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Protein

SEC14-like protein 3

Gene

SEC14L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 3
Alternative name(s):
Tocopherol-associated protein 2
Gene namesi
Name:SEC14L3
Synonyms:TAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100012.11
HGNCiHGNC:18655 SEC14L3
MIMi612824 gene
neXtProtiNX_Q9UDX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi266629
OpenTargetsiENSG00000100012
PharmGKBiPA134960743

Chemistry databases

DrugBankiDB00163 Vitamin E

Polymorphism and mutation databases

BioMutaiSEC14L3
DMDMi29428056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107581 – 400SEC14-like protein 3Add BLAST400

Proteomic databases

EPDiQ9UDX4
PaxDbiQ9UDX4
PeptideAtlasiQ9UDX4
PRIDEiQ9UDX4

PTM databases

iPTMnetiQ9UDX4
PhosphoSitePlusiQ9UDX4

Expressioni

Gene expression databases

BgeeiENSG00000100012
CleanExiHS_SEC14L3
HS_TAP2
ExpressionAtlasiQ9UDX4 baseline and differential
GenevisibleiQ9UDX4 HS

Organism-specific databases

HPAiHPA059450

Interactioni

Protein-protein interaction databases

BioGridi129297, 3 interactors
STRINGi9606.ENSP00000215812

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 23Combined sources14
Turni24 – 26Combined sources3
Helixi27 – 29Combined sources3
Helixi35 – 44Combined sources10
Turni45 – 47Combined sources3
Helixi49 – 65Combined sources17
Helixi68 – 73Combined sources6
Helixi78 – 83Combined sources6
Beta strandi86 – 91Combined sources6
Beta strandi97 – 102Combined sources6
Helixi108 – 112Combined sources5
Helixi117 – 142Combined sources26
Beta strandi149 – 154Combined sources6
Helixi160 – 163Combined sources4
Helixi165 – 181Combined sources17
Beta strandi186 – 193Combined sources8
Helixi198 – 205Combined sources8
Helixi206 – 208Combined sources3
Helixi211 – 215Combined sources5
Beta strandi217 – 219Combined sources3
Helixi224 – 231Combined sources8
Helixi234 – 236Combined sources3
Helixi239 – 241Combined sources3
Beta strandi243 – 245Combined sources3
Turni255 – 257Combined sources3
Helixi266 – 268Combined sources3
Beta strandi279 – 285Combined sources7
Beta strandi289 – 296Combined sources8
Beta strandi302 – 308Combined sources7
Beta strandi310 – 312Combined sources3
Beta strandi314 – 324Combined sources11
Helixi330 – 332Combined sources3
Beta strandi333 – 342Combined sources10
Beta strandi345 – 347Combined sources3
Beta strandi349 – 354Combined sources6
Beta strandi359 – 366Combined sources8
Beta strandi371 – 384Combined sources14
Helixi388 – 391Combined sources4
Helixi392 – 396Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UYBX-ray1.50A1-400[»]
ProteinModelPortaliQ9UDX4
SMRiQ9UDX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini275 – 383GOLDPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000232201
HOVERGENiHBG055336
InParanoidiQ9UDX4
OMAiDHQNTEP
OrthoDBiEOG091G0MI9
PhylomeDBiQ9UDX4
TreeFamiTF313988

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEALLRKYM EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY
110 120 130 140 150
DIIGPLDPKG LLFSVTKQDL LKTKMRDCER ILHECDLQTE RLGKKIETIV
160 170 180 190 200
MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE NYPETLKFML IVKATKLFPV
210 220 230 240 250
GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ FGGTLTDPDG
260 270 280 290 300
NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED
360 370 380 390 400
GNLTCSEAGV YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV
Length:400
Mass (Da):46,048
Last modified:May 1, 2000 - v1
Checksum:i07F880D25B66CC19
GO
Isoform 2 (identifier: Q9UDX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):39,174
Checksum:i831C914C0A5FE469
GO
Isoform 3 (identifier: Q9UDX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MSGRVGDLSP...DHILDWQPPE → M

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):36,922
Checksum:i0F9B9BBD477DF986
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024627103I → T1 PublicationCorresponds to variant dbSNP:rs4820853Ensembl.1
Natural variantiVAR_024628214R → H. Corresponds to variant dbSNP:rs2269961Ensembl.1
Natural variantiVAR_022097335D → E1 PublicationCorresponds to variant dbSNP:rs2240345Ensembl.1
Natural variantiVAR_061787364R → C. Corresponds to variant dbSNP:rs35764129Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455531 – 78MSGRV…WQPPE → M in isoform 3. CuratedAdd BLAST78
Alternative sequenceiVSP_0455541 – 59Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158086 mRNA Translation: AAO21870.1
AC004832 Genomic DNA Translation: AAF19258.1
BC101001 mRNA Translation: AAI01002.1
BC101002 mRNA Translation: AAI01003.1
BC101004 mRNA Translation: AAI01005.1
CCDSiCCDS13877.1 [Q9UDX4-1]
CCDS58800.1 [Q9UDX4-3]
CCDS58801.1 [Q9UDX4-2]
RefSeqiNP_001244307.1, NM_001257378.1 [Q9UDX4-3]
NP_001244308.1, NM_001257379.1 [Q9UDX4-2]
NP_001244311.1, NM_001257382.1 [Q9UDX4-2]
NP_777635.1, NM_174975.4 [Q9UDX4-1]
UniGeneiHs.505601

Genome annotation databases

EnsembliENST00000215812; ENSP00000215812; ENSG00000100012 [Q9UDX4-1]
ENST00000401751; ENSP00000383896; ENSG00000100012 [Q9UDX4-2]
ENST00000402286; ENSP00000385004; ENSG00000100012 [Q9UDX4-3]
ENST00000540910; ENSP00000439752; ENSG00000100012 [Q9UDX4-3]
GeneIDi266629
KEGGihsa:266629
UCSCiuc003ahy.4 human [Q9UDX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS14L3_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX4
Secondary accession number(s): E7EN74
, E9PE57, Q495V8, Q495W0, Q495W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health