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Protein

Gamma-adducin

Gene

ADD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148700-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.
SIGNORiQ9UEY8.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-adducin
Alternative name(s):
Adducin-like protein 70
Gene namesi
Name:ADD3
Synonyms:ADDL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:245. ADD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi120.
MalaCardsiADD3.
OpenTargetsiENSG00000148700.
Orphaneti210141. Inherited congenital spastic tetraplegia.
PharmGKBiPA24567.

Polymorphism and mutation databases

BioMutaiADD3.
DMDMi12643881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002185362 – 706Gamma-adducinAdd BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei59PhosphothreonineBy similarity1
Modified residuei64PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei414PhosphoserineBy similarity1
Modified residuei423PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei585PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei598PhosphothreonineBy similarity1
Modified residuei600PhosphoserineBy similarity1
Modified residuei673PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei679PhosphoserineBy similarity1
Modified residuei681PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1
Modified residuei693PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UEY8.
PaxDbiQ9UEY8.
PeptideAtlasiQ9UEY8.
PRIDEiQ9UEY8.

PTM databases

iPTMnetiQ9UEY8.
PhosphoSitePlusiQ9UEY8.

Miscellaneous databases

PMAP-CutDBQ9UEY8.

Expressioni

Tissue specificityi

Isoform 1 is ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000148700.
CleanExiHS_ADD3.
ExpressionAtlasiQ9UEY8. baseline and differential.
GenevisibleiQ9UEY8. HS.

Organism-specific databases

HPAiCAB009797.
HPA035696.

Interactioni

Subunit structurei

Heterodimer of an alpha and a gamma subunit.

Protein-protein interaction databases

BioGridi106633. 31 interactors.
IntActiQ9UEY8. 20 interactors.
STRINGi9606.ENSP00000348381.

Structurei

3D structure databases

ProteinModelPortaliQ9UEY8.
SMRiQ9UEY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni684 – 701Interaction with calmodulinSequence analysisAdd BLAST18

Domaini

Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3699. Eukaryota.
COG0235. LUCA.
GeneTreeiENSGT00390000016462.
HOGENOMiHOG000116349.
HOVERGENiHBG004180.
InParanoidiQ9UEY8.
KOiK18622.
OMAiKEQDHII.
OrthoDBiEOG091G0324.
PhylomeDBiQ9UEY8.
TreeFamiTF313003.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR027772. ADD3.
IPR001303. Aldolase_II/adducin_N.
[Graphical view]
PANTHERiPTHR10672:SF5. PTHR10672:SF5. 1 hit.
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 2 (identifier: Q9UEY8-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDASQGVI TTPPPPSMPH KERYFDRINE NDPEYIRERN MSPDLRQDFN
60 70 80 90 100
MMEQRKRVTQ ILQSPAFRED LECLIQEQMK KGHNPTGLLA LQQIADYIMA
110 120 130 140 150
NSFSGFSSPP LSLGMVTPIN DLPGADTSSY VKGEKLTRCK LASLYRLVDL
160 170 180 190 200
FGWAHLANTY ISVRISKEQD HIIIIPRGLS FSEATASNLV KVNIIGEVVD
210 220 230 240 250
QGSTNLKIDH TGFSPHAAIY STRPDVKCVI HIHTLATAAV SSMKCGILPI
260 270 280 290 300
SQESLLLGDV AYYDYQGSLE EQEERIQLQK VLGPSCKVLV LRNHGVVALG
310 320 330 340 350
ETLEEAFHYI FNVQLACEIQ VQALAGAGGV DNLHVLDFQK YKAFTYTVAA
360 370 380 390 400
SGGGGVNMGS HQKWKVGEIE FEGLMRTLDN LGYRTGYAYR HPLIREKPRH
410 420 430 440 450
KSDVEIPATV TAFSFEDDTV PLSPLKYMAQ RQQREKTRWL NSPNTYMKVN
460 470 480 490 500
VPEESRNGET SPRTKITWMK AEDSSKVSGG TPIKIEDPNQ FVPLNTNPNE
510 520 530 540 550
VLEKRNKIRE QNRYDLKTAG PQSQLLAGIV VDKPPSTMQF EDDDHGPPAP
560 570 580 590 600
PNPFSHLTEG ELEEYKRTIE RKQQGLEDAE QELLSDDASS VSQIQSQTQS
610 620 630 640 650
PQNVPEKLEE NHELFSKSFI SMEVPVMVVN GKDDMHDVED ELAKRVSRLS
660 670 680 690 700
TSTTIENIEI TIKSPEKIEE VLSPEGSPSK SPSKKKKKFR TPSFLKKNKK

KEKVEA
Length:706
Mass (Da):79,155
Last modified:May 1, 2000 - v1
Checksum:iEB8EAF602A4D7B41
GO
Isoform 1 (identifier: Q9UEY8-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     576-607: Missing.

Show »
Length:674
Mass (Da):75,671
Checksum:i28935F90F7C17BD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50FN → SS in BAA23783 (PubMed:8893809).Curated2
Sequence conflicti60Q → R in BAA23783 (PubMed:8893809).Curated1
Sequence conflicti362Q → P in AAB17126 (Ref. 2) Curated1
Sequence conflicti420V → M in AAB17126 (Ref. 2) Curated1
Sequence conflicti421P → L in BAA23783 (PubMed:8893809).Curated1
Sequence conflicti426 – 433KYMAQRQQ → QIHGTRGNK in AAB17126 (Ref. 2) Curated8
Sequence conflicti484K → Q in AAB17126 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000188576 – 607Missing in isoform 1. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67031 mRNA. Translation: BAA23783.1.
U37122 mRNA. Translation: AAB17126.1.
Y14372
, Y14373, Y14374, Y14375, Y14376, Y14377, Y14378, Y14379, Y14380, Y14381, Y14382, Y14383, Y14384 Genomic DNA. Translation: CAB51805.1.
Y14372
, Y14373, Y14374, Y14375, Y14376, Y14377, Y14378, Y14379, Y14380, Y14381, Y14382, Y14384 Genomic DNA. Translation: CAB51806.1.
BX647403 mRNA. Translation: CAI46048.1.
AL590628 Genomic DNA. Translation: CAH71739.1.
CH471066 Genomic DNA. Translation: EAW49573.1.
CH471066 Genomic DNA. Translation: EAW49574.1.
BC062559 mRNA. Translation: AAH62559.1.
CCDSiCCDS7561.1. [Q9UEY8-1]
CCDS7562.1. [Q9UEY8-2]
PIRiJC7164.
RefSeqiNP_001112.2. NM_001121.3. [Q9UEY8-2]
NP_001307520.1. NM_001320591.1. [Q9UEY8-1]
NP_001307521.1. NM_001320592.1. [Q9UEY8-1]
NP_001307522.1. NM_001320593.1. [Q9UEY8-1]
NP_001307523.1. NM_001320594.1.
NP_058432.1. NM_016824.4. [Q9UEY8-1]
NP_063968.1. NM_019903.4. [Q9UEY8-2]
UniGeneiHs.501012.

