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Q9UF02 (CCG5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name=TARP gamma-5
Gene names
Name:CACNG5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform ofGRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Voltage-dependent calcium channel gamma-5 subunit
PRO_0000164681

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane176 – 19621Helical; Potential

Experimental info

Sequence conflict191 – 27585SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UF02 [UniParc].

Last modified May 10, 2002. Version 2.
Checksum: 889E04DAC036C2AE

FASTA27530,903
        10         20         30         40         50         60 
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI KMSLHSGLWR 

        70         80         90        100        110        120 
VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILNNI 

       130        140        150        160        170        180 
GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA 

       190        200        210        220        230        240 
FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG 

       250        260        270 
RSPSDISSEA SLQMNSNYPA LLKCPDYDQM SSSPC 

« Hide

References

« Hide 'large scale' references
[1]"Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Calcium channel gamma subunits provide insights into the evolution of this gene family."
Chu P.-J., Robertson H.M., Best P.M.
Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF142621 expand/collapse EMBL AC list , AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
AF148220 mRNA. Translation: AAF00132.1.
AF361351 mRNA. Translation: AAL50046.1.
AF458898 mRNA. Translation: AAM00595.1.
AK290171 mRNA. Translation: BAF82860.1.
BC101607 mRNA. Translation: AAI01608.1.
BC101633 mRNA. Translation: AAI01634.1.
CCDSCCDS11665.1.
RefSeqNP_665810.1. NM_145811.2.
UniGeneHs.278907.

3D structure databases

ProteinModelPortalQ9UF02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000169565.

Chemistry

ChEMBLCHEMBL2363032.

PTM databases

PhosphoSiteQ9UF02.

Polymorphism databases

DMDM20532390.

Proteomic databases

PaxDbQ9UF02.
PRIDEQ9UF02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000169565; ENSP00000169565; ENSG00000075429.
ENST00000307139; ENSP00000303092; ENSG00000075429.
ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneID27091.
KEGGhsa:27091.
UCSCuc010wqi.2. human.

Organism-specific databases

CTD27091.
GeneCardsGC17P064873.
HGNCHGNC:1409. CACNG5.
HPAHPA050115.
MIM606405. gene.
neXtProtNX_Q9UF02.
PharmGKBPA26019.
GenAtlasSearch...

Phylogenomic databases

eggNOGeuNOG01540.
HOGENOMHOG000233439.
HOVERGENHBG025923.
KOK04870.
OMAMSLCGRK.
OrthoDBEOG71P2BZ.
PhylomeDBQ9UF02.
TreeFamTF327980.

Gene expression databases

BgeeQ9UF02.
CleanExHS_CACNG5.
GenevestigatorQ9UF02.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.
ProtoNetSearch...

Other

GenomeRNAi27091.
NextBio49715.
PROQ9UF02.
SOURCESearch...

Entry information

Entry nameCCG5_HUMAN
AccessionPrimary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6 expand/collapse secondary AC list , Q547R3, Q8WXS7, Q9UHM3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM