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Protein

Tight junction protein ZO-2

Gene

TJP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in tight junctions and adherens junctions.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • guanylate kinase activity Source: ProtInc
  • protein binding, bridging Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

  • establishment of endothelial intestinal barrier Source: UniProtKB
  • hippo signaling Source: Reactome
  • intestinal absorption Source: UniProtKB
  • regulation of membrane permeability Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-2028269 Signaling by Hippo
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins
SIGNORiQ9UDY2

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-2
Alternative name(s):
Tight junction protein 2
Zona occludens protein 2
Zonula occludens protein 2
Gene namesi
Name:TJP2
Synonyms:X104, ZO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119139.16
HGNCiHGNC:11828 TJP2
MIMi607709 gene
neXtProtiNX_Q9UDY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

Pathology & Biotechi

Involvement in diseasei

Familial hypercholanemia (FHCA)1 Publication
The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
See also OMIM:607748
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01600448V → A in FHCA. 1 PublicationCorresponds to variant dbSNP:rs121918299EnsemblClinVar.1
Cholestasis, progressive familial intrahepatic, 4 (PFIC4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.
See also OMIM:615878

Keywords - Diseasei

Disease mutation, Intrahepatic cholestasis

Organism-specific databases

DisGeNETi9414
MalaCardsiTJP2
MIMi607748 phenotype
615878 phenotype
OpenTargetsiENSG00000119139
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
238475 Familial hypercholanemia
79304 Progressive familial intrahepatic cholestasis type 2
PharmGKBiPA36533

Polymorphism and mutation databases

BioMutaiTJP2
DMDMi317373313

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945431 – 1190Tight junction protein ZO-2Add BLAST1190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1
Modified residuei168PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei398PhosphoserineBy similarity1
Modified residuei400PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei455PhosphothreonineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei574PhosphotyrosineBy similarity1
Modified residuei702PhosphoserineCombined sources1
Modified residuei902PhosphoserineBy similarity1
Modified residuei905PhosphothreonineBy similarity1
Modified residuei913PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei925PhosphothreonineCombined sources1
Modified residuei933PhosphothreonineCombined sources1
Modified residuei966PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei1006PhosphoserineBy similarity1
Modified residuei1067PhosphoserineCombined sources1
Modified residuei1068PhosphoserineCombined sources1
Modified residuei1118PhosphotyrosineCombined sources1
Modified residuei1131PhosphothreonineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UDY2
PaxDbiQ9UDY2
PeptideAtlasiQ9UDY2
PRIDEiQ9UDY2

PTM databases

iPTMnetiQ9UDY2
PhosphoSitePlusiQ9UDY2

Expressioni

Tissue specificityi

This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.1 Publication

Gene expression databases

BgeeiENSG00000119139
CleanExiHS_TJP2
ExpressionAtlasiQ9UDY2 baseline and differential
GenevisibleiQ9UDY2 HS

Organism-specific databases

HPAiCAB009228
HPA001813

Interactioni

Subunit structurei

Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB. Interacts with USP53 (via the C-terminal region) (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LASP1Q148479EBI-1042602,EBI-742828

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein binding, bridging Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114809, 75 interactors
ELMiQ9UDY2
IntActiQ9UDY2, 38 interactors
MINTiQ9UDY2
STRINGi9606.ENSP00000438262

Structurei

Secondary structure

11190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi306 – 311Combined sources6
Beta strandi315 – 317Combined sources3
Beta strandi321 – 332Combined sources12
Helixi337 – 341Combined sources5
Beta strandi349 – 353Combined sources5
Helixi363 – 372Combined sources10
Turni373 – 375Combined sources3
Beta strandi376 – 381Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OSGNMR-A/B306-385[»]
3E17X-ray1.75A/B306-384[»]
ProteinModelPortaliQ9UDY2
SMRiQ9UDY2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UDY2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 120PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini307 – 385PDZ 2PROSITE-ProRule annotationAdd BLAST79
Domaini509 – 590PDZ 3PROSITE-ProRule annotationAdd BLAST82
Domaini604 – 669SH3PROSITE-ProRule annotationAdd BLAST66
Domaini678 – 876Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1188 – 1190Interaction with SCRIB1 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1162 – 1165Poly-Glu4

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3580 Eukaryota
ENOG410XQP3 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000230923
HOVERGENiHBG017627
InParanoidiQ9UDY2
KOiK06098
OrthoDBiEOG091G0AJZ
PhylomeDBiQ9UDY2
TreeFamiTF315957

Family and domain databases

CDDicd12027 SH3_ZO-2, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR005417 ZO
IPR005419 ZO-2
IPR035598 ZO-2_SH3
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01597 ZONOCCLUDNS
PR01599 ZONOCCLUDNS2
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 3 hits
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 3 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 3 hits
PS50002 SH3, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform A1 (identifier: Q9UDY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG
60 70 80 90 100
GRDNPHFENG ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF
110 120 130 140 150
AVQQLRKSGK VAAIVVKRPR KVQVAALQAS PPLDQDDRAF EVMDEFDGRS
160 170 180 190 200
FRSGYSERSR LNSHGGRSRS WEDSPERGRP HERARSRERD LSRDRSRGRS
210 220 230 240 250
LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS RGRSIDQDYE
260 270 280 290 300
RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR
310 320 330 340 350
GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII
360 370 380 390 400
LKINGTVTEN MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS
410 420 430 440 450
EIEDISEIES NRSFSPEERR HQYSDYDYHS SSEKLKERPS SREDTPSRLS
460 470 480 490 500
RMGATPTPFK STGDIAGTVV PETNKEPRYQ EDPPAPQPKA APRTFLRPSP
510 520 530 540 550
EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE GTSAEQEGLQ
560 570 580 590 600
EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA
610 620 630 640 650
CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI
660 670 680 690 700
GNELEKGLIP NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR
710 720 730 740 750
KSREDLTAVV SVSTKFPAYE RVLLREAGFK RPVVLFGPIA DIAMEKLANE
760 770 780 790 800
LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR QIIEQDKHAL LDVTPKAVDL
810 820 830 840 850
LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF DQANKLKKTC
860 870 880 890 900
AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR
910 920 930 940 950
MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT
960 970 980 990 1000
RSSEPVQHEE SIRKPSPEPR AQMRRAASSD QLRDNSPPPA FKPEPPKAKT
1010 1020 1030 1040 1050
QNKEESYDFS KSYEYKSNPS AVAGNETPGA STKGYPPPVA AKPTFGRSIL
1060 1070 1080 1090 1100
KPSTPIPPQE GEEVGESSEE QDNAPKSVLG KVKIFEKMDH KARLQRMQEL
1110 1120 1130 1140 1150
QEAQNARIEI AQKHPDIYAV PIKTHKPDPG TPQHTSSRPP EPQKAPSRPY
1160 1170 1180 1190
QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL
Note: Produced by alternative promoter usage.
Length:1,190
Mass (Da):133,958
Last modified:January 11, 2011 - v2
Checksum:i27305B723043BF6C
GO
Isoform A2 (identifier: Q9UDY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     961-1107: Missing.

Note: Produced by alternative splicing of isoform A1.
Show »
Length:1,043
Mass (Da):117,758
Checksum:i6EE97CE690160E91
GO
Isoform A3 (identifier: Q9UDY2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     961-993: SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKP → VRRGRPRAGTGEPGVFLALSWTAVCSGCCGRHS
     994-1190: Missing.

Note: Produced by alternative splicing of isoform A1.
Show »
Length:993
Mass (Da):111,663
Checksum:iD469C9A73851A6D3
GO
Isoform C1 (identifier: Q9UDY2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,167
Mass (Da):131,368
Checksum:i91F7D588687D179E
GO
Isoform C2 (identifier: Q9UDY2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     961-1107: Missing.

Note: Produced by alternative splicing of isoform C1.
Show »
Length:1,020
Mass (Da):115,168
Checksum:i4A49BF3F0718D771
GO
Isoform 6 (identifier: Q9UDY2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MPVRGDRGFPPRRELSGWL → MKTAQALHRMWIQAVKKLRRWKG
     961-997: Missing.

Note: No experimental confirmation available.
Show »
Length:1,157
Mass (Da):130,446
Checksum:i30C98BC65E29BC85
GO
Isoform 7 (identifier: Q9UDY2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MPVRGDRGFPPRRELSGWLR → MKTAQALHRMWIQAVKKLRRWKGRVSPSASSPLVFPNLSSWEGEGSKTILT

Note: No experimental confirmation available.
Show »
Length:1,221
Mass (Da):137,342
Checksum:iE185339B2A2F37B4
GO

Sequence cautioni

The sequence AAA61300 differs from that shown. Reason: Frameshift at positions 1086, 1092 and 1095.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411N → T in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti411N → T in AAM28524 (Ref. 3) Curated1
Sequence conflicti718A → V in BAH13722 (PubMed:14702039).Curated1
Sequence conflicti782I → V in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti782I → V in AAM28524 (Ref. 3) Curated1
Sequence conflicti808P → S in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti812 – 814FFN → SFT in AAA61300 (PubMed:7951235).Curated3
Sequence conflicti834K → N in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti842Q → H in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti996P → S in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti1093R → G in AAA61300 (PubMed:7951235).Curated1
Sequence conflicti1110I → L in BAH13722 (PubMed:14702039).Curated1
Sequence conflicti1136S → N in AAB41794 (Ref. 9) Curated1
Sequence conflicti1155 – 1158GSYG → RSFC in AAB41794 (Ref. 9) Curated4
Sequence conflicti1165 – 1167EYR → IRS in AAB41794 (Ref. 9) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01600448V → A in FHCA. 1 PublicationCorresponds to variant dbSNP:rs121918299EnsemblClinVar.1
Natural variantiVAR_030798482D → ECombined sources4 PublicationsCorresponds to variant dbSNP:rs2309428EnsemblClinVar.1
Natural variantiVAR_046675668M → I1 PublicationCorresponds to variant dbSNP:rs34774441EnsemblClinVar.1
Natural variantiVAR_046676711S → P. Corresponds to variant dbSNP:rs35797487EnsemblClinVar.1
Natural variantiVAR_046677822K → N1 PublicationCorresponds to variant dbSNP:rs1049624Ensembl.1
Natural variantiVAR_046678829N → D1 PublicationCorresponds to variant dbSNP:rs1049625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069531 – 23Missing in isoform C1 and isoform C2. CuratedAdd BLAST23
Alternative sequenceiVSP_0461141 – 20MPVRG…SGWLR → MKTAQALHRMWIQAVKKLRR WKGRVSPSASSPLVFPNLSS WEGEGSKTILT in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0461151 – 19MPVRG…LSGWL → MKTAQALHRMWIQAVKKLRR WKG in isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_003149961 – 1107Missing in isoform A2 and isoform C2. CuratedAdd BLAST147
Alternative sequenceiVSP_046116961 – 997Missing in isoform 6. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_007835961 – 993SIRKP…PAFKP → VRRGRPRAGTGEPGVFLALS WTAVCSGCCGRHS in isoform A3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_007836994 – 1190Missing in isoform A3. 1 PublicationAdd BLAST197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27476 mRNA Translation: AAA61300.1 Frameshift.
AF177533
, AF043195, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177530, AF177531, AF177532 Genomic DNA Translation: AAD20387.2
AF177533
, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177530, AF177531, AF177532 Genomic DNA Translation: AAC02527.2
AF177533
, AF043195, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177532 Genomic DNA Translation: AAD56218.2
AF177533
, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177532 Genomic DNA Translation: AAD56219.2
AF489824 mRNA Translation: AAM28524.1
AK295034 mRNA Translation: BAH11954.1
AK302483 mRNA Translation: BAH13722.1
AL162730 Genomic DNA No translation available.
AL358113 Genomic DNA No translation available.
AL590238 Genomic DNA No translation available.
BC027592 mRNA Translation: AAH27592.1
AF083892 mRNA Translation: AAC33121.1
AF083893 mRNA Translation: AAC33122.1
U84581 mRNA Translation: AAB41794.1
CCDSiCCDS55315.1 [Q9UDY2-6]
CCDS55316.1 [Q9UDY2-7]
CCDS55317.1 [Q9UDY2-4]
CCDS6627.1 [Q9UDY2-1]
CCDS6628.1 [Q9UDY2-2]
PIRiI54378
RefSeqiNP_001163886.1, NM_001170415.1 [Q9UDY2-6]
NP_001163887.1, NM_001170416.1 [Q9UDY2-7]
NP_004808.2, NM_004817.3 [Q9UDY2-1]
XP_011517508.1, XM_011519206.2 [Q9UDY2-3]
XP_011517509.1, XM_011519207.2 [Q9UDY2-3]
XP_011517510.1, XM_011519208.2 [Q9UDY2-3]
XP_011517511.1, XM_011519209.2 [Q9UDY2-3]
UniGeneiHs.50382
Hs.736223

Genome annotation databases

EnsembliENST00000348208; ENSP00000345893; ENSG00000119139 [Q9UDY2-2]
ENST00000377245; ENSP00000366453; ENSG00000119139 [Q9UDY2-1]
ENST00000453658; ENSP00000392178; ENSG00000119139 [Q9UDY2-4]
ENST00000535702; ENSP00000442090; ENSG00000119139 [Q9UDY2-6]
ENST00000539225; ENSP00000438262; ENSG00000119139 [Q9UDY2-7]
GeneIDi9414
KEGGihsa:9414
UCSCiuc004ahd.4 human [Q9UDY2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZO2_HUMAN
AccessioniPrimary (citable) accession number: Q9UDY2
Secondary accession number(s): A2A3H9
, B7Z2R8, B7Z7T6, F5H301, F5H886, Q15883, Q5VXL0, Q5VXL1, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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