Genome annotation databases

EnsembliENST00000277900; ENSP00000277900; ENSG00000148700. [Q9UEY8-2]
ENST00000356080; ENSP00000348381; ENSG00000148700. [Q9UEY8-1]
ENST00000360162; ENSP00000353286; ENSG00000148700. [Q9UEY8-2]
GeneIDi120.
KEGGihsa:120.
UCSCiuc001kys.5. human. [Q9UEY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67031 mRNA. Translation: BAA23783.1.
U37122 mRNA. Translation: AAB17126.1.
Y14372
, Y14373, Y14374, Y14375, Y14376, Y14377, Y14378, Y14379, Y14380, Y14381, Y14382, Y14383, Y14384 Genomic DNA. Translation: CAB51805.1.
Y14372
, Y14373, Y14374, Y14375, Y14376, Y14377, Y14378, Y14379, Y14380, Y14381, Y14382, Y14384 Genomic DNA. Translation: CAB51806.1.
BX647403 mRNA. Translation: CAI46048.1.
AL590628 Genomic DNA. Translation: CAH71739.1.
CH471066 Genomic DNA. Translation: EAW49573.1.
CH471066 Genomic DNA. Translation: EAW49574.1.
BC062559 mRNA. Translation: AAH62559.1.
CCDSiCCDS7561.1. [Q9UEY8-1]
CCDS7562.1. [Q9UEY8-2]
PIRiJC7164.
RefSeqiNP_001112.2. NM_001121.3. [Q9UEY8-2]
NP_001307520.1. NM_001320591.1. [Q9UEY8-1]
NP_001307521.1. NM_001320592.1. [Q9UEY8-1]
NP_001307522.1. NM_001320593.1. [Q9UEY8-1]
NP_001307523.1. NM_001320594.1.
NP_058432.1. NM_016824.4. [Q9UEY8-1]
NP_063968.1. NM_019903.4. [Q9UEY8-2]
UniGeneiHs.501012.

3D structure databases

ProteinModelPortaliQ9UEY8.
SMRiQ9UEY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106633. 31 interactors.
IntActiQ9UEY8. 20 interactors.
STRINGi9606.ENSP00000348381.

PTM databases

iPTMnetiQ9UEY8.
PhosphoSitePlusiQ9UEY8.

Polymorphism and mutation databases

BioMutaiADD3.
DMDMi12643881.

Proteomic databases

EPDiQ9UEY8.
PaxDbiQ9UEY8.
PeptideAtlasiQ9UEY8.
PRIDEiQ9UEY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277900; ENSP00000277900; ENSG00000148700. [Q9UEY8-2]
ENST00000356080; ENSP00000348381; ENSG00000148700. [Q9UEY8-1]
ENST00000360162; ENSP00000353286; ENSG00000148700. [Q9UEY8-2]
GeneIDi120.
KEGGihsa:120.
UCSCiuc001kys.5. human. [Q9UEY8-1]

Organism-specific databases

CTDi120.
DisGeNETi120.
GeneCardsiADD3.
H-InvDBHIX0170444.
HGNCiHGNC:245. ADD3.
HPAiCAB009797.
HPA035696.
MalaCardsiADD3.
MIMi601568. gene.
neXtProtiNX_Q9UEY8.
OpenTargetsiENSG00000148700.
Orphaneti210141. Inherited congenital spastic tetraplegia.
PharmGKBiPA24567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3699. Eukaryota.
COG0235. LUCA.
GeneTreeiENSGT00390000016462.
HOGENOMiHOG000116349.
HOVERGENiHBG004180.
InParanoidiQ9UEY8.
KOiK18622.
OMAiKEQDHII.
OrthoDBiEOG091G0324.
PhylomeDBiQ9UEY8.
TreeFamiTF313003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148700-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.
SIGNORiQ9UEY8.

Miscellaneous databases

ChiTaRSiADD3. human.
GeneWikiiADD3.
GenomeRNAii120.
PMAP-CutDBQ9UEY8.
PROiQ9UEY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148700.
CleanExiHS_ADD3.
ExpressionAtlasiQ9UEY8. baseline and differential.
GenevisibleiQ9UEY8. HS.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiIPR027772. ADD3.
IPR001303. Aldolase_II/adducin_N.
[Graphical view]
PANTHERiPTHR10672:SF5. PTHR10672:SF5. 1 hit.
PfamiPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTiSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMiSSF53639. SSF53639. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADDG_HUMAN
AccessioniPrimary (citable) accession number: Q9UEY8
Secondary accession number(s): D3DRA8
, O43243, Q5VU09, Q92773, Q9UEY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.