Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

24-kDa subunit of complex I

Gene

NDUFV2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

[2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron-sulfur (2Fe-2S)UniRule annotation
Metal bindingi122 – 1221Iron-sulfur (2Fe-2S)UniRule annotation
Metal bindingi158 – 1581Iron-sulfur (2Fe-2S)UniRule annotation
Metal bindingi162 – 1621Iron-sulfur (2Fe-2S)UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

2Fe-2SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
24-kDa subunit of complex IImported (EC:1.6.5.3Imported)
Gene namesi
Name:NDUFV2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ9UEH5.
PeptideAtlasiQ9UEH5.
PRIDEiQ9UEH5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327268.

Structurei

3D structure databases

ProteinModelPortaliQ9UEH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3196. Eukaryota.
COG1905. LUCA.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UEH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRHVRNLHKT AMQNGAGGAL FVHRDTPENN PDTPFDFTPE NYKRIEAIVK
60 70 80 90 100
NYPEGHKAAA VLPVLDLAQR QNGWLPISAM NKVAEVLQVP PMRVYEVATF
110 120 130 140 150
YTMYNRKPVG KYYIQVCTTT PCMLRNSDSI LEAIQKKLGI KVGETTPDKL
160 170 180 190 200
FTLIEVECLG ACVNAPMVQI NDNYYEDLTA KDIEEIIDEL KAGKIPKPGP
210 220 230
RSGRFSCEPA GGLTSLTEPP KGPGFGVQAG L
Length:231
Mass (Da):25,430
Last modified:May 1, 2000 - v1
Checksum:i3D82E318D3B86068
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88548 Genomic DNA. Translation: BAA25988.1.
UniGeneiHs.464572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88548 Genomic DNA. Translation: BAA25988.1.
UniGeneiHs.464572.

3D structure databases

ProteinModelPortaliQ9UEH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327268.

Proteomic databases

PaxDbiQ9UEH5.
PeptideAtlasiQ9UEH5.
PRIDEiQ9UEH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3196. Eukaryota.
COG1905. LUCA.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.

Miscellaneous databases

ChiTaRSiNDUFV2. human.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease."
    Hattori N., Yoshino H., Tanaka M., Suzuki H., Mizuno Y.
    Genomics 49:52-58(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UEH5_HUMAN
AccessioniPrimary (citable) accession number: Q9UEH5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.