Q9UEY6 (Q9UEY6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Anion exchanger 2 type a EMBL AAF19583.2

Gene names

Name:

SLC4A2 EMBL AAF19583.2

Organism

Homo sapiens (Human) EMBL AAF19583.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1241 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	inorganic anion exchanger activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9UEY6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D2FDA72E20D70D64	FASTA	1,241	136,981
	10 20 30 40 50 60 MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE 70 80 90 100 110 120 EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 130 140 150 160 170 180 IEEGEEDEDE ASEAEGARAL TQPSPVSTPS SVQFFLQEDD SADRKAERTS PSSPAPLPHQ 190 200 210 220 230 240 EATPRASKGA QAGTQVEEAE AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR 250 260 270 280 290 300 IGSMTGAEQA LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG 310 320 330 340 350 360 REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE EDVEEETERW 370 380 390 400 410 420 GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ VVEQMVISDQ IKAEDRANVL 430 440 450 460 470 480 RALLLKHSHP SDEKDFSFPR NISAGSLGSL LGHHHGQGAE SDPHVTEPLM GGVPETRLEV 490 500 510 520 530 540 ERERDVPPPA PPAGITRSKS KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA 550 560 570 580 590 600 VELDAVLEVP VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT 610 620 630 640 650 660 AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL EPKSAQDKAL 670 680 690 700 710 720 LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF RDALDPQCLA AVIFIYFAAL 730 740 750 760 770 780 SPAITFGGLL GEKTQDLIGV SELIMSTALQ GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS 790 800 810 820 830 840 FCSSNHLEYL VGRVWIGFWL VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF 850 860 870 880 890 900 YKLVKIFQEH PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT 910 920 930 940 950 960 ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV DYSIEDTYTQ 970 980 990 1000 1010 1020 KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP AILVFILIFM ETQITTLIIS 1030 1040 1050 1060 1070 1080 KKERMLQKGS GFHLDLLLIV AMGGICALFG LPWLAAATVR SVTHANALTV MSKAVAPGDK 1090 1100 1110 1120 1130 1140 PKIQEVKEQR VTGLLVALLV GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH 1150 1160 1170 1180 1190 1200 LLLMPPKHHP DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR 1210 1220 1230 1240 MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V

References

[1]	"Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene." Medina J.F., Acin A., Prieto J. Genomics 39:74-85(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene." Medina J.F., Lecanda J., Acin A., Ciesielczyk P., Prieto J. Biochem. Biophys. Res. Commun. 267:228-235(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U76669, U76667, U76668 Genomic DNA. Translation: AAF19583.2.
IPI	IPI00383597.
UniGene	Hs.647069.
3D structure databases
HSSP	HSSP built from PDB template 1BTQ based on UniProtKB P02730.
ProteinModelPortal	Q9UEY6.
SMR	Q9UEY6. Positions 692-733, 1133-1165.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UEY6.
Proteomic databases
PRIDE	Q9UEY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004326.
Gene expression databases
ArrayExpress	Q9UEY6.
Family and domain databases
Gene3D	3.40.1100.10. 1 hit.
InterPro	IPR001717. Anion_exchange. IPR002978. Anion_exchange_2. IPR018241. Anion_exchange_CS. IPR013769. Band3_cytoplasmic_dom. IPR011531. HCO3_transpt_C. IPR003020. HCO3_transpt_euk. IPR016152. PTrfase/Anion_transptr. [Graphical view]
PANTHER	PTHR11453. PTHR11453. 1 hit. PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfam	PF07565. Band_3_cyto. 1 hit. PF00955. HCO3_cotransp. 1 hit. [Graphical view]
PRINTS	PR00165. ANIONEXCHNGR. PR01188. ANIONEXHNGR2. PR01231. HCO3TRNSPORT.
SUPFAM	SSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMs	TIGR00834. ae. 1 hit.
PROSITE	PS00219. ANION_EXCHANGER_1. 1 hit. PS00220. ANION_EXCHANGER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC4A2. human.

Entry information

Entry name

Q9UEY6_HUMAN

Accession

Primary (citable) accession number: Q9UEY6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.