Q9UDY2 (ZO2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tight junction protein ZO-2

Alternative name(s):
Tight junction protein 2
Zona occludens protein 2
Zonula occludens protein 2

Gene names

Name:	TJP2
Synonyms:	X104, ZO2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1190 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in tight junctions and adherens junctions.
Subunit structure	Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB. Ref.10 Ref.15 Ref.19
Subcellular location	Cell junction › adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junction › tight junction By similarity. Nucleus By similarity. Note: Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures By similarity.
Tissue specificity	This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. Ref.2
Involvement in disease	Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Note: The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Ref.20
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.
Sequence caution	The sequence AAA61300.1 differs from that shown. Reason: Frameshift at positions 1086, 1092 and 1095.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Nucleus Tight junction
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular component disassembly involved in execution phase of apoptosis Traceable author statement. Source: Reactome hippo signaling cascade Traceable author statement. Source: Reactome
Cellular_component	adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome nucleoplasm Traceable author statement. Source: Reactome plasma membrane Inferred from direct assay. Source: HPA tight junction Inferred from direct assay PubMed 22006950. Source: MGI
Molecular_function	guanylate kinase activity Traceable author statement PubMed 8824195. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform A1 (identifier: Q9UDY2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by alternative promoter usage.

Isoform A2 (identifier: Q9UDY2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     961-1107: Missing.

Note: Produced by alternative splicing of isoform A1.

Isoform A3 (identifier: Q9UDY2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     961-993: SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKP → VRRGRPRAGTGEPGVFLALSWTAVCSGCCGRHS
     994-1190: Missing.

Note: Produced by alternative splicing of isoform A1.

Isoform C1 (identifier: Q9UDY2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: Produced by alternative promoter usage.

Isoform C2 (identifier: Q9UDY2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     961-1107: Missing.

Note: Produced by alternative splicing of isoform C1.

Isoform 6 (identifier: Q9UDY2-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MPVRGDRGFPPRRELSGWL → MKTAQALHRMWIQAVKKLRRWKG
     961-997: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9UDY2-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MPVRGDRGFPPRRELSGWLR → MKTAQALHRMWIQAVKKLRRWKGRVSPSASSPLVFPNLSSWEGEGSKTILT

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1190

1190

Tight junction protein ZO-2

PRO_0000094543

Regions

Domain

33 – 120

88

PDZ 1

Domain

307 – 385

79

PDZ 2

Domain

509 – 590

82

PDZ 3

Domain

604 – 669

66

SH3

Domain

678 – 876

199

Guanylate kinase-like

Region

1188 – 1190

3

Interaction with SCRIB

Compositional bias

1162 – 1165

4

Poly-Glu

Amino acid modifications

Modified residue

130

1

Phosphoserine Ref.11 Ref.17 Ref.18

Modified residue

153

1

Phosphoserine Ref.18

Modified residue

168

1

Phosphoserine Ref.18

Modified residue

170

1

Phosphoserine Ref.13 Ref.17

Modified residue

174

1

Phosphoserine Ref.12 Ref.13 Ref.17 Ref.18

Modified residue

200

1

Phosphoserine Ref.18

Modified residue

220

1

Phosphoserine Ref.18

Modified residue

244

1

Phosphoserine Ref.12 Ref.13 Ref.16 Ref.17 Ref.18

Modified residue

265

1

Phosphotyrosine By similarity

Modified residue

266

1

Phosphoserine Ref.13

Modified residue

292

1

Phosphoserine By similarity

Modified residue

294

1

Phosphoserine By similarity

Modified residue

296

1

Phosphoserine By similarity

Modified residue

400

1

Phosphoserine Ref.13

Modified residue

430

1

Phosphoserine Ref.18

Modified residue

455

1

Phosphothreonine Ref.13

Modified residue

702

1

Phosphoserine Ref.12

Modified residue

920

1

Phosphoserine Ref.13 Ref.17

Modified residue

925

1

Phosphothreonine Ref.13 Ref.17

Modified residue

933

1

Phosphothreonine Ref.13

Modified residue

966

1

Phosphoserine Ref.12

Modified residue

978

1

Phosphoserine Ref.13 Ref.18

Modified residue

986

1

Phosphoserine Ref.12 Ref.13 Ref.17 Ref.18

Modified residue

1006

1

Phosphoserine By similarity

Modified residue

1067

1

Phosphoserine Ref.13 Ref.18

Modified residue

1068

1

Phosphoserine Ref.13 Ref.18

Modified residue

1118

1

Phosphotyrosine By similarity

Modified residue

1131

1

Phosphothreonine Ref.13

Modified residue

1147

1

Phosphoserine Ref.18

Modified residue

1159

1

Phosphoserine Ref.13 Ref.16 Ref.17 Ref.18

Natural variations

Alternative sequence

1 – 23

23

Missing in isoform C1 and isoform C2.

VSP_006953

Alternative sequence

1 – 20

20

MPVRG…SGWLR → MKTAQALHRMWIQAVKKLRR WKGRVSPSASSPLVFPNLSS WEGEGSKTILT in isoform 7.

VSP_046114

Alternative sequence

1 – 19

19

MPVRG…LSGWL → MKTAQALHRMWIQAVKKLRR WKG in isoform 6.

VSP_046115

Alternative sequence

961 – 1107

147

Missing in isoform A2 and isoform C2.

VSP_003149

Alternative sequence

961 – 997

37

Missing in isoform 6.

VSP_046116

Alternative sequence

961 – 993

33

SIRKP…PAFKP → VRRGRPRAGTGEPGVFLALS WTAVCSGCCGRHS in isoform A3.

VSP_007835

Alternative sequence

994 – 1190

197

Missing in isoform A3.

VSP_007836

Natural variant

48

1

V → A in FHCA. Ref.20

VAR_016004

Natural variant

482

1

D → E. Ref.1 Ref.2 Ref.3 Ref.4 Ref.21
Corresponds to variant rs2309428 [ dbSNP | Ensembl ].

VAR_030798

Natural variant

668

1

M → I. Ref.4
Corresponds to variant rs34774441 [ dbSNP | Ensembl ].

VAR_046675

Natural variant

711

1

S → P.
Corresponds to variant rs35797487 [ dbSNP | Ensembl ].

VAR_046676

Natural variant

822

1

K → N. Ref.1
Corresponds to variant rs1049624 [ dbSNP | Ensembl ].

VAR_046677

Natural variant

829

1

N → D. Ref.1
Corresponds to variant rs1049625 [ dbSNP | Ensembl ].

VAR_046678

Experimental info

Sequence conflict

411

1

N → T in AAA61300. Ref.1

Sequence conflict

411

1

N → T in AAM28524. Ref.3

Sequence conflict

718

1

A → V in BAH13722. Ref.4

Sequence conflict

782

1

I → V in AAA61300. Ref.1

Sequence conflict

782

1

I → V in AAM28524. Ref.3

Sequence conflict

808

1

P → S in AAA61300. Ref.1

Sequence conflict

812 – 814

3

FFN → SFT in AAA61300. Ref.1

Sequence conflict

834

1

K → N in AAA61300. Ref.1

Sequence conflict

842

1

Q → H in AAA61300. Ref.1

Sequence conflict

996

1

P → S in AAA61300. Ref.1

Sequence conflict

1093

1

R → G in AAA61300. Ref.1

Sequence conflict

1110

1

I → L in BAH13722. Ref.4

Sequence conflict

1136

1

S → N in AAB41794. Ref.9

Sequence conflict

1155 – 1158

4

GSYG → RSFC in AAB41794. Ref.9

Sequence conflict

1165 – 1167

3

EYR → IRS in AAB41794. Ref.9

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1190

Helix Strand Turn

Details...

Beta strand

306 – 311

6

Beta strand

315 – 317

3

Beta strand

321 – 332

12

Helix

337 – 341

5

Beta strand

349 – 353

5

Helix

363 – 372

10

Turn

373 – 375

3

Beta strand

376 – 381

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform A1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 27305B723043BF6C	FASTA	1,190	133,958
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EDPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 1000 1010 1020 SIRKPSPEPR AQMRRAASSD QLRDNSPPPA FKPEPPKAKT QNKEESYDFS KSYEYKSNPS 1030 1040 1050 1060 1070 1080 AVAGNETPGA STKGYPPPVA AKPTFGRSIL KPSTPIPPQE GEEVGESSEE QDNAPKSVLG 1090 1100 1110 1120 1130 1140 KVKIFEKMDH KARLQRMQEL QEAQNARIEI AQKHPDIYAV PIKTHKPDPG TPQHTSSRPP 1150 1160 1170 1180 1190 EPQKAPSRPY QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL
	Isoform A2 [UniParc]. Checksum: 6EE97CE690160E91	FASTA	1,043	117,758
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EDPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 1000 1010 1020 IEIAQKHPDI YAVPIKTHKP DPGTPQHTSS RPPEPQKAPS RPYQDTRGSY GSDAEEEEYR 1030 1040 QQLSEHSKRG YYGQSARYRD TEL
	Isoform A3 [UniParc]. Checksum: D469C9A73851A6D3	FASTA	993	111,663
	10 20 30 40 50 60 MPVRGDRGFP PRRELSGWLR APGMEELIWE QYTVTLQKDS KRGFGIAVSG GRDNPHFENG 70 80 90 100 110 120 ETSIVISDVL PGGPADGLLQ ENDRVVMVNG TPMEDVLHSF AVQQLRKSGK VAAIVVKRPR 130 140 150 160 170 180 KVQVAALQAS PPLDQDDRAF EVMDEFDGRS FRSGYSERSR LNSHGGRSRS WEDSPERGRP 190 200 210 220 230 240 HERARSRERD LSRDRSRGRS LERGLDQDHA RTRDRSRGRS LERGLDHDFG PSRDRDRDRS 250 260 270 280 290 300 RGRSIDQDYE RAYHRAYDPD YERAYSPEYR RGARHDARSR GPRSRSREHP HSRSPSPEPR 310 320 330 340 350 360 GRPGPIGVLL MKSRANEEYG LRLGSQIFVK EMTRTGLATK DGNLHEGDII LKINGTVTEN 370 380 390 400 410 420 MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPSLNDSDS EIEDISEIES NRSFSPEERR 430 440 450 460 470 480 HQYSDYDYHS SSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ 490 500 510 520 530 540 EDPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND VGIFVAGIQE 550 560 570 580 590 600 GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADVYRDILA 610 620 630 640 650 660 CGRGDSFFIR SHFECEKETP QSLAFTRGEV FRVVDTLYDG KLGNWLAVRI GNELEKGLIP 670 680 690 700 710 720 NKSRAEQMAS VQNAQRDNAG DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE 730 740 750 760 770 780 RVLLREAGFK RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR 790 800 810 820 830 840 QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP TSNKSSRKLF 850 860 870 880 890 900 DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG EAVWVSEGKM EGMDDDPEDR 910 920 930 940 950 960 MSYLTAMGAD YLSCDSRLIS DFEDTDGEGG AYTDNELDEP AEEPLVSSIT RSSEPVQHEE 970 980 990 VRRGRPRAGT GEPGVFLALS WTAVCSGCCG RHS
	Isoform C1 [UniParc]. Checksum: 91F7D588687D179E	FASTA	1,167	131,368
	10 20 30 40 50 60 MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG PADGLLQEND 70 80 90 100 110 120 RVVMVNGTPM EDVLHSFAVQ QLRKSGKVAA IVVKRPRKVQ VAALQASPPL DQDDRAFEVM 130 140 150 160 170 180 DEFDGRSFRS GYSERSRLNS HGGRSRSWED SPERGRPHER ARSRERDLSR DRSRGRSLER 190 200 210 220 230 240 GLDQDHARTR DRSRGRSLER GLDHDFGPSR DRDRDRSRGR SIDQDYERAY HRAYDPDYER 250 260 270 280 290 300 AYSPEYRRGA RHDARSRGPR SRSREHPHSR SPSPEPRGRP GPIGVLLMKS RANEEYGLRL 310 320 330 340 350 360 GSQIFVKEMT RTGLATKDGN LHEGDIILKI NGTVTENMSL TDARKLIEKS RGKLQLVVLR 370 380 390 400 410 420 DSQQTLINIP SLNDSDSEIE DISEIESNRS FSPEERRHQY SDYDYHSSSE KLKERPSSRE 430 440 450 460 470 480 DTPSRLSRMG ATPTPFKSTG DIAGTVVPET NKEPRYQEDP PAPQPKAAPR TFLRPSPEDE 490 500 510 520 530 540 AIYGPNTKMV RFKKGDSVGL RLAGGNDVGI FVAGIQEGTS AEQEGLQEGD QILKVNTQDF 550 560 570 580 590 600 RGLVREDAVL YLLEIPKGEM VTILAQSRAD VYRDILACGR GDSFFIRSHF ECEKETPQSL 610 620 630 640 650 660 AFTRGEVFRV VDTLYDGKLG NWLAVRIGNE LEKGLIPNKS RAEQMASVQN AQRDNAGDRA 670 680 690 700 710 720 DFWRMRGQRS GVKKNLRKSR EDLTAVVSVS TKFPAYERVL LREAGFKRPV VLFGPIADIA 730 740 750 760 770 780 MEKLANELPD WFQTAKTEPK DAGSEKSTGV VRLNTVRQII EQDKHALLDV TPKAVDLLNY 790 800 810 820 830 840 TQWFPIVIFF NPDSRQGVKT MRQRLNPTSN KSSRKLFDQA NKLKKTCAHL FTATINLNSA 850 860 870 880 890 900 NDSWFGSLKD TIQHQQGEAV WVSEGKMEGM DDDPEDRMSY LTAMGADYLS CDSRLISDFE 910 920 930 940 950 960 DTDGEGGAYT DNELDEPAEE PLVSSITRSS EPVQHEESIR KPSPEPRAQM RRAASSDQLR 970 980 990 1000 1010 1020 DNSPPPAFKP EPPKAKTQNK EESYDFSKSY EYKSNPSAVA GNETPGASTK GYPPPVAAKP 1030 1040 1050 1060 1070 1080 TFGRSILKPS TPIPPQEGEE VGESSEEQDN APKSVLGKVK IFEKMDHKAR LQRMQELQEA 1090 1100 1110 1120 1130 1140 QNARIEIAQK HPDIYAVPIK THKPDPGTPQ HTSSRPPEPQ KAPSRPYQDT RGSYGSDAEE 1150 1160 EEYRQQLSEH SKRGYYGQSA RYRDTEL
	Isoform C2 [UniParc]. Checksum: 4A49BF3F0718D771	FASTA	1,020	115,168
	10 20 30 40 50 60 MEELIWEQYT VTLQKDSKRG FGIAVSGGRD NPHFENGETS IVISDVLPGG PADGLLQEND 70 80 90 100 110 120 RVVMVNGTPM EDVLHSFAVQ QLRKSGKVAA IVVKRPRKVQ VAALQASPPL DQDDRAFEVM 130 140 150 160 170 180 DEFDGRSFRS GYSERSRLNS HGGRSRSWED SPERGRPHER ARSRERDLSR DRSRGRSLER 190 200 210 220 230 240 GLDQDHARTR DRSRGRSLER GLDHDFGPSR DRDRDRSRGR SIDQDYERAY HRAYDPDYER 250 260 270 280 290 300 AYSPEYRRGA RHDARSRGPR SRSREHPHSR SPSPEPRGRP GPIGVLLMKS RANEEYGLRL 310 320 330 340 350 360 GSQIFVKEMT RTGLATKDGN LHEGDIILKI NGTVTENMSL TDARKLIEKS RGKLQLVVLR 370 380 390 400 410 420 DSQQTLINIP SLNDSDSEIE DISEIESNRS FSPEERRHQY SDYDYHSSSE KLKERPSSRE 430 440 450 460 470 480 DTPSRLSRMG ATPTPFKSTG DIAGTVVPET NKEPRYQEDP PAPQPKAAPR TFLRPSPEDE 490 500 510 520 530 540 AIYGPNTKMV RFKKGDSVGL RLAGGNDVGI FVAGIQEGTS AEQEGLQEGD QILKVNTQDF 550 560 570 580 590 600 RGLVREDAVL YLLEIPKGEM VTILAQSRAD VYRDILACGR GDSFFIRSHF ECEKETPQSL 610 620 630 640 650 660 AFTRGEVFRV VDTLYDGKLG NWLAVRIGNE LEKGLIPNKS RAEQMASVQN AQRDNAGDRA 670 680 690 700 710 720 DFWRMRGQRS GVKKNLRKSR EDLTAVVSVS TKFPAYERVL LREAGFKRPV VLFGPIADIA 730 740 750 760 770 780 MEKLANELPD WFQTAKTEPK DAGSEKSTGV VRLNTVRQII EQDKHALLDV TPKAVDLLNY 790 800 810 820 830 840 TQWFPIVIFF NPDSRQGVKT MRQRLNPTSN KSSRKLFDQA NKLKKTCAHL FTATINLNSA 850 860 870 880 890 900 NDSWFGSLKD TIQHQQGEAV WVSEGKMEGM DDDPEDRMSY LTAMGADYLS CDSRLISDFE 910 920 930 940 950 960 DTDGEGGAYT DNELDEPAEE PLVSSITRSS EPVQHEEIEI AQKHPDIYAV PIKTHKPDPG 970 980 990 1000 1010 1020 TPQHTSSRPP EPQKAPSRPY QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL
	Isoform 6 [UniParc]. Checksum: 30C98BC65E29BC85	FASTA	1,157	130,446
	10 20 30 40 50 60 MKTAQALHRM WIQAVKKLRR WKGRAPGMEE LIWEQYTVTL QKDSKRGFGI AVSGGRDNPH 70 80 90 100 110 120 FENGETSIVI SDVLPGGPAD GLLQENDRVV MVNGTPMEDV LHSFAVQQLR KSGKVAAIVV 130 140 150 160 170 180 KRPRKVQVAA LQASPPLDQD DRAFEVMDEF DGRSFRSGYS ERSRLNSHGG RSRSWEDSPE 190 200 210 220 230 240 RGRPHERARS RERDLSRDRS RGRSLERGLD QDHARTRDRS RGRSLERGLD HDFGPSRDRD 250 260 270 280 290 300 RDRSRGRSID QDYERAYHRA YDPDYERAYS PEYRRGARHD ARSRGPRSRS REHPHSRSPS 310 320 330 340 350 360 PEPRGRPGPI GVLLMKSRAN EEYGLRLGSQ IFVKEMTRTG LATKDGNLHE GDIILKINGT 370 380 390 400 410 420 VTENMSLTDA RKLIEKSRGK LQLVVLRDSQ QTLINIPSLN DSDSEIEDIS EIESNRSFSP 430 440 450 460 470 480 EERRHQYSDY DYHSSSEKLK ERPSSREDTP SRLSRMGATP TPFKSTGDIA GTVVPETNKE 490 500 510 520 530 540 PRYQEDPPAP QPKAAPRTFL RPSPEDEAIY GPNTKMVRFK KGDSVGLRLA GGNDVGIFVA 550 560 570 580 590 600 GIQEGTSAEQ EGLQEGDQIL KVNTQDFRGL VREDAVLYLL EIPKGEMVTI LAQSRADVYR 610 620 630 640 650 660 DILACGRGDS FFIRSHFECE KETPQSLAFT RGEVFRVVDT LYDGKLGNWL AVRIGNELEK 670 680 690 700 710 720 GLIPNKSRAE QMASVQNAQR DNAGDRADFW RMRGQRSGVK KNLRKSREDL TAVVSVSTKF 730 740 750 760 770 780 PAYERVLLRE AGFKRPVVLF GPIADIAMEK LANELPDWFQ TAKTEPKDAG SEKSTGVVRL 790 800 810 820 830 840 NTVRQIIEQD KHALLDVTPK AVDLLNYTQW FPIVIFFNPD SRQGVKTMRQ RLNPTSNKSS 850 860 870 880 890 900 RKLFDQANKL KKTCAHLFTA TINLNSANDS WFGSLKDTIQ HQQGEAVWVS EGKMEGMDDD 910 920 930 940 950 960 PEDRMSYLTA MGADYLSCDS RLISDFEDTD GEGGAYTDNE LDEPAEEPLV SSITRSSEPV 970 980 990 1000 1010 1020 QHEEAKTQNK EESYDFSKSY EYKSNPSAVA GNETPGASTK GYPPPVAAKP TFGRSILKPS 1030 1040 1050 1060 1070 1080 TPIPPQEGEE VGESSEEQDN APKSVLGKVK IFEKMDHKAR LQRMQELQEA QNARIEIAQK 1090 1100 1110 1120 1130 1140 HPDIYAVPIK THKPDPGTPQ HTSSRPPEPQ KAPSRPYQDT RGSYGSDAEE EEYRQQLSEH 1150 SKRGYYGQSA RYRDTEL
	Isoform 7 [UniParc]. Checksum: E185339B2A2F37B4	FASTA	1,221	137,342
	10 20 30 40 50 60 MKTAQALHRM WIQAVKKLRR WKGRVSPSAS SPLVFPNLSS WEGEGSKTIL TAPGMEELIW 70 80 90 100 110 120 EQYTVTLQKD SKRGFGIAVS GGRDNPHFEN GETSIVISDV LPGGPADGLL QENDRVVMVN 130 140 150 160 170 180 GTPMEDVLHS FAVQQLRKSG KVAAIVVKRP RKVQVAALQA SPPLDQDDRA FEVMDEFDGR 190 200 210 220 230 240 SFRSGYSERS RLNSHGGRSR SWEDSPERGR PHERARSRER DLSRDRSRGR SLERGLDQDH 250 260 270 280 290 300 ARTRDRSRGR SLERGLDHDF GPSRDRDRDR SRGRSIDQDY ERAYHRAYDP DYERAYSPEY 310 320 330 340 350 360 RRGARHDARS RGPRSRSREH PHSRSPSPEP RGRPGPIGVL LMKSRANEEY GLRLGSQIFV 370 380 390 400 410 420 KEMTRTGLAT KDGNLHEGDI ILKINGTVTE NMSLTDARKL IEKSRGKLQL VVLRDSQQTL 430 440 450 460 470 480 INIPSLNDSD SEIEDISEIE SNRSFSPEER RHQYSDYDYH SSSEKLKERP SSREDTPSRL 490 500 510 520 530 540 SRMGATPTPF KSTGDIAGTV VPETNKEPRY QEDPPAPQPK AAPRTFLRPS PEDEAIYGPN 550 560 570 580 590 600 TKMVRFKKGD SVGLRLAGGN DVGIFVAGIQ EGTSAEQEGL QEGDQILKVN TQDFRGLVRE 610 620 630 640 650 660 DAVLYLLEIP KGEMVTILAQ SRADVYRDIL ACGRGDSFFI RSHFECEKET PQSLAFTRGE 670 680 690 700 710 720 VFRVVDTLYD GKLGNWLAVR IGNELEKGLI PNKSRAEQMA SVQNAQRDNA GDRADFWRMR 730 740 750 760 770 780 GQRSGVKKNL RKSREDLTAV VSVSTKFPAY ERVLLREAGF KRPVVLFGPI ADIAMEKLAN 790 800 810 820 830 840 ELPDWFQTAK TEPKDAGSEK STGVVRLNTV RQIIEQDKHA LLDVTPKAVD LLNYTQWFPI 850 860 870 880 890 900 VIFFNPDSRQ GVKTMRQRLN PTSNKSSRKL FDQANKLKKT CAHLFTATIN LNSANDSWFG 910 920 930 940 950 960 SLKDTIQHQQ GEAVWVSEGK MEGMDDDPED RMSYLTAMGA DYLSCDSRLI SDFEDTDGEG 970 980 990 1000 1010 1020 GAYTDNELDE PAEEPLVSSI TRSSEPVQHE ESIRKPSPEP RAQMRRAASS DQLRDNSPPP 1030 1040 1050 1060 1070 1080 AFKPEPPKAK TQNKEESYDF SKSYEYKSNP SAVAGNETPG ASTKGYPPPV AAKPTFGRSI 1090 1100 1110 1120 1130 1140 LKPSTPIPPQ EGEEVGESSE EQDNAPKSVL GKVKIFEKMD HKARLQRMQE LQEAQNARIE 1150 1160 1170 1180 1190 1200 IAQKHPDIYA VPIKTHKPDP GTPQHTSSRP PEPQKAPSRP YQDTRGSYGS DAEEEEYRQQ 1210 1220 LSEHSKRGYY GQSARYRDTE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb." Duclos F., Rodius F., Wrogemann K., Mandel J.-L., Koenig M. Hum. Mol. Genet. 3:909-914(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1), VARIANTS GLU-482; ASN-822 AND ASP-829. Tissue: Brain.
[2]	"Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues." Chlenski A., Ketels K.V., Korovaitseva G.I., Talamonti M.S., Oyasu R., Scarpelli D.G. Biochim. Biophys. Acta 1493:319-324(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A1; C1; A2 AND C2), TISSUE SPECIFICITY, ALTERNATIVE PROMOTER USAGE, VARIANT GLU-482. Tissue: Pancreas.
[3]	"LIM protein KyoT2 interacts with human tight junction protein ZO-2-i3." Yan H.H., Rong L., Qiang S., Jian W., Peng Z., Hua H., Hui Z.W. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A3), VARIANT GLU-482.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANTS GLU-482 AND ILE-668. Tissue: Brain and Testis.
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1). Tissue: Testis.
[7]	"Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma." Chlenski A., Ketels K.V., Tsao M.-S., Talamonti M.S., Anderson M.R., Oyasu R., Scarpelli D.G. Int. J. Cancer 82:137-144(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-166 (ISOFORMS A1/A2/A3), NUCLEOTIDE SEQUENCE [MRNA] OF 1-119 (ISOFORMS C1/C2). Tissue: Pancreas.
[8]	"Zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells." Chlenski A., Ketels K.V., Engeriser J.L., Talamonti M.S., Tsao M.-S., Koutnikova H., Oyasu R., Scarpelli D.G. Int. J. Cancer 83:349-358(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS A1 AND C1), ALTERNATIVE PROMOTER USAGE. Tissue: Pancreas.
[9]	Adams L.D., Werny I., Schwartz S.M. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1047-1167. Tissue: Aortic smooth muscle.
[10]	"hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells." Metais J.-Y., Navarro C., Santoni M.-J., Audebert S., Borg J.-P. FEBS Lett. 579:3725-3730(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SCRIB.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-244; SER-702; SER-966 AND SER-986, MASS SPECTROMETRY. Tissue: Platelet.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-174; SER-244; SER-266; SER-400; THR-455; SER-920; THR-925; THR-933; SER-978; SER-986; SER-1067; SER-1068; THR-1131 AND SER-1159, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[15]	"Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)." Aho S., Lupo J., Coly P.-A., Sabine A., Castellazzi M., Morand P., Sergeant A., Manet E., Boyer V., Gruffat H. Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH UBN1.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-1159, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-170; SER-174; SER-244; SER-920; THR-925; SER-986 AND SER-1159, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-153; SER-168; SER-174; SER-200; SER-220; SER-244; SER-430; SER-978; SER-986; SER-1067; SER-1068; SER-1147 AND SER-1159, MASS SPECTROMETRY.
[19]	"Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins." Wu J., Yang Y., Zhang J., Ji P., Du W., Jiang P., Xie D., Huang H., Wu M., Zhang G., Wu J., Shi Y. J. Biol. Chem. 282:35988-35999(2007) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 306-385, SUBUNIT.
[20]	"Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT." Carlton V.E.H., Harris B.Z., Puffenberger E.G., Batta A.K., Knisely A.S., Robinson D.L., Strauss K.A., Shneider B.L., Lim W.A., Salen G., Morton D.H., Bull L.N. Nat. Genet. 34:91-96(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT FHCA ALA-48.
[21]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-482, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L27476 mRNA. Translation: AAA61300.1. Frameshift.
AF177533 , AF043195, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177530, AF177531, AF177532 Genomic DNA. Translation: AAD20387.2.
AF177533 , AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177530, AF177531, AF177532 Genomic DNA. Translation: AAC02527.2.
AF177533 , AF043195, AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177532 Genomic DNA. Translation: AAD56218.2.
AF177533 , AF043196, AF043197, AF177518, AF177519, AF177520, AF177521, AF177522, AF177523, AF177524, AF177525, AF177526, AF177527, AF177528, AF177529, AF177532 Genomic DNA. Translation: AAD56219.2.
AF489824 mRNA. Translation: AAM28524.1.
AK295034 mRNA. Translation: BAH11954.1.
AK302483 mRNA. Translation: BAH13722.1.
AL162730 Genomic DNA. No translation available.
AL358113 Genomic DNA. Translation: CAH70867.1.
AL358113 Genomic DNA. Translation: CAH70868.1.
AL358113 Genomic DNA. Translation: CAM13389.1.
AL590238 Genomic DNA. No translation available.
BC027592 mRNA. Translation: AAH27592.1.
AF083892 mRNA. Translation: AAC33121.1.
AF083893 mRNA. Translation: AAC33122.1.
U84581 mRNA. Translation: AAB41794.1.

IPI

IPI00003843.
IPI00216245.
IPI00216246.
IPI00332453.
IPI00797934.
IPI00955022.
IPI00955040.

PIR

I54378.

RefSeq

NP_001163886.1. NM_001170415.1.
NP_001163887.1. NM_001170416.1.
NP_001164101.1. NM_001170630.1.
NP_004808.2. NM_004817.3.
NP_963923.1. NM_201629.3.

UniGene

Hs.50382.
Hs.736223.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OSG	NMR	-	A/B	306-385	[»]
3E17	X-ray	1.75	A/B	306-384	[»]

ProteinModelPortal

Q9UDY2.

SMR

Q9UDY2. Positions 21-129, 306-384, 508-887.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UDY2. 4 interactions.

MINT

MINT-1207536.

STRING

9606.ENSP00000366453.

PTM databases

PhosphoSite

Q9UDY2.

Polymorphism databases

DMDM

13634076.

Proteomic databases

PaxDb

Q9UDY2.

PRIDE

Q9UDY2.

Protocols and materials databases

DNASU

9414.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000265384; ENSP00000265384; ENSG00000119139.
ENST00000348208; ENSP00000345893; ENSG00000119139.
ENST00000377245; ENSP00000366453; ENSG00000119139.
ENST00000453658; ENSP00000392178; ENSG00000119139.
ENST00000535702; ENSP00000442090; ENSG00000119139.
ENST00000539225; ENSP00000438262; ENSG00000119139.

GeneID

9414.

KEGG

hsa:9414.

UCSC

uc004ahd.3. human.
uc004ahe.3. human.
uc004ahf.3. human.
uc011lrs.2. human.

Organism-specific databases

CTD

9414.

GeneCards

GC09P071766.

HGNC

HGNC:11828. TJP2.

HPA

CAB009228.
HPA001813.

MIM

607709. gene.
607748. phenotype.

neXtProt

NX_Q9UDY2.

Orphanet

90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
238475. Familial hypercholanemia.

PharmGKB

PA36533.

GenAtlas

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Phylogenomic databases

eggNOG

NOG239704.

HOVERGEN

HBG017627.

InParanoid

Q9UDY2.

KO

K06098.

OrthoDB

EOG4Q2DDQ.

PhylomeDB

Q9UDY2.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_578. Apoptosis.

Gene expression databases

ArrayExpress

Q9UDY2.

Bgee

Q9UDY2.

CleanEx

HS_TJP2.

Genevestigator

Q9UDY2.

GermOnline

ENSG00000119139. Homo sapiens.

Family and domain databases

InterPro

IPR008144. Guanylate_kin.
IPR008145. Guanylate_kin/L-typ_Ca_channel.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005419. ZonOcculS2.
[Graphical view]

Pfam

PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]

PRINTS

PR01597. ZONOCCLUDNS.
PR01599. ZONOCCLUDNS2.

SMART

SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 3 hits.
SSF50044. SH3. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. False negative.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

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Other

EvolutionaryTrace

Q9UDY2.

GenomeRNAi

9414.

NextBio

35268.

SOURCE

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Entry information

Entry name

ZO2_HUMAN

Accession

Primary (citable) accession number: Q9UDY2
Secondary accession number(s): A2A3H9 , B7Z2R8, B7Z7T6, F5H301, F5H886, Q15883, Q5VXL0, Q5VXL1, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 142 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.