Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UDY4 (DNJB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily B member 4
Alternative name(s):
Heat shock 40 kDa protein 1 homolog
Short name=HSP40 homolog
Short name=Heat shock protein 40 homolog
Human liver DnaJ-like protein
Gene names
Name:DNAJB4
Synonyms:DNAJW, HLJ1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable chaperone.

Subunit structure

Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1. Ref.7 Ref.8 Ref.13

Subcellular location

Cytoplasm. Cell membrane. Note: Cytoplasmic according to Ref.10 and membrane-associated according to Ref.8. Ref.8 Ref.10

Tissue specificity

Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver. Ref.1

Induction

By heat shock. Ref.1

Sequence similarities

Contains 1 J domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 337336DnaJ homolog subfamily B member 4
PRO_0000071021

Regions

Domain2 – 7069J

Amino acid modifications

Modified residue1221Phosphoserine Ref.9 Ref.11
Modified residue1481Phosphoserine Ref.11

Sequences

Sequence LengthMass (Da)Tools
Q9UDY4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C7A9C613F73BCDAC

FASTA33737,807
        10         20         30         40         50         60 
MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE AYEVLSDPKK 

        70         80         90        100        110        120 
REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA FFGGSNPFEI FFGRRMGGGR 

       130        140        150        160        170        180 
DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG PSRLKQDPPV IHELRVSLEE IYSGCTKRMK 

       190        200        210        220        230        240 
ISRKRLNADG RSYRSEDKIL TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH 

       250        260        270        280        290        300 
PKFKRDGSNI IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF 

       310        320        330 
PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver."
Hoe K.L., Won M., Chung K.S., Jang Y.J., Lee S.B., Kim D.U., Lee J.W., Yun J.H., Yoo H.S.
Biochim. Biophys. Acta 1383:4-8(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[5]Won M., Moon K.-M., Lee C.-E., Yoo H.-S.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[6]Bienvenut W.V., Waridel P., Quadroni M.
Submitted (MAR-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 45-59; 166-177; 219-236; 260-275 AND 293-302, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[7]"Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures."
Borges J.C., Fischer H., Craievich A.F., Ramos C.H.I.
J. Biol. Chem. 280:13671-13681(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: HOMODIMERIZATION.
[8]"A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor."
Ancevska-Taneva N., Onoprishvili I., Andria M.L., Hiller J.M., Simon E.J.
Brain Res. 1081:28-33(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OPRM1.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Preparation of the anti-HLJ1 monoclonal antibodies and establishment of method for detection of the antigen."
Lin X., Ma L., Wang J., Tan Y., Wen Q., Luo W., Su J., Lin Y., Wang X.
Sheng Wu Gong Cheng Xue Bao 24:1293-1299(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells."
Lei J.X., Cassone C.G., Luebbert C., Liu Q.Y.
Mol. Neurodegener. 6:9-9(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SDIM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40992 mRNA. Translation: AAC14483.2.
AK313205 mRNA. Translation: BAG36021.1.
CH471059 Genomic DNA. Translation: EAX06354.1.
BC034721 mRNA. Translation: AAH34721.1.
U41290 Genomic DNA. Translation: AAB07346.1. Frameshift.
PIRG02272.
RefSeqNP_008965.2. NM_007034.3.
UniGeneHs.13852.

3D structure databases

ProteinModelPortalQ9UDY4.
SMRQ9UDY4. Positions 1-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116263. 14 interactions.
IntActQ9UDY4. 8 interactions.
MINTMINT-1142940.
STRING9606.ENSP00000359799.

PTM databases

PhosphoSiteQ9UDY4.

Polymorphism databases

DMDM8928155.

Proteomic databases

PaxDbQ9UDY4.
PRIDEQ9UDY4.

Protocols and materials databases

DNASU11080.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370763; ENSP00000359799; ENSG00000162616.
GeneID11080.
KEGGhsa:11080.
UCSCuc001dij.3. human.

Organism-specific databases

CTD11080.
GeneCardsGC01P078444.
HGNCHGNC:14886. DNAJB4.
HPACAB004995.
HPA028383.
HPA028385.
MIM611327. gene.
neXtProtNX_Q9UDY4.
PharmGKBPA27416.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2214.
HOVERGENHBG066727.
InParanoidQ9UDY4.
KOK09510.
OMAYYHILGI.
PhylomeDBQ9UDY4.
TreeFamTF105141.

Gene expression databases

ArrayExpressQ9UDY4.
BgeeQ9UDY4.
CleanExHS_DNAJB4.
GenevestigatorQ9UDY4.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDNAJB4.
GenomeRNAi11080.
NextBio42126.
PROQ9UDY4.
SOURCESearch...

Entry information

Entry nameDNJB4_HUMAN
AccessionPrimary (citable) accession number: Q9UDY4
Secondary accession number(s): B2R824, Q13431
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM