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Q9UEW3

- MARCO_HUMAN

UniProt

Q9UEW3 - MARCO_HUMAN

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Protein

Macrophage receptor MARCO

Gene
MARCO, SCARA2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

GO - Molecular functioni

  1. scavenger receptor activity Source: InterPro
  2. signaling pattern recognition receptor activity Source: ProtInc
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic cell clearance Source: Ensembl
  2. cell surface receptor signaling pathway Source: ProtInc
  3. innate immune response Source: UniProtKB-KW
  4. pattern recognition receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_163699. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Scavenger receptor class A member 2
Gene namesi
Name:MARCO
Synonyms:SCARA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6895. MARCO.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei44 – 6421Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini65 – 520456Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. endocytic vesicle membrane Source: Reactome
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Macrophage receptor MARCOPRO_0000181630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi136 – 1361N-linked (GlcNAc...)2 Publications
Disulfide bondi447 ↔ 5081 Publication
Disulfide bondi460 ↔ 5181 Publication
Disulfide bondi488 ↔ 4981 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UEW3.
PeptideAtlasiQ9UEW3.
PRIDEiQ9UEW3.

PTM databases

PhosphoSiteiQ9UEW3.

Expressioni

Gene expression databases

ArrayExpressiQ9UEW3.
BgeeiQ9UEW3.
CleanExiHS_MARCO.
GenevestigatoriQ9UEW3.

Organism-specific databases

HPAiHPA008847.

Interactioni

Subunit structurei

Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands By similarity.

Protein-protein interaction databases

BioGridi114232. 2 interactions.
IntActiQ9UEW3. 1 interaction.
STRINGi9606.ENSP00000318916.

Structurei

3D structure databases

ProteinModelPortaliQ9UEW3.
SMRiQ9UEW3. Positions 424-519.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 419273Collagen-likeAdd
BLAST
Domaini424 – 51996SRCRAdd
BLAST

Sequence similaritiesi

Contains 1 SRCR domain.

Keywords - Domaini

Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297041.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ9UEW3.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG7HHWSF.
PhylomeDBiQ9UEW3.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UEW3-1 [UniParc]FASTAAdd to Basket

« Hide

MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV    50
IYLILLTAGA GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA 100
HPGEHLAQGA SRLQVLQAQL TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ 150
GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK GAMGRDGATG PSGPQGPPGV 200
KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK GETGTKGEKG 250
DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ 300
GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS 350
KGDTGLQGQQ GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG 400
VKGSSGEQGV KGEKGERGEN SVSVRIVGSS NRGRAEVYYS GTWGTICDDE 450
WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK 500
NSWGHHDCSH EEDAGVECSV 520
Length:520
Mass (Da):52,658
Last modified:May 1, 2000 - v1
Checksum:i8CFC5F6F99EEBA8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti282 – 2821F → S.
Corresponds to variant rs6761637 [ dbSNP | Ensembl ].
VAR_024650

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131L → F in AAD41064. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035819 mRNA. Translation: AAC08800.1.
AF128186
, AF128172, AF128173, AF128174, AF128175, AF128176, AF128177, AF128178, AF128179, AF128180, AF128181, AF128182, AF128183, AF128184, AF128185 Genomic DNA. Translation: AAD41064.1.
BC016004 mRNA. Translation: AAH16004.1.
CCDSiCCDS2124.1.
RefSeqiNP_006761.1. NM_006770.3.
UniGeneiHs.67726.

Genome annotation databases

EnsembliENST00000327097; ENSP00000318916; ENSG00000019169.
GeneIDi8685.
KEGGihsa:8685.
UCSCiuc002tln.1. human.

Polymorphism databases

DMDMi17380151.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035819 mRNA. Translation: AAC08800.1 .
AF128186
, AF128172 , AF128173 , AF128174 , AF128175 , AF128176 , AF128177 , AF128178 , AF128179 , AF128180 , AF128181 , AF128182 , AF128183 , AF128184 , AF128185 Genomic DNA. Translation: AAD41064.1 .
BC016004 mRNA. Translation: AAH16004.1 .
CCDSi CCDS2124.1.
RefSeqi NP_006761.1. NM_006770.3.
UniGenei Hs.67726.

3D structure databases

ProteinModelPortali Q9UEW3.
SMRi Q9UEW3. Positions 424-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114232. 2 interactions.
IntActi Q9UEW3. 1 interaction.
STRINGi 9606.ENSP00000318916.

PTM databases

PhosphoSitei Q9UEW3.

Polymorphism databases

DMDMi 17380151.

Proteomic databases

PaxDbi Q9UEW3.
PeptideAtlasi Q9UEW3.
PRIDEi Q9UEW3.

Protocols and materials databases

DNASUi 8685.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327097 ; ENSP00000318916 ; ENSG00000019169 .
GeneIDi 8685.
KEGGi hsa:8685.
UCSCi uc002tln.1. human.

Organism-specific databases

CTDi 8685.
GeneCardsi GC02P119794.
HGNCi HGNC:6895. MARCO.
HPAi HPA008847.
MIMi 604870. gene.
neXtProti NX_Q9UEW3.
PharmGKBi PA30638.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297041.
HOGENOMi HOG000085659.
HOVERGENi HBG004933.
InParanoidi Q9UEW3.
KOi K13884.
OMAi SHNCNHN.
OrthoDBi EOG7HHWSF.
PhylomeDBi Q9UEW3.
TreeFami TF330855.

Enzyme and pathway databases

Reactomei REACT_163699. Scavenging by Class A Receptors.

Miscellaneous databases

GeneWikii MARCO.
GenomeRNAii 8685.
NextBioi 32573.
PROi Q9UEW3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UEW3.
Bgeei Q9UEW3.
CleanExi HS_MARCO.
Genevestigatori Q9UEW3.

Family and domain databases

Gene3Di 3.10.250.10. 1 hit.
InterProi IPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF01391. Collagen. 4 hits.
PF00530. SRCR. 1 hit.
[Graphical view ]
PRINTSi PR00258. SPERACTRCPTR.
SMARTi SM00202. SR. 1 hit.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 1 hit.
PROSITEi PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region."
    Elomaa O., Sankala M., Pikkarainen T., Bergmann U., Tuuttila A., Raatikainen-Ahokas A., Sariola H., Tryggvason K.
    J. Biol. Chem. 273:4530-4538(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISULFIDE BONDS.
  2. "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor."
    Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K.
    Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
    Tissue: Plasma.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
    Tissue: Liver.

Entry informationi

Entry nameiMARCO_HUMAN
AccessioniPrimary (citable) accession number: Q9UEW3
Secondary accession number(s): Q9Y5S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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