Q9UDX4 (S14L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SEC14-like protein 3

Alternative name(s):
Tocopherol-associated protein 2

Gene names

Name:	SEC14L3
Synonyms:	TAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Sequence similarities	Contains 1 CRAL-TRIO domain. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	Transport
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UDX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UDX4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UDX4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	SEC14-like protein 3		PRO_0000210758
Regions
	Domain	76 – 249	174	CRAL-TRIO
	Domain	275 – 383	109	GOLD
Natural variations
	Alternative sequence	1 – 78	78	MSGRV…WQPPE → M in isoform 3.		VSP_045553
	Alternative sequence	1 – 59	59	Missing in isoform 2.		VSP_045554
	Natural variant	103	1	I → T. Ref.3 Corresponds to variant rs4820853 [ dbSNP | Ensembl ].		VAR_024627
	Natural variant	214	1	R → H. Corresponds to variant rs2269961 [ dbSNP | Ensembl ].		VAR_024628
	Natural variant	335	1	D → E. Ref.3 Corresponds to variant rs2240345 [ dbSNP | Ensembl ].		VAR_022097
	Natural variant	364	1	R → C. Corresponds to variant rs35764129 [ dbSNP | Ensembl ].		VAR_061787

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 07F880D25B66CC19	FASTA	400	46,048
	10 20 30 40 50 60 MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ KSEALLRKYM 70 80 90 100 110 120 EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY DIIGPLDPKG LLFSVTKQDL 130 140 150 160 170 180 LKTKMRDCER ILHECDLQTE RLGKKIETIV MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE 190 200 210 220 230 240 NYPETLKFML IVKATKLFPV GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ 250 260 270 280 290 300 FGGTLTDPDG NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG 310 320 330 340 350 360 CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED GNLTCSEAGV 370 380 390 400 YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
	Isoform 2 [UniParc]. Checksum: 831C914C0A5FE469	FASTA	341	39,174
	10 20 30 40 50 60 MEFRKTMDID HILDWQPPEV IQKYMPGGLC GYDRDGCPVW YDIIGPLDPK GLLFSVTKQD 70 80 90 100 110 120 LLKTKMRDCE RILHECDLQT ERLGKKIETI VMIFDCEGLG LKHFWKPLVE VYQEFFGLLE 130 140 150 160 170 180 ENYPETLKFM LIVKATKLFP VGYNLMKPFL SEDTRRKIIV LGNNWKEGLL KLISPEELPA 190 200 210 220 230 240 QFGGTLTDPD GNPKCLTKIN YGGEIPKSMY VRDQVKTQYE HSVQINRGSS HQVEYEILFP 250 260 270 280 290 300 GCVLRWQFSS DGADIGFGVF LKTKMGERQR AGEMTDVLPS QRYNAHMVPE DGNLTCSEAG 310 320 330 340 VYVLRFDNTY SFVHAKKVSF TVEVLLPDEG MQKYDKELTP V
	Isoform 3 [UniParc]. Checksum: 0F9B9BBD477DF986	FASTA	323	36,922
	10 20 30 40 50 60 MVIQKYMPGG LCGYDRDGCP VWYDIIGPLD PKGLLFSVTK QDLLKTKMRD CERILHECDL 70 80 90 100 110 120 QTERLGKKIE TIVMIFDCEG LGLKHFWKPL VEVYQEFFGL LEENYPETLK FMLIVKATKL 130 140 150 160 170 180 FPVGYNLMKP FLSEDTRRKI IVLGNNWKEG LLKLISPEEL PAQFGGTLTD PDGNPKCLTK 190 200 210 220 230 240 INYGGEIPKS MYVRDQVKTQ YEHSVQINRG SSHQVEYEIL FPGCVLRWQF SSDGADIGFG 250 260 270 280 290 300 VFLKTKMGER QRAGEMTDVL PSQRYNAHMV PEDGNLTCSE AGVYVLRFDN TYSFVHAKKV 310 320 SFTVEVLLPD EGMQKYDKEL TPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of novel human SEC14p-like proteins: ligand binding and functional properties." Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A. Free Radic. Biol. Med. 34:1458-1472(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-103 AND GLU-335.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158086 mRNA. Translation: AAO21870.1. AC004832 Genomic DNA. Translation: AAF19258.1. BC101001 mRNA. Translation: AAI01002.1. BC101002 mRNA. Translation: AAI01003.1. BC101004 mRNA. Translation: AAI01005.1.
IPI	IPI00893808. IPI00894077. IPI00894186.
RefSeq	NP_001244307.1. NM_001257378.1. NP_001244308.1. NM_001257379.1. NP_001244311.1. NM_001257382.1. NP_777635.1. NM_174975.4.
UniGene	Hs.505601.
3D structure databases
ProteinModelPortal	Q9UDX4.
ModBase	Search...
PTM databases
PhosphoSite	Q9UDX4.
Polymorphism databases
DMDM	29428056.
Proteomic databases
PaxDb	Q9UDX4.
PRIDE	Q9UDX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000215812; ENSP00000215812; ENSG00000100012. ENST00000401751; ENSP00000383896; ENSG00000100012. ENST00000402286; ENSP00000385004; ENSG00000100012. ENST00000539629; ENSP00000444691; ENSG00000100012. ENST00000540910; ENSP00000439752; ENSG00000100012.
GeneID	266629.
KEGG	hsa:266629.
UCSC	uc003ahy.3. human.
Organism-specific databases
CTD	266629.
GeneCards	GC22M030843.
HGNC	HGNC:18655. SEC14L3.
MIM	612824. gene.
neXtProt	NX_Q9UDX4.
PharmGKB	PA134960743.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG309458.
HOGENOM	HOG000232201.
HOVERGEN	HBG055336.
InParanoid	Q9UDX4.
OMA	AKMRDCE.
PhylomeDB	Q9UDX4.
Gene expression databases
ArrayExpress	Q9UDX4.
Bgee	Q9UDX4.
CleanEx	HS_SEC14L3. HS_TAP2.
Genevestigator	Q9UDX4.
GermOnline	ENSG00000100012. Homo sapiens.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR001071. CRAL-bd_toc_tran. IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. IPR009038. GOLD. [Graphical view]
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
PRINTS	PR00180. CRETINALDHBP.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF101576. GOLD. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00163. Vitamin E.
GenomeRNAi	266629.
NextBio	93258.
SOURCE	Search...

Entry information

Entry name

S14L3_HUMAN

Accession

Primary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74 , E9PE57, Q495V8, Q495W0, Q495W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.