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Q9UE57

- Q9UE57_HUMAN

UniProt

Q9UE57 - Q9UE57_HUMAN

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Protein
Submitted name: Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

GO - Biological processi

  1. DNA replication Source: Ensembl
  2. actin cytoskeleton organization Source: Ensembl
  3. blood vessel morphogenesis Source: Ensembl
  4. branching involved in salivary gland morphogenesis Source: Ensembl
  5. cell growth Source: Ensembl
  6. cell projection assembly Source: Ensembl
  7. cellular response to mycophenolic acid Source: Ensembl
  8. embryonic placenta development Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. heart development Source: Ensembl
  11. metanephric glomerular endothelium development Source: Ensembl
  12. metanephric glomerular mesangial cell development Source: Ensembl
  13. metanephric glomerular mesangial cell proliferation involved in metanephros development Source: Ensembl
  14. negative regulation of cell migration Source: Ensembl
  15. paracrine signaling Source: Ensembl
  16. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  17. positive regulation of MAP kinase activity Source: Ensembl
  18. positive regulation of cell division Source: UniProtKB-KW
  19. positive regulation of endothelial cell proliferation Source: Ensembl
  20. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  21. positive regulation of glomerular filtration Source: Ensembl
  22. positive regulation of metanephric mesenchymal cell migration Source: Ensembl
  23. positive regulation of smooth muscle cell migration Source: Ensembl
  24. positive regulation of smooth muscle cell proliferation Source: Ensembl
  25. positive regulation of transcription, DNA-templated Source: Ensembl
  26. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to estradiol Source: Ensembl
  29. response to hypoxia Source: Ensembl
  30. response to insulin Source: Ensembl
  31. substrate-dependent cell migration Source: Ensembl
  32. transforming growth factor beta receptor signaling pathway Source: Ensembl
  33. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotations, MitogenUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ9UE57.
BgeeiQ9UE57.

Structurei

3D structure databases

ProteinModelPortaliQ9UE57.

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotation

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UE57-1 [UniParc]FASTAAdd to Basket

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SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC   50
NNRNVQCRPT QVQLRPVQ 68
Length:68
Mass (Da):7,791
Last modified:May 1, 2000 - v1
Checksum:iF649D9CB18AFE7BA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei68 – 681Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00560 Genomic DNA. Translation: CAA25227.1.
UniGeneiHs.1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00560 Genomic DNA. Translation: CAA25227.1 .
UniGenei Hs.1976.

3D structure databases

ProteinModelPortali Q9UE57.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q9UE57.
Bgeei Q9UE57.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view ]
Pfami PF00341. PDGF. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
    Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F., Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P., Waterfield M.D.
    EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UE57_HUMAN
AccessioniPrimary (citable) accession number: Q9UE57
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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