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Protein

DnaJ homolog subfamily B member 4

Gene

DNAJB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).1 Publication

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • protein folding Source: InterPro
  • response to heat Source: ProtInc
  • response to unfolded protein Source: ProtInc

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 4
Alternative name(s):
Heat shock 40 kDa protein 1 homolog
Short name:
HSP40 homolog
Short name:
Heat shock protein 40 homolog
Human liver DnaJ-like protein
Gene namesi
Name:DNAJB4
Synonyms:DNAJW, HLJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162616.8.
HGNCiHGNC:14886. DNAJB4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11080.
OpenTargetsiENSG00000162616.
PharmGKBiPA27416.

Polymorphism and mutation databases

BioMutaiDNAJB4.
DMDMi8928155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000710212 – 337DnaJ homolog subfamily B member 4Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UDY4.
MaxQBiQ9UDY4.
PaxDbiQ9UDY4.
PeptideAtlasiQ9UDY4.
PRIDEiQ9UDY4.

PTM databases

iPTMnetiQ9UDY4.
PhosphoSitePlusiQ9UDY4.

Expressioni

Tissue specificityi

Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.1 Publication

Inductioni

By heat shock.1 Publication

Gene expression databases

BgeeiENSG00000162616.
CleanExiHS_DNAJB4.
ExpressionAtlasiQ9UDY4. baseline and differential.
GenevisibleiQ9UDY4. HS.

Organism-specific databases

HPAiCAB004995.
HPA028383.
HPA028385.

Interactioni

Subunit structurei

Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1.2 Publications

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi116263. 65 interactors.
IntActiQ9UDY4. 30 interactors.
MINTiMINT-1142940.
STRINGi9606.ENSP00000359799.

Structurei

3D structure databases

ProteinModelPortaliQ9UDY4.
SMRiQ9UDY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 70JPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOVERGENiHBG066727.
InParanoidiQ9UDY4.
KOiK09510.
OMAiMDGRTIP.
OrthoDBiEOG091G0DLS.
PhylomeDBiQ9UDY4.
TreeFamiTF105141.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR002939. DnaJ_C.
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UDY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE
60 70 80 90 100
AYEVLSDPKK REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA
110 120 130 140 150
FFGGSNPFEI FFGRRMGGGR DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG
160 170 180 190 200
PSRLKQDPPV IHELRVSLEE IYSGCTKRMK ISRKRLNADG RSYRSEDKIL
210 220 230 240 250
TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH PKFKRDGSNI
260 270 280 290 300
IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF
310 320 330
PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS
Length:337
Mass (Da):37,807
Last modified:May 1, 2000 - v1
Checksum:iC7A9C613F73BCDAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40992 mRNA. Translation: AAC14483.2.
AK313205 mRNA. Translation: BAG36021.1.
CH471059 Genomic DNA. Translation: EAX06354.1.
BC034721 mRNA. Translation: AAH34721.1.
U41290 Genomic DNA. Translation: AAB07346.1. Frameshift.
CCDSiCCDS684.1.
PIRiG02272.
RefSeqiNP_001304028.1. NM_001317099.1.
NP_001304029.1. NM_001317100.1.
NP_001304030.1. NM_001317101.1.
NP_001304031.1. NM_001317102.1.
NP_001304032.1. NM_001317103.1.
NP_008965.2. NM_007034.4.
UniGeneiHs.13852.
Hs.690049.

Genome annotation databases

EnsembliENST00000370763; ENSP00000359799; ENSG00000162616.
GeneIDi11080.
KEGGihsa:11080.
UCSCiuc001dij.4. human.

Similar proteinsi

Entry informationi

Entry nameiDNJB4_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY4
Secondary accession number(s): B2R824, Q13431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot