Reviewed, UniProtKB/Swiss-Prot Q9UDY2 (ZO2_HUMAN)

Names and origin

Protein names

Recommended name:
    Tight junction protein ZO-2
Alternative name(s):
    Zonula occludens protein 2
    Zona occludens protein 2
    Tight junction protein 2

Gene names

Name:	TJP2
Synonyms:	X104, ZO2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in tight junctions and adherens junctions.
Subunit structure	Interacts with occludin and SAFB. Interaction with SAFB occurs in the nucleus.
Subcellular location	Cell junction › adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic sideBy similarity. Cell junction › tight junctionBy similarity. NucleusBy similarity. Note= Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures By similarity.
Tissue specificity	This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. In brain and skeletal muscle, only isoform A1 is detectable. Isoform C1 is found in normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in normal tissue.
Involvement in disease	Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.
Sequence caution	The sequence AAA61300.1 differs from that shown. Reason: Frameshift at positions 1086, 1092 and 1095.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Nucleus Tight junction
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	guanylate kinase activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRAF6	Q9Y4K3	1	EBI-1042602,EBI-359276
YWHAB	P31946	1	EBI-1042602,EBI-359815
YWHAG	P61981	1	EBI-1042602,EBI-359832
YWHAQ	P27348	1	EBI-1042602,EBI-359854
YWHAZ	P63104	1	EBI-1042602,EBI-347088

Alternative products

This entry describes 5 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform A1 (identifier: Q9UDY2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: Produced by alternative promoter usage.

Isoform A2 (identifier: Q9UDY2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     961-1108: Missing.

Notes: Produced by alternative splicing of isoform A1.

Isoform A3 (identifier: Q9UDY2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     961-993: SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKP → VRRGRPRAGTGEPGVFLALSWTAVCSGCCGRHS
     994-1190: Missing.

Notes: Produced by alternative splicing of isoform A1.

Isoform C1 (identifier: Q9UDY2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Notes: Produced by alternative promoter usage.

Isoform C2 (identifier: Q9UDY2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     961-1108: Missing.

