Vesicle transport through interaction with t-SNAREs homolog 1B

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

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Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

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Q9UEU0 (VTI1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1B

Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 1
Vti1-rp1

Gene names

Name:	VTI1B
Synonyms:	VTI1, VTI1L, VTI1L1, VTI2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Function	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Subunit structure	Found in a complex with VAMP8 and STX7 in the liver. Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, STX8 and VAMP8 By similarity.
Subcellular location	Endomembrane system; Single-pass type IV membrane protein. Cytoplasmic granule.
Tissue specificity	Expressed in all tissues examined.
Sequence similarities	Belongs to the VTI1 family.

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.1. Source: ProtInc cellular membrane fusion Traceable author statement Ref.1. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle docking involved in exocytosis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 19224922. Source: UniProtKB endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 232

232

Vesicle transport through interaction with t-SNAREs homolog 1B

PRO_0000218228

Topological domain

1 – 208

208

Cytoplasmic Potential

Transmembrane

209 – 229

Helical; Anchor for type IV membrane protein; Potential

Topological domain

230 – 232

Vesicular Potential

Coiled coil

35 – 98

Potential

Coiled coil

161 – 198

Potential

Alternative sequence

1 – 61

Missing in isoform Short.

VSP_006753

Sequence conflict

D → N in AAC52016. Ref.1

232

Helix Strand Turn

Details...

Sequence		Length	Mass (Da)
Isoform Long [UniParc]. Last modified February 20, 2007. Version 3. Checksum: B421C2863235B9B1 Show »	FASTA	232	26,688
10 20 30 40 50 60 MASSAASSEH FEKLHEIFRG LHEDLQGVPE RLLGTAGTEE KKKLIRDFDE KQQEANETLA 70 80 90 100 110 120 EMEEELRYAP LSFRNPMMSK LRNYRKDLAK LHREVRSTPL TATPGGRGDM KYGIYAVENE 130 140 150 160 170 180 HMNRLQSQRA MLLQGTESLN RATQSIERSH RIATETDQIG SEIIEELGEQ RDQLERTKSR 190 200 210 220 230 LVNTSENLSK SRKILRSMSR KVTTNKLLLS IIILLELAIL GGLVYYKFFR SH « Hide
Isoform Short [UniParc]. Checksum: 7BC64529E0DBE12C Show »	FASTA	171	19,810
10 20 30 40 50 60 MEEELRYAPL SFRNPMMSKL RNYRKDLAKL HREVRSTPLT ATPGGRGDMK YGIYAVENEH 70 80 90 100 110 120 MNRLQSQRAM LLQGTESLNR ATQSIERSHR IATETDQIGS EIIEELGEQR DQLERTKSRL 130 140 150 160 170 VNTSENLSKS RKILRSMSRK VTTNKLLLSI IILLELAILG GLVYYKFFRS H « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways." Fischer von Mollard G., Stevens T.H. J. Biol. Chem. 273:2624-2630(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT). Tissue: Glioblastoma and Hypothalamus.
[2]	"A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts." Li H.-C., Tahara H., Tsuyama N., Ide T. Biochem. Biophys. Res. Commun. 247:70-74(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Fibroblast.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). Tissue: Kidney.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

EMBL
GenBank
DDBJ

AF035824 mRNA. Translation: AAC52016.1.
AF060902 mRNA. Translation: AAC73059.1.
CR456757 mRNA. Translation: CAG33038.1.
CR542095 mRNA. Translation: CAG46892.1.
BT019348 mRNA. Translation: AAV38155.1.
BC003142 mRNA. Translation: AAH03142.1.

IPI

IPI00063784.
IPI00386818.

RefSeq

NP_006361.1. NM_006370.2.

UniGene

Hs.741177.

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2V8S	X-ray	2.22	V	1-96	[»]

ProteinModelPortal

Q9UEU0.

ModBase

Search...

IntAct

Q9UEU0. 5 interactions.

MINT

MINT-1429590.

STRING

9606.ENSP00000216456.

PhosphoSite

Q9UEU0.

DMDM

126302613.

PaxDb

Q9UEU0.

PRIDE

Q9UEU0.

DNASU

10490.

StructuralBiologyKnowledgebase

Search...

Ensembl

ENST00000554659; ENSP00000450731; ENSG00000100568.

GeneID

10490.

KEGG

hsa:10490.

UCSC

uc001xjt.3. human.

CTD

10490.

GeneCards

GC14M068117.

HGNC

HGNC:17793. VTI1B.

MIM

603207. gene.

neXtProt

NX_Q9UEU0.

PharmGKB

PA134861090.

GenAtlas

Search...

eggNOG

NOG291765.

HOGENOM

HOG000116573.

HOVERGEN

HBG058837.

InParanoid

Q9UEU0.

K08493.

OMA

MMSKLRT.

OrthoDB

EOG4M399K.

PhylomeDB

Q9UEU0.

ArrayExpress

Q9UEU0.

Bgee

Q9UEU0.

Genevestigator

Q9UEU0.

GermOnline

ENSG00000100568. Homo sapiens.

InterPro

IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]

Pfam

PF05008. V-SNARE. 1 hit.
[Graphical view]

SMART

SM00397. t_SNARE. 1 hit.
[Graphical view]

SUPFAM

SSF47661. t-snare. 1 hit.

ProtoNet

Search...

ChiTaRS

VTI1B. human.

EvolutionaryTrace

Q9UEU0.

GenomeRNAi

10490.

NextBio

39804.

SOURCE

Search...

Entry name

VTI1B_HUMAN

Accession

Primary (citable) accession number: Q9UEU0
Secondary accession number(s): O43547, Q96J28

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: Q9UEU0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: Q9UEU0-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-61: Missing.