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Q9UF02

- CCG5_HUMAN

UniProt

Q9UF02 - CCG5_HUMAN

Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

CACNG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.By similarity

    GO - Molecular functioni

    1. ion transmembrane transporter activity Source: ProtInc
    2. voltage-gated calcium channel activity Source: ProtInc

    GO - Biological processi

    1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    2. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-5 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-5 subunit
    Transmembrane AMPAR regulatory protein gamma-5
    Short name:
    TARP gamma-5
    Gene namesi
    Name:CACNG5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1409. CACNG5.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. postsynaptic density Source: UniProtKB
    4. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26019.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Voltage-dependent calcium channel gamma-5 subunitPRO_0000164681Add
    BLAST

    Proteomic databases

    PaxDbiQ9UF02.
    PRIDEiQ9UF02.

    PTM databases

    PhosphoSiteiQ9UF02.

    Expressioni

    Gene expression databases

    BgeeiQ9UF02.
    CleanExiHS_CACNG5.
    GenevestigatoriQ9UF02.

    Organism-specific databases

    HPAiHPA050115.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000169565.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UF02.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGieuNOG01540.
    HOGENOMiHOG000233439.
    HOVERGENiHBG025923.
    KOiK04870.
    OMAiMSLCGRK.
    OrthoDBiEOG71P2BZ.
    PhylomeDBiQ9UF02.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008369. VDCC_g5su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01793. VDCCGAMMA5.

    Sequencei

    Sequence statusi: Complete.

    Q9UF02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI    50
    KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA 100
    TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV 150
    LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF 200
    MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA 250
    SLQMNSNYPA LLKCPDYDQM SSSPC 275
    Length:275
    Mass (Da):30,903
    Last modified:May 10, 2002 - v2
    Checksum:i889E04DAC036C2AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 27585SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089. (PubMed:10613843)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142621
    , AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
    AF148220 mRNA. Translation: AAF00132.1.
    AF361351 mRNA. Translation: AAL50046.1.
    AF458898 mRNA. Translation: AAM00595.1.
    AK290171 mRNA. Translation: BAF82860.1.
    BC101607 mRNA. Translation: AAI01608.1.
    BC101633 mRNA. Translation: AAI01634.1.
    CCDSiCCDS11665.1.
    RefSeqiNP_665810.1. NM_145811.2.
    UniGeneiHs.278907.

    Genome annotation databases

    EnsembliENST00000307139; ENSP00000303092; ENSG00000075429.
    ENST00000533854; ENSP00000436836; ENSG00000075429.
    GeneIDi27091.
    KEGGihsa:27091.
    UCSCiuc010wqi.2. human.

    Polymorphism databases

    DMDMi20532390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142621
    , AF142618 , AF142619 , AF142620 Genomic DNA. Translation: AAF03089.1 .
    AF148220 mRNA. Translation: AAF00132.1 .
    AF361351 mRNA. Translation: AAL50046.1 .
    AF458898 mRNA. Translation: AAM00595.1 .
    AK290171 mRNA. Translation: BAF82860.1 .
    BC101607 mRNA. Translation: AAI01608.1 .
    BC101633 mRNA. Translation: AAI01634.1 .
    CCDSi CCDS11665.1.
    RefSeqi NP_665810.1. NM_145811.2.
    UniGenei Hs.278907.

    3D structure databases

    ProteinModelPortali Q9UF02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000169565.

    Chemistry

    ChEMBLi CHEMBL2363032.

    PTM databases

    PhosphoSitei Q9UF02.

    Polymorphism databases

    DMDMi 20532390.

    Proteomic databases

    PaxDbi Q9UF02.
    PRIDEi Q9UF02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307139 ; ENSP00000303092 ; ENSG00000075429 .
    ENST00000533854 ; ENSP00000436836 ; ENSG00000075429 .
    GeneIDi 27091.
    KEGGi hsa:27091.
    UCSCi uc010wqi.2. human.

    Organism-specific databases

    CTDi 27091.
    GeneCardsi GC17P064873.
    HGNCi HGNC:1409. CACNG5.
    HPAi HPA050115.
    MIMi 606405. gene.
    neXtProti NX_Q9UF02.
    PharmGKBi PA26019.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi euNOG01540.
    HOGENOMi HOG000233439.
    HOVERGENi HBG025923.
    KOi K04870.
    OMAi MSLCGRK.
    OrthoDBi EOG71P2BZ.
    PhylomeDBi Q9UF02.
    TreeFami TF327980.

    Miscellaneous databases

    GenomeRNAii 27091.
    NextBioi 49715.
    PROi Q9UF02.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UF02.
    CleanExi HS_CACNG5.
    Genevestigatori Q9UF02.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008369. VDCC_g5su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01793. VDCCGAMMA5.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
      Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
      Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
      Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
      EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiCCG5_HUMAN
    AccessioniPrimary (citable) accession number: Q9UF02
    Secondary accession number(s): A8K2A6
    , Q547R3, Q8WXS7, Q9UHM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3