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Protein

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Gene

MALT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei415By similarity1
Active sitei464By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: UniProtKB
  • peptidase activity Source: BHF-UCL
  • protein self-association Source: UniProtKB
  • signal transducer activity Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • B-1 B cell differentiation Source: Ensembl
  • defense response Source: UniProtKB
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • innate immune response Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • nuclear export Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of interleukin-2 production Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • positive regulation of protein ubiquitination Source: BHF-UCL
  • positive regulation of T cell activation Source: UniProtKB
  • positive regulation of T cell cytokine production Source: UniProtKB
  • protein oligomerization Source: UniProtKB
  • proteolysis Source: BHF-UCL
  • regulation of apoptotic process Source: MGI
  • regulation of T cell receptor signaling pathway Source: Ensembl
  • response to fungus Source: Ensembl
  • response to molecule of bacterial origin Source: Ensembl
  • stimulatory C-type lectin receptor signaling pathway Source: Reactome
  • T cell proliferation Source: Ensembl
  • T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172175-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5660668. CLEC7A/inflammasome pathway.
SignaLinkiQ9UDY8.
SIGNORiQ9UDY8.

Protein family/group databases

MEROPSiC14.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC:3.4.22.-)
Alternative name(s):
MALT lymphoma-associated translocation
Paracaspase
Gene namesi
Name:MALT1
Synonyms:MLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:6819. MALT1.

Subcellular locationi

GO - Cellular componenti

  • CBM complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 12 (IMD12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens.
See also OMIM:615468
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07085789S → I in IMD12. 1 PublicationCorresponds to variant rs398123058dbSNPEnsembl.1

A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi464C → A: Slight decrease in NF-kappa-B activation. 1 Publication1
Mutagenesisi653E → A: Abolishes binding to TRAF6. 1 Publication1
Mutagenesisi806E → A: Abolishes binding to TRAF6. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127Breakpoint for translocation to form BIRC2-MALT12
Sitei216 – 217Breakpoint for translocation to form BIRC2-MALT12
Sitei320 – 321Breakpoint for translocation to form BIRC2-MALT12
Sitei323 – 324Breakpoint for translocation to form BIRC2-MALT12
Sitei329 – 330Breakpoint for translocation to form BIRC2-MALT12

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10892.
MalaCardsiMALT1.
MIMi615468. phenotype.
OpenTargetsiENSG00000172175.
Orphaneti397964. Combined immunodeficiency due to MALT1 deficiency.
52417. MALT lymphoma.
PharmGKBiPA30568.

Chemistry databases

ChEMBLiCHEMBL3632452.

Polymorphism and mutation databases

BioMutaiMALT1.
DMDMi20455075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000728212 – 824Mucosa-associated lymphoid tissue lymphoma translocation protein 1Add BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Disulfide bondi147 ↔ 190PROSITE-ProRule annotation
Disulfide bondi248 ↔ 290PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9UDY8.
PaxDbiQ9UDY8.
PeptideAtlasiQ9UDY8.
PRIDEiQ9UDY8.

PTM databases

iPTMnetiQ9UDY8.
PhosphoSitePlusiQ9UDY8.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Gene expression databases

BgeeiENSG00000172175.
CleanExiHS_MALT1.
ExpressionAtlasiQ9UDY8. baseline and differential.
GenevisibleiQ9UDY8. HS.

Organism-specific databases

HPAiCAB004494.
HPA003865.
HPA048432.

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL10O9599915EBI-1047372,EBI-958922
CARD11Q9BXL72EBI-1047372,EBI-7006141
CASP8Q1479010EBI-1047372,EBI-78060
IKBKGQ9Y6K94EBI-1047372,EBI-81279
SHARPINQ9H0F62EBI-1047372,EBI-3942966
SQSTM1Q135012EBI-1047372,EBI-307104
TRAF6Q9Y4K35EBI-1047372,EBI-359276
UBCP0CG484EBI-1047372,EBI-3390054

GO - Molecular functioni

  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi116098. 34 interactors.
DIPiDIP-42833N.
IntActiQ9UDY8. 25 interactors.
MINTiMINT-2844237.
STRINGi9606.ENSP00000319279.

Structurei

Secondary structure

1824
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 32Combined sources3
Helixi35 – 45Combined sources11
Helixi54 – 60Combined sources7
Helixi71 – 78Combined sources8
Helixi79 – 82Combined sources4
Helixi88 – 98Combined sources11
Helixi103 – 121Combined sources19
Beta strandi129 – 131Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi142 – 147Combined sources6
Turni151 – 154Combined sources4
Beta strandi155 – 162Combined sources8
Beta strandi172 – 177Combined sources6
Helixi182 – 184Combined sources3
Beta strandi186 – 193Combined sources8
Beta strandi204 – 209Combined sources6
Helixi213 – 215Combined sources3
Beta strandi228 – 231Combined sources4
Beta strandi236 – 238Combined sources3
Beta strandi244 – 247Combined sources4
Beta strandi249 – 251Combined sources3
Beta strandi257 – 262Combined sources6
Beta strandi272 – 279Combined sources8
Helixi282 – 284Combined sources3
Beta strandi286 – 293Combined sources8
Beta strandi298 – 300Combined sources3
Beta strandi304 – 308Combined sources5
Beta strandi343 – 349Combined sources7
Beta strandi354 – 356Combined sources3
Helixi362 – 375Combined sources14
Beta strandi379 – 385Combined sources7
Helixi388 – 400Combined sources13
Beta strandi407 – 414Combined sources8
Beta strandi416 – 419Combined sources4
Beta strandi422 – 425Combined sources4
Helixi436 – 438Combined sources3
Beta strandi439 – 441Combined sources3
Helixi442 – 451Combined sources10
Beta strandi455 – 463Combined sources9
Beta strandi486 – 492Combined sources7
Beta strandi499 – 501Combined sources3
Beta strandi507 – 509Combined sources3
Helixi510 – 515Combined sources6
Turni516 – 520Combined sources5
Beta strandi521 – 523Combined sources3
Helixi525 – 536Combined sources12
Turni540 – 545Combined sources6
Beta strandi549 – 552Combined sources4
Turni571 – 573Combined sources3
Helixi574 – 582Combined sources9
Beta strandi590 – 593Combined sources4
Beta strandi599 – 608Combined sources10
Beta strandi611 – 620Combined sources10
Beta strandi625 – 633Combined sources9
Helixi637 – 639Combined sources3
Helixi643 – 645Combined sources3
Beta strandi646 – 650Combined sources5
Helixi651 – 654Combined sources4
Helixi660 – 662Combined sources3
Beta strandi668 – 672Combined sources5
Helixi675 – 677Combined sources3
Beta strandi683 – 692Combined sources10
Beta strandi695 – 697Combined sources3
Beta strandi699 – 706Combined sources8
Helixi711 – 714Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G7RX-ray2.70A/B29-126[»]
3BFOX-ray1.15A/B/C/D226-325[»]
3K0WX-ray2.80A128-337[»]
3UO8X-ray1.90B/C339-719[»]
3UOAX-ray1.75B/C339-719[»]
3V4OX-ray2.10A329-569[»]
3V55X-ray1.81A334-719[»]
4I1PX-ray2.40A/C339-719[»]
4I1RX-ray2.70A339-719[»]
ProteinModelPortaliQ9UDY8.
SMRiQ9UDY8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UDY8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126DeathAdd BLAST88
Domaini125 – 201Ig-like C2-type 1Add BLAST77
Domaini212 – 305Ig-like C2-type 2Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 562Caspase-likeAdd BLAST215

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi369 – 376Nuclear export signal8

