Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UE35

- Q9UE35_HUMAN

UniProt

Q9UE35 - Q9UE35_HUMAN

Protein
Submitted name:

Estrogen receptor

Gene

estrogen receptor

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: InterPro
    3. estrogen receptor activity Source: InterPro
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    5. steroid binding Source: InterPro

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. antral ovarian follicle growth Source: Ensembl
    3. cellular response to estrogen stimulus Source: Ensembl
    4. epithelial cell development Source: Ensembl
    5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    6. male gonad development Source: Ensembl
    7. mammary gland alveolus development Source: Ensembl
    8. mammary gland branching involved in pregnancy Source: Ensembl
    9. positive regulation of fibroblast proliferation Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    12. prostate epithelial cord elongation Source: Ensembl
    13. regulation of apoptotic process Source: Ensembl
    14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    15. uterus development Source: Ensembl
    16. vagina development Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Estrogen receptorImported
    Submitted name:
    Estrogen receptor proteinImported
    Gene namesi
    Name:estrogen receptorImported
    Synonyms:ESR1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:3467. ESR1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000202497.
    HOVERGENiHBG108344.

    Family and domain databases

    InterProiIPR001292. Oestr_rcpt.
    [Graphical view]
    PfamiPF02159. Oest_recep. 1 hit.
    [Graphical view]
    PRINTSiPR00543. OESTROGENR.

    Sequencei

    Sequence statusi: Fragment.

    Q9UE35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA    50
    VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 100
    NSVSPSPLML LHPPP 115
    Length:115
    Mass (Da):12,088
    Last modified:May 1, 2000 - v1
    Checksum:i370CC8A5AF3300B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei115 – 1151Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035695 Genomic DNA. No translation available.
    AL049821 Genomic DNA. No translation available.
    AL078582 Genomic DNA. No translation available.
    AL356311 Genomic DNA. No translation available.
    AL590993 Genomic DNA. No translation available.
    KF454881 Genomic DNA. No translation available.
    KF458326 Genomic DNA. No translation available.
    KF458327 Genomic DNA. No translation available.
    X62462 Genomic DNA. Translation: CAA44322.1.
    PIRiA94284. QRHUE.
    UniGeneiHs.208124.
    Hs.744830.

    Genome annotation databases

    EnsembliENST00000446550; ENSP00000411105; ENSG00000091831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035695 Genomic DNA. No translation available.
    AL049821 Genomic DNA. No translation available.
    AL078582 Genomic DNA. No translation available.
    AL356311 Genomic DNA. No translation available.
    AL590993 Genomic DNA. No translation available.
    KF454881 Genomic DNA. No translation available.
    KF458326 Genomic DNA. No translation available.
    KF458327 Genomic DNA. No translation available.
    X62462 Genomic DNA. Translation: CAA44322.1 .
    PIRi A94284. QRHUE.
    UniGenei Hs.208124.
    Hs.744830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000446550 ; ENSP00000411105 ; ENSG00000091831 .

    Organism-specific databases

    HGNCi HGNC:3467. ESR1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000202497.
    HOVERGENi HBG108344.

    Miscellaneous databases

    ChiTaRSi ESR1. human.

    Family and domain databases

    InterProi IPR001292. Oestr_rcpt.
    [Graphical view ]
    Pfami PF02159. Oest_recep. 1 hit.
    [Graphical view ]
    PRINTSi PR00543. OESTROGENR.
    ProtoNeti Search...

    Publicationsi

    1. "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."
      Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., Chambon P.
      Nature 320:134-139(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BreastImported.
    2. "Genomic organisation of the human oestrogen receptor gene."
      Ponglikitmongkol M, Green S., Chambon P.
      EMBO J. 7:3385-3388(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BreastImported.
    3. "Sequence analysis of the 5' flanking region of the human estrogen receptor gene."
      Keaveney M., Klug J., Gannon F.
      DNA Seq. 2:347-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BreastImported.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ9UE35_HUMAN
    AccessioniPrimary (citable) accession number: Q9UE35
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3