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Protein

Macrophage receptor MARCO

Gene

MARCO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).By similarity2 Publications

GO - Molecular functioni

  • G-protein coupled receptor binding Source: ARUK-UCL
  • scavenger receptor activity Source: InterPro
  • signaling pattern recognition receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-3000480. Scavenging by Class A Receptors.
SIGNORiQ9UEW3.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Scavenger receptor class A member 2
Gene namesi
Name:MARCO
Synonyms:SCARA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000019169.10.
HGNCiHGNC:6895. MARCO.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
Transmembranei44 – 64Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini65 – 520ExtracellularBy similarityAdd BLAST456

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8685.
OpenTargetsiENSG00000019169.
PharmGKBiPA30638.

Polymorphism and mutation databases

BioMutaiMARCO.
DMDMi17380151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001816301 – 520Macrophage receptor MARCOAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi447 ↔ 508PROSITE-ProRule annotation1 Publication
Disulfide bondi460 ↔ 518PROSITE-ProRule annotation1 Publication
Disulfide bondi488 ↔ 498PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UEW3.
PeptideAtlasiQ9UEW3.
PRIDEiQ9UEW3.

PTM databases

iPTMnetiQ9UEW3.
PhosphoSitePlusiQ9UEW3.

Expressioni

Tissue specificityi

Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).2 Publications

Gene expression databases

BgeeiENSG00000019169.
CleanExiHS_MARCO.
ExpressionAtlasiQ9UEW3. baseline and differential.
GenevisibleiQ9UEW3. HS.

Organism-specific databases

HPAiHPA063793.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: ARUK-UCL

Protein-protein interaction databases

BioGridi114232. 3 interactors.
IntActiQ9UEW3. 3 interactors.
STRINGi9606.ENSP00000318916.

Structurei

3D structure databases

ProteinModelPortaliQ9UEW3.
SMRiQ9UEW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 419Collagen-likeAdd BLAST273
Domaini424 – 519SRCRPROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHK7. Eukaryota.
ENOG410YHJF. LUCA.
GeneTreeiENSGT00900000140830.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ9UEW3.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG091G02XD.
PhylomeDBiQ9UEW3.
TreeFamiTF330855.

Family and domain databases

Gene3Di2.160.20.50. 4 hits.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR016133. Insect_cyst_antifreeze_prot.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR036772. SRCR-like_dom_sf.
PfamiView protein in Pfam
PF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
PRINTSiPR00258. SPERACTRCPTR.
SMARTiView protein in SMART
SM00202. SR. 1 hit.
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiView protein in PROSITE
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UEW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV
60 70 80 90 100
IYLILLTAGA GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA
110 120 130 140 150
HPGEHLAQGA SRLQVLQAQL TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ
160 170 180 190 200
GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK GAMGRDGATG PSGPQGPPGV
210 220 230 240 250
KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK GETGTKGEKG
260 270 280 290 300
DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ
310 320 330 340 350
GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS
360 370 380 390 400
KGDTGLQGQQ GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG
410 420 430 440 450
VKGSSGEQGV KGEKGERGEN SVSVRIVGSS NRGRAEVYYS GTWGTICDDE
460 470 480 490 500
WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK
510 520
NSWGHHDCSH EEDAGVECSV
Length:520
Mass (Da):52,658
Last modified:May 1, 2000 - v1
Checksum:i8CFC5F6F99EEBA8D
GO
Isoform 2 (identifier: Q9UEW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):43,865
Checksum:i7AE35AA6D0EB5DF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → F in AAD41064 (PubMed:10331948).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024650282F → S. Corresponds to variant dbSNP:rs6761637Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566981 – 78Missing in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035819 mRNA. Translation: AAC08800.1.
AF128186
, AF128172, AF128173, AF128174, AF128175, AF128176, AF128177, AF128178, AF128179, AF128180, AF128181, AF128182, AF128183, AF128184, AF128185 Genomic DNA. Translation: AAD41064.1.
AK301407 mRNA. Translation: BAG62941.1.
AC013457 Genomic DNA. No translation available.
BC016004 mRNA. Translation: AAH16004.1.
CCDSiCCDS2124.1. [Q9UEW3-1]
RefSeqiNP_006761.1. NM_006770.3. [Q9UEW3-1]
XP_011510384.1. XM_011512082.1. [Q9UEW3-1]
UniGeneiHs.67726.

Genome annotation databases

EnsembliENST00000327097; ENSP00000318916; ENSG00000019169. [Q9UEW3-1]
GeneIDi8685.
KEGGihsa:8685.
UCSCiuc002tln.2. human. [Q9UEW3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMARCO_HUMAN
AccessioniPrimary (citable) accession number: Q9UEW3
Secondary accession number(s): B4DW79, Q9Y5S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot