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Q9UDX4 (S14L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
Gene names
Name:SEC14L3
Synonyms:TAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Sequence similarities

Contains 1 CRAL-TRIO domain.

Contains 1 GOLD domain.

Ontologies

Keywords
   Biological processTransport
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandLipid-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: InterPro

intracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UDX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UDX4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UDX4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400SEC14-like protein 3
PRO_0000210758

Regions

Domain76 – 249174CRAL-TRIO
Domain275 – 383109GOLD

Natural variations

Alternative sequence1 – 7878MSGRV…WQPPE → M in isoform 3.
VSP_045553
Alternative sequence1 – 5959Missing in isoform 2.
VSP_045554
Natural variant1031I → T. Ref.3
Corresponds to variant rs4820853 [ dbSNP | Ensembl ].
VAR_024627
Natural variant2141R → H.
Corresponds to variant rs2269961 [ dbSNP | Ensembl ].
VAR_024628
Natural variant3351D → E. Ref.3
Corresponds to variant rs2240345 [ dbSNP | Ensembl ].
VAR_022097
Natural variant3641R → C.
Corresponds to variant rs35764129 [ dbSNP | Ensembl ].
VAR_061787

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 07F880D25B66CC19

FASTA40046,048
        10         20         30         40         50         60 
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ KSEALLRKYM 

        70         80         90        100        110        120 
EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY DIIGPLDPKG LLFSVTKQDL 

       130        140        150        160        170        180 
LKTKMRDCER ILHECDLQTE RLGKKIETIV MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE 

       190        200        210        220        230        240 
NYPETLKFML IVKATKLFPV GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ 

       250        260        270        280        290        300 
FGGTLTDPDG NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG 

       310        320        330        340        350        360 
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED GNLTCSEAGV 

       370        380        390        400 
YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV 

« Hide

Isoform 2 [UniParc].

Checksum: 831C914C0A5FE469
Show »

FASTA34139,174
Isoform 3 [UniParc].

Checksum: 0F9B9BBD477DF986
Show »

FASTA32336,922

References

« Hide 'large scale' references
[1]"Cloning of novel human SEC14p-like proteins: ligand binding and functional properties."
Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.
Free Radic. Biol. Med. 34:1458-1472(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-103 AND GLU-335.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY158086 mRNA. Translation: AAO21870.1.
AC004832 Genomic DNA. Translation: AAF19258.1.
BC101001 mRNA. Translation: AAI01002.1.
BC101002 mRNA. Translation: AAI01003.1.
BC101004 mRNA. Translation: AAI01005.1.
CCDSCCDS13877.1. [Q9UDX4-1]
CCDS58800.1. [Q9UDX4-3]
CCDS58801.1. [Q9UDX4-2]
RefSeqNP_001244307.1. NM_001257378.1. [Q9UDX4-3]
NP_001244308.1. NM_001257379.1. [Q9UDX4-2]
NP_001244311.1. NM_001257382.1. [Q9UDX4-2]
NP_777635.1. NM_174975.4. [Q9UDX4-1]
UniGeneHs.505601.

3D structure databases

ProteinModelPortalQ9UDX4.
SMRQ9UDX4. Positions 1-397.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00163. Vitamin E.

PTM databases

PhosphoSiteQ9UDX4.

Polymorphism databases

DMDM29428056.

Proteomic databases

MaxQBQ9UDX4.
PaxDbQ9UDX4.
PRIDEQ9UDX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000215812; ENSP00000215812; ENSG00000100012. [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012. [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012. [Q9UDX4-3]
ENST00000539629; ENSP00000444691; ENSG00000100012. [Q9UDX4-2]
ENST00000540910; ENSP00000439752; ENSG00000100012. [Q9UDX4-3]
GeneID266629.
KEGGhsa:266629.
UCSCuc003ahy.3. human. [Q9UDX4-1]
uc003ahz.3. human.

Organism-specific databases

CTD266629.
GeneCardsGC22M030843.
HGNCHGNC:18655. SEC14L3.
HPAHPA059450.
MIM612824. gene.
neXtProtNX_Q9UDX4.
PharmGKBPA134960743.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309458.
HOGENOMHOG000232201.
HOVERGENHBG055336.
InParanoidQ9UDX4.
OMAAKMRDCE.
OrthoDBEOG7N8ZVD.
PhylomeDBQ9UDX4.
TreeFamTF313988.

Gene expression databases

ArrayExpressQ9UDX4.
BgeeQ9UDX4.
CleanExHS_SEC14L3.
HS_TAP2.
GenevestigatorQ9UDX4.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
InterProIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view]
PfamPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSPR00180. CRETINALDHBP.
SMARTSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi266629.
NextBio93258.
PROQ9UDX4.
SOURCESearch...

Entry information

Entry nameS14L3_HUMAN
AccessionPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74 expand/collapse secondary AC list , E9PE57, Q495V8, Q495W0, Q495W1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM