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Q9UDX4

- S14L3_HUMAN

UniProt

Q9UDX4 - S14L3_HUMAN

Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SEC14-like protein 3
    Alternative name(s):
    Tocopherol-associated protein 2
    Gene namesi
    Name:SEC14L3
    Synonyms:TAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18655. SEC14L3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960743.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400SEC14-like protein 3PRO_0000210758Add
    BLAST

    Proteomic databases

    MaxQBiQ9UDX4.
    PaxDbiQ9UDX4.
    PRIDEiQ9UDX4.

    PTM databases

    PhosphoSiteiQ9UDX4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UDX4.
    BgeeiQ9UDX4.
    CleanExiHS_SEC14L3.
    HS_TAP2.
    GenevestigatoriQ9UDX4.

    Organism-specific databases

    HPAiHPA059450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UDX4.
    SMRiQ9UDX4. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 249174CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 383109GOLDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 1 GOLD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG309458.
    HOGENOMiHOG000232201.
    HOVERGENiHBG055336.
    InParanoidiQ9UDX4.
    OMAiAKMRDCE.
    OrthoDBiEOG7N8ZVD.
    PhylomeDBiQ9UDX4.
    TreeFamiTF313988.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    InterProiIPR001071. CRAL-bd_toc_tran.
    IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR009038. GOLD.
    [Graphical view]
    PfamiPF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view]
    PRINTSiPR00180. CRETINALDHBP.
    SMARTiSM01100. CRAL_TRIO_N. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF101576. SSF101576. 1 hit.
    SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ    50
    KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY 100
    DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV 150
    MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV 200
    GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG 250
    NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG 300
    CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED 350
    GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV 400
    Length:400
    Mass (Da):46,048
    Last modified:May 1, 2000 - v1
    Checksum:i07F880D25B66CC19
    GO
    Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:341
    Mass (Da):39,174
    Checksum:i831C914C0A5FE469
    GO
    Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: MSGRVGDLSP...DHILDWQPPE → M

    Note: No experimental confirmation available.

    Show »
    Length:323
    Mass (Da):36,922
    Checksum:i0F9B9BBD477DF986
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031I → T.1 Publication
    Corresponds to variant rs4820853 [ dbSNP | Ensembl ].
    VAR_024627
    Natural varianti214 – 2141R → H.
    Corresponds to variant rs2269961 [ dbSNP | Ensembl ].
    VAR_024628
    Natural varianti335 – 3351D → E.1 Publication
    Corresponds to variant rs2240345 [ dbSNP | Ensembl ].
    VAR_022097
    Natural varianti364 – 3641R → C.
    Corresponds to variant rs35764129 [ dbSNP | Ensembl ].
    VAR_061787

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7878MSGRV…WQPPE → M in isoform 3. CuratedVSP_045553Add
    BLAST
    Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_045554Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158086 mRNA. Translation: AAO21870.1.
    AC004832 Genomic DNA. Translation: AAF19258.1.
    BC101001 mRNA. Translation: AAI01002.1.
    BC101002 mRNA. Translation: AAI01003.1.
    BC101004 mRNA. Translation: AAI01005.1.
    CCDSiCCDS13877.1. [Q9UDX4-1]
    CCDS58800.1. [Q9UDX4-3]
    CCDS58801.1. [Q9UDX4-2]
    RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
    NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
    NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
    NP_777635.1. NM_174975.4. [Q9UDX4-1]
    UniGeneiHs.505601.

    Genome annotation databases

    EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
    ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
    ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
    ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
    GeneIDi266629.
    KEGGihsa:266629.
    UCSCiuc003ahy.3. human. [Q9UDX4-1]
    uc003ahz.3. human.

    Polymorphism databases

    DMDMi29428056.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158086 mRNA. Translation: AAO21870.1 .
    AC004832 Genomic DNA. Translation: AAF19258.1 .
    BC101001 mRNA. Translation: AAI01002.1 .
    BC101002 mRNA. Translation: AAI01003.1 .
    BC101004 mRNA. Translation: AAI01005.1 .
    CCDSi CCDS13877.1. [Q9UDX4-1 ]
    CCDS58800.1. [Q9UDX4-3 ]
    CCDS58801.1. [Q9UDX4-2 ]
    RefSeqi NP_001244307.1. NM_001257378.1. [Q9UDX4-3 ]
    NP_001244308.1. NM_001257379.1. [Q9UDX4-2 ]
    NP_001244311.1. NM_001257382.1. [Q9UDX4-2 ]
    NP_777635.1. NM_174975.4. [Q9UDX4-1 ]
    UniGenei Hs.505601.

    3D structure databases

    ProteinModelPortali Q9UDX4.
    SMRi Q9UDX4. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00163. Vitamin E.

    PTM databases

    PhosphoSitei Q9UDX4.

    Polymorphism databases

    DMDMi 29428056.

    Proteomic databases

    MaxQBi Q9UDX4.
    PaxDbi Q9UDX4.
    PRIDEi Q9UDX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215812 ; ENSP00000215812 ; ENSG00000100012 . [Q9UDX4-1 ]
    ENST00000401751 ; ENSP00000383896 ; ENSG00000100012 . [Q9UDX4-2 ]
    ENST00000402286 ; ENSP00000385004 ; ENSG00000100012 . [Q9UDX4-3 ]
    ENST00000540910 ; ENSP00000439752 ; ENSG00000100012 . [Q9UDX4-3 ]
    GeneIDi 266629.
    KEGGi hsa:266629.
    UCSCi uc003ahy.3. human. [Q9UDX4-1 ]
    uc003ahz.3. human.

    Organism-specific databases

    CTDi 266629.
    GeneCardsi GC22M030843.
    HGNCi HGNC:18655. SEC14L3.
    HPAi HPA059450.
    MIMi 612824. gene.
    neXtProti NX_Q9UDX4.
    PharmGKBi PA134960743.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309458.
    HOGENOMi HOG000232201.
    HOVERGENi HBG055336.
    InParanoidi Q9UDX4.
    OMAi AKMRDCE.
    OrthoDBi EOG7N8ZVD.
    PhylomeDBi Q9UDX4.
    TreeFami TF313988.

    Miscellaneous databases

    GenomeRNAii 266629.
    NextBioi 93258.
    PROi Q9UDX4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UDX4.
    Bgeei Q9UDX4.
    CleanExi HS_SEC14L3.
    HS_TAP2.
    Genevestigatori Q9UDX4.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    InterProi IPR001071. CRAL-bd_toc_tran.
    IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR009038. GOLD.
    [Graphical view ]
    Pfami PF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00180. CRETINALDHBP.
    SMARTi SM01100. CRAL_TRIO_N. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101576. SSF101576. 1 hit.
    SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties."
      Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.
      Free Radic. Biol. Med. 34:1458-1472(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-103 AND GLU-335.

    Entry informationi

    Entry nameiS14L3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UDX4
    Secondary accession number(s): E7EN74
    , E9PE57, Q495V8, Q495W0, Q495W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3