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Protein

G antigen 2D

Gene

GAGE2D

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

GO - Biological processi

  • cellular defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2D
Short name:
GAGE-2D
Alternative name(s):
Cancer/testis antigen 4.8
Short name:
CT4.8
G antigen 8
Short name:
GAGE-8
Gene namesi
Name:GAGE2D
AND
Name:GAGE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31959 GAGE2D
HGNC:4106 GAGE8
MIMi300638 gene
300735 gene
neXtProtiNX_Q9UEU5

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389275

Polymorphism and mutation databases

BioMutaiGAGE2D
DMDMi21759147

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483461 – 116G antigen 2DAdd BLAST116

Proteomic databases

MaxQBiQ9UEU5
PaxDbiQ9UEU5
PeptideAtlasiQ9UEU5
PRIDEiQ9UEU5
ProteomicsDBi84157
TopDownProteomicsiQ9UEU5

PTM databases

iPTMnetiQ9UEU5
PhosphoSitePlusiQ9UEU5

Expressioni

Tissue specificityi

Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.

Gene expression databases

CleanExiHS_GAGE8

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ9UEU5, 3 interactors
STRINGi9606.ENSP00000386110

Structurei

3D structure databases

ProteinModelPortaliQ9UEU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOVERGENiHBG056227
InParanoidiQ9UEU5
PhylomeDBiQ9UEU5
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UEU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,764
Last modified:May 1, 2000 - v1
Checksum:iDD3052939E66F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055473 mRNA Translation: AAC33676.1
BX649339 Genomic DNA Translation: CAI95422.1
BC018052 mRNA Translation: AAH18052.1
BC143620 mRNA Translation: AAI43621.1
RefSeqiNP_001091877.1, NM_001098407.1
NP_001120672.2, NM_001127200.2
NP_036328.1, NM_012196.1
UniGeneiHs.695912

Genome annotation databases

GeneIDi100101629
26749
729408
KEGGihsa:100101629
hsa:26749
hsa:729408

Similar proteinsi

Entry informationi

Entry nameiGGE2D_HUMAN
AccessioniPrimary (citable) accession number: Q9UEU5
Secondary accession number(s): A6NG46
, A6NNR8, B7ZL76, Q4V325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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