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Q9UDY8

- MALT1_HUMAN

UniProt

Q9UDY8 - MALT1_HUMAN

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Protein
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Gene
MALT1, MLT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Breakpoint for translocation to form BIRC2-MALT1
Sitei216 – 2172Breakpoint for translocation to form BIRC2-MALT1
Sitei320 – 3212Breakpoint for translocation to form BIRC2-MALT1
Sitei323 – 3242Breakpoint for translocation to form BIRC2-MALT1
Sitei329 – 3302Breakpoint for translocation to form BIRC2-MALT1
Active sitei415 – 4151 By similarity
Active sitei464 – 4641 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. peptidase activity Source: BHF-UCL
  3. protein binding Source: UniProtKB
  4. protein self-association Source: UniProtKB
  5. signal transducer activity Source: UniProtKB
  6. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. B-1 B cell differentiation Source: Ensembl
  2. Fc-epsilon receptor signaling pathway Source: Reactome
  3. T cell proliferation Source: Ensembl
  4. T cell receptor signaling pathway Source: UniProtKB
  5. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  6. defense response Source: UniProtKB
  7. innate immune response Source: Reactome
  8. negative regulation of apoptotic process Source: UniProtKB
  9. nuclear export Source: UniProtKB
  10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  11. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  12. positive regulation of T cell activation Source: UniProtKB
  13. positive regulation of T cell cytokine production Source: UniProtKB
  14. positive regulation of interleukin-2 production Source: UniProtKB
  15. positive regulation of protein ubiquitination Source: BHF-UCL
  16. protein oligomerization Source: UniProtKB
  17. protein ubiquitination Source: GOC
  18. proteolysis Source: BHF-UCL
  19. regulation of T cell receptor signaling pathway Source: Ensembl
  20. regulation of apoptotic process Source: MGI
  21. response to fungus Source: Ensembl
  22. response to molecule of bacterial origin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinkiQ9UDY8.

Protein family/group databases

MEROPSiC14.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC:3.4.22.-)
Alternative name(s):
MALT lymphoma-associated translocation
Paracaspase
Gene namesi
Name:MALT1
Synonyms:MLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6819. MALT1.

Subcellular locationi

Cytoplasmperinuclear region. Nucleus
Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.1 Publication

GO - Cellular componenti

  1. CBM complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Reactome
  4. nucleolus Source: HPA
  5. nucleus Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  7. plasma membrane Source: Reactome
  8. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 12 (IMD12) [MIM:615468]: A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891S → I in IMD12. 1 Publication
VAR_070857
A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi464 – 4641C → A: Slight decrease in NF-kappa-B activation. 1 Publication
Mutagenesisi653 – 6531E → A: Abolishes binding to TRAF6. 1 Publication
Mutagenesisi806 – 8061E → A: Abolishes binding to TRAF6. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615468. phenotype.
Orphaneti52417. MALT lymphoma.
PharmGKBiPA30568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 824823Mucosa-associated lymphoid tissue lymphoma translocation protein 1
PRO_0000072821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei135 – 1351Phosphoserine1 Publication
Disulfide bondi147 ↔ 190 Reviewed prediction
Disulfide bondi248 ↔ 290 Reviewed prediction

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9UDY8.
PaxDbiQ9UDY8.
PRIDEiQ9UDY8.

PTM databases

PhosphoSiteiQ9UDY8.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Gene expression databases

ArrayExpressiQ9UDY8.
BgeeiQ9UDY8.
CleanExiHS_MALT1.
GenevestigatoriQ9UDY8.

Organism-specific databases

HPAiCAB004494.
HPA003865.
HPA048432.

