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Q9UDY6 (TRI10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 10
Alternative name(s):
B30-RING finger protein
RING finger protein 9
Gene names
Name:TRIM10
Synonyms:RFB30, RNF9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to play an important role in erythropoiesis By similarity.

Subcellular location

Cytoplasm Ref.2.

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processerythrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q9UDY6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q9UDY6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     369-481: VSIDLAHGGS...GRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Tripartite motif-containing protein 10
PRO_0000056211

Regions

Domain292 – 481190B30.2/SPRY
Zinc finger16 – 6146RING-type
Zinc finger94 – 13542B box-type
Coiled coil150 – 17728 Potential

Natural variations

Alternative sequence369 – 481113VSIDL…FSLSS → WMARVPGDSGCCQFCSPPSV LGTEVAA in isoform Beta.
VSP_005748
Natural variant651R → H.
Corresponds to variant rs12212092 [ dbSNP | Ensembl ].
VAR_052127
Natural variant1191V → M.
Corresponds to variant rs17194446 [ dbSNP | Ensembl ].
VAR_052128

Experimental info

Sequence conflict1041E → G in CAB52384. Ref.1
Sequence conflict1041E → SR in AAG53495. Ref.2
Sequence conflict1041E → SR in AAG53496. Ref.2
Sequence conflict1671E → K in AAG53495. Ref.2
Sequence conflict1671E → K in AAG53496. Ref.2
Sequence conflict3361Y → S in CAB52384. Ref.1
Sequence conflict3361Y → S in AAG53495. Ref.2
Sequence conflict3771G → A in CAB52384. Ref.1
Sequence conflict3771G → A in AAG53495. Ref.2
Isoform Beta:
Sequence conflict3791C → G in AAG53496. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified July 19, 2004. Version 3.
Checksum: 49A1A11F391F5F98

FASTA48155,037
        10         20         30         40         50         60 
MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 

        70         80         90        100        110        120 
KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 

       130        140        150        160        170        180 
CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST 

       190        200        210        220        230        240 
KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE 

       250        260        270        280        290        300 
EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK 

       310        320        330        340        350        360 
LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI 

       370        380        390        400        410        420 
TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE GVWAVRLAWG FVSALGSFPT 

       430        440        450        460        470        480 
RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR EPIYTFTASF TRKVIPFFGL WGRGSSFSLS 


S 

« Hide

Isoform Beta [UniParc].

Checksum: EDEFCB7027B6C15D
Show »

FASTA39545,252

References

« Hide 'large scale' references
[1]"Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions."
Henry J., Ribouchon M.-T., Depetris D., Mattei M.-G., Offer C., Tazi-Ahnini R., Pontarotti P.
Immunogenetics 46:383-395(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA).
Tissue: Testis.
[2]"The tripartite motif family identifies cell compartments."
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), SUBCELLULAR LOCATION.
[3]"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. expand/collapse author list , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[4]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07829 Genomic DNA. Translation: CAB52384.1.
AF220122 mRNA. Translation: AAG53495.1.
AF220123 mRNA. Translation: AAG53496.1.
AB202085 Genomic DNA. Translation: BAE78605.1.
AB103595 Genomic DNA. Translation: BAF31256.1.
BA000025 Genomic DNA. Translation: BAB63332.1.
AB088089 Genomic DNA. Translation: BAC54921.1.
AL669914 Genomic DNA. Translation: CAI18187.1.
AL669914 Genomic DNA. Translation: CAI18188.1.
AL671859 Genomic DNA. Translation: CAI17586.1.
AL671859 Genomic DNA. Translation: CAI17587.1.
AL844220 Genomic DNA. Translation: CAI18609.1.
AL844220 Genomic DNA. Translation: CAI18610.1.
BX005441 Genomic DNA. Translation: CAM26237.1.
BX005441 Genomic DNA. Translation: CAM26238.1.
BX927221 Genomic DNA. Translation: CAQ10308.1.
BX927221 Genomic DNA. Translation: CAQ10309.1.
CR753815 Genomic DNA. Translation: CAP58479.1.
CR753815 Genomic DNA. Translation: CAP58480.1.
CR759838 Genomic DNA. Translation: CAQ11091.1.
CR759838 Genomic DNA. Translation: CAQ11092.1.
CR788282 Genomic DNA. Translation: CAQ07456.1.
CR788282 Genomic DNA. Translation: CAQ07457.1.
CH471081 Genomic DNA. Translation: EAX03268.1.
CH471081 Genomic DNA. Translation: EAX03269.1.
BC093926 mRNA. Translation: AAH93926.1.
BC113419 mRNA. Translation: AAI13420.1.
RefSeqNP_006769.2. NM_006778.3.
NP_439893.2. NM_052828.2.
UniGeneHs.709483.

