Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UDY8

- MALT1_HUMAN

UniProt

Q9UDY8 - MALT1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Gene

MALT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Breakpoint for translocation to form BIRC2-MALT1
Sitei216 – 2172Breakpoint for translocation to form BIRC2-MALT1
Sitei320 – 3212Breakpoint for translocation to form BIRC2-MALT1
Sitei323 – 3242Breakpoint for translocation to form BIRC2-MALT1
Sitei329 – 3302Breakpoint for translocation to form BIRC2-MALT1
Active sitei415 – 4151By similarity
Active sitei464 – 4641By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. peptidase activity Source: BHF-UCL
  3. protein self-association Source: UniProtKB
  4. signal transducer activity Source: UniProtKB
  5. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. B-1 B cell differentiation Source: Ensembl
  3. defense response Source: UniProtKB
  4. Fc-epsilon receptor signaling pathway Source: Reactome
  5. innate immune response Source: Reactome
  6. negative regulation of apoptotic process Source: UniProtKB
  7. nuclear export Source: UniProtKB
  8. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  9. positive regulation of interleukin-2 production Source: UniProtKB
  10. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  11. positive regulation of protein ubiquitination Source: BHF-UCL
  12. positive regulation of T cell activation Source: UniProtKB
  13. positive regulation of T cell cytokine production Source: UniProtKB
  14. protein oligomerization Source: UniProtKB
  15. protein ubiquitination Source: GOC
  16. proteolysis Source: BHF-UCL
  17. regulation of apoptotic process Source: MGI
  18. regulation of T cell receptor signaling pathway Source: Ensembl
  19. response to fungus Source: Ensembl
  20. response to molecule of bacterial origin Source: Ensembl
  21. T cell proliferation Source: Ensembl
  22. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinkiQ9UDY8.

Protein family/group databases

MEROPSiC14.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC:3.4.22.-)
Alternative name(s):
MALT lymphoma-associated translocation
Paracaspase
Gene namesi
Name:MALT1
Synonyms:MLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6819. MALT1.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication. Nucleus 1 Publication
Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

GO - Cellular componenti

  1. CBM complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Reactome
  4. nucleolus Source: HPA
  5. nucleus Source: UniProtKB
  6. plasma membrane Source: Reactome
  7. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 12 (IMD12) [MIM:615468]: A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891S → I in IMD12. 1 Publication
VAR_070857
A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi464 – 4641C → A: Slight decrease in NF-kappa-B activation. 1 Publication
Mutagenesisi653 – 6531E → A: Abolishes binding to TRAF6. 1 Publication
Mutagenesisi806 – 8061E → A: Abolishes binding to TRAF6. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615468. phenotype.
Orphaneti397964. Combined immunodeficiency due to MALT1 deficiency.
52417. MALT lymphoma.
PharmGKBiPA30568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 824823Mucosa-associated lymphoid tissue lymphoma translocation protein 1PRO_0000072821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei135 – 1351Phosphoserine1 Publication
Disulfide bondi147 ↔ 190PROSITE-ProRule annotation
Disulfide bondi248 ↔ 290PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9UDY8.
PaxDbiQ9UDY8.
PRIDEiQ9UDY8.

PTM databases

PhosphoSiteiQ9UDY8.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Gene expression databases

BgeeiQ9UDY8.
CleanExiHS_MALT1.
ExpressionAtlasiQ9UDY8. baseline and differential.
GenevestigatoriQ9UDY8.

Organism-specific databases

HPAiCAB004494.
HPA003865.
HPA048432.

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL10O9599912EBI-1047372,EBI-958922
CASP8Q1479010EBI-1047372,EBI-78060
IKBKGQ9Y6K92EBI-1047372,EBI-81279
SQSTM1Q135012EBI-1047372,EBI-307104
TRAF6Q9Y4K33EBI-1047372,EBI-359276
UBCP0CG484EBI-1047372,EBI-3390054

Protein-protein interaction databases

BioGridi116098. 31 interactions.
DIPiDIP-42833N.
IntActiQ9UDY8. 19 interactions.
MINTiMINT-2844237.
STRINGi9606.ENSP00000319279.