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL10O9599912EBI-1047372,EBI-958922
CASP8Q1479010EBI-1047372,EBI-78060
IKBKGQ9Y6K92EBI-1047372,EBI-81279
SQSTM1Q135012EBI-1047372,EBI-307104
TRAF6Q9Y4K33EBI-1047372,EBI-359276
UBCP0CG484EBI-1047372,EBI-3390054

Protein-protein interaction databases

BioGridi116098. 31 interactions.
DIPiDIP-42833N.
IntActiQ9UDY8. 19 interactions.
MINTiMINT-2844237.
STRINGi9606.ENSP00000319279.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323
Helixi35 – 4511
Helixi54 – 607
Helixi71 – 788
Helixi79 – 824
Helixi88 – 9811
Helixi103 – 12119
Beta strandi129 – 1313
Beta strandi136 – 1394
Beta strandi142 – 1476
Turni151 – 1544
Beta strandi155 – 1628
Beta strandi172 – 1776
Helixi182 – 1843
Beta strandi186 – 1938
Beta strandi204 – 2096
Helixi213 – 2153
Beta strandi228 – 2314
Beta strandi236 – 2383
Beta strandi244 – 2474
Beta strandi249 – 2513
Beta strandi257 – 2626
Beta strandi272 – 2798
Helixi282 – 2843
Beta strandi286 – 2938
Beta strandi298 – 3003
Beta strandi304 – 3085
Beta strandi343 – 3497
Beta strandi354 – 3563
Helixi362 – 37514
Beta strandi379 – 3857
Helixi388 – 40013
Beta strandi407 – 4148
Beta strandi416 – 4194
Beta strandi422 – 4254
Helixi436 – 4383
Beta strandi439 – 4413
Helixi442 – 45110
Beta strandi455 – 4639
Beta strandi486 – 4927
Beta strandi499 – 5013
Beta strandi507 – 5093
Helixi510 – 5156
Turni516 – 5205
Beta strandi521 – 5233
Helixi525 – 53612
Turni540 – 5456
Beta strandi549 – 5524
Turni571 – 5733
Helixi574 – 5829
Beta strandi590 – 5934
Beta strandi599 – 60810
Beta strandi611 – 62010
Beta strandi625 – 6339
Helixi637 – 6393
Helixi643 – 6453
Beta strandi646 – 6505
Helixi651 – 6544
Helixi660 – 6623
Beta strandi668 – 6725
Helixi675 – 6773
Beta strandi683 – 69210
Beta strandi695 – 6973
Beta strandi699 – 7068
Helixi711 – 7144

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G7RX-ray2.70A/B29-126[»]
3BFOX-ray1.15A/B/C/D226-325[»]
3K0WX-ray2.80A128-337[»]
3UO8X-ray1.90B/C339-719[»]
3UOAX-ray1.75B/C339-719[»]
3V4OX-ray2.10A329-569[»]
3V55X-ray1.81A334-719[»]
4I1RX-ray2.70A339-719[»]
ProteinModelPortaliQ9UDY8.
SMRiQ9UDY8. Positions 42-124, 128-308, 336-715.

Miscellaneous databases

EvolutionaryTraceiQ9UDY8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12688Death
Add
BLAST
Domaini125 – 20177Ig-like C2-type 1
Add
BLAST
Domaini212 – 30594Ig-like C2-type 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 562215Caspase-like
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi369 – 3768Nuclear export signal

Sequence similaritiesi

Belongs to the peptidase C14B family.
Contains 1 death domain.

