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Q9UEW3

- MARCO_HUMAN

UniProt

Q9UEW3 - MARCO_HUMAN

Protein

Macrophage receptor MARCO

Gene

MARCO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

    GO - Molecular functioni

    1. scavenger receptor activity Source: InterPro
    2. signaling pattern recognition receptor activity Source: ProtInc
    3. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. apoptotic cell clearance Source: Ensembl
    2. cell surface receptor signaling pathway Source: ProtInc
    3. innate immune response Source: UniProtKB-KW
    4. pattern recognition receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_163699. Scavenging by Class A Receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Macrophage receptor MARCO
    Alternative name(s):
    Macrophage receptor with collagenous structure
    Scavenger receptor class A member 2
    Gene namesi
    Name:MARCO
    Synonyms:SCARA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6895. MARCO.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. endocytic vesicle membrane Source: Reactome
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30638.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Macrophage receptor MARCOPRO_0000181630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi136 – 1361N-linked (GlcNAc...)2 Publications
    Disulfide bondi447 ↔ 5081 PublicationPROSITE-ProRule annotation
    Disulfide bondi460 ↔ 5181 PublicationPROSITE-ProRule annotation
    Disulfide bondi488 ↔ 4981 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UEW3.
    PeptideAtlasiQ9UEW3.
    PRIDEiQ9UEW3.

    PTM databases

    PhosphoSiteiQ9UEW3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UEW3.
    BgeeiQ9UEW3.
    CleanExiHS_MARCO.
    GenevestigatoriQ9UEW3.

    Organism-specific databases

    HPAiHPA008847.

    Interactioni

    Subunit structurei

    Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114232. 2 interactions.
    IntActiQ9UEW3. 1 interaction.
    STRINGi9606.ENSP00000318916.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UEW3.
    SMRiQ9UEW3. Positions 424-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 520456ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 419273Collagen-likeAdd
    BLAST
    Domaini424 – 51996SRCRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 collagen-like domain.Curated
    Contains 1 SRCR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297041.
    HOGENOMiHOG000085659.
    HOVERGENiHBG004933.
    InParanoidiQ9UEW3.
    KOiK13884.
    OMAiSHNCNHN.
    OrthoDBiEOG7HHWSF.
    PhylomeDBiQ9UEW3.
    TreeFamiTF330855.

    Family and domain databases

    Gene3Di3.10.250.10. 1 hit.
    InterProiIPR008160. Collagen.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view]
    PfamiPF01391. Collagen. 4 hits.
    PF00530. SRCR. 1 hit.
    [Graphical view]
    PRINTSiPR00258. SPERACTRCPTR.
    SMARTiSM00202. SR. 1 hit.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 1 hit.
    PROSITEiPS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UEW3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV    50
    IYLILLTAGA GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA 100
    HPGEHLAQGA SRLQVLQAQL TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ 150
    GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK GAMGRDGATG PSGPQGPPGV 200
    KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK GETGTKGEKG 250
    DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ 300
    GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS 350
    KGDTGLQGQQ GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG 400
    VKGSSGEQGV KGEKGERGEN SVSVRIVGSS NRGRAEVYYS GTWGTICDDE 450
    WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK 500
    NSWGHHDCSH EEDAGVECSV 520
    Length:520
    Mass (Da):52,658
    Last modified:May 1, 2000 - v1
    Checksum:i8CFC5F6F99EEBA8D
    GO
    Isoform 2 (identifier: Q9UEW3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:442
    Mass (Da):43,865
    Checksum:i7AE35AA6D0EB5DF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131L → F in AAD41064. (PubMed:10331948)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti282 – 2821F → S.
    Corresponds to variant rs6761637 [ dbSNP | Ensembl ].
    VAR_024650

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7878Missing in isoform 2. 1 PublicationVSP_056698Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035819 mRNA. Translation: AAC08800.1.
    AF128186
    , AF128172, AF128173, AF128174, AF128175, AF128176, AF128177, AF128178, AF128179, AF128180, AF128181, AF128182, AF128183, AF128184, AF128185 Genomic DNA. Translation: AAD41064.1.
    AK301407 mRNA. Translation: BAG62941.1.
    AC013457 Genomic DNA. No translation available.
    BC016004 mRNA. Translation: AAH16004.1.
    CCDSiCCDS2124.1.
    RefSeqiNP_006761.1. NM_006770.3.
    UniGeneiHs.67726.

    Genome annotation databases

    EnsembliENST00000327097; ENSP00000318916; ENSG00000019169.
    ENST00000541757; ENSP00000441769; ENSG00000019169.
    GeneIDi8685.
    KEGGihsa:8685.
    UCSCiuc002tln.1. human.

    Polymorphism databases

    DMDMi17380151.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035819 mRNA. Translation: AAC08800.1 .
    AF128186
    , AF128172 , AF128173 , AF128174 , AF128175 , AF128176 , AF128177 , AF128178 , AF128179 , AF128180 , AF128181 , AF128182 , AF128183 , AF128184 , AF128185 Genomic DNA. Translation: AAD41064.1 .
    AK301407 mRNA. Translation: BAG62941.1 .
    AC013457 Genomic DNA. No translation available.
    BC016004 mRNA. Translation: AAH16004.1 .
    CCDSi CCDS2124.1.
    RefSeqi NP_006761.1. NM_006770.3.
    UniGenei Hs.67726.

    3D structure databases

    ProteinModelPortali Q9UEW3.
    SMRi Q9UEW3. Positions 424-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114232. 2 interactions.
    IntActi Q9UEW3. 1 interaction.
    STRINGi 9606.ENSP00000318916.

    PTM databases

    PhosphoSitei Q9UEW3.

    Polymorphism databases

    DMDMi 17380151.

    Proteomic databases

    PaxDbi Q9UEW3.
    PeptideAtlasi Q9UEW3.
    PRIDEi Q9UEW3.

    Protocols and materials databases

    DNASUi 8685.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327097 ; ENSP00000318916 ; ENSG00000019169 .
    ENST00000541757 ; ENSP00000441769 ; ENSG00000019169 .
    GeneIDi 8685.
    KEGGi hsa:8685.
    UCSCi uc002tln.1. human.

    Organism-specific databases

    CTDi 8685.
    GeneCardsi GC02P119794.
    HGNCi HGNC:6895. MARCO.
    HPAi HPA008847.
    MIMi 604870. gene.
    neXtProti NX_Q9UEW3.
    PharmGKBi PA30638.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297041.
    HOGENOMi HOG000085659.
    HOVERGENi HBG004933.
    InParanoidi Q9UEW3.
    KOi K13884.
    OMAi SHNCNHN.
    OrthoDBi EOG7HHWSF.
    PhylomeDBi Q9UEW3.
    TreeFami TF330855.

    Enzyme and pathway databases

    Reactomei REACT_163699. Scavenging by Class A Receptors.

    Miscellaneous databases

    GeneWikii MARCO.
    GenomeRNAii 8685.
    NextBioi 32573.
    PROi Q9UEW3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UEW3.
    Bgeei Q9UEW3.
    CleanExi HS_MARCO.
    Genevestigatori Q9UEW3.

    Family and domain databases

    Gene3Di 3.10.250.10. 1 hit.
    InterProi IPR008160. Collagen.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view ]
    Pfami PF01391. Collagen. 4 hits.
    PF00530. SRCR. 1 hit.
    [Graphical view ]
    PRINTSi PR00258. SPERACTRCPTR.
    SMARTi SM00202. SR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 1 hit.
    PROSITEi PS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region."
      Elomaa O., Sankala M., Pikkarainen T., Bergmann U., Tuuttila A., Raatikainen-Ahokas A., Sariola H., Tryggvason K.
      J. Biol. Chem. 273:4530-4538(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISULFIDE BONDS.
    2. "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor."
      Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K.
      Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Synovium.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
      Tissue: Plasma.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
      Tissue: Liver.

    Entry informationi

    Entry nameiMARCO_HUMAN
    AccessioniPrimary (citable) accession number: Q9UEW3
    Secondary accession number(s): B4DW79, Q9Y5S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3