Sequence similaritiesi

Belongs to the peptidase C14B family.Curated
Contains 1 death domain.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IG3U. Eukaryota.
COG4249. LUCA.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ9UDY8.
KOiK07369.
OMAiHPDNKEQ.
OrthoDBiEOG091G01PI.
PhylomeDBiQ9UDY8.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033540. MALT1.
IPR001309. Pept_C14_p20.
[Graphical view]
PANTHERiPTHR22576:SF29. PTHR22576:SF29. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLGDPLQA LPPSAAPTGP LLAPPAGATL NRLREPLLRR LSELLDQAPE
60 70 80 90 100
GRGWRRLAEL AGSRGRLRLS CLDLEQCSLK VLEPEGSPSL CLLKLMGEKG
110 120 130 140 150
CTVTELSDFL QAMEHTEVLQ LLSPPGIKIT VNPESKAVLA GQFVKLCCRA
160 170 180 190 200
TGHPFVQYQW FKMNKEIPNG NTSELIFNAV HVKDAGFYVC RVNNNFTFEF
210 220 230 240 250
SQWSQLDVCD IPESFQRSVD GVSESKLQIC VEPTSQKLMP GSTLVLQCVA
260 270 280 290 300
VGSPIPHYQW FKNELPLTHE TKKLYMVPYV DLEHQGTYWC HVYNDRDSQD
310 320 330 340 350
SKKVEIIIGR TDEAVECTED ELNNLGHPDN KEQTTDQPLA KDKVALLIGN
360 370 380 390 400
MNYREHPKLK APLVDVYELT NLLRQLDFKV VSLLDLTEYE MRNAVDEFLL
410 420 430 440 450
LLDKGVYGLL YYAGHGYENF GNSFMVPVDA PNPYRSENCL CVQNILKLMQ
460 470 480 490 500
EKETGLNVFL LDMCRKRNDY DDTIPILDAL KVTANIVFGY ATCQGAEAFE
510 520 530 540 550
IQHSGLANGI FMKFLKDRLL EDKKITVLLD EVAEDMGKCH LTKGKQALEI
560 570 580 590 600
RSSLSEKRAL TDPIQGTEYS AESLVRNLQW AKAHELPESM CLKFDCGVQI
610 620 630 640 650
QLGFAAEFSN VMIIYTSIVY KPPEIIMCDA YVTDFPLDLD IDPKDANKGT
660 670 680 690 700
PEETGSYLVS KDLPKHCLYT RLSSLQKLKE HLVFTVCLSY QYSGLEDTVE
710 720 730 740 750
DKQEVNVGKP LIAKLDMHRG LGRKTCFQTC LMSNGPYQSS AATSGGAGHY
760 770 780 790 800
HSLQDPFHGV YHSHPGNPSN VTPADSCHCS RTPDAFISSF AHHASCHFSR
810 820
SNVPVETTDE IPFSFSDRLR ISEK
Length:824
Mass (Da):92,272
Last modified:May 1, 2000 - v1
Checksum:i28AFB80DA025F8AB
GO
Isoform 2 (identifier: Q9UDY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-319: Missing.

Show »
Length:813
Mass (Da):91,081
Checksum:i45D05E0DBF81DF5B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07085789S → I in IMD12. 1 PublicationCorresponds to variant rs398123058dbSNPEnsembl.1
Natural variantiVAR_048620641I → V.Corresponds to variant rs35533328dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000844309 – 319Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130356 mRNA. Translation: AAD38507.2.
AB026118 mRNA. Translation: BAA83099.1.
AF316597 mRNA. Translation: AAG38589.1.
BC030143 mRNA. Translation: AAH30143.1.
AL137399 mRNA. Translation: CAB70725.1.
CCDSiCCDS11967.1. [Q9UDY8-1]
CCDS11968.1. [Q9UDY8-2]
PIRiT46456.
RefSeqiNP_006776.1. NM_006785.3. [Q9UDY8-1]
NP_776216.1. NM_173844.2. [Q9UDY8-2]
UniGeneiHs.601217.

