Q9UDX3 (S14L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SEC14-like protein 4

Alternative name(s):
Tocopherol-associated protein 3

Gene names

Name:	SEC14L4
Synonyms:	TAP3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Sequence similarities	Contains 1 CRAL-TRIO domain. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	Transport
Coding sequence diversity	Polymorphism
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	SEC14-like protein 4		PRO_0000210760
Regions
	Domain	76 – 249	174	CRAL-TRIO
	Domain	252 – 383	132	GOLD
Natural variations
	Natural variant	3	1	S → G. Corresponds to variant rs9608956 [ dbSNP | Ensembl ].		VAR_024629
	Natural variant	124	1	R → G. Corresponds to variant rs9606739 [ dbSNP | Ensembl ].		VAR_051914
	Natural variant	200	1	V → M. Corresponds to variant rs17738540 [ dbSNP | Ensembl ].		VAR_051915
	Natural variant	211	1	E → K. Corresponds to variant rs17738527 [ dbSNP | Ensembl ].		VAR_051916

Sequences

	Sequence		Length	Mass (Da)
	Q9UDX3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7C8763DDA202EB5A	FASTA	406	46,644
	10 20 30 40 50 60 MSSRVGDLSP QQQEALARFR ENLQDLLPIL PNADDYFLLR WLRARNFDLQ KSEDMLRRHM 70 80 90 100 110 120 EFRKQQDLDN IVTWQPPEVI QLYDSGGLCG YDYEGCPVYF NIIGSLDPKG LLLSASKQDM 130 140 150 160 170 180 IRKRIKVCEL LLHECELQTQ KLGRKIEMAL MVFDMEGLSL KHLWKPAVEV YQQFFSILEA 190 200 210 220 230 240 NYPETLKNLI VIRAPKLFPV AFNLVKSFMS EETRRKIVIL GDNWKQELTK FISPDQLPVE 250 260 270 280 290 300 FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CEQVRLQYEH TRSVGRGSSL QVENEILFPG 310 320 330 340 350 360 CVLRWQFASD GGDIGFGVFL KTKMGEQQSA REMTEVLPSQ RYNAHMVPED GSLTCLQAGV 370 380 390 400 YVLRFDNTYS RMHAKKLSYT VEVLLPDKAS EETLQSLKAM RPSPTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of novel human SEC14p-like proteins: ligand binding and functional properties." Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A. Free Radic. Biol. Med. 34:1458-1472(2003) [PubMed: 12757856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158085 mRNA. Translation: AAO21869.1. AC004832 Genomic DNA. Translation: AAF19259.1.
IPI	IPI00004815.
RefSeq	NP_777637.1. NM_174977.3.
UniGene	Hs.517541.
3D structure databases
ProteinModelPortal	Q9UDX3.
SMR	Q9UDX3. Positions 1-397.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UDX3.
Polymorphism databases
DMDM	29337003.
Proteomic databases
PRIDE	Q9UDX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255858; ENSP00000255858; ENSG00000133488.
GeneID	284904.
KEGG	hsa:284904.
UCSC	uc003aid.1. human.
Organism-specific databases
CTD	284904.
GeneCards	GC22M030884.
H-InvDB	HIX0016372.
HGNC	HGNC:20627. SEC14L4.
MIM	612825. gene.
neXtProt	NX_Q9UDX3.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074580.
HOGENOM	HBG506277.
HOVERGEN	HBG055336.
InParanoid	Q9UDX3.
OMA	LLHECEL.
OrthoDB	EOG4FXR7J.
PhylomeDB	Q9UDX3.
Gene expression databases
ArrayExpress	Q9UDX3.
Bgee	Q9UDX3.
CleanEx	HS_SEC14L4.
Genevestigator	Q9UDX3.
GermOnline	ENSG00000133488. Homo sapiens.
Family and domain databases
InterPro	IPR001071. CRAL-bd_toc_tran. IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. IPR009038. GOLD. [Graphical view]
Gene3D	G3DSA:3.40.525.10. CRAL_bd_TRIO_C. 1 hit. G3DSA:1.10.8.20. G3DSA:1.10.8.20. 1 hit.
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
PRINTS	PR00180. CRETINALDHBP.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF101576. GOLD. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00163. Vitamin E.
NextBio	95165.
SOURCE	Search...

Entry information

Entry name

S14L4_HUMAN

Accession

Primary (citable) accession number: Q9UDX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.