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Q9UE57 (Q9UE57_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismHomo sapiens (Human) EMBL CAA25227.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
   Molecular functionGrowth factor SAAS SAAS000072 RuleBase RU003818
Mitogen SAAS SAAS029034 RuleBase RU003819
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: Ensembl

actin cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

blood vessel morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell growth

Inferred from electronic annotation. Source: Ensembl

cell projection assembly

Inferred from electronic annotation. Source: Ensembl

cellular response to mycophenolic acid

Inferred from electronic annotation. Source: Ensembl

embryonic placenta development

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

metanephric glomerular endothelium development

Inferred from electronic annotation. Source: Ensembl

metanephric glomerular mesangial cell development

Inferred from electronic annotation. Source: Ensembl

metanephric glomerular mesangial cell proliferation involved in metanephros development

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

paracrine signaling

Inferred from electronic annotation. Source: Ensembl

platelet-derived growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of glomerular filtration

Inferred from electronic annotation. Source: Ensembl

positive regulation of metanephric mesenchymal cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

substrate-dependent cell migration

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL CAA25227.1
Non-terminal residue681 EMBL CAA25227.1

Sequences

Sequence LengthMass (Da)Tools
Q9UE57 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F649D9CB18AFE7BA

FASTA687,791
        10         20         30         40         50         60 
SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC NNRNVQCRPT 


QVQLRPVQ 

« Hide

References

[1]"The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F., Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P., Waterfield M.D.
EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00560 Genomic DNA. Translation: CAA25227.1.
UniGeneHs.1976.

3D structure databases

ProteinModelPortalQ9UE57.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ9UE57.
BgeeQ9UE57.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9UE57_HUMAN
AccessionPrimary (citable) accession number: Q9UE57
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.