Q9UDY6 (TRI10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 10

Alternative name(s):
B30-RING finger protein
RING finger protein 9

Gene names

Name:	TRIM10
Synonyms:	RFB30, RNF9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Seems to play an important role in erythropoiesis By similarity.
Subcellular location	Cytoplasm Ref.2.
Sequence similarities	Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	erythrocyte differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q9UDY6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q9UDY6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     369-481: VSIDLAHGGS...GRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Tripartite motif-containing protein 10		PRO_0000056211
Regions
	Domain	292 – 481	190	B30.2/SPRY
	Zinc finger	16 – 61	46	RING-type
	Zinc finger	94 – 135	42	B box-type
	Coiled coil	150 – 177	28	Potential
Natural variations
	Alternative sequence	369 – 481	113	VSIDL…FSLSS → WMARVPGDSGCCQFCSPPSV LGTEVAA in isoform Beta.		VSP_005748
	Natural variant	65	1	R → H. Corresponds to variant rs12212092 [ dbSNP | Ensembl ].		VAR_052127
	Natural variant	119	1	V → M. Corresponds to variant rs17194446 [ dbSNP | Ensembl ].		VAR_052128
Experimental info
	Sequence conflict	104	1	E → G in CAB52384. Ref.1
	Sequence conflict	104	1	E → SR in AAG53495. Ref.2
	Sequence conflict	104	1	E → SR in AAG53496. Ref.2
	Sequence conflict	167	1	E → K in AAG53495. Ref.2
	Sequence conflict	167	1	E → K in AAG53496. Ref.2
	Sequence conflict	336	1	Y → S in CAB52384. Ref.1
	Sequence conflict	336	1	Y → S in AAG53495. Ref.2
	Sequence conflict	377	1	G → A in CAB52384. Ref.1
	Sequence conflict	377	1	G → A in AAG53495. Ref.2
Isoform Beta:
	Sequence conflict	379	1	C → G in AAG53496. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified July 19, 2004. Version 3. Checksum: 49A1A11F391F5F98	FASTA	481	55,037
	10 20 30 40 50 60 MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 70 80 90 100 110 120 KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 130 140 150 160 170 180 CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST 190 200 210 220 230 240 KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE 250 260 270 280 290 300 EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK 310 320 330 340 350 360 LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI 370 380 390 400 410 420 TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE GVWAVRLAWG FVSALGSFPT 430 440 450 460 470 480 RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR EPIYTFTASF TRKVIPFFGL WGRGSSFSLS S
	Isoform Beta [UniParc]. Checksum: EDEFCB7027B6C15D	FASTA	395	45,252
	10 20 30 40 50 60 MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 70 80 90 100 110 120 KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 130 140 150 160 170 180 CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST 190 200 210 220 230 240 KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE 250 260 270 280 290 300 EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK 310 320 330 340 350 360 LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI 370 380 390 TGGRHTWVWM ARVPGDSGCC QFCSPPSVLG TEVAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions." Henry J., Ribouchon M.-T., Depetris D., Mattei M.-G., Offer C., Tazi-Ahnini R., Pontarotti P. Immunogenetics 46:383-395(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA). Tissue: Testis.
[2]	"The tripartite motif family identifies cell compartments." Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A. EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), SUBCELLULAR LOCATION.
[3]	"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S. Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Peripheral blood leukocyte.
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA). Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07829 Genomic DNA. Translation: CAB52384.1. AF220122 mRNA. Translation: AAG53495.1. AF220123 mRNA. Translation: AAG53496.1. AB202085 Genomic DNA. Translation: BAE78605.1. AB103595 Genomic DNA. Translation: BAF31256.1. BA000025 Genomic DNA. Translation: BAB63332.1. AB088089 Genomic DNA. Translation: BAC54921.1. AL669914 Genomic DNA. Translation: CAI18187.1. AL669914 Genomic DNA. Translation: CAI18188.1. AL671859 Genomic DNA. Translation: CAI17586.1. AL671859 Genomic DNA. Translation: CAI17587.1. AL844220 Genomic DNA. Translation: CAI18609.1. AL844220 Genomic DNA. Translation: CAI18610.1. BX005441 Genomic DNA. Translation: CAM26237.1. BX005441 Genomic DNA. Translation: CAM26238.1. BX927221 Genomic DNA. Translation: CAQ10308.1. BX927221 Genomic DNA. Translation: CAQ10309.1. CR753815 Genomic DNA. Translation: CAP58479.1. CR753815 Genomic DNA. Translation: CAP58480.1. CR759838 Genomic DNA. Translation: CAQ11091.1. CR759838 Genomic DNA. Translation: CAQ11092.1. CR788282 Genomic DNA. Translation: CAQ07456.1. CR788282 Genomic DNA. Translation: CAQ07457.1. CH471081 Genomic DNA. Translation: EAX03268.1. CH471081 Genomic DNA. Translation: EAX03269.1. BC093926 mRNA. Translation: AAH93926.1. BC113419 mRNA. Translation: AAI13420.1.
IPI	IPI00009524. IPI00216582.
RefSeq	NP_006769.2. NM_006778.3. NP_439893.2. NM_052828.2.
UniGene	Hs.709483.
3D structure databases
ProteinModelPortal	Q9UDY6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UDY6. 1 interaction.
STRING	9606.ENSP00000390497.
PTM databases
PhosphoSite	Q9UDY6.
Polymorphism databases
DMDM	50403805.
Proteomic databases
PaxDb	Q9UDY6.
PRIDE	Q9UDY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259941; ENSP00000259941; ENSG00000137394. ENST00000354038; ENSP00000343695; ENSG00000137394. ENST00000376704; ENSP00000365894; ENSG00000204613. ENST00000413055; ENSP00000393787; ENSG00000227472. ENST00000416714; ENSP00000405578; ENSG00000229381. ENST00000417411; ENSP00000393576; ENSG00000237192. ENST00000426996; ENSP00000397440; ENSG00000227472. ENST00000428611; ENSP00000412370; ENSG00000229346. ENST00000431258; ENSP00000395598; ENSG00000235025. ENST00000446013; ENSP00000398404; ENSG00000237703. ENST00000447465; ENSP00000393976; ENSG00000235025. ENST00000448645; ENSP00000399446; ENSG00000229346. ENST00000449208; ENSP00000390497; ENSG00000237703. ENST00000449742; ENSP00000397073; ENSG00000204613. ENST00000451727; ENSP00000391445; ENSG00000237192. ENST00000456988; ENSP00000410849; ENSG00000229381.
GeneID	10107.
KEGG	hsa:10107.
UCSC	uc003npo.3. human.
Organism-specific databases
CTD	10107.
GeneCards	GC06M030119.
H-InvDB	HIX0032788.
HGNC	HGNC:10072. TRIM10.
HPA	HPA043325.
MIM	605701. gene.
neXtProt	NX_Q9UDY6.
PharmGKB	PA35536.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG301877.
HOGENOM	HOG000234133.
HOVERGEN	HBG001357.
InParanoid	Q9UDY6.
KO	K12002.
OMA	EEPPTCP.
OrthoDB	EOG4BG8W2.
Gene expression databases
ArrayExpress	Q9UDY6.
Bgee	Q9UDY6.
CleanEx	HS_TRIM10.
Genevestigator	Q9UDY6.
GermOnline	ENSG00000204613. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRIM10. human.
GenomeRNAi	10107.
NextBio	38229.
SOURCE	Search...

Entry information

Entry name

TRI10_HUMAN

Accession

Primary (citable) accession number: Q9UDY6
Secondary accession number(s): A6NF84 , Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.