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Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

CACNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

  • ion transmembrane transporter activity Source: ProtInc
  • voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
Gene namesi
Name:CACNG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1409. CACNG5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26019.

Polymorphism and mutation databases

BioMutaiCACNG5.
DMDMi20532390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Voltage-dependent calcium channel gamma-5 subunitPRO_0000164681Add
BLAST

Proteomic databases

PaxDbiQ9UF02.
PRIDEiQ9UF02.

PTM databases

PhosphoSiteiQ9UF02.

Expressioni

Gene expression databases

BgeeiQ9UF02.
CleanExiHS_CACNG5.
GenevisibleiQ9UF02. HS.

Organism-specific databases

HPAiHPA050115.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi117993. 37 interactions.
STRINGi9606.ENSP00000303092.

Structurei

3D structure databases

ProteinModelPortaliQ9UF02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGieuNOG01540.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ9UF02.
KOiK04870.
OMAiAEDLYRP.
OrthoDBiEOG71P2BZ.
PhylomeDBiQ9UF02.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q9UF02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,903
Last modified:May 10, 2002 - v2
Checksum:i889E04DAC036C2AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 27585SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089 (PubMed:10613843).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142621
, AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
AF148220 mRNA. Translation: AAF00132.1.
AF361351 mRNA. Translation: AAL50046.1.
AF458898 mRNA. Translation: AAM00595.1.
AK290171 mRNA. Translation: BAF82860.1.
BC101607 mRNA. Translation: AAI01608.1.
BC101633 mRNA. Translation: AAI01634.1.
CCDSiCCDS11665.1.
RefSeqiNP_665810.1. NM_145811.2.
UniGeneiHs.278907.

Genome annotation databases

EnsembliENST00000307139; ENSP00000303092; ENSG00000075429.
ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneIDi27091.
KEGGihsa:27091.
UCSCiuc010wqi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142621
, AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
AF148220 mRNA. Translation: AAF00132.1.
AF361351 mRNA. Translation: AAL50046.1.
AF458898 mRNA. Translation: AAM00595.1.
AK290171 mRNA. Translation: BAF82860.1.
BC101607 mRNA. Translation: AAI01608.1.
BC101633 mRNA. Translation: AAI01634.1.
CCDSiCCDS11665.1.
RefSeqiNP_665810.1. NM_145811.2.
UniGeneiHs.278907.

3D structure databases

ProteinModelPortaliQ9UF02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117993. 37 interactions.
STRINGi9606.ENSP00000303092.

Chemistry

ChEMBLiCHEMBL2363032.

PTM databases

PhosphoSiteiQ9UF02.

Polymorphism and mutation databases

BioMutaiCACNG5.
DMDMi20532390.

Proteomic databases

PaxDbiQ9UF02.
PRIDEiQ9UF02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307139; ENSP00000303092; ENSG00000075429.
ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneIDi27091.
KEGGihsa:27091.
UCSCiuc010wqi.2. human.

Organism-specific databases

CTDi27091.
GeneCardsiGC17P064873.
HGNCiHGNC:1409. CACNG5.
HPAiHPA050115.
MIMi606405. gene.
neXtProtiNX_Q9UF02.
PharmGKBiPA26019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGieuNOG01540.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ9UF02.
KOiK04870.
OMAiAEDLYRP.
OrthoDBiEOG71P2BZ.
PhylomeDBiQ9UF02.
TreeFamiTF327980.

Miscellaneous databases

GenomeRNAii27091.
NextBioi49715.
PROiQ9UF02.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UF02.
CleanExiHS_CACNG5.
GenevisibleiQ9UF02. HS.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
    Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
    Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
    Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
    EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiCCG5_HUMAN
AccessioniPrimary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6
, Q547R3, Q8WXS7, Q9UHM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: June 24, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.