Notes: Produced by alternative splicing of isoform C1.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1190	1190	Tight junction protein ZO-2
Regions
	Domain	33 – 120	88	PDZ 1
	Domain	307 – 385	79	PDZ 2
	Domain	509 – 590	82	PDZ 3
	Domain	604 – 669	66	SH3
	Domain	678 – 876	199	Guanylate kinase-like
	Compositional bias	1162 – 1165	4	Poly-Glu
Amino acid modifications
	Modified residue	130	1	Phosphoserine
	Modified residue	168	1	Phosphoserine
	Modified residue	170	1	Phosphoserine
	Modified residue	174	1	Phosphoserine
	Modified residue	192	1	Phosphoserine
	Modified residue	244	1	Phosphoserine
	Modified residue	261	1	Phosphotyrosine
	Modified residue	265	1	Phosphotyrosine By similarity
	Modified residue	266	1	Phosphoserine
	Modified residue	296	1	Phosphoserine
	Modified residue	394	1	Phosphoserine
	Modified residue	398	1	Phosphoserine
	Modified residue	400	1	Phosphoserine
	Modified residue	415	1	Phosphoserine
	Modified residue	440	1	Phosphoserine
	Modified residue	441	1	Phosphoserine
	Modified residue	445	1	Phosphothreonine
	Modified residue	574	1	Phosphotyrosine
	Modified residue	702	1	Phosphoserine
	Modified residue	966	1	Phosphoserine
	Modified residue	978	1	Phosphoserine
	Modified residue	986	1	Phosphoserine
	Modified residue	1118	1	Phosphotyrosine
	Modified residue	1131	1	Phosphothreonine
	Modified residue	1159	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 23	23	Missing in isoform C1 and isoform C2.
	Alternative sequence	961 – 1108	148	Missing in isoform A2 and isoform C2.
	Alternative sequence	961 – 993	33	SIRKP…PAFKP → VRRGRPRAGTGEPGVFLALS WTAVCSGCCGRHS in isoform A3.
	Alternative sequence	994 – 1190	197	Missing in isoform A3.
	Natural variant	48	1	V → A in FHCA.
	Natural variant	482	1	E → D: dbSNP rs2309428.
Experimental info
	Sequence conflict	411	1	N → T in AAA61300. Ref.1
	Sequence conflict	411	1	N → T in AAM28524. Ref.3
	Sequence conflict	782	1	I → V in AAA61300. Ref.1
	Sequence conflict	782	1	I → V in AAM28524. Ref.3
	Sequence conflict	808	1	P → S in AAA61300. Ref.1
	Sequence conflict	812 – 814	3	FFN → SFT in AAA61300. Ref.1
	Sequence conflict	822	1	K → N in AAA61300. Ref.1
	Sequence conflict	829	1	N → D in AAA61300. Ref.1
	Sequence conflict	834	1	K → N in AAA61300. Ref.1
	Sequence conflict	842	1	Q → H in AAA61300. Ref.1
	Sequence conflict	996	1	P → S in AAA61300. Ref.1
	Sequence conflict	1136	1	S → N in AAB41794. Ref.8
	Sequence conflict	1155 – 1158	4	GSYG → RSFC in AAB41794. Ref.8
	Sequence conflict	1165 – 1167	3	EYR → IRS Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform A1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: BE2BE6F181467058	FASTA	1,190	133,972
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EEPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 1000 1010 1020 SIRKPSPEPR AQMRRAASSD QLRDNSPPPA FKPEPPKAKT QNKEESYDFS KSYEYKSNPS 1030 1040 1050 1060 1070 1080 AVAGNETPGA STKGYPPPVA AKPTFGRSIL KPSTPIPPQE GEEVGESSEE QDNAPKSVLG 1090 1100 1110 1120 1130 1140 KVKIFEKMDH KARLQRMQEL QEAQNARIEI AQKHPDIYAV PIKTHKPDPG TPQHTSSRPP 1150 1160 1170 1180 1190 EPQKAPSRPY QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL
	Isoform A2 [UniParc]. Checksum: ECBAD3D0FA2BF09C		1,042	117,659
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EEPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 1000 1010 1020 EIAQKHPDIY AVPIKTHKPD PGTPQHTSSR PPEPQKAPSR PYQDTRGSYG SDAEEEEYRQ 1030 1040 QLSEHSKRGY YGQSARYRDT EL
	Isoform A3 [UniParc]. Checksum: 9A6279A73851A6D3		993	111,677
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EEPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 VRRGRPRAGT GEPGVFLALS WTAVCSGCCG RHS
	Isoform C1 [UniParc]. Checksum: 08EC680BD978D8AA		1,167	131,382
	10 20 30 40 50 60 MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG PADGLLQEND 70 80 90 100 110 120 RVVMVNGTPM EDVLHSFAVQ QLRKSGKVAA IVVKRPRKVQ VAALQASPPL DQDDRAFEVM 130 140 150 160 170 180 DEFDGRSFRS GYSERSRLNS HGGRSRSWED SPERGRPHER ARSRERDLSR DRSRGRSLER 190 200 210 220 230 240 GLDQDHARTR DRSRGRSLER GLDHDFGPSR DRDRDRSRGR SIDQDYERAY HRAYDPDYER 250 260 270 280 290 300 AYSPEYRRGA RHDARSRGPR SRSREHPHSR SPSPEPRGRP GPIGVLLMKS RANEEYGLRL 310 320 330 340 350 360 GSQIFVKEMT RTGLATKDGN LHEGDIILKI NGTVTENMSL TDARKLIEKS RGKLQLVVLR 370 380 390 400 410 420 DSQQTLINIP SLNDSDSEIE DISEIESNRS FSPEERRHQY SDYDYHSSSE KLKERPSSRE 430 440 450 460 470 480 DTPSRLSRMG ATPTPFKSTG DIAGTVVPET NKEPRYQEEP PAPQPKAAPR TFLRPSPEDE 490 500 510 520 530 540 AIYGPNTKMV RFKKGDSVGL RLAGGNDVGI FVAGIQEGTS AEQEGLQEGD QILKVNTQDF 550 560 570 580 590 600 RGLVREDAVL YLLEIPKGEM VTILAQSRAD VYRDILACGR GDSFFIRSHF ECEKETPQSL 610 620 630 640 650 660 AFTRGEVFRV VDTLYDGKLG NWLAVRIGNE LEKGLIPNKS RAEQMASVQN AQRDNAGDRA 670 680 690 700 710 720 DFWRMRGQRS GVKKNLRKSR EDLTAVVSVS TKFPAYERVL LREAGFKRPV VLFGPIADIA 730 740 750 760 770 780 MEKLANELPD WFQTAKTEPK DAGSEKSTGV VRLNTVRQII EQDKHALLDV TPKAVDLLNY 790 800 810 820 830 840 TQWFPIVIFF NPDSRQGVKT MRQRLNPTSN KSSRKLFDQA NKLKKTCAHL FTATINLNSA 850 860 870 880 890 900 NDSWFGSLKD TIQHQQGEAV WVSEGKMEGM DDDPEDRMSY LTAMGADYLS CDSRLISDFE 910 920 930 940 950 960 DTDGEGGAYT DNELDEPAEE PLVSSITRSS EPVQHEESIR KPSPEPRAQM RRAASSDQLR 970 980 990 1000 1010 1020 DNSPPPAFKP EPPKAKTQNK EESYDFSKSY EYKSNPSAVA GNETPGASTK GYPPPVAAKP 1030 1040 1050 1060 1070 1080 TFGRSILKPS TPIPPQEGEE VGESSEEQDN APKSVLGKVK IFEKMDHKAR LQRMQELQEA 1090 1100 1110 1120 1130 1140 QNARIEIAQK HPDIYAVPIK THKPDPGTPQ HTSSRPPEPQ KAPSRPYQDT RGSYGSDAEE 1150 1160 EEYRQQLSEH SKRGYYGQSA RYRDTEL
	Isoform C2 [UniParc]. Checksum: DC790A47F4F210A3		1,019	115,069
	10 20 30 40 50 60 MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG PADGLLQEND 70 80 90 100 110 120 RVVMVNGTPM EDVLHSFAVQ QLRKSGKVAA IVVKRPRKVQ VAALQASPPL DQDDRAFEVM 130 140 150 160 170 180 DEFDGRSFRS GYSERSRLNS HGGRSRSWED SPERGRPHER ARSRERDLSR DRSRGRSLER 190 200 210 220 230 240 GLDQDHARTR DRSRGRSLER GLDHDFGPSR DRDRDRSRGR SIDQDYERAY HRAYDPDYER 250 260 270 280 290 300 AYSPEYRRGA RHDARSRGPR SRSREHPHSR SPSPEPRGRP GPIGVLLMKS RANEEYGLRL 310 320 330 340 350 360 GSQIFVKEMT RTGLATKDGN LHEGDIILKI NGTVTENMSL TDARKLIEKS RGKLQLVVLR 370 380 390 400 410 420 DSQQTLINIP SLNDSDSEIE DISEIESNRS FSPEERRHQY SDYDYHSSSE KLKERPSSRE 430 440 450 460 470 480 DTPSRLSRMG ATPTPFKSTG DIAGTVVPET NKEPRYQEEP PAPQPKAAPR TFLRPSPEDE 490 500 510 520 530 540 AIYGPNTKMV RFKKGDSVGL RLAGGNDVGI FVAGIQEGTS AEQEGLQEGD QILKVNTQDF 550 560 570 580 590 600 RGLVREDAVL YLLEIPKGEM VTILAQSRAD VYRDILACGR GDSFFIRSHF ECEKETPQSL 610 620 630 640 650 660 AFTRGEVFRV VDTLYDGKLG NWLAVRIGNE LEKGLIPNKS RAEQMASVQN AQRDNAGDRA 670 680 690 700 710 720 DFWRMRGQRS GVKKNLRKSR EDLTAVVSVS TKFPAYERVL LREAGFKRPV VLFGPIADIA 730 740 750 760 770 780 MEKLANELPD WFQTAKTEPK DAGSEKSTGV VRLNTVRQII EQDKHALLDV TPKAVDLLNY 790 800 810 820 830 840 TQWFPIVIFF NPDSRQGVKT MRQRLNPTSN KSSRKLFDQA NKLKKTCAHL FTATINLNSA 850 860 870 880 890 900 NDSWFGSLKD TIQHQQGEAV WVSEGKMEGM DDDPEDRMSY LTAMGADYLS CDSRLISDFE 910 920 930 940 950 960 DTDGEGGAYT DNELDEPAEE PLVSSITRSS EPVQHEEEIA QKHPDIYAVP IKTHKPDPGT 970 980 990 1000 1010 PQHTSSRPPE PQKAPSRPYQ DTRGSYGSDA EEEEYRQQLS EHSKRGYYGQ SARYRDTEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb." Duclos F., Rodius F., Wrogemann K., Mandel J.-L., Koenig M. Hum. Mol. Genet. 3:909-914(1994) [PubMed: 7951235] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1). Tissue: Brain.
[2]	"Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues." Chlenski A., Ketels K.V., Korovaitseva G.I., Talamonti M.S., Oyasu R., Scarpelli D.G. Biochim. Biophys. Acta 1493:319-324(2000) [PubMed: 11018256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A1; C1; A2 AND C2), ALTERNATIVE PROMOTER USAGE. Tissue: Pancreas.
[3]	"LIM protein KyoT2 interacts with human tight junction protein ZO-2-i3." Yan H.H., Rong L., Qiang S., Jian W., Peng Z., Hua H., Hui Z.W. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A3).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J.,