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Q9UF02

- CCG5_HUMAN

UniProt

Q9UF02 - CCG5_HUMAN

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Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene
CACNG5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.

GO - Molecular functioni

  1. ion transmembrane transporter activity Source: ProtInc
  2. voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

  1. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  2. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
Gene namesi
Name:CACNG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1409. CACNG5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Transmembranei129 – 14921Helical; Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. postsynaptic density Source: UniProtKB
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Voltage-dependent calcium channel gamma-5 subunitPRO_0000164681Add
BLAST

Proteomic databases

PaxDbiQ9UF02.
PRIDEiQ9UF02.

PTM databases

PhosphoSiteiQ9UF02.

Expressioni

Gene expression databases

BgeeiQ9UF02.
CleanExiHS_CACNG5.
GenevestigatoriQ9UF02.

Organism-specific databases

HPAiHPA050115.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000169565.

Structurei

3D structure databases

ProteinModelPortaliQ9UF02.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGieuNOG01540.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
KOiK04870.
OMAiMSLCGRK.
OrthoDBiEOG71P2BZ.
PhylomeDBiQ9UF02.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q9UF02-1 [UniParc]FASTAAdd to Basket

« Hide

MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI    50
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA 100
TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV 150
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF 200
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA 250
SLQMNSNYPA LLKCPDYDQM SSSPC 275
Length:275
Mass (Da):30,903
Last modified:May 10, 2002 - v2
Checksum:i889E04DAC036C2AE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 27585SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF142621
, AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
AF148220 mRNA. Translation: AAF00132.1.
AF361351 mRNA. Translation: AAL50046.1.
AF458898 mRNA. Translation: AAM00595.1.
AK290171 mRNA. Translation: BAF82860.1.
BC101607 mRNA. Translation: AAI01608.1.
BC101633 mRNA. Translation: AAI01634.1.
CCDSiCCDS11665.1.
RefSeqiNP_665810.1. NM_145811.2.
UniGeneiHs.278907.

Genome annotation databases

EnsembliENST00000169565; ENSP00000169565; ENSG00000075429.
ENST00000307139; ENSP00000303092; ENSG00000075429.
ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneIDi27091.
KEGGihsa:27091.
UCSCiuc010wqi.2. human.

Polymorphism databases

DMDMi20532390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF142621
, AF142618 , AF142619 , AF142620 Genomic DNA. Translation: AAF03089.1 .
AF148220 mRNA. Translation: AAF00132.1 .
AF361351 mRNA. Translation: AAL50046.1 .
AF458898 mRNA. Translation: AAM00595.1 .
AK290171 mRNA. Translation: BAF82860.1 .
BC101607 mRNA. Translation: AAI01608.1 .
BC101633 mRNA. Translation: AAI01634.1 .
CCDSi CCDS11665.1.
RefSeqi NP_665810.1. NM_145811.2.
UniGenei Hs.278907.

3D structure databases

ProteinModelPortali Q9UF02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000169565.

Chemistry

ChEMBLi CHEMBL2363032.

PTM databases

PhosphoSitei Q9UF02.

Polymorphism databases

DMDMi 20532390.

Proteomic databases

PaxDbi Q9UF02.
PRIDEi Q9UF02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000169565 ; ENSP00000169565 ; ENSG00000075429 .
ENST00000307139 ; ENSP00000303092 ; ENSG00000075429 .
ENST00000533854 ; ENSP00000436836 ; ENSG00000075429 .
GeneIDi 27091.
KEGGi hsa:27091.
UCSCi uc010wqi.2. human.

Organism-specific databases

CTDi 27091.
GeneCardsi GC17P064873.
HGNCi HGNC:1409. CACNG5.
HPAi HPA050115.
MIMi 606405. gene.
neXtProti NX_Q9UF02.
PharmGKBi PA26019.
GenAtlasi Search...

Phylogenomic databases

eggNOGi euNOG01540.
HOGENOMi HOG000233439.
HOVERGENi HBG025923.
KOi K04870.
OMAi MSLCGRK.
OrthoDBi EOG71P2BZ.
PhylomeDBi Q9UF02.
TreeFami TF327980.

Miscellaneous databases

GenomeRNAii 27091.
NextBioi 49715.
PROi Q9UF02.
SOURCEi Search...

Gene expression databases

Bgeei Q9UF02.
CleanExi HS_CACNG5.
Genevestigatori Q9UF02.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
    Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
    Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
    Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
    EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiCCG5_HUMAN
AccessioniPrimary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6
, Q547R3, Q8WXS7, Q9UHM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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