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Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
Gene namesi
Name:SEC14L3
Synonyms:TAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18655. SEC14L3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: InterPro
  • intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi266629.
OpenTargetsiENSG00000100012.
PharmGKBiPA134960743.

Chemistry databases

DrugBankiDB00163. Vitamin E.

Polymorphism and mutation databases

BioMutaiSEC14L3.
DMDMi29428056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107581 – 400SEC14-like protein 3Add BLAST400

Proteomic databases

PaxDbiQ9UDX4.
PeptideAtlasiQ9UDX4.
PRIDEiQ9UDX4.

PTM databases

iPTMnetiQ9UDX4.
PhosphoSitePlusiQ9UDX4.

Expressioni

Gene expression databases

BgeeiENSG00000100012.
CleanExiHS_SEC14L3.
HS_TAP2.
ExpressionAtlasiQ9UDX4. baseline and differential.
GenevisibleiQ9UDX4. HS.

Organism-specific databases

HPAiHPA059450.

Interactioni

Protein-protein interaction databases

BioGridi129297. 3 interactors.
STRINGi9606.ENSP00000215812.

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 23Combined sources14
Turni24 – 26Combined sources3
Helixi27 – 29Combined sources3
Helixi35 – 44Combined sources10
Turni45 – 47Combined sources3
Helixi49 – 65Combined sources17
Helixi68 – 73Combined sources6
Helixi78 – 83Combined sources6
Beta strandi86 – 91Combined sources6
Beta strandi97 – 102Combined sources6
Helixi108 – 112Combined sources5
Helixi117 – 142Combined sources26
Beta strandi149 – 154Combined sources6
Helixi160 – 163Combined sources4
Helixi165 – 181Combined sources17
Beta strandi186 – 193Combined sources8
Helixi198 – 205Combined sources8
Helixi206 – 208Combined sources3
Helixi211 – 215Combined sources5
Beta strandi217 – 219Combined sources3
Helixi224 – 231Combined sources8
Helixi234 – 236Combined sources3
Helixi239 – 241Combined sources3
Beta strandi243 – 245Combined sources3
Turni255 – 257Combined sources3
Helixi266 – 268Combined sources3
Beta strandi279 – 285Combined sources7
Beta strandi289 – 296Combined sources8
Beta strandi302 – 308Combined sources7
Beta strandi310 – 312Combined sources3
Beta strandi314 – 324Combined sources11
Helixi330 – 332Combined sources3
Beta strandi333 – 342Combined sources10
Beta strandi345 – 347Combined sources3
Beta strandi349 – 354Combined sources6
Beta strandi359 – 366Combined sources8
Beta strandi371 – 384Combined sources14
Helixi388 – 391Combined sources4
Helixi392 – 396Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4.
SMRiQ9UDX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini275 – 383GOLDPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX4.
OMAiFRTESSE.
OrthoDBiEOG091G0MI9.
PhylomeDBiQ9UDX4.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY
110 120 130 140 150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV
160 170 180 190 200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV
210 220 230 240 250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG
260 270 280 290 300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED
360 370 380 390 400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Length:400
Mass (Da):46,048
Last modified:May 1, 2000 - v1
Checksum:i07F880D25B66CC19
GO
Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):39,174
Checksum:i831C914C0A5FE469
GO
Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):36,922
Checksum:i0F9B9BBD477DF986
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024627103I → T.1 PublicationCorresponds to variant rs4820853dbSNPEnsembl.1
Natural variantiVAR_024628214R → H.Corresponds to variant rs2269961dbSNPEnsembl.1
Natural variantiVAR_022097335D → E.1 PublicationCorresponds to variant rs2240345dbSNPEnsembl.1
Natural variantiVAR_061787364R → C.Corresponds to variant rs35764129dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455531 – 78MSGRV…WQPPE → M in isoform 3. CuratedAdd BLAST78
Alternative sequenceiVSP_0455541 – 59Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSiCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneiHs.505601.

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneIDi266629.
KEGGihsa:266629.
UCSCiuc003ahy.4. human. [Q9UDX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSiCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneiHs.505601.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4.
SMRiQ9UDX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129297. 3 interactors.
STRINGi9606.ENSP00000215812.

Chemistry databases

DrugBankiDB00163. Vitamin E.

PTM databases

iPTMnetiQ9UDX4.
PhosphoSitePlusiQ9UDX4.

Polymorphism and mutation databases

BioMutaiSEC14L3.
DMDMi29428056.

Proteomic databases

PaxDbiQ9UDX4.
PeptideAtlasiQ9UDX4.
PRIDEiQ9UDX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneIDi266629.
KEGGihsa:266629.
UCSCiuc003ahy.4. human. [Q9UDX4-1]

Organism-specific databases

CTDi266629.
DisGeNETi266629.
GeneCardsiSEC14L3.
HGNCiHGNC:18655. SEC14L3.
HPAiHPA059450.
MIMi612824. gene.
neXtProtiNX_Q9UDX4.
OpenTargetsiENSG00000100012.
PharmGKBiPA134960743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX4.
OMAiFRTESSE.
OrthoDBiEOG091G0MI9.
PhylomeDBiQ9UDX4.
TreeFamiTF313988.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100012-MONOMER.

Miscellaneous databases

GenomeRNAii266629.
PROiQ9UDX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100012.
CleanExiHS_SEC14L3.
HS_TAP2.
ExpressionAtlasiQ9UDX4. baseline and differential.
GenevisibleiQ9UDX4. HS.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS14L3_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74
, E9PE57, Q495V8, Q495W0, Q495W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.