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Q9UDY4

- DNJB4_HUMAN

UniProt

Q9UDY4 - DNJB4_HUMAN

Protein

DnaJ homolog subfamily B member 4

Gene

DNAJB4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probable chaperone.

    GO - Molecular functioni

    1. chaperone binding Source: UniProt
    2. protein binding Source: UniProtKB
    3. unfolded protein binding Source: ProtInc

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to heat Source: ProtInc
    3. response to unfolded protein Source: ProtInc

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily B member 4
    Alternative name(s):
    Heat shock 40 kDa protein 1 homolog
    Short name:
    HSP40 homolog
    Short name:
    Heat shock protein 40 homolog
    Human liver DnaJ-like protein
    Gene namesi
    Name:DNAJB4
    Synonyms:DNAJW, HLJ1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14886. DNAJB4.

    Subcellular locationi

    Cytoplasm. Cell membrane
    Note: Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: HPA
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27416.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 337336DnaJ homolog subfamily B member 4PRO_0000071021Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Phosphoserine2 Publications
    Modified residuei148 – 1481Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UDY4.
    PaxDbiQ9UDY4.
    PRIDEiQ9UDY4.

    PTM databases

    PhosphoSiteiQ9UDY4.

    Expressioni

    Tissue specificityi

    Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.1 Publication

    Inductioni

    By heat shock.1 Publication

    Gene expression databases

    ArrayExpressiQ9UDY4.
    BgeeiQ9UDY4.
    CleanExiHS_DNAJB4.
    GenevestigatoriQ9UDY4.

    Organism-specific databases

    HPAiCAB004995.
    HPA028383.
    HPA028385.

    Interactioni

    Subunit structurei

    Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.2 Publications

    Protein-protein interaction databases

    BioGridi116263. 15 interactions.
    IntActiQ9UDY4. 10 interactions.
    MINTiMINT-1142940.
    STRINGi9606.ENSP00000359799.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UDY4.
    SMRiQ9UDY4. Positions 1-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7069JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2214.
    HOVERGENiHBG066727.
    InParanoidiQ9UDY4.
    KOiK09510.
    OMAiIEFDVSF.
    PhylomeDBiQ9UDY4.
    TreeFamiTF105141.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UDY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE    50
    AYEVLSDPKK REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA 100
    FFGGSNPFEI FFGRRMGGGR DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG 150
    PSRLKQDPPV IHELRVSLEE IYSGCTKRMK ISRKRLNADG RSYRSEDKIL 200
    TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH PKFKRDGSNI 250
    IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF 300
    PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS 337
    Length:337
    Mass (Da):37,807
    Last modified:May 1, 2000 - v1
    Checksum:iC7A9C613F73BCDAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40992 mRNA. Translation: AAC14483.2.
    AK313205 mRNA. Translation: BAG36021.1.
    CH471059 Genomic DNA. Translation: EAX06354.1.
    BC034721 mRNA. Translation: AAH34721.1.
    U41290 Genomic DNA. Translation: AAB07346.1. Frameshift.
    CCDSiCCDS684.1.
    PIRiG02272.
    RefSeqiNP_008965.2. NM_007034.3.
    UniGeneiHs.13852.

    Genome annotation databases

    EnsembliENST00000370763; ENSP00000359799; ENSG00000162616.
    GeneIDi11080.
    KEGGihsa:11080.
    UCSCiuc001dij.3. human.

    Polymorphism databases

    DMDMi8928155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40992 mRNA. Translation: AAC14483.2 .
    AK313205 mRNA. Translation: BAG36021.1 .
    CH471059 Genomic DNA. Translation: EAX06354.1 .
    BC034721 mRNA. Translation: AAH34721.1 .
    U41290 Genomic DNA. Translation: AAB07346.1 . Frameshift.
    CCDSi CCDS684.1.
    PIRi G02272.
    RefSeqi NP_008965.2. NM_007034.3.
    UniGenei Hs.13852.

    3D structure databases

    ProteinModelPortali Q9UDY4.
    SMRi Q9UDY4. Positions 1-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116263. 15 interactions.
    IntActi Q9UDY4. 10 interactions.
    MINTi MINT-1142940.
    STRINGi 9606.ENSP00000359799.

    PTM databases

    PhosphoSitei Q9UDY4.

    Polymorphism databases

    DMDMi 8928155.

    Proteomic databases

    MaxQBi Q9UDY4.
    PaxDbi Q9UDY4.
    PRIDEi Q9UDY4.

    Protocols and materials databases

    DNASUi 11080.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370763 ; ENSP00000359799 ; ENSG00000162616 .
    GeneIDi 11080.
    KEGGi hsa:11080.
    UCSCi uc001dij.3. human.

    Organism-specific databases

    CTDi 11080.
    GeneCardsi GC01P078444.
    HGNCi HGNC:14886. DNAJB4.
    HPAi CAB004995.
    HPA028383.
    HPA028385.
    MIMi 611327. gene.
    neXtProti NX_Q9UDY4.
    PharmGKBi PA27416.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2214.
    HOVERGENi HBG066727.
    InParanoidi Q9UDY4.
    KOi K09510.
    OMAi IEFDVSF.
    PhylomeDBi Q9UDY4.
    TreeFami TF105141.

    Miscellaneous databases

    GeneWikii DNAJB4.
    GenomeRNAii 11080.
    NextBioi 42126.
    PROi Q9UDY4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UDY4.
    Bgeei Q9UDY4.
    CleanExi HS_DNAJB4.
    Genevestigatori Q9UDY4.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver."
      Hoe K.L., Won M., Chung K.S., Jang Y.J., Lee S.B., Kim D.U., Lee J.W., Yun J.H., Yoo H.S.
      Biochim. Biophys. Acta 1383:4-8(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. Won M., Moon K.-M., Lee C.-E., Yoo H.-S.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    6. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 45-59; 166-177; 219-236; 260-275 AND 293-302, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic kidney.
    7. "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures."
      Borges J.C., Fischer H., Craievich A.F., Ramos C.H.I.
      J. Biol. Chem. 280:13671-13681(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMODIMERIZATION.
    8. "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor."
      Ancevska-Taneva N., Onoprishvili I., Andria M.L., Hiller J.M., Simon E.J.
      Brain Res. 1081:28-33(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OPRM1.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen."
      Lin X., Ma L., Wang J., Tan Y., Wen Q., Luo W., Su J., Lin Y., Wang X.
      Sheng Wu Gong Cheng Xue Bao 24:1293-1299(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells."
      Lei J.X., Cassone C.G., Luebbert C., Liu Q.Y.
      Mol. Neurodegener. 6:9-9(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SDIM1.

    Entry informationi

    Entry nameiDNJB4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UDY4
    Secondary accession number(s): B2R824, Q13431
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3