Q9UF02 (CCG5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-5 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name=TARP gamma-5

Gene names

Name:

CACNG5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from sequence or structural similarity. Source: UniProtKB cell junction Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	voltage-gated calcium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Voltage-dependent calcium channel gamma-5 subunit		PRO_0000164681
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
Experimental info
	Sequence conflict	191 – 275	85	SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UF02 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: 889E04DAC036C2AE	FASTA	275	30,903
	10 20 30 40 50 60 MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI KMSLHSGLWR 70 80 90 100 110 120 VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILNNI 130 140 150 160 170 180 GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA 190 200 210 220 230 240 FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG 250 260 270 RSPSDISSEA SLQMNSNYPA LLKCPDYDQM SSSPC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication." Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L. Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Calcium channel gamma subunits provide insights into the evolution of this gene family." Chu P.-J., Robertson H.M., Best P.M. Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression." Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C. EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF142621 , AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1. AF148220 mRNA. Translation: AAF00132.1. AF361351 mRNA. Translation: AAL50046.1. AF458898 mRNA. Translation: AAM00595.1. AK290171 mRNA. Translation: BAF82860.1. BC101607 mRNA. Translation: AAI01608.1. BC101633 mRNA. Translation: AAI01634.1.
IPI	IPI00004272.
RefSeq	NP_665810.1. NM_145811.2.
UniGene	Hs.278907.
3D structure databases
ProteinModelPortal	Q9UF02.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000169565.
PTM databases
PhosphoSite	Q9UF02.
Polymorphism databases
DMDM	20532390.
Proteomic databases
PaxDb	Q9UF02.
PRIDE	Q9UF02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000169565; ENSP00000169565; ENSG00000075429. ENST00000307139; ENSP00000303092; ENSG00000075429. ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneID	27091.
KEGG	hsa:27091.
UCSC	uc010wqi.2. human.
Organism-specific databases
CTD	27091.
GeneCards	GC17P064873.
HGNC	HGNC:1409. CACNG5.
HPA	HPA050115.
MIM	606405. gene.
neXtProt	NX_Q9UF02.
PharmGKB	PA26019.
GenAtlas	Search...
Phylogenomic databases
eggNOG	euNOG01540.
HOGENOM	HOG000233439.
HOVERGEN	HBG025923.
KO	K04870.
OMA	IILPQNQ.
OrthoDB	EOG40S0G8.
Gene expression databases
Bgee	Q9UF02.
CleanEx	HS_CACNG5.
Genevestigator	Q9UF02.
GermOnline	ENSG00000075429. Homo sapiens.
Family and domain databases
InterPro	IPR004031. PMP22/EMP/MP20/Claudin. IPR008369. VDCC_g5su. IPR008368. VDCC_gsu. [Graphical view]
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01793. VDCCGAMMA5.
ProtoNet	Search...
Other
GenomeRNAi	27091.
NextBio	49715.
SOURCE	Search...

Entry information

Entry name

CCG5_HUMAN

Accession

Primary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6 , Q547R3, Q8WXS7, Q9UHM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 10, 2002
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.