11-4 ]
RefSeqi NP_001123505.1. NM_001130033.1. [Q9UF11-2 ]
NP_001123506.1. NM_001130034.1. [Q9UF11-3 ]
NP_001123507.1. NM_001130035.1. [Q9UF11-4 ]
NP_001123508.1. NM_001130036.1. [Q9UF11-4 ]
NP_067023.1. NM_021200.2. [Q9UF11-1 ]
UniGenei Hs.445489.

3D structure databases

ProteinModelPortali Q9UF11.
SMRi Q9UF11. Positions 21-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121807. 1 interaction.
IntActi Q9UF11. 2 interactions.
STRINGi 9606.ENSP00000346127.

PTM databases

PhosphoSitei Q9UF11.

Polymorphism databases

DMDMi 48474683.

Proteomic databases

MaxQBi Q9UF11.
PaxDbi Q9UF11.
PRIDEi Q9UF11.

Protocols and materials databases

DNASUi 58473.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227214 ; ENSP00000227214 ; ENSG00000021300 . [Q9UF11-4 ]
ENST00000354190 ; ENSP00000346127 ; ENSG00000021300 . [Q9UF11-1 ]
ENST00000398492 ; ENSP00000381505 ; ENSG00000021300 . [Q9UF11-2 ]
ENST00000398494 ; ENSP00000381507 ; ENSG00000021300 . [Q9UF11-3 ]
ENST00000535129 ; ENSP00000442616 ; ENSG00000021300 . [Q9UF11-4 ]
GeneIDi 58473.
KEGGi hsa:58473.
UCSCi uc001oua.3. human. [Q9UF11-1 ]
uc001oub.3. human. [Q9UF11-2 ]
uc001oud.3. human. [Q9UF11-4 ]

Organism-specific databases

CTDi 58473.
GeneCardsi GC11P073357.
HGNCi HGNC:19079. PLEKHB1.
MIMi 607651. gene.
neXtProti NX_Q9UF11.
PharmGKBi PA38787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44470.
HOVERGENi HBG060487.
InParanoidi Q9UF11.
OMAi AWKTALM.
OrthoDBi EOG7CZK73.
PhylomeDBi Q9UF11.
TreeFami TF331787.

Miscellaneous databases

ChiTaRSi PLEKHB1. human.
GenomeRNAii 58473.
NextBioi 64900.
PROi Q9UF11.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UF11.
Bgeei Q9UF11.
CleanExi HS_PLEKHB1.
Genevestigatori Q9UF11.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments."
    Xu S., Ladak R., Swanson D.A., Soltyk A., Sun H., Ploder L., Vidgen D., Duncan A.M.V., Garami E., McInnes R.R., Valle D.
    J. Biol. Chem. 274:35676-35685(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), INTERACTION WITH TRANSDUCIN, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain and Retina.
  2. "KPL1, which encodes a novel PH domain-containing protein, is induced during ciliated cell differentiation of rat tracheal epithelial cells."
    Andrews K.L., Potdar P.D., Nettesheim P., Ostrowski L.E.
    Exp. Lung Res. 26:257-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain, Retina and Tracheal epithelium.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Amygdala, Corpus callosum, Stomach and Subthalamic nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Skin.

Entry informationi

Entry nameiPKHB1_HUMAN
AccessioniPrimary (citable) accession number: Q9UF11
Secondary accession number(s): A8K0Q5
, B2RBP1, B7Z716, Q9UBF5, Q9UI37, Q9UI44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi