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Protein
Submitted name:

Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. blood vessel morphogenesis Source: Ensembl
  3. branching involved in salivary gland morphogenesis Source: Ensembl
  4. cell growth Source: Ensembl
  5. cell projection assembly Source: Ensembl
  6. cellular response to mycophenolic acid Source: Ensembl
  7. DNA replication Source: Ensembl
  8. embryonic placenta development Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. heart development Source: Ensembl
  11. metanephric glomerular endothelium development Source: Ensembl
  12. metanephric glomerular mesangial cell development Source: Ensembl
  13. metanephric glomerular mesangial cell proliferation involved in metanephros development Source: Ensembl
  14. negative regulation of cell migration Source: Ensembl
  15. paracrine signaling Source: Ensembl
  16. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  17. positive regulation of cell division Source: UniProtKB-KW
  18. positive regulation of endothelial cell proliferation Source: Ensembl
  19. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  20. positive regulation of glomerular filtration Source: Ensembl
  21. positive regulation of MAP kinase activity Source: Ensembl
  22. positive regulation of metanephric mesenchymal cell migration Source: Ensembl
  23. positive regulation of smooth muscle cell migration Source: Ensembl
  24. positive regulation of smooth muscle cell proliferation Source: Ensembl
  25. positive regulation of transcription, DNA-templated Source: Ensembl
  26. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to estradiol Source: Ensembl
  29. response to hypoxia Source: Ensembl
  30. response to insulin Source: Ensembl
  31. substrate-dependent cell migration Source: Ensembl
  32. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation, MitogenUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene c-sis for PDGF B chain (platelet-derived growth factor)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9UE57.
ExpressionAtlasiQ9UE57. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UE57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotation

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UE57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SLTIAEPAMI AECKTRTEVF EISRRLIDRT NANFLVWPPC VEVQRCSGCC
60
NNRNVQCRPT QVQLRPVQ
Length:68
Mass (Da):7,791
Last modified:May 1, 2000 - v1
Checksum:iF649D9CB18AFE7BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei68 – 681Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00560 Genomic DNA. Translation: CAA25227.1.
UniGeneiHs.1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00560 Genomic DNA. Translation: CAA25227.1.
UniGeneiHs.1976.

3D structure databases

ProteinModelPortaliQ9UE57.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9UE57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ9UE57.
ExpressionAtlasiQ9UE57. baseline and differential.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
    Johnsson A., Heldin C.H., Wasteson A., Westermark B., Deuel T.F., Huang J.S., Seeburg P.H., Gray A., Ullrich A., Scrace G., Stroobant P., Waterfield M.D.
    EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UE57_HUMAN
AccessioniPrimary (citable) accession number: Q9UE57
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.