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Q9UDX4

- S14L3_HUMAN

UniProt

Q9UDX4 - S14L3_HUMAN

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Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
Gene namesi
Name:SEC14L3
Synonyms:TAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:18655. SEC14L3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: InterPro
  3. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400SEC14-like protein 3PRO_0000210758Add
BLAST

Proteomic databases

MaxQBiQ9UDX4.
PaxDbiQ9UDX4.
PRIDEiQ9UDX4.

PTM databases

PhosphoSiteiQ9UDX4.

Expressioni

Gene expression databases

BgeeiQ9UDX4.
CleanExiHS_SEC14L3.
HS_TAP2.
ExpressionAtlasiQ9UDX4. baseline and differential.
GenevestigatoriQ9UDX4.

Organism-specific databases

HPAiHPA059450.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4.
SMRiQ9UDX4. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 249174CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 383109GOLDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309458.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX4.
OMAiAKMRDCE.
OrthoDBiEOG7N8ZVD.
PhylomeDBiQ9UDX4.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY
110 120 130 140 150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV
160 170 180 190 200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV
210 220 230 240 250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG
260 270 280 290 300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED
360 370 380 390 400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Length:400
Mass (Da):46,048
Last modified:May 1, 2000 - v1
Checksum:i07F880D25B66CC19
GO
Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Show »
Length:341
Mass (Da):39,174
Checksum:i831C914C0A5FE469
GO
Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Note: No experimental confirmation available.

Show »
Length:323
Mass (Da):36,922
Checksum:i0F9B9BBD477DF986
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031I → T.1 Publication
Corresponds to variant rs4820853 [ dbSNP | Ensembl ].
VAR_024627
Natural varianti214 – 2141R → H.
Corresponds to variant rs2269961 [ dbSNP | Ensembl ].
VAR_024628
Natural varianti335 – 3351D → E.1 Publication
Corresponds to variant rs2240345 [ dbSNP | Ensembl ].
VAR_022097
Natural varianti364 – 3641R → C.
Corresponds to variant rs35764129 [ dbSNP | Ensembl ].
VAR_061787

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878MSGRV…WQPPE → M in isoform 3. CuratedVSP_045553Add
BLAST
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_045554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSiCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqiNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneiHs.505601.

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneIDi266629.
KEGGihsa:266629.
UCSCiuc003ahy.3. human. [Q9UDX4-1]
uc003ahz.3. human.

Polymorphism databases

DMDMi29428056.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA. Translation: AAO21870.1 .
AC004832 Genomic DNA. Translation: AAF19258.1 .
BC101001 mRNA. Translation: AAI01002.1 .
BC101002 mRNA. Translation: AAI01003.1 .
BC101004 mRNA. Translation: AAI01005.1 .
CCDSi CCDS13877.1. [Q9UDX4-1 ]
CCDS58800.1. [Q9UDX4-3 ]
CCDS58801.1. [Q9UDX4-2 ]
RefSeqi NP_001244307.1. NM_001257378.1. [Q9UDX4-3 ]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2 ]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2 ]
NP_777635.1. NM_174975.4. [Q9UDX4-1 ]
UniGenei Hs.505601.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4UYB X-ray 1.50 A 1-400 [» ]
ProteinModelPortali Q9UDX4.
SMRi Q9UDX4. Positions 1-397.
ModBasei Search...
MobiDBi Search...

Chemistry

DrugBanki DB00163. Vitamin E.

PTM databases

PhosphoSitei Q9UDX4.

Polymorphism databases

DMDMi 29428056.

Proteomic databases

MaxQBi Q9UDX4.
PaxDbi Q9UDX4.
PRIDEi Q9UDX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215812 ; ENSP00000215812 ; ENSG00000100012 . [Q9UDX4-1 ]
ENST00000401751 ; ENSP00000383896 ; ENSG00000100012 . [Q9UDX4-2 ]
ENST00000402286 ; ENSP00000385004 ; ENSG00000100012 . [Q9UDX4-3 ]
ENST00000540910 ; ENSP00000439752 ; ENSG00000100012 . [Q9UDX4-3 ]
GeneIDi 266629.
KEGGi hsa:266629.
UCSCi uc003ahy.3. human. [Q9UDX4-1 ]
uc003ahz.3. human.

Organism-specific databases

CTDi 266629.
GeneCardsi GC22M030843.
HGNCi HGNC:18655. SEC14L3.
HPAi HPA059450.
MIMi 612824. gene.
neXtProti NX_Q9UDX4.
PharmGKBi PA134960743.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309458.
GeneTreei ENSGT00550000074580.
HOGENOMi HOG000232201.
HOVERGENi HBG055336.
InParanoidi Q9UDX4.
OMAi AKMRDCE.
OrthoDBi EOG7N8ZVD.
PhylomeDBi Q9UDX4.
TreeFami TF313988.

Miscellaneous databases

GenomeRNAii 266629.
NextBioi 93258.
PROi Q9UDX4.
SOURCEi Search...

Gene expression databases

Bgeei Q9UDX4.
CleanExi HS_SEC14L3.
HS_TAP2.
ExpressionAtlasi Q9UDX4. baseline and differential.
Genevestigatori Q9UDX4.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
InterProi IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view ]
PRINTSi PR00180. CRETINALDHBP.
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties."
    Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.
    Free Radic. Biol. Med. 34:1458-1472(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-103 AND GLU-335.

Entry informationi

Entry nameiS14L3_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74
, E9PE57, Q495V8, Q495W0, Q495W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3