Q9UEW3 (MARCO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Macrophage receptor MARCO

Alternative name(s):
Macrophage receptor with collagenous structure
Scavenger receptor class A member 2

Gene names

Name:	MARCO
Synonyms:	SCARA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Subunit structure	Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Probable.
Sequence similarities	Contains 1 collagen-like domain. Contains 1 SRCR domain.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Collagen Signal-anchor Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	pattern recognition receptor activity Traceable author statement Ref.2. Source: ProtInc scavenger receptor activity Inferred from electronic annotation. Source: InterPro transmembrane signaling receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Macrophage receptor MARCO		PRO_0000181630
Regions
	Topological domain	1 – 43	43	Cytoplasmic Potential
	Transmembrane	44 – 64	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	65 – 520	456	Extracellular Potential
	Domain	147 – 419	273	Collagen-like
	Domain	424 – 519	96	SRCR
Amino acid modifications
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Glycosylation	136	1	N-linked (GlcNAc...) Ref.4 Ref.5
	Disulfide bond	447 ↔ 508		Ref.1
	Disulfide bond	460 ↔ 518		Ref.1
	Disulfide bond	488 ↔ 498		Ref.1
Natural variations
	Natural variant	282	1	F → S. Corresponds to variant rs6761637 [ dbSNP | Ensembl ].		VAR_024650
Experimental info
	Sequence conflict	13	1	L → F in AAD41064. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UEW3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8CFC5F6F99EEBA8D	FASTA	520	52,658
	10 20 30 40 50 60 MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV IYLILLTAGA 70 80 90 100 110 120 GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA HPGEHLAQGA SRLQVLQAQL 130 140 150 160 170 180 TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK 190 200 210 220 230 240 GAMGRDGATG PSGPQGPPGV KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK 250 260 270 280 290 300 GETGTKGEKG DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ 310 320 330 340 350 360 GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS KGDTGLQGQQ 370 380 390 400 410 420 GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG VKGSSGEQGV KGEKGERGEN 430 440 450 460 470 480 SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ 490 500 510 520 IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region." Elomaa O., Sankala M., Pikkarainen T., Bergmann U., Tuuttila A., Raatikainen-Ahokas A., Sariola H., Tryggvason K. J. Biol. Chem. 273:4530-4538(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISULFIDE BONDS.
[2]	"Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor." Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K. Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136, MASS SPECTROMETRY. Tissue: Plasma.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF035819 mRNA. Translation: AAC08800.1. AF128186 , AF128172, AF128173, AF128174, AF128175, AF128176, AF128177, AF128178, AF128179, AF128180, AF128181, AF128182, AF128183, AF128184, AF128185 Genomic DNA. Translation: AAD41064.1. BC016004 mRNA. Translation: AAH16004.1.
IPI	IPI00009521.
RefSeq	NP_006761.1. NM_006770.3.
UniGene	Hs.67726.
3D structure databases
ProteinModelPortal	Q9UEW3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UEW3. 1 interaction.
STRING	9606.ENSP00000318916.
PTM databases
PhosphoSite	Q9UEW3.
Polymorphism databases
DMDM	17380151.
Proteomic databases
PaxDb	Q9UEW3.
PeptideAtlas	Q9UEW3.
PRIDE	Q9UEW3.
Protocols and materials databases
DNASU	8685.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327097; ENSP00000318916; ENSG00000019169.
GeneID	8685.
KEGG	hsa:8685.
UCSC	uc002tln.1. human.
Organism-specific databases
CTD	8685.
GeneCards	GC02P119794.
HGNC	HGNC:6895. MARCO.
HPA	HPA008847.
MIM	604870. gene.
neXtProt	NX_Q9UEW3.
PharmGKB	PA30638.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297041.
HOGENOM	HOG000085659.
HOVERGEN	HBG004933.
InParanoid	Q9UEW3.
KO	K13884.
OMA	WVRVSHE.
OrthoDB	EOG4DZ1VK.
PhylomeDB	Q9UEW3.
Gene expression databases
ArrayExpress	Q9UEW3.
Bgee	Q9UEW3.
CleanEx	HS_MARCO.
Genevestigator	Q9UEW3.
GermOnline	ENSG00000019169. Homo sapiens.
Family and domain databases
InterPro	IPR008160. Collagen. IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF01391. Collagen. 4 hits. PF00530. SRCR. 1 hit. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 1 hit. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 1 hit.
PROSITE	PS00420. SRCR_1. 1 hit. PS50287. SRCR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8685.
NextBio	32573.
SOURCE	Search...

Entry information

Entry name

MARCO_HUMAN

Accession

Primary (citable) accession number: Q9UEW3
Secondary accession number(s): Q9Y5S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.