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Q9UE57

- Q9UE57_HUMAN

UniProt

Q9UE57 - Q9UE57_HUMAN

Protein
Submitted name:

Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. blood vessel morphogenesis Source: Ensembl
    3. branching involved in salivary gland morphogenesis Source: Ensembl
    4. cell growth Source: Ensembl
    5. cell projection assembly Source: Ensembl
    6. cellular response to mycophenolic acid Source: Ensembl
    7. DNA replication Source: Ensembl
    8. embryonic placenta development Source: Ensembl
    9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    10. heart development Source: Ensembl
    11. metanephric glomerular endothelium development Source: Ensembl
    12. metanephric glomerular mesangial cell development Source: Ensembl
    13. metanephric glomerular mesangial cell proliferation involved in metanephros development Source: Ensembl
    14. negative regulation of cell migration Source: Ensembl
    15. paracrine signaling Source: Ensembl
    16. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    17. positive regulation of cell division Source: UniProtKB-KW
    18. positive regulation of endothelial cell proliferation Source: Ensembl
    19. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    20. positive regulation of glomerular filtration Source: Ensembl
    21. positive regulation of MAP kinase activity Source: Ensembl
    22. positive regulation of metanephric mesenchymal cell migration Source: Ensembl
    23. positive regulation of smooth muscle cell migration Source: Ensembl
    24. positive regulation of smooth muscle cell proliferation Source: Ensembl
    25. positive regulation of transcription, DNA-templated Source: Ensembl
    26. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    27. response to drug Source: Ensembl
    28. response to estradiol Source: Ensembl
    29. response to hypoxia Source: Ensembl
    30. response to insulin Source: Ensembl
    31. substrate-dependent cell migration Source: Ensembl
    32. transforming growth factor beta receptor signaling pathway Source: Ensembl
    33. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. cytoplasm Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UE57.
    BgeeiQ9UE57.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UE57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.UniRule annotation

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UE57-1 [UniParc]FASTAAdd to Basket

    « Hide

    SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC   50
    NNRNVQCRPT QVQLRPVQ 68
    Length:68
    Mass (Da):7,791
    Last modified:May 1, 2000 - v1
    Checksum:iF649D9CB18AFE7BA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei68 – 681Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00560 Genomic DNA. Translation: CAA25227.1.
    UniGeneiHs.1976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00560 Genomic DNA. Translation: CAA25227.1 .
    UniGenei Hs.1976.

    3D structure databases

    ProteinModelPortali Q9UE57.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q9UE57.
    Bgeei Q9UE57.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
      Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F., Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P., Waterfield M.D.
      EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UE57_HUMAN
    AccessioniPrimary (citable) accession number: Q9UE57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.