Q9UE57 (Q9UE57_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor) EMBL CAA25227.1
Organism	Homo sapiens (Human) EMBL CAA25227.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	68 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
Molecular function	Growth factor RuleBase RU003818 SAAS SAAS023581 Mitogen RuleBase RU003819
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: Compara actin cytoskeleton organization Inferred from electronic annotation. Source: Compara blood vessel morphogenesis Inferred from electronic annotation. Source: Compara branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara cell growth Inferred from electronic annotation. Source: Compara cell projection assembly Inferred from electronic annotation. Source: Compara cellular response to mycophenolic acid Inferred from electronic annotation. Source: Compara embryonic placenta development Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara metanephric glomerular endothelium development Inferred from electronic annotation. Source: Compara metanephric glomerular mesangial cell development Inferred from electronic annotation. Source: Compara metanephric glomerular mesangial cell proliferation involved in metanephros development Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara paracrine signaling Inferred from electronic annotation. Source: Compara platelet-derived growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of glomerular filtration Inferred from electronic annotation. Source: Compara positive regulation of metanephric mesenchymal cell migration Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara substrate-dependent cell migration Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	cell surface binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAA25227.1
	Non-terminal residue	68	1	EMBL CAA25227.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UE57 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F649D9CB18AFE7BA	FASTA	68	7,791
	10 20 30 40 50 60 SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC NNRNVQCRPT QVQLRPVQ

References

[1]	"The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor." Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F., Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P., Waterfield M.D. EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00560 Genomic DNA. Translation: CAA25227.1.
IPI	IPI00877974.
UniGene	Hs.1976.
3D structure databases
HSSP	HSSP built from PDB template 1PDG based on UniProtKB P01127.
ProteinModelPortal	Q9UE57.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UE57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q9UE57.
Bgee	Q9UE57.
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. [Graphical view]
Pfam	PF00341. PDGF. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UE57_HUMAN

Accession

Primary (citable) accession number: Q9UE57

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.