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Protein

Voltage-dependent calcium channel gamma-5 subunit

Gene

CACNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

  • channel regulator activity Source: GO_Central
  • ion transmembrane transporter activity Source: ProtInc
  • voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

  • cardiac conduction Source: Reactome
  • regulation of AMPA receptor activity Source: UniProtKB
  • transmission of nerve impulse Source: GO_Central
  • transport Source: ProtInc

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-5576892. Phase 0 - rapid depolarisation.
R-HSA-5576893. Phase 2 - plateau phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-5 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-5 subunit
Transmembrane AMPAR regulatory protein gamma-5
Short name:
TARP gamma-5
Gene namesi
Name:CACNG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000075429.8.
HGNCiHGNC:1409. CACNG5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi27091.
OpenTargetsiENSG00000075429.
PharmGKBiPA26019.

Chemistry databases

ChEMBLiCHEMBL2363032.

Polymorphism and mutation databases

BioMutaiCACNG5.
DMDMi20532390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646811 – 275Voltage-dependent calcium channel gamma-5 subunitAdd BLAST275

Proteomic databases

PaxDbiQ9UF02.
PeptideAtlasiQ9UF02.
PRIDEiQ9UF02.

PTM databases

iPTMnetiQ9UF02.
PhosphoSitePlusiQ9UF02.

Expressioni

Gene expression databases

BgeeiENSG00000075429.
CleanExiHS_CACNG5.
GenevisibleiQ9UF02. HS.

Organism-specific databases

HPAiHPA050115.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi117993. 41 interactors.
STRINGi9606.ENSP00000303092.

Structurei

3D structure databases

ProteinModelPortaliQ9UF02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiQ9UF02.
KOiK04870.
OMAiLKCPEYE.
OrthoDBiEOG091G0F73.
PhylomeDBiQ9UF02.
TreeFamiTF327980.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
PANTHERiPTHR12107:SF4. PTHR12107:SF4. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q9UF02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILNNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG RSPSDISSEA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,903
Last modified:May 10, 2002 - v2
Checksum:i889E04DAC036C2AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 275SAGVM…SSSPC → VKPVTLSMDRLGLGTAPLSR GEWGWGRRDIPQPFWTPDHP LYFPSSSQNVSLSYLSGSPP ARMSPGPCSCPHVHFPPHSS CVLCRPQPREMRQAPAASPS SAVFSL in AAF03089 (PubMed:10613843).CuratedAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142621
, AF142618, AF142619, AF142620 Genomic DNA. Translation: AAF03089.1.
AF148220 mRNA. Translation: AAF00132.1.
AF361351 mRNA. Translation: AAL50046.1.
AF458898 mRNA. Translation: AAM00595.1.
AK290171 mRNA. Translation: BAF82860.1.
BC101607 mRNA. Translation: AAI01608.1.
BC101633 mRNA. Translation: AAI01634.1.
CCDSiCCDS11665.1.
RefSeqiNP_665810.1. NM_145811.2.
UniGeneiHs.278907.

Genome annotation databases

EnsembliENST00000307139; ENSP00000303092; ENSG00000075429.
ENST00000533854; ENSP00000436836; ENSG00000075429.
GeneIDi27091.
KEGGihsa:27091.
UCSCiuc010wqi.3. human.

Similar proteinsi

Entry informationi

Entry nameiCCG5_HUMAN
AccessioniPrimary (citable) accession number: Q9UF02
Secondary accession number(s): A8K2A6
, Q547R3, Q8WXS7, Q9UHM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families