Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 629

Gene

ZNF629

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri569 – 59123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri842 – 86423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 629
Alternative name(s):
Zinc finger protein 65
Gene namesi
Name:ZNF629
Synonyms:KIAA0326, ZNF65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29008. ZNF629.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930939.

Polymorphism and mutation databases

BioMutaiZNF629.
DMDMi134035371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Zinc finger protein 629PRO_0000280426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei616 – 6161PhosphoserineCombined sources
Cross-linki688 – 688Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki840 – 840Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UEG4.
MaxQBiQ9UEG4.
PaxDbiQ9UEG4.
PRIDEiQ9UEG4.

PTM databases

iPTMnetiQ9UEG4.
PhosphoSiteiQ9UEG4.

Expressioni

Gene expression databases

BgeeiQ9UEG4.
CleanExiHS_ZNF629.
GenevisibleiQ9UEG4. HS.

Organism-specific databases

HPAiHPA019550.
HPA056051.

Interactioni

Protein-protein interaction databases

BioGridi116942. 12 interactions.
IntActiQ9UEG4. 1 interaction.
STRINGi9606.ENSP00000262525.

Structurei

3D structure databases

ProteinModelPortaliQ9UEG4.
SMRiQ9UEG4. Positions 142-865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri569 – 59123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri842 – 86423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UEG4.
OMAiPTPSDWT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UEG4.
TreeFamiTF350847.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UEG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPETALWGP DLQGPEQSPN DAHRGAESEN EEESPRQESS GEEIIMGDPA
60 70 80 90 100
QSPESKDSTE MSLERSSQDP SVPQNPPTPL GHSNPLDHQI PLDPPAPEVV
110 120 130 140 150
PTPSDWTKAC EASWQWGALT TWNSPPVVPA NEPSLRELVQ GRPAGAEKPY
160 170 180 190 200
ICNECGKSFS QWSKLLRHQR IHTGERPNTC SECGKSFTQS SHLVQHQRTH
210 220 230 240 250
TGEKPYKCPD CGKCFSWSSN LVQHQRTHTG EKPYKCTECE KAFTQSTNLI
260 270 280 290 300
KHQRSHTGEK PYKCGECRRA FYRSSDLIQH QATHTGEKPY KCPECGKRFG
310 320 330 340 350
QNHNLLKHQK IHAGEKPYRC TECGKSFIQS SELTQHQRTH TGEKPYECLE
360 370 380 390 400
CGKSFGHSST LIKHQRTHLR EDPFKCPVCG KTFTLSATLL RHQRTHTGER
410 420 430 440 450
PYKCPECGKS FSVSSNLINH QRIHRGERPY ICADCGKSFI MSSTLIRHQR
460 470 480 490 500
IHTGEKPYKC SDCGKSFIRS SHLIQHRRTH TGEKPYKCPE CGKSFSQSSN
510 520 530 540 550
LITHVRTHMD ENLFVCSDCG KAFLEAHELE QHRVIHERGK TPARRAQGDS
560 570 580 590 600
LLGLGDPSLL TPPPGAKPHK CLVCGKGFND EGIFMQHQRI HIGENPYKNA
610 620 630 640 650
DGLIAHAAPK PPQLRSPRLP FRGNSYPGAA EGRAEAPGQP LKPPEGQEGF
660 670 680 690 700
SQRRGLLSSK TYICSHCGES FLDRSVLLQH QLTHGNEKPF LFPDYRIGLG
710 720 730 740 750
EGAGPSPFLS GKPFKCPECK QSFGLSSELL LHQKVHAGGK SSQKSPELGK
760 770 780 790 800
SSSVLLEHLR SPLGARPYRC SDCRASFLDR VALTRHQETH TQEKPPNPED
810 820 830 840 850
PPPEAVTLST DQEGEGETPT PTESSSHGEG QNPKTLVEEK PYLCPECGAG
860
FTEVAALLLH RSCHPGVSL
Length:869
Mass (Da):96,620
Last modified:March 20, 2007 - v2
Checksum:iA3C1B86589BD57F5
GO

Sequence cautioni

The sequence BAA20784.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti707 – 7071P → A.
Corresponds to variant rs8050758 [ dbSNP | Ensembl ].
VAR_052883

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002324 mRNA. Translation: BAA20784.1. Different initiation.
M88374 Genomic DNA. Translation: AAA61332.1.
CCDSiCCDS45463.1.
PIRiH45193.
RefSeqiNP_001073886.1. NM_001080417.1.
UniGeneiHs.301094.

Genome annotation databases

EnsembliENST00000262525; ENSP00000262525; ENSG00000102870.
GeneIDi23361.
KEGGihsa:23361.
UCSCiuc002dzs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002324 mRNA. Translation: BAA20784.1. Different initiation.
M88374 Genomic DNA. Translation: AAA61332.1.
CCDSiCCDS45463.1.
PIRiH45193.
RefSeqiNP_001073886.1. NM_001080417.1.
UniGeneiHs.301094.

3D structure databases

ProteinModelPortaliQ9UEG4.
SMRiQ9UEG4. Positions 142-865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116942. 12 interactions.
IntActiQ9UEG4. 1 interaction.
STRINGi9606.ENSP00000262525.

PTM databases

iPTMnetiQ9UEG4.
PhosphoSiteiQ9UEG4.

Polymorphism and mutation databases

BioMutaiZNF629.
DMDMi134035371.

Proteomic databases

EPDiQ9UEG4.
MaxQBiQ9UEG4.
PaxDbiQ9UEG4.
PRIDEiQ9UEG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262525; ENSP00000262525; ENSG00000102870.
GeneIDi23361.
KEGGihsa:23361.
UCSCiuc002dzs.1. human.

Organism-specific databases

CTDi23361.
GeneCardsiZNF629.
HGNCiHGNC:29008. ZNF629.
HPAiHPA019550.
HPA056051.
neXtProtiNX_Q9UEG4.
PharmGKBiPA134930939.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UEG4.
OMAiPTPSDWT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UEG4.
TreeFamiTF350847.

Miscellaneous databases

ChiTaRSiZNF629. human.
GenomeRNAii23361.
NextBioi45395.
PROiQ9UEG4.

Gene expression databases

BgeeiQ9UEG4.
CleanExiHS_ZNF629.
GenevisibleiQ9UEG4. HS.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Characterization and mapping of human genes encoding zinc finger proteins."
    Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-255.
    Tissue: Placenta.
  3. "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes."
    Lichter P., Bray P., Ried T., Dawid I.B., Ward D.C.
    Genomics 13:999-1007(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-616, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-688 AND LYS-840, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN629_HUMAN
AccessioniPrimary (citable) accession number: Q9UEG4
Secondary accession number(s): Q15938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.