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Q9UEU5

- GGE2D_HUMAN

UniProt

Q9UEU5 - GGE2D_HUMAN

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Protein

G antigen 2D

Gene

GAGE2D

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular defense response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2D
Short name:
GAGE-2D
Alternative name(s):
Cancer/testis antigen 4.8
Short name:
CT4.8
G antigen 8
Short name:
GAGE-8
Gene namesi
Name:GAGE2D
AND
Name:GAGE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:31959. GAGE2D.
HGNC:4106. GAGE8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116G antigen 2DPRO_0000148346Add
BLAST

Proteomic databases

MaxQBiQ9UEU5.
PaxDbiQ9UEU5.

PTM databases

PhosphoSiteiQ9UEU5.

Expressioni

Tissue specificityi

Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.

Gene expression databases

BgeeiQ9UEU5.
CleanExiHS_GAGE8.
GenevestigatoriQ9UEU5.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GMCL1P1Q8NEA92EBI-751641,EBI-745707

Protein-protein interaction databases

IntActiQ9UEU5. 1 interaction.
MINTiMINT-1453243.

Structurei

3D structure databases

ProteinModelPortaliQ9UEU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG293879.
HOVERGENiHBG056227.
InParanoidiQ9UEU5.
OrthoDBiEOG7XM316.
PhylomeDBiQ9UEU5.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UEU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,764
Last modified:May 1, 2000 - v1
Checksum:iDD3052939E66F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055473 mRNA. Translation: AAC33676.1.
BX649339 Genomic DNA. Translation: CAI95422.1.
BC018052 mRNA. Translation: AAH18052.1.
BC143620 mRNA. Translation: AAI43621.1.
RefSeqiNP_001091877.1. NM_001098407.1.
NP_036328.1. NM_012196.1.
UniGeneiHs.695911.
Hs.695912.

Genome annotation databases

GeneIDi100101629.
729408.
KEGGihsa:100101629.
hsa:729408.
UCSCiuc004dnp.4. human.

Polymorphism databases

DMDMi21759147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055473 mRNA. Translation: AAC33676.1 .
BX649339 Genomic DNA. Translation: CAI95422.1 .
BC018052 mRNA. Translation: AAH18052.1 .
BC143620 mRNA. Translation: AAI43621.1 .
RefSeqi NP_001091877.1. NM_001098407.1.
NP_036328.1. NM_012196.1.
UniGenei Hs.695911.
Hs.695912.

3D structure databases

ProteinModelPortali Q9UEU5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9UEU5. 1 interaction.
MINTi MINT-1453243.

PTM databases

PhosphoSitei Q9UEU5.

Polymorphism databases

DMDMi 21759147.

Proteomic databases

MaxQBi Q9UEU5.
PaxDbi Q9UEU5.

Protocols and materials databases

DNASUi 100101629.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100101629.
729408.
KEGGi hsa:100101629.
hsa:729408.
UCSCi uc004dnp.4. human.

Organism-specific databases

CTDi 100101629.
729408.
GeneCardsi GC0XP049262.
GC0XU990292.
HGNCi HGNC:31959. GAGE2D.
HGNC:4106. GAGE8.
HPAi HPA043232.
MIMi 300638. gene.
300735. gene.
neXtProti NX_Q9UEU5.
PharmGKBi PA162389275.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293879.
HOVERGENi HBG056227.
InParanoidi Q9UEU5.
OrthoDBi EOG7XM316.
PhylomeDBi Q9UEU5.
TreeFami TF340669.

Miscellaneous databases

NextBioi 130155.
PROi Q9UEU5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UEU5.
CleanExi HS_GAGE8.
Genevestigatori Q9UEU5.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Placenta.
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGGE2D_HUMAN
AccessioniPrimary (citable) accession number: Q9UEU5
Secondary accession number(s): A6NG46
, A6NNR8, B7ZL76, Q4V325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3