ID   Q9UE57_HUMAN            Unreviewed;        68 AA.
AC   Q9UE57;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 101.
DE   RecName: Full=Platelet-derived growth factor subunit B {ECO:0000256|ARBA:ARBA00018117};
DE   AltName: Full=PDGF-2 {ECO:0000256|ARBA:ARBA00031888};
DE   AltName: Full=Platelet-derived growth factor B chain {ECO:0000256|ARBA:ARBA00032481};
DE   AltName: Full=Platelet-derived growth factor beta polypeptide {ECO:0000256|ARBA:ARBA00032702};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAA25227.1};
RN   [1] {ECO:0000313|EMBL:CAA25227.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6329745;
RA   Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F.,
RA   Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P.,
RA   Waterfield M.D.;
RT   "The c-sis gene encodes a precursor of the B chain of platelet-derived
RT   growth factor.";
RL   EMBO J. 3:921-928(1984).
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X00560; CAA25227.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UE57; -.
DR   PeptideAtlas; Q9UE57; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:UniProt.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR   PANTHER; PTHR11633:SF2; PLATELET-DERIVED GROWTH FACTOR SUBUNIT B; 1.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU003818};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          1..68
FT                   /note="Platelet-derived growth factor (PDGF) family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50278"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAA25227.1"
FT   NON_TER         68
FT                   /evidence="ECO:0000313|EMBL:CAA25227.1"
SQ   SEQUENCE   68 AA;  7791 MW;  F649D9CB18AFE7BA CRC64;
     SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC NNRNVQCRPT
     QVQLRPVQ
//