Structurei

Secondary structure

1
824
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323Combined sources
Helixi35 – 4511Combined sources
Helixi54 – 607Combined sources
Helixi71 – 788Combined sources
Helixi79 – 824Combined sources
Helixi88 – 9811Combined sources
Helixi103 – 12119Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi136 – 1394Combined sources
Beta strandi142 – 1476Combined sources
Turni151 – 1544Combined sources
Beta strandi155 – 1628Combined sources
Beta strandi172 – 1776Combined sources
Helixi182 – 1843Combined sources
Beta strandi186 – 1938Combined sources
Beta strandi204 – 2096Combined sources
Helixi213 – 2153Combined sources
Beta strandi228 – 2314Combined sources
Beta strandi236 – 2383Combined sources
Beta strandi244 – 2474Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi257 – 2626Combined sources
Beta strandi272 – 2798Combined sources
Helixi282 – 2843Combined sources
Beta strandi286 – 2938Combined sources
Beta strandi298 – 3003Combined sources
Beta strandi304 – 3085Combined sources
Beta strandi343 – 3497Combined sources
Beta strandi354 – 3563Combined sources
Helixi362 – 37514Combined sources
Beta strandi379 – 3857Combined sources
Helixi388 – 40013Combined sources
Beta strandi407 – 4148Combined sources
Beta strandi416 – 4194Combined sources
Beta strandi422 – 4254Combined sources
Helixi436 – 4383Combined sources
Beta strandi439 – 4413Combined sources
Helixi442 – 45110Combined sources
Beta strandi455 – 4639Combined sources
Beta strandi486 – 4927Combined sources
Beta strandi499 – 5013Combined sources
Beta strandi507 – 5093Combined sources
Helixi510 – 5156Combined sources
Turni516 – 5205Combined sources
Beta strandi521 – 5233Combined sources
Helixi525 – 53612Combined sources
Turni540 – 5456Combined sources
Beta strandi549 – 5524Combined sources
Turni571 – 5733Combined sources
Helixi574 – 5829Combined sources
Beta strandi590 – 5934Combined sources
Beta strandi599 – 60810Combined sources
Beta strandi611 – 62010Combined sources
Beta strandi625 – 6339Combined sources
Helixi637 – 6393Combined sources
Helixi643 – 6453Combined sources
Beta strandi646 – 6505Combined sources
Helixi651 – 6544Combined sources
Helixi660 – 6623Combined sources
Beta strandi668 – 6725Combined sources
Helixi675 – 6773Combined sources
Beta strandi683 – 69210Combined sources
Beta strandi695 – 6973Combined sources
Beta strandi699 – 7068Combined sources
Helixi711 – 7144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G7RX-ray2.70A/B29-126[»]
3BFOX-ray1.15A/B/C/D226-325[»]
3K0WX-ray2.80A128-337[»]
3UO8X-ray1.90B/C339-719[»]
3UOAX-ray1.75B/C339-719[»]
3V4OX-ray2.10A329-569[»]
3V55X-ray1.81A334-719[»]
4I1PX-ray2.40A/C339-719[»]
4I1RX-ray2.70A339-719[»]
ProteinModelPortaliQ9UDY8.
SMRiQ9UDY8. Positions 42-124, 128-308, 339-717.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UDY8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12688DeathAdd
BLAST
Domaini125 – 20177Ig-like C2-type 1Add
BLAST
Domaini212 – 30594Ig-like C2-type 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 562215Caspase-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi369 – 3768Nuclear export signal

Sequence similaritiesi

Belongs to the peptidase C14B family.Curated
Contains 1 death domain.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG4249.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ9UDY8.
KOiK07369.
OMAiMNKEIPN.
OrthoDBiEOG7673BH.
PhylomeDBiQ9UDY8.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UDY8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLGDPLQA LPPSAAPTGP LLAPPAGATL NRLREPLLRR LSELLDQAPE
60 70 80 90 100
GRGWRRLAEL AGSRGRLRLS CLDLEQCSLK VLEPEGSPSL CLLKLMGEKG
110 120 130 140 150
CTVTELSDFL QAMEHTEVLQ LLSPPGIKIT VNPESKAVLA GQFVKLCCRA
160 170 180 190 200
TGHPFVQYQW FKMNKEIPNG NTSELIFNAV HVKDAGFYVC RVNNNFTFEF
210 220 230 240 250
SQWSQLDVCD IPESFQRSVD GVSESKLQIC VEPTSQKLMP GSTLVLQCVA
260 270 280 290 300
VGSPIPHYQW FKNELPLTHE TKKLYMVPYV DLEHQGTYWC HVYNDRDSQD
310 320 330 340 350
SKKVEIIIGR TDEAVECTED ELNNLGHPDN KEQTTDQPLA KDKVALLIGN
360 370 380 390 400
MNYREHPKLK APLVDVYELT NLLRQLDFKV VSLLDLTEYE MRNAVDEFLL
410 420 430 440 450
LLDKGVYGLL YYAGHGYENF GNSFMVPVDA PNPYRSENCL CVQNILKLMQ
460 470 480 490 500
EKETGLNVFL LDMCRKRNDY DDTIPILDAL KVTANIVFGY ATCQGAEAFE
510 520 530 540 550
IQHSGLANGI FMKFLKDRLL EDKKITVLLD EVAEDMGKCH LTKGKQALEI
560 570 580 590 600
RSSLSEKRAL TDPIQGTEYS AESLVRNLQW AKAHELPESM CLKFDCGVQI
610 620 630 640 650
QLGFAAEFSN VMIIYTSIVY KPPEIIMCDA YVTDFPLDLD IDPKDANKGT
660 670 680 690 700
PEETGSYLVS KDLPKHCLYT RLSSLQKLKE HLVFTVCLSY QYSGLEDTVE
710 720 730 740 750
DKQEVNVGKP LIAKLDMHRG LGRKTCFQTC LMSNGPYQSS AATSGGAGHY
760 770 780 790 800
HSLQDPFHGV YHSHPGNPSN VTPADSCHCS RTPDAFISSF AHHASCHFSR
810 820
SNVPVETTDE IPFSFSDRLR ISEK
Length:824
Mass (Da):92,272
Last modified:May 1, 2000 - v1
Checksum:i28AFB80DA025F8AB
GO
Isoform 2 (identifier: Q9UDY8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-319: Missing.

Show »
Length:813
Mass (Da):91,081
Checksum:i45D05E0DBF81DF5B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891S → I in IMD12. 1 Publication
VAR_070857
Natural varianti641 – 6411I → V.
Corresponds to variant rs35533328 [ dbSNP | Ensembl ].
VAR_048620

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei309 – 31911Missing in isoform 2. 2 PublicationsVSP_000844Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130356 mRNA. Translation: AAD38507.2.
AB026118 mRNA. Translation: BAA83099.1.
AF316597 mRNA. Translation: AAG38589.1.
BC030143 mRNA. Translation: AAH30143.1.
AL137399 mRNA. Translation: CAB70725.1.
CCDSiCCDS11967.1. [Q9UDY8-1]
CCDS11968.1. [Q9UDY8-2]
PIRiT46456.
RefSeqiNP_006776.1. NM_006785.3. [Q9UDY8-1]
NP_776216.1. NM_173844.2. [Q9UDY8-2]
UniGeneiHs.601217.

Genome annotation databases

EnsembliENST00000345724; ENSP00000304161; ENSG00000172175. [Q9UDY8-2]
ENST00000348428; ENSP00000319279; ENSG00000172175. [Q9UDY8-1]
GeneIDi10892.
KEGGihsa:10892.
UCSCiuc002lhm.1. human. [Q9UDY8-1]
uc002lhn.1. human. [Q9UDY8-2]

Polymorphism databases

DMDMi20455075.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130356 mRNA. Translation: AAD38507.2 .
AB026118 mRNA. Translation: BAA83099.1 .
AF316597 mRNA. Translation: AAG38589.1 .
BC030143 mRNA. Translation: AAH30143.1 .
AL137399 mRNA. Translation: CAB70725.1 .
CCDSi CCDS11967.1. [Q9UDY8-1 ]
CCDS11968.1. [Q9UDY8-2 ]
PIRi T46456.
RefSeqi NP_006776.1. NM_006785.3. [Q9UDY8-1 ]
NP_776216.1. NM_173844.2. [Q9UDY8-2 ]
UniGenei Hs.601217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G7R X-ray 2.70 A/B 29-126 [» ]
3BFO X-ray 1.15 A/B/C/D 226-325 [» ]
3K0W X-ray 2.80 A 128-337 [» ]
3UO8 X-ray 1.90 B/C 339-719 [» ]
3UOA X-ray 1.75 B/C 339-719 [» ]
3V4O X-ray 2.10 A 329-569 [» ]
3V55 X-ray 1.81 A 334-719 [» ]
4I1P X-ray 2.40 A/C 339-719 [» ]
4I1R X-ray 2.70 A 339-719 [» ]
ProteinModelPortali Q9UDY8.
SMRi Q9UDY8. Positions 42-124, 128-308, 339-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116098. 31 interactions.
DIPi DIP-42833N.
IntActi Q9UDY8. 19 interactions.
MINTi MINT-2844237.
STRINGi 9606.ENSP00000319279.

Protein family/group databases

MEROPSi C14.026.

PTM databases

PhosphoSitei Q9UDY8.

Polymorphism databases

DMDMi 20455075.

Proteomic databases

MaxQBi Q9UDY8.
PaxDbi Q9UDY8.
PRIDEi Q9UDY8.

Protocols and materials databases

DNASUi 10892.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345724 ; ENSP00000304161 ; ENSG00000172175 . [Q9UDY8-2 ]
ENST00000348428 ; ENSP00000319279 ; ENSG00000172175 . [Q9UDY8-1 ]
GeneIDi 10892.
KEGGi hsa:10892.
UCSCi uc002lhm.1. human. [Q9UDY8-1 ]
uc002lhn.1. human. [Q9UDY8-2 ]

Organism-specific databases

CTDi 10892.
GeneCardsi GC18P056339.
HGNCi HGNC:6819. MALT1.
HPAi CAB004494.
HPA003865.
HPA048432.
MIMi 604860. gene.
615468. phenotype.
neXtProti NX_Q9UDY8.
Orphaneti 397964. Combined immunodeficiency due to MALT1 deficiency.
52417. MALT lymphoma.
PharmGKBi PA30568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4249.
GeneTreei ENSGT00390000018044.
HOGENOMi HOG000113471.
HOVERGENi HBG052402.
InParanoidi Q9UDY8.
KOi K07369.
OMAi MNKEIPN.
OrthoDBi EOG7673BH.
PhylomeDBi Q9UDY8.
TreeFami TF319744.

Enzyme and pathway databases

Reactomei REACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinki Q9UDY8.

Miscellaneous databases

ChiTaRSi MALT1. human.
EvolutionaryTracei Q9UDY8.
GeneWikii MALT1.
GenomeRNAii 10892.
NextBioi 41357.
PROi Q9UDY8.
SOURCEi Search...

Gene expression databases

Bgeei Q9UDY8.
CleanExi HS_MALT1.
ExpressionAtlasi Q9UDY8. baseline and differential.
Genevestigatori Q9UDY8.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas."
    Dierlamm J., Baens M., Wlodarska I., Stefanova-Ouzounova M., Hernandez J.M., Hossfeld D.K., De Wolf-Peeters C., Hagemeijer A., Van den Berghe H., Marynen P.
    Blood 93:3601-3609(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
  2. "A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue."
    Akagi T., Motegi M., Tamura A., Suzuki R., Hosokawa Y., Suzuki H., Ota H., Nakamura S., Morishima Y., Taniwaki M., Seto M.
    Oncogene 18:5785-5794(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION.
  3. "Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma."
    Uren A.G., O'Rourke K., Aravind L., Pisabarro M.T., Seshagiri S., Koonin E.V., Dixit V.M.
    Mol. Cell 6:961-967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: B-cell.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 598-824.
    Tissue: Testis.
  6. "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18).(q21;q21)."
    Suzuki H., Motegi M., Akagi T., Hosokawa Y., Seto M.
    Blood 94:3270-3271(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  7. "API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products."
    Motegi M., Yonezumi M., Suzuki H., Suzuki R., Hosokawa Y., Hosaka S., Kodera Y., Morishima Y., Nakamura S., Seto M.
    Am. J. Pathol. 156:807-812(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION.
  8. "Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway."
    Lucas P.C., Yonezumi M., Inohara N., McAllister-Lucas L.M., Abazeed M.E., Chen F.F., Yamaoka S., Seto M., Nunez G.
    J. Biol. Chem. 276:19012-19019(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-464.
  9. "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: OLIGOMERIZATION, INTERACTION WITH TRAF6, MUTAGENESIS OF GLU-653 AND GLU-806.
  10. "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A UBIQUITIN LIGASE.
  11. "MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10."
    Nakagawa M., Hosokawa Y., Yonezumi M., Izumiyama K., Suzuki R., Tsuzuki S., Asaka M., Seto M.
    Blood 106:4210-4216(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
  12. Cited for: FUNCTION.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT IMD12 ILE-89.

Entry informationi

Entry nameiMALT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY8
Secondary accession number(s): Q9NTB7, Q9ULX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3