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Q9UE35 (Q9UE35_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Estrogen receptor protein EMBL CAA44322.1
Gene names
Name:estrogen receptor EMBL CAA44322.1
Synonyms:ESR1 Ensembl ENSP00000411105
OrganismHomo sapiens (Human) [Reference proteome] EMBL CAA44322.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length115 AA.
Sequence statusFragment.
Protein existencePredicted

Ontologies

Keywords
   Molecular functionReceptor EMBL CAA44322.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processandrogen metabolic process

Inferred from electronic annotation. Source: Ensembl

antral ovarian follicle growth

Inferred from electronic annotation. Source: Ensembl

cellular response to estrogen stimulus

Inferred from electronic annotation. Source: Ensembl

epithelial cell development

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation involved in mammary gland duct elongation

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from electronic annotation. Source: Ensembl

mammary gland alveolus development

Inferred from electronic annotation. Source: Ensembl

mammary gland branching involved in pregnancy

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

Inferred from electronic annotation. Source: Ensembl

prostate epithelial cord elongation

Inferred from electronic annotation. Source: Ensembl

regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in prostate gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

uterus development

Inferred from electronic annotation. Source: Ensembl

vagina development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

chromatin binding

Inferred from electronic annotation. Source: Ensembl

estrogen receptor activity

Inferred from electronic annotation. Source: InterPro

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from electronic annotation. Source: Ensembl

steroid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1151 EMBL CAA44322.1 Ensembl ENSP00000411105

Sequences

Sequence LengthMass (Da)Tools
Q9UE35 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 370CC8A5AF3300B7

FASTA11512,088
        10         20         30         40         50         60 
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY 

        70         80         90        100        110 
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPP 

« Hide

References

« Hide 'large scale' references
[1]"Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."
Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., Chambon P.
Nature 320:134-139(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Breast EMBL CAA44322.1.
[2]"Genomic organisation of the human oestrogen receptor gene."
Ponglikitmongkol M, Green S., Chambon P.
EMBO J. 7:3385-3388(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Breast EMBL CAA44322.1.
[3]"Sequence analysis of the 5' flanking region of the human estrogen receptor gene."
Keaveney M., Klug J., Gannon F.
DNA Seq. 2:347-358(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Breast EMBL CAA44322.1.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035695 Genomic DNA. No translation available.
AL049821 Genomic DNA. No translation available.
AL078582 Genomic DNA. No translation available.
AL356311 Genomic DNA. No translation available.
AL590993 Genomic DNA. No translation available.
X62462 Genomic DNA. Translation: CAA44322.1.
PIRQRHUE. A94284.
UniGeneHs.208124.
Hs.744830.

3D structure databases

ProteinModelPortalQ9UE35.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000446550; ENSP00000411105; ENSG00000091831.

Organism-specific databases

HGNCHGNC:3467. ESR1.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000202497.
HOVERGENHBG108344.

Family and domain databases

InterProIPR001292. Oestr_rcpt.
[Graphical view]
PfamPF02159. Oest_recep. 1 hit.
[Graphical view]
PRINTSPR00543. OESTROGENR.
ProtoNetSearch...

Other

ChiTaRSESR1. human.

Entry information

Entry nameQ9UE35_HUMAN
AccessionPrimary (citable) accession number: Q9UE35
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.