3D structure databases

ProteinModelPortalQ9UDY6.
SMRQ9UDY6. Positions 7-60, 90-135, 311-468.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115413. 6 interactions.
IntActQ9UDY6. 1 interaction.
STRING9606.ENSP00000390497.

PTM databases

PhosphoSiteQ9UDY6.

Polymorphism databases

DMDM50403805.

Proteomic databases

PaxDbQ9UDY6.
PRIDEQ9UDY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259941; ENSP00000259941; ENSG00000137394. [Q9UDY6-2]
ENST00000354038; ENSP00000343695; ENSG00000137394. [Q9UDY6-1]
ENST00000376704; ENSP00000365894; ENSG00000204613. [Q9UDY6-2]
ENST00000413055; ENSP00000393787; ENSG00000227472. [Q9UDY6-2]
ENST00000416714; ENSP00000405578; ENSG00000229381. [Q9UDY6-2]
ENST00000417411; ENSP00000393576; ENSG00000237192. [Q9UDY6-2]
ENST00000426996; ENSP00000397440; ENSG00000227472. [Q9UDY6-1]
ENST00000428611; ENSP00000412370; ENSG00000229346. [Q9UDY6-2]
ENST00000431258; ENSP00000395598; ENSG00000235025. [Q9UDY6-1]
ENST00000446013; ENSP00000398404; ENSG00000237703. [Q9UDY6-2]
ENST00000447465; ENSP00000393976; ENSG00000235025. [Q9UDY6-2]
ENST00000448645; ENSP00000399446; ENSG00000229346. [Q9UDY6-1]
ENST00000449208; ENSP00000390497; ENSG00000237703. [Q9UDY6-1]
ENST00000449742; ENSP00000397073; ENSG00000204613. [Q9UDY6-1]
ENST00000451727; ENSP00000391445; ENSG00000237192. [Q9UDY6-1]
ENST00000456988; ENSP00000410849; ENSG00000229381. [Q9UDY6-1]
GeneID10107.
KEGGhsa:10107.
UCSCuc003npn.2. human. [Q9UDY6-2]
uc003npo.3. human. [Q9UDY6-1]

Organism-specific databases

CTD10107.
GeneCardsGC06M030119.
GC06Mi30056.
GC06Mj30109.
GC06Mk30110.
GC06Ml30164.
GC06Mm30198.
GC06Mn30109.
GC06Mo30109.
H-InvDBHIX0032788.
HGNCHGNC:10072. TRIM10.
HPAHPA043325.
MIM605701. gene.
neXtProtNX_Q9UDY6.
PharmGKBPA35536.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301877.
HOGENOMHOG000234133.
HOVERGENHBG001357.
InParanoidQ9UDY6.
KOK12002.
OMAEEICRFS.
OrthoDBEOG7M98G0.
PhylomeDBQ9UDY6.
TreeFamTF342569.

Gene expression databases

BgeeQ9UDY6.
CleanExHS_TRIM10.
GenevestigatorQ9UDY6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM10. human.
GenomeRNAi10107.
NextBio38229.
PROQ9UDY6.
SOURCESearch...

Entry information

Entry nameTRI10_HUMAN
AccessionPrimary (citable) accession number: Q9UDY6
Secondary accession number(s): A6NF84 expand/collapse secondary AC list , Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM