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Q9UEW3 (MARCO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Scavenger receptor class A member 2
Gene names
Name:MARCO
Synonyms:SCARA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Subunit structure

Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Sequence similarities

Contains 1 collagen-like domain.

Contains 1 SRCR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Macrophage receptor MARCO
PRO_0000181630

Regions

Topological domain1 – 4343Cytoplasmic Potential
Transmembrane44 – 6421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain65 – 520456Extracellular Potential
Domain147 – 419273Collagen-like
Domain424 – 51996SRCR

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Ref.4 Ref.5
Disulfide bond447 ↔ 508 Ref.1
Disulfide bond460 ↔ 518 Ref.1
Disulfide bond488 ↔ 498 Ref.1

Natural variations

Natural variant2821F → S.
Corresponds to variant rs6761637 [ dbSNP | Ensembl ].
VAR_024650

Experimental info

Sequence conflict131L → F in AAD41064. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9UEW3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8CFC5F6F99EEBA8D

FASTA52052,658
        10         20         30         40         50         60 
MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV IYLILLTAGA 

        70         80         90        100        110        120 
GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA HPGEHLAQGA SRLQVLQAQL 

       130        140        150        160        170        180 
TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK 

       190        200        210        220        230        240 
GAMGRDGATG PSGPQGPPGV KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK 

       250        260        270        280        290        300 
GETGTKGEKG DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ 

       310        320        330        340        350        360 
GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS KGDTGLQGQQ 

       370        380        390        400        410        420 
GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG VKGSSGEQGV KGEKGERGEN 

       430        440        450        460        470        480 
SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ 

       490        500        510        520 
IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region."
Elomaa O., Sankala M., Pikkarainen T., Bergmann U., Tuuttila A., Raatikainen-Ahokas A., Sariola H., Tryggvason K.
J. Biol. Chem. 273:4530-4538(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISULFIDE BONDS.
[2]"Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor."
Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K.
Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
Tissue: Plasma.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF035819 mRNA. Translation: AAC08800.1.
AF128186 expand/collapse EMBL AC list , AF128172, AF128173, AF128174, AF128175, AF128176, AF128177, AF128178, AF128179, AF128180, AF128181, AF128182, AF128183, AF128184, AF128185 Genomic DNA. Translation: AAD41064.1.
BC016004 mRNA. Translation: AAH16004.1.
RefSeqNP_006761.1. NM_006770.3.
UniGeneHs.67726.

3D structure databases

ProteinModelPortalQ9UEW3.
SMRQ9UEW3. Positions 140-177, 424-519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114232. 2 interactions.
IntActQ9UEW3. 1 interaction.
STRING9606.ENSP00000318916.

PTM databases

PhosphoSiteQ9UEW3.

Polymorphism databases

DMDM17380151.

Proteomic databases

PaxDbQ9UEW3.
PeptideAtlasQ9UEW3.
PRIDEQ9UEW3.

Protocols and materials databases

DNASU8685.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327097; ENSP00000318916; ENSG00000019169.
GeneID8685.
KEGGhsa:8685.
UCSCuc002tln.1. human.

Organism-specific databases

CTD8685.
GeneCardsGC02P119794.
HGNCHGNC:6895. MARCO.
HPAHPA008847.
MIM604870. gene.
neXtProtNX_Q9UEW3.
PharmGKBPA30638.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297041.
HOGENOMHOG000085659.
HOVERGENHBG004933.
InParanoidQ9UEW3.
KOK13884.
OMASHNCNHN.
OrthoDBEOG7HHWSF.
PhylomeDBQ9UEW3.
TreeFamTF330855.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

ArrayExpressQ9UEW3.
BgeeQ9UEW3.
CleanExHS_MARCO.
GenevestigatorQ9UEW3.

Family and domain databases

Gene3D3.10.250.10. 1 hit.
InterProIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamPF01391. Collagen. 4 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
SMARTSM00202. SR. 1 hit.
[Graphical view]
SUPFAMSSF56487. SSF56487. 1 hit.
PROSITEPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMARCO.
GenomeRNAi8685.
NextBio32573.
PROQ9UEW3.
SOURCESearch...

Entry information

Entry nameMARCO_HUMAN
AccessionPrimary (citable) accession number: Q9UEW3
Secondary accession number(s): Q9Y5S3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM