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Q9UEU5

- GGE2D_HUMAN

UniProt

Q9UEU5 - GGE2D_HUMAN

Protein

G antigen 2D

Gene

GAGE2D

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cellular defense response Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 2D
    Short name:
    GAGE-2D
    Alternative name(s):
    Cancer/testis antigen 4.8
    Short name:
    CT4.8
    G antigen 8
    Short name:
    GAGE-8
    Gene namesi
    Name:GAGE2D
    AND
    Name:GAGE8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:31959. GAGE2D.
    HGNC:4106. GAGE8.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162389275.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116G antigen 2DPRO_0000148346Add
    BLAST

    Proteomic databases

    MaxQBiQ9UEU5.
    PaxDbiQ9UEU5.

    PTM databases

    PhosphoSiteiQ9UEU5.

    Expressioni

    Tissue specificityi

    Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.

    Gene expression databases

    BgeeiQ9UEU5.
    CleanExiHS_GAGE8.
    GenevestigatoriQ9UEU5.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GMCL1P1Q8NEA92EBI-751641,EBI-745707

    Protein-protein interaction databases

    IntActiQ9UEU5. 1 interaction.
    MINTiMINT-1453243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UEU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG293879.
    HOVERGENiHBG056227.
    InParanoidiQ9UEU5.
    OrthoDBiEOG7XM316.
    PhylomeDBiQ9UEU5.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UEU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ    50
    DPAAAQEGED EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN 100
    PEEVKTPEEG EKQSQC 116
    Length:116
    Mass (Da):12,764
    Last modified:May 1, 2000 - v1
    Checksum:iDD3052939E66F19A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055473 mRNA. Translation: AAC33676.1.
    BX649339 Genomic DNA. Translation: CAI95422.1.
    BC018052 mRNA. Translation: AAH18052.1.
    BC143620 mRNA. Translation: AAI43621.1.
    CCDSiCCDS43941.1.
    RefSeqiNP_001091877.1. NM_001098407.1.
    NP_036328.1. NM_012196.1.
    UniGeneiHs.695911.
    Hs.695912.

    Genome annotation databases

    GeneIDi100101629.
    729408.
    KEGGihsa:100101629.
    hsa:729408.
    UCSCiuc004dnp.4. human.

    Polymorphism databases

    DMDMi21759147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055473 mRNA. Translation: AAC33676.1 .
    BX649339 Genomic DNA. Translation: CAI95422.1 .
    BC018052 mRNA. Translation: AAH18052.1 .
    BC143620 mRNA. Translation: AAI43621.1 .
    CCDSi CCDS43941.1.
    RefSeqi NP_001091877.1. NM_001098407.1.
    NP_036328.1. NM_012196.1.
    UniGenei Hs.695911.
    Hs.695912.

    3D structure databases

    ProteinModelPortali Q9UEU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UEU5. 1 interaction.
    MINTi MINT-1453243.

    PTM databases

    PhosphoSitei Q9UEU5.

    Polymorphism databases

    DMDMi 21759147.

    Proteomic databases

    MaxQBi Q9UEU5.
    PaxDbi Q9UEU5.

    Protocols and materials databases

    DNASUi 100101629.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100101629.
    729408.
    KEGGi hsa:100101629.
    hsa:729408.
    UCSCi uc004dnp.4. human.

    Organism-specific databases

    CTDi 100101629.
    729408.
    GeneCardsi GC0XP049257.
    GC0XU990292.
    HGNCi HGNC:31959. GAGE2D.
    HGNC:4106. GAGE8.
    HPAi HPA043232.
    MIMi 300638. gene.
    300735. gene.
    neXtProti NX_Q9UEU5.
    PharmGKBi PA162389275.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293879.
    HOVERGENi HBG056227.
    InParanoidi Q9UEU5.
    OrthoDBi EOG7XM316.
    PhylomeDBi Q9UEU5.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 130155.
    PROi Q9UEU5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UEU5.
    CleanExi HS_GAGE8.
    Genevestigatori Q9UEU5.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Placenta.
    4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGGE2D_HUMAN
    AccessioniPrimary (citable) accession number: Q9UEU5
    Secondary accession number(s): A6NG46
    , A6NNR8, B7ZL76, Q4V325
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3