Genome annotation databases

EnsembliENST00000345724; ENSP00000304161; ENSG00000172175. [Q9UDY8-2]
ENST00000348428; ENSP00000319279; ENSG00000172175. [Q9UDY8-1]
GeneIDi10892.
KEGGihsa:10892.
UCSCiuc002lhm.3. human. [Q9UDY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130356 mRNA. Translation: AAD38507.2.
AB026118 mRNA. Translation: BAA83099.1.
AF316597 mRNA. Translation: AAG38589.1.
BC030143 mRNA. Translation: AAH30143.1.
AL137399 mRNA. Translation: CAB70725.1.
CCDSiCCDS11967.1. [Q9UDY8-1]
CCDS11968.1. [Q9UDY8-2]
PIRiT46456.
RefSeqiNP_006776.1. NM_006785.3. [Q9UDY8-1]
NP_776216.1. NM_173844.2. [Q9UDY8-2]
UniGeneiHs.601217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G7RX-ray2.70A/B29-126[»]
3BFOX-ray1.15A/B/C/D226-325[»]
3K0WX-ray2.80A128-337[»]
3UO8X-ray1.90B/C339-719[»]
3UOAX-ray1.75B/C339-719[»]
3V4OX-ray2.10A329-569[»]
3V55X-ray1.81A334-719[»]
4I1PX-ray2.40A/C339-719[»]
4I1RX-ray2.70A339-719[»]
ProteinModelPortaliQ9UDY8.
SMRiQ9UDY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116098. 34 interactors.
DIPiDIP-42833N.
IntActiQ9UDY8. 25 interactors.
MINTiMINT-2844237.
STRINGi9606.ENSP00000319279.

Chemistry databases

ChEMBLiCHEMBL3632452.

Protein family/group databases

MEROPSiC14.026.

PTM databases

iPTMnetiQ9UDY8.
PhosphoSitePlusiQ9UDY8.

Polymorphism and mutation databases

BioMutaiMALT1.
DMDMi20455075.

Proteomic databases

EPDiQ9UDY8.
PaxDbiQ9UDY8.
PeptideAtlasiQ9UDY8.
PRIDEiQ9UDY8.

Protocols and materials databases

DNASUi10892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345724; ENSP00000304161; ENSG00000172175. [Q9UDY8-2]
ENST00000348428; ENSP00000319279; ENSG00000172175. [Q9UDY8-1]
GeneIDi10892.
KEGGihsa:10892.
UCSCiuc002lhm.3. human. [Q9UDY8-1]

Organism-specific databases

CTDi10892.
DisGeNETi10892.
GeneCardsiMALT1.
HGNCiHGNC:6819. MALT1.
HPAiCAB004494.
HPA003865.
HPA048432.
MalaCardsiMALT1.
MIMi604860. gene.
615468. phenotype.
neXtProtiNX_Q9UDY8.
OpenTargetsiENSG00000172175.
Orphaneti397964. Combined immunodeficiency due to MALT1 deficiency.
52417. MALT lymphoma.
PharmGKBiPA30568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG3U. Eukaryota.
COG4249. LUCA.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ9UDY8.
KOiK07369.
OMAiHPDNKEQ.
OrthoDBiEOG091G01PI.
PhylomeDBiQ9UDY8.
TreeFamiTF319744.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172175-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5660668. CLEC7A/inflammasome pathway.
SignaLinkiQ9UDY8.
SIGNORiQ9UDY8.

Miscellaneous databases

ChiTaRSiMALT1. human.
EvolutionaryTraceiQ9UDY8.
GeneWikiiMALT1.
GenomeRNAii10892.
PROiQ9UDY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172175.
CleanExiHS_MALT1.
ExpressionAtlasiQ9UDY8. baseline and differential.
GenevisibleiQ9UDY8. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033540. MALT1.
IPR001309. Pept_C14_p20.
[Graphical view]
PANTHERiPTHR22576:SF29. PTHR22576:SF29. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY8
Secondary accession number(s): Q9NTB7, Q9ULX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.