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG4249.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ9UDY8.
KOiK07369.
OMAiMNKEIPN.
OrthoDBiEOG7673BH.
PhylomeDBiQ9UDY8.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UDY8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLLGDPLQA LPPSAAPTGP LLAPPAGATL NRLREPLLRR LSELLDQAPE    50
GRGWRRLAEL AGSRGRLRLS CLDLEQCSLK VLEPEGSPSL CLLKLMGEKG 100
CTVTELSDFL QAMEHTEVLQ LLSPPGIKIT VNPESKAVLA GQFVKLCCRA 150
TGHPFVQYQW FKMNKEIPNG NTSELIFNAV HVKDAGFYVC RVNNNFTFEF 200
SQWSQLDVCD IPESFQRSVD GVSESKLQIC VEPTSQKLMP GSTLVLQCVA 250
VGSPIPHYQW FKNELPLTHE TKKLYMVPYV DLEHQGTYWC HVYNDRDSQD 300
SKKVEIIIGR TDEAVECTED ELNNLGHPDN KEQTTDQPLA KDKVALLIGN 350
MNYREHPKLK APLVDVYELT NLLRQLDFKV VSLLDLTEYE MRNAVDEFLL 400
LLDKGVYGLL YYAGHGYENF GNSFMVPVDA PNPYRSENCL CVQNILKLMQ 450
EKETGLNVFL LDMCRKRNDY DDTIPILDAL KVTANIVFGY ATCQGAEAFE 500
IQHSGLANGI FMKFLKDRLL EDKKITVLLD EVAEDMGKCH LTKGKQALEI 550
RSSLSEKRAL TDPIQGTEYS AESLVRNLQW AKAHELPESM CLKFDCGVQI 600
QLGFAAEFSN VMIIYTSIVY KPPEIIMCDA YVTDFPLDLD IDPKDANKGT 650
PEETGSYLVS KDLPKHCLYT RLSSLQKLKE HLVFTVCLSY QYSGLEDTVE 700
DKQEVNVGKP LIAKLDMHRG LGRKTCFQTC LMSNGPYQSS AATSGGAGHY 750
HSLQDPFHGV YHSHPGNPSN VTPADSCHCS RTPDAFISSF AHHASCHFSR 800
SNVPVETTDE IPFSFSDRLR ISEK 824
Length:824
Mass (Da):92,272
Last modified:May 1, 2000 - v1
Checksum:i28AFB80DA025F8AB
GO
Isoform 2 (identifier: Q9UDY8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-319: Missing.

Show »
Length:813
Mass (Da):91,081
Checksum:i45D05E0DBF81DF5B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891S → I in IMD12. 1 Publication
VAR_070857
Natural varianti641 – 6411I → V.
Corresponds to variant rs35533328 [ dbSNP | Ensembl ].
VAR_048620

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei309 – 31911Missing in isoform 2.
VSP_000844Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130356 mRNA. Translation: AAD38507.2.
AB026118 mRNA. Translation: BAA83099.1.
AF316597 mRNA. Translation: AAG38589.1.
BC030143 mRNA. Translation: AAH30143.1.
AL137399 mRNA. Translation: CAB70725.1.
CCDSiCCDS11967.1. [Q9UDY8-1]
CCDS11968.1. [Q9UDY8-2]
PIRiT46456.
RefSeqiNP_006776.1. NM_006785.3. [Q9UDY8-1]
NP_776216.1. NM_173844.2. [Q9UDY8-2]
UniGeneiHs.601217.

Genome annotation databases

EnsembliENST00000345724; ENSP00000304161; ENSG00000172175. [Q9UDY8-2]
ENST00000348428; ENSP00000319279; ENSG00000172175. [Q9UDY8-1]
GeneIDi10892.
KEGGihsa:10892.
UCSCiuc002lhm.1. human. [Q9UDY8-1]
uc002lhn.1. human. [Q9UDY8-2]

Polymorphism databases

DMDMi20455075.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130356 mRNA. Translation: AAD38507.2 .
AB026118 mRNA. Translation: BAA83099.1 .
AF316597 mRNA. Translation: AAG38589.1 .
BC030143 mRNA. Translation: AAH30143.1 .
AL137399 mRNA. Translation: CAB70725.1 .
CCDSi CCDS11967.1. [Q9UDY8-1 ]
CCDS11968.1. [Q9UDY8-2 ]
PIRi T46456.
RefSeqi NP_006776.1. NM_006785.3. [Q9UDY8-1 ]
NP_776216.1. NM_173844.2. [Q9UDY8-2 ]
UniGenei Hs.601217.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G7R X-ray 2.70 A/B 29-126 [» ]
3BFO X-ray 1.15 A/B/C/D 226-325 [» ]
3K0W X-ray 2.80 A 128-337 [» ]
3UO8 X-ray 1.90 B/C 339-719 [» ]
3UOA X-ray 1.75 B/C 339-719 [» ]
3V4O X-ray 2.10 A 329-569 [» ]
3V55 X-ray 1.81 A 334-719 [» ]
4I1R X-ray 2.70 A 339-719 [» ]
ProteinModelPortali Q9UDY8.
SMRi Q9UDY8. Positions 42-124, 128-308, 336-715.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116098. 31 interactions.
DIPi DIP-42833N.
IntActi Q9UDY8. 19 interactions.
MINTi MINT-2844237.
STRINGi 9606.ENSP00000319279.

Protein family/group databases

MEROPSi C14.026.

PTM databases

PhosphoSitei Q9UDY8.

Polymorphism databases

DMDMi 20455075.

Proteomic databases

MaxQBi Q9UDY8.
PaxDbi Q9UDY8.
PRIDEi Q9UDY8.

Protocols and materials databases

DNASUi 10892.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345724 ; ENSP00000304161 ; ENSG00000172175 . [Q9UDY8-2 ]
ENST00000348428 ; ENSP00000319279 ; ENSG00000172175 . [Q9UDY8-1 ]
GeneIDi 10892.
KEGGi hsa:10892.
UCSCi uc002lhm.1. human. [Q9UDY8-1 ]
uc002lhn.1. human. [Q9UDY8-2 ]

Organism-specific databases

CTDi 10892.
GeneCardsi GC18P056339.
HGNCi HGNC:6819. MALT1.
HPAi CAB004494.
HPA003865.
HPA048432.
MIMi 604860. gene.
615468. phenotype.
neXtProti NX_Q9UDY8.
Orphaneti 52417. MALT lymphoma.
PharmGKBi PA30568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4249.
HOGENOMi HOG000113471.
HOVERGENi HBG052402.
InParanoidi Q9UDY8.
KOi K07369.
OMAi MNKEIPN.
OrthoDBi EOG7673BH.
PhylomeDBi Q9UDY8.
TreeFami TF319744.

Enzyme and pathway databases

Reactomei REACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinki Q9UDY8.

Miscellaneous databases

ChiTaRSi MALT1. human.
EvolutionaryTracei Q9UDY8.
GeneWikii MALT1.
GenomeRNAii 10892.
NextBioi 41357.
PROi Q9UDY8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UDY8.
Bgeei Q9UDY8.
CleanExi HS_MALT1.
Genevestigatori Q9UDY8.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas."
    Dierlamm J., Baens M., Wlodarska I., Stefanova-Ouzounova M., Hernandez J.M., Hossfeld D.K., De Wolf-Peeters C., Hagemeijer A., Van den Berghe H., Marynen P.
    Blood 93:3601-3609(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
  2. "A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue."
    Akagi T., Motegi M., Tamura A., Suzuki R., Hosokawa Y., Suzuki H., Ota H., Nakamura S., Morishima Y., Taniwaki M., Seto M.
    Oncogene 18:5785-5794(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION.
  3. "Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma."
    Uren A.G., O'Rourke K., Aravind L., Pisabarro M.T., Seshagiri S., Koonin E.V., Dixit V.M.
    Mol. Cell 6:961-967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: B-cell.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 598-824.
    Tissue: Testis.
  6. "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18).(q21;q21)."
    Suzuki H., Motegi M., Akagi T., Hosokawa Y., Seto M.
    Blood 94:3270-3271(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  7. "API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products."
    Motegi M., Yonezumi M., Suzuki H., Suzuki R., Hosokawa Y., Hosaka S., Kodera Y., Morishima Y., Nakamura S., Seto M.
    Am. J. Pathol. 156:807-812(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION.
  8. "Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway."
    Lucas P.C., Yonezumi M., Inohara N., McAllister-Lucas L.M., Abazeed M.E., Chen F.F., Yamaoka S., Seto M., Nunez G.
    J. Biol. Chem. 276:19012-19019(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-464.
  9. "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: OLIGOMERIZATION, INTERACTION WITH TRAF6, MUTAGENESIS OF GLU-653 AND GLU-806.
  10. "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A UBIQUITIN LIGASE.
  11. "MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10."
    Nakagawa M., Hosokawa Y., Yonezumi M., Izumiyama K., Suzuki R., Tsuzuki S., Asaka M., Seto M.
    Blood 106:4210-4216(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
  12. Cited for: FUNCTION.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT IMD12 ILE-89.

Entry informationi

Entry nameiMALT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY8
Secondary accession number(s): Q9NTB7, Q9ULX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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