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Protein

SEC14-like protein 4

Gene

SEC14L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 4
Alternative name(s):
Tocopherol-associated protein 3
Gene namesi
Name:SEC14L4
Synonyms:TAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:20627. SEC14L4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133488.
PharmGKBiPA134979694.

Chemistry databases

DrugBankiDB00163. Vitamin E.

Polymorphism and mutation databases

BioMutaiSEC14L4.
DMDMi29337003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107601 – 406SEC14-like protein 4Add BLAST406

Proteomic databases

EPDiQ9UDX3.
PaxDbiQ9UDX3.
PeptideAtlasiQ9UDX3.
PRIDEiQ9UDX3.

PTM databases

iPTMnetiQ9UDX3.
PhosphoSitePlusiQ9UDX3.

Expressioni

Gene expression databases

BgeeiENSG00000133488.
CleanExiHS_SEC14L4.
ExpressionAtlasiQ9UDX3. baseline and differential.
GenevisibleiQ9UDX3. HS.

Organism-specific databases

HPAiHPA069748.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BMFQ96LC93EBI-10320311,EBI-3919268
INCA1Q0VD863EBI-10320311,EBI-6509505
RELQ048643EBI-10320311,EBI-307352
TCF4P158843EBI-10320311,EBI-533224
USHBP1Q8N6Y05EBI-10320311,EBI-739895

Protein-protein interaction databases

BioGridi129974. 8 interactors.
IntActiQ9UDX3. 15 interactors.
STRINGi9606.ENSP00000255858.

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 22Combined sources13
Turni23 – 26Combined sources4
Helixi27 – 29Combined sources3
Helixi35 – 44Combined sources10
Turni45 – 47Combined sources3
Helixi49 – 65Combined sources17
Helixi68 – 73Combined sources6
Helixi78 – 83Combined sources6
Beta strandi86 – 91Combined sources6
Beta strandi97 – 101Combined sources5
Helixi108 – 114Combined sources7
Helixi117 – 142Combined sources26
Beta strandi149 – 154Combined sources6
Helixi160 – 163Combined sources4
Helixi165 – 181Combined sources17
Beta strandi186 – 193Combined sources8
Helixi198 – 205Combined sources8
Helixi206 – 208Combined sources3
Helixi211 – 215Combined sources5
Beta strandi217 – 219Combined sources3
Helixi224 – 228Combined sources5
Turni229 – 231Combined sources3
Helixi234 – 236Combined sources3
Helixi239 – 241Combined sources3
Beta strandi243 – 245Combined sources3
Turni255 – 257Combined sources3
Helixi266 – 268Combined sources3
Beta strandi279 – 284Combined sources6
Beta strandi289 – 296Combined sources8
Beta strandi302 – 312Combined sources11
Beta strandi314 – 320Combined sources7
Beta strandi322 – 326Combined sources5
Turni330 – 332Combined sources3
Beta strandi333 – 342Combined sources10
Turni344 – 346Combined sources3
Beta strandi349 – 354Combined sources6
Beta strandi357 – 366Combined sources10
Beta strandi375 – 384Combined sources10
Helixi388 – 396Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TLGX-ray1.77A/B1-406[»]
ProteinModelPortaliQ9UDX3.
SMRiQ9UDX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini252 – 383GOLDPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX3.
OMAiHECELQT.
OrthoDBiEOG091G0MI9.
PhylomeDBiQ9UDX3.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRVGDLSP QQQEALARFR ENLQDLLPIL PNADDYFLLR WLRARNFDLQ
60 70 80 90 100
KSEDMLRRHM EFRKQQDLDN IVTWQPPEVI QLYDSGGLCG YDYEGCPVYF
110 120 130 140 150
NIIGSLDPKG LLLSASKQDM IRKRIKVCEL LLHECELQTQ KLGRKIEMAL
160 170 180 190 200
MVFDMEGLSL KHLWKPAVEV YQQFFSILEA NYPETLKNLI VIRAPKLFPV
210 220 230 240 250
AFNLVKSFMS EETRRKIVIL GDNWKQELTK FISPDQLPVE FGGTMTDPDG
260 270 280 290 300
NPKCLTKINY GGEVPKSYYL CEQVRLQYEH TRSVGRGSSL QVENEILFPG
310 320 330 340 350
CVLRWQFASD GGDIGFGVFL KTKMGEQQSA REMTEVLPSQ RYNAHMVPED
360 370 380 390 400
GSLTCLQAGV YVLRFDNTYS RMHAKKLSYT VEVLLPDKAS EETLQSLKAM

RPSPTQ
Length:406
Mass (Da):46,644
Last modified:May 1, 2000 - v1
Checksum:i7C8763DDA202EB5A
GO
Isoform 2 (identifier: Q9UDX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-406: Missing.

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):41,318
Checksum:iCB53B2467B9C8C1E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246293S → G.Corresponds to variant rs9608956dbSNPEnsembl.1
Natural variantiVAR_051914124R → G.Corresponds to variant rs9606739dbSNPEnsembl.1
Natural variantiVAR_051915200V → M.Corresponds to variant rs17738540dbSNPEnsembl.1
Natural variantiVAR_051916211E → K.Corresponds to variant rs17738527dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045200361 – 406Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158085 mRNA. Translation: AAO21869.1.
AC004832 Genomic DNA. Translation: AAF19259.1.
BC139912 mRNA. Translation: AAI39913.1.
CCDSiCCDS13878.1. [Q9UDX3-1]
CCDS54517.1. [Q9UDX3-2]
RefSeqiNP_001154840.1. NM_001161368.1. [Q9UDX3-2]
NP_777637.1. NM_174977.3. [Q9UDX3-1]
UniGeneiHs.517541.

Genome annotation databases

EnsembliENST00000255858; ENSP00000255858; ENSG00000133488. [Q9UDX3-1]
ENST00000381982; ENSP00000371412; ENSG00000133488. [Q9UDX3-2]
GeneIDi284904.
KEGGihsa:284904.
UCSCiuc003aid.4. human. [Q9UDX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158085 mRNA. Translation: AAO21869.1.
AC004832 Genomic DNA. Translation: AAF19259.1.
BC139912 mRNA. Translation: AAI39913.1.
CCDSiCCDS13878.1. [Q9UDX3-1]
CCDS54517.1. [Q9UDX3-2]
RefSeqiNP_001154840.1. NM_001161368.1. [Q9UDX3-2]
NP_777637.1. NM_174977.3. [Q9UDX3-1]
UniGeneiHs.517541.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TLGX-ray1.77A/B1-406[»]
ProteinModelPortaliQ9UDX3.
SMRiQ9UDX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129974. 8 interactors.
IntActiQ9UDX3. 15 interactors.
STRINGi9606.ENSP00000255858.

Chemistry databases

DrugBankiDB00163. Vitamin E.

PTM databases

iPTMnetiQ9UