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Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
Gene namesi
Name:SEC14L3
Synonyms:TAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18655. SEC14L3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: InterPro
  3. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400SEC14-like protein 3PRO_0000210758Add
BLAST

Proteomic databases

MaxQBiQ9UDX4.
PaxDbiQ9UDX4.
PRIDEiQ9UDX4.

PTM databases

PhosphoSiteiQ9UDX4.

Expressioni

Gene expression databases

BgeeiQ9UDX4.
CleanExiHS_SEC14L3.
HS_TAP2.
ExpressionAtlasiQ9UDX4. baseline and differential.
GenevestigatoriQ9UDX4.

Organism-specific databases

HPAiHPA059450.

Structurei

Secondary structure

1
400
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2314Combined sources
Turni24 – 263Combined sources
Helixi27 – 293Combined sources
Helixi35 – 4410Combined sources
Turni45 – 473Combined sources
Helixi49 – 6517Combined sources
Helixi68 – 736Combined sources
Helixi78 – 836Combined sources
Beta strandi86 – 916Combined sources
Beta strandi97 – 1026Combined sources
Helixi108 – 1125Combined sources
Helixi117 – 14226Combined sources
Beta strandi149 – 1546Combined sources
Helixi160 – 1634Combined sources
Helixi165 – 18117Combined sources
Beta strandi186 – 1938Combined sources
Helixi198 – 2058Combined sources
Helixi206 – 2083Combined sources
Helixi211 – 2155Combined sources
Beta strandi217 – 2193Combined sources
Helixi224 – 2318Combined sources
Helixi234 – 2363Combined sources
Helixi239 – 2413Combined sources
Beta strandi243 – 2453Combined sources
Turni255 – 2573Combined sources
Helixi266 – 2683Combined sources
Beta strandi279 – 2857Combined sources
Beta strandi289 – 2968Combined sources
Beta strandi302 – 3087Combined sources
Beta strandi310 – 3123Combined sources
Beta strandi314 – 32411Combined sources
Helixi330 – 3323Combined sources
Beta strandi333 – 34210Combined sources
Beta strandi345 – 3473Combined sources
Beta strandi349 – 3546Combined sources
Beta strandi359 – 3668Combined sources
Beta strandi371 – 38414Combined sources
Helixi388 – 3914Combined sources
Helixi392 – 3965Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4.
SMRiQ9UDX4. Positions 1-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 249174CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 383109GOLDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309458.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX4.
OMAiSMDIDHI.
OrthoDBiEOG7N8ZVD.
PhylomeDBiQ9UDX4.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY
110 120 130 140 150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV
160 170 180 190 200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV
210 220 230 240 250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG
260 270 280 290 300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED
360 370 380 390 400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Length:400
Mass (Da):46,048
Last modified:April 30, 2000 - v1
Checksum:i07F880D25B66CC19
GO
Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Show »
Length:341
Mass (Da):39,174
Checksum:i831C914C0A5FE469
GO
Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Note: No experimental confirmation available.

Show »
Length:323
Mass (Da):36,922
Checksum:i0F9B9BBD477DF986
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031I → T.1 Publication
Corresponds to variant rs4820853 [ dbSNP | Ensembl ].
VAR_024627
Natural varianti214 – 2141R → H.
Corresponds to variant rs2269961 [ dbSNP | Ensembl ].
VAR_024628
Natural varianti335 – 3351D → E.1 Publication
Corresponds to variant rs2240345 [ dbSNP | Ensembl ].
VAR_022097
Natural varianti364 – 3641R → C.
Corresponds to variant rs35764129 [ dbSNP | Ensembl ].
VAR_061787

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878MSGRV…WQPPE → M in isoform 3. CuratedVSP_045553Add
BLAST
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_045554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSiCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneiHs.505601.

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneIDi266629.
KEGGihsa:266629.
UCSCiuc003ahy.3. human. [Q9UDX4-1]
uc003ahz.3. human.

Polymorphism databases

DMDMi29428056.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSiCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneiHs.505601.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4.
SMRiQ9UDX4. Positions 1-400.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00163. Vitamin E.

PTM databases

PhosphoSiteiQ9UDX4.

Polymorphism databases

DMDMi29428056.

Proteomic databases

MaxQBiQ9UDX4.
PaxDbiQ9UDX4.
PRIDEiQ9UDX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneIDi266629.
KEGGihsa:266629.
UCSCiuc003ahy.3. human. [Q9UDX4-1]
uc003ahz.3. human.

Organism-specific databases

CTDi266629.
GeneCardsiGC22M030843.
HGNCiHGNC:18655. SEC14L3.
HPAiHPA059450.
MIMi612824. gene.
neXtProtiNX_Q9UDX4.
PharmGKBiPA134960743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309458.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX4.
OMAiSMDIDHI.
OrthoDBiEOG7N8ZVD.
PhylomeDBiQ9UDX4.
TreeFamiTF313988.

Miscellaneous databases

GenomeRNAii266629.
NextBioi93258.
PROiQ9UDX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UDX4.
CleanExiHS_SEC14L3.
HS_TAP2.
ExpressionAtlasiQ9UDX4. baseline and differential.
GenevestigatoriQ9UDX4.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties."
    Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.
    Free Radic. Biol. Med. 34:1458-1472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-103 AND GLU-335.

Entry informationi

Entry nameiS14L3_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74
, E9PE57, Q495V8, Q495W0, Q495W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2003
Last sequence update: April 30, 2000
Last modified: January 6, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.