Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G antigen 2D

Gene

GAGE2D

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular defense response Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068990-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2D
Short name:
GAGE-2D
Alternative name(s):
Cancer/testis antigen 4.8
Short name:
CT4.8
G antigen 8
Short name:
GAGE-8
Gene namesi
Name:GAGE2D
AND
Name:GAGE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31959. GAGE2D.
HGNC:4106. GAGE8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389275.

Polymorphism and mutation databases

BioMutaiGAGE2D.
DMDMi21759147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483461 – 116G antigen 2DAdd BLAST116

Proteomic databases

MaxQBiQ9UEU5.
PaxDbiQ9UEU5.
PeptideAtlasiQ9UEU5.
PRIDEiQ9UEU5.
TopDownProteomicsiQ9UEU5.

PTM databases

iPTMnetiQ9UEU5.
PhosphoSitePlusiQ9UEU5.

Expressioni

Tissue specificityi

Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.

Gene expression databases

BgeeiENSG00000240257.
CleanExiHS_GAGE8.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE75EBI-751641,EBI-10172181
GMCL1P1Q8NEA97EBI-751641,EBI-745707

Protein-protein interaction databases

IntActiQ9UEU5. 3 interactors.
MINTiMINT-1453243.

Structurei

3D structure databases

ProteinModelPortaliQ9UEU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOVERGENiHBG056227.
InParanoidiQ9UEU5.
PhylomeDBiQ9UEU5.
TreeFamiTF340669.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UEU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,764
Last modified:May 1, 2000 - v1
Checksum:iDD3052939E66F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055473 mRNA. Translation: AAC33676.1.
BX649339 Genomic DNA. Translation: CAI95422.1.
BC018052 mRNA. Translation: AAH18052.1.
BC143620 mRNA. Translation: AAI43621.1.
RefSeqiNP_001091877.1. NM_001098407.1.
NP_001120672.2. NM_001127200.2.
NP_036328.1. NM_012196.1.
UniGeneiHs.695912.

Genome annotation databases

GeneIDi100101629.
26749.
729408.
KEGGihsa:100101629.
hsa:26749.
hsa:729408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055473 mRNA. Translation: AAC33676.1.
BX649339 Genomic DNA. Translation: CAI95422.1.
BC018052 mRNA. Translation: AAH18052.1.
BC143620 mRNA. Translation: AAI43621.1.
RefSeqiNP_001091877.1. NM_001098407.1.
NP_001120672.2. NM_001127200.2.
NP_036328.1. NM_012196.1.
UniGeneiHs.695912.

3D structure databases

ProteinModelPortaliQ9UEU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UEU5. 3 interactors.
MINTiMINT-1453243.

PTM databases

iPTMnetiQ9UEU5.
PhosphoSitePlusiQ9UEU5.

Polymorphism and mutation databases

BioMutaiGAGE2D.
DMDMi21759147.

Proteomic databases

MaxQBiQ9UEU5.
PaxDbiQ9UEU5.
PeptideAtlasiQ9UEU5.
PRIDEiQ9UEU5.
TopDownProteomicsiQ9UEU5.

Protocols and materials databases

DNASUi100101629.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100101629.
26749.
729408.
KEGGihsa:100101629.
hsa:26749.
hsa:729408.

Organism-specific databases

CTDi100101629.
26749.
729408.
GeneCardsiGAGE2D.
GAGE8.
HGNCiHGNC:31959. GAGE2D.
HGNC:4106. GAGE8.
HPAiHPA043232.
MIMi300638. gene.
300735. gene.
neXtProtiNX_Q9UEU5.
PharmGKBiPA162389275.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOVERGENiHBG056227.
InParanoidiQ9UEU5.
PhylomeDBiQ9UEU5.
TreeFamiTF340669.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068990-MONOMER.

Miscellaneous databases

PROiQ9UEU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240257.
CleanExiHS_GAGE8.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGE2D_HUMAN
AccessioniPrimary (citable) accession number: Q9UEU5
Secondary accession number(s): A6NG46
, A6NNR8, B7ZL76, Q4V325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.