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Protein

Mitochondrial fission process protein 1

Gene

MTFP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitochondrial fission Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission process protein 1
Alternative name(s):
Mitochondrial 18 kDa protein
Short name:
MTP18
Gene namesi
Name:MTFP1
Synonyms:MTP18
ORF Names:HSPC242, My022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26945. MTFP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiMTFP1.
DMDMi52783151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Mitochondrial fission process protein 1PRO_0000212411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231N6-succinyllysineBy similarity

Proteomic databases

EPDiQ9UDX5.
MaxQBiQ9UDX5.
PaxDbiQ9UDX5.
PeptideAtlasiQ9UDX5.
PRIDEiQ9UDX5.
TopDownProteomicsiQ9UDX5-1. [Q9UDX5-1]

PTM databases

iPTMnetiQ9UDX5.
PhosphoSiteiQ9UDX5.

Expressioni

Inductioni

Expression is regulated by the phosphatidylinositol (PI) 3-kinase pathway.1 Publication

Gene expression databases

BgeeiENSG00000242114.
ExpressionAtlasiQ9UDX5. baseline and differential.
GenevisibleiQ9UDX5. HS.

Interactioni

Protein-protein interaction databases

BioGridi119597. 9 interactions.
STRINGi9606.ENSP00000266263.

Structurei

3D structure databases

ProteinModelPortaliQ9UDX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MTFP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3945. Eukaryota.
ENOG4111JTM. LUCA.
GeneTreeiENSGT00390000004019.
HOGENOMiHOG000293217.
HOVERGENiHBG052517.
InParanoidiQ9UDX5.
KOiK17981.
OMAiWQMLASV.
OrthoDBiEOG091G0PGM.
PhylomeDBiQ9UDX5.
TreeFamiTF324605.

Family and domain databases

InterProiIPR019560. Mitochondrial_18_kDa_protein_.
[Graphical view]
PfamiPF10558. MTP18. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEPQPRGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVASS
60 70 80 90 100
YVLADAIDKG KKAGEVPSPE AGRSARVTVA VVDTFVWQAL ASVAIPGFTI
110 120 130 140 150
NRVCAASLYV LGTATRWPLA VRKWTTTALG LLTIPIIIHP IDRSVDFLLD
160
SSLRKLYPTV GKPSSS
Length:166
Mass (Da):18,010
Last modified:May 1, 2000 - v1
Checksum:i447D3BA5CC1ACA2D
GO
Isoform 2 (identifier: Q9UDX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-166: PSPEAGRSAR...YPTVGKPSSS → GGFPPGLQPA...TWVGLSWTEA

Show »
Length:135
Mass (Da):14,513
Checksum:iBEE06B767A4D8585
GO

Sequence cautioni

The sequence AAF36162 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAG43136 differs from that shown. Reason: Frameshift at positions 66 and 84. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921S → A in AAG43136 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 166100PSPEA…KPSSS → GGFPPGLQPAQALPNSGEAQ LLLIILWYLACASASCFMST SYSCQGMWTPGSLVSKDPGT WVGLSWTEA in isoform 2. CuratedVSP_041425Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151076 mRNA. Translation: AAF36162.1. Sequence problems.
AF060924 mRNA. Translation: AAG43136.1. Frameshift.
CR456345 mRNA. Translation: CAG30231.1.
AC004832 Genomic DNA. Translation: AAF19257.1.
BC001608 mRNA. Translation: AAH01608.1.
BC009300 mRNA. Translation: AAH09300.1.
BC014446 mRNA. Translation: AAH14446.1.
BC030989 mRNA. Translation: AAH30989.1.
BC038831 mRNA. Translation: AAH38831.1.
BC046132 mRNA. Translation: AAH46132.1.
CCDSiCCDS33634.1. [Q9UDX5-2]
CCDS33635.1. [Q9UDX5-1]
RefSeqiNP_001003704.1. NM_001003704.2. [Q9UDX5-2]
NP_057582.2. NM_016498.4. [Q9UDX5-1]
UniGeneiHs.713636.

Genome annotation databases

EnsembliENST00000266263; ENSP00000266263; ENSG00000242114. [Q9UDX5-1]
ENST00000355143; ENSP00000347267; ENSG00000242114. [Q9UDX5-2]
GeneIDi51537.
KEGGihsa:51537.
UCSCiuc003ahw.3. human. [Q9UDX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151076 mRNA. Translation: AAF36162.1. Sequence problems.
AF060924 mRNA. Translation: AAG43136.1. Frameshift.
CR456345 mRNA. Translation: CAG30231.1.
AC004832 Genomic DNA. Translation: AAF19257.1.
BC001608 mRNA. Translation: AAH01608.1.
BC009300 mRNA. Translation: AAH09300.1.
BC014446 mRNA. Translation: AAH14446.1.
BC030989 mRNA. Translation: AAH30989.1.
BC038831 mRNA. Translation: AAH38831.1.
BC046132 mRNA. Translation: AAH46132.1.
CCDSiCCDS33634.1. [Q9UDX5-2]
CCDS33635.1. [Q9UDX5-1]
RefSeqiNP_001003704.1. NM_001003704.2. [Q9UDX5-2]
NP_057582.2. NM_016498.4. [Q9UDX5-1]
UniGeneiHs.713636.

3D structure databases

ProteinModelPortaliQ9UDX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119597. 9 interactions.
STRINGi9606.ENSP00000266263.

PTM databases

iPTMnetiQ9UDX5.
PhosphoSiteiQ9UDX5.

Polymorphism and mutation databases

BioMutaiMTFP1.
DMDMi52783151.

Proteomic databases

EPDiQ9UDX5.
MaxQBiQ9UDX5.
PaxDbiQ9UDX5.
PeptideAtlasiQ9UDX5.
PRIDEiQ9UDX5.
TopDownProteomicsiQ9UDX5-1. [Q9UDX5-1]

Protocols and materials databases

DNASUi51537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266263; ENSP00000266263; ENSG00000242114. [Q9UDX5-1]
ENST00000355143; ENSP00000347267; ENSG00000242114. [Q9UDX5-2]
GeneIDi51537.
KEGGihsa:51537.
UCSCiuc003ahw.3. human. [Q9UDX5-1]

Organism-specific databases

CTDi51537.
GeneCardsiMTFP1.
H-InvDBHIX0213393.
HGNCiHGNC:26945. MTFP1.
MIMi610235. gene.
neXtProtiNX_Q9UDX5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3945. Eukaryota.
ENOG4111JTM. LUCA.
GeneTreeiENSGT00390000004019.
HOGENOMiHOG000293217.
HOVERGENiHBG052517.
InParanoidiQ9UDX5.
KOiK17981.
OMAiWQMLASV.
OrthoDBiEOG091G0PGM.
PhylomeDBiQ9UDX5.
TreeFamiTF324605.

Miscellaneous databases

GeneWikiiMTP18.
GenomeRNAii51537.
PROiQ9UDX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242114.
ExpressionAtlasiQ9UDX5. baseline and differential.
GenevisibleiQ9UDX5. HS.

Family and domain databases

InterProiIPR019560. Mitochondrial_18_kDa_protein_.
[Graphical view]
PfamiPF10558. MTP18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTFP1_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX5
Secondary accession number(s): A6NFQ5, Q9H3K1, Q9P0N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.