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Protein

Tripartite motif-containing protein 10

Gene

TRIM10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play an important role in erythropoiesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 10
Alternative name(s):
B30-RING finger protein
RING finger protein 9
Gene namesi
Name:TRIM10
Synonyms:RFB30, RNF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204613.10.
HGNCiHGNC:10072. TRIM10.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10107.
OpenTargetsiENSG00000204613.
PharmGKBiPA35536.

Polymorphism and mutation databases

BioMutaiTRIM10.
DMDMi50403805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562111 – 481Tripartite motif-containing protein 10Add BLAST481

Proteomic databases

EPDiQ9UDY6.
PaxDbiQ9UDY6.
PeptideAtlasiQ9UDY6.
PRIDEiQ9UDY6.

PTM databases

PhosphoSitePlusiQ9UDY6.

Expressioni

Gene expression databases

BgeeiENSG00000204613.
CleanExiHS_TRIM10.
GenevisibleiQ9UDY6. HS.

Organism-specific databases

HPAiHPA043325.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115413. 26 interactors.
IntActiQ9UDY6. 10 interactors.
STRINGi9606.ENSP00000397073.

Structurei

3D structure databases

ProteinModelPortaliQ9UDY6.
SMRiQ9UDY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 481B30.2/SPRYPROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 177Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118838.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9UDY6.
KOiK12002.
OMAiTRYCEIP.
OrthoDBiEOG093708UY.
PhylomeDBiQ9UDY6.
TreeFamiTF342569.

Family and domain databases

CDDicd00021. BBOX. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom_sf.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9UDY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD
60 70 80 90 100
LEESPTCPLC KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ
110 120 130 140 150
EHGEKIYFFC EDDEMQLCVV CREAGEHATH TMRFLEDAAA PYREQIHKCL
160 170 180 190 200
KCLRKEREEI QEIQSRENKR MQVLLTQVST KRQQVISEFA HLRKFLEEQQ
210 220 230 240 250
SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE EKNERPAREL
260 270 280 290 300
LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK
310 320 330 340 350
LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR
360 370 380 390 400
ATCVLAHTGI TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE
410 420 430 440 450
GVWAVRLAWG FVSALGSFPT RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR
460 470 480
EPIYTFTASF TRKVIPFFGL WGRGSSFSLS S
Length:481
Mass (Da):55,037
Last modified:July 19, 2004 - v3
Checksum:i49A1A11F391F5F98
GO
Isoform Beta (identifier: Q9UDY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-481: VSIDLAHGGS...GRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA

Show »
Length:395
Mass (Da):45,252
Checksum:iEDEFCB7027B6C15D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → G in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti104E → SR in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti104E → SR in AAG53496 (PubMed:11331580).Curated1
Sequence conflicti167E → K in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti167E → K in AAG53496 (PubMed:11331580).Curated1
Sequence conflicti336Y → S in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti336Y → S in AAG53495 (PubMed:11331580).Curated1
Sequence conflicti377G → A in CAB52384 (PubMed:9271628).Curated1
Sequence conflicti377G → A in AAG53495 (PubMed:11331580).Curated1
Isoform Beta (identifier: Q9UDY6-2)
Sequence conflicti379C → G in AAG53496 (PubMed:11331580).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05212765R → H. Corresponds to variant dbSNP:rs12212092Ensembl.1
Natural variantiVAR_052128119V → M. Corresponds to variant dbSNP:rs17194446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005748369 – 481VSIDL…FSLSS → WMARVPGDSGCCQFCSPPSV LGTEVAA in isoform Beta. 2 PublicationsAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07829 Genomic DNA. Translation: CAB52384.1.
AF220122 mRNA. Translation: AAG53495.1.
AF220123 mRNA. Translation: AAG53496.1.
AB202085 Genomic DNA. Translation: BAE78605.1.
AB103595 Genomic DNA. Translation: BAF31256.1.
BA000025 Genomic DNA. Translation: BAB63332.1.
AB088089 Genomic DNA. Translation: BAC54921.1.
AL669914 Genomic DNA. No translation available.
AL671859 Genomic DNA. No translation available.
AL844220 Genomic DNA. No translation available.
BX005441 Genomic DNA. No translation available.
BX927221 Genomic DNA. No translation available.
CR753815 Genomic DNA. No translation available.
CR759838 Genomic DNA. No translation available.
CR788282 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03268.1.
CH471081 Genomic DNA. Translation: EAX03269.1.
BC093926 mRNA. Translation: AAH93926.1.
BC113419 mRNA. Translation: AAI13420.1.
CCDSiCCDS34375.1. [Q9UDY6-1]
CCDS4676.1. [Q9UDY6-2]
RefSeqiNP_006769.2. NM_006778.3. [Q9UDY6-1]
NP_439893.2. NM_052828.2. [Q9UDY6-2]
UniGeneiHs.709483.

Genome annotation databases

EnsembliENST00000259941; ENSP00000259941; ENSG00000137394. [Q9UDY6-2]
ENST00000354038; ENSP00000343695; ENSG00000137394. [Q9UDY6-1]
ENST00000376704; ENSP00000365894; ENSG00000204613. [Q9UDY6-2]
ENST00000413055; ENSP00000393787; ENSG00000227472. [Q9UDY6-2]
ENST00000416714; ENSP00000405578; ENSG00000229381. [Q9UDY6-2]
ENST00000417411; ENSP00000393576; ENSG00000237192. [Q9UDY6-2]
ENST00000426996; ENSP00000397440; ENSG00000227472. [Q9UDY6-1]
ENST00000428611; ENSP00000412370; ENSG00000229346. [Q9UDY6-2]
ENST00000431258; ENSP00000395598; ENSG00000235025. [Q9UDY6-1]
ENST00000446013; ENSP00000398404; ENSG00000237703. [Q9UDY6-2]
ENST00000447465; ENSP00000393976; ENSG00000235025. [Q9UDY6-2]
ENST00000448645; ENSP00000399446; ENSG00000229346. [Q9UDY6-1]
ENST00000449208; ENSP00000390497; ENSG00000237703. [Q9UDY6-1]
ENST00000449742; ENSP00000397073; ENSG00000204613. [Q9UDY6-1]
ENST00000451727; ENSP00000391445; ENSG00000237192. [Q9UDY6-1]
ENST00000456988; ENSP00000410849; ENSG00000229381. [Q9UDY6-1]
GeneIDi10107.
KEGGihsa:10107.
UCSCiuc003npn.3. human. [Q9UDY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI10_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY6
Secondary accession number(s): A6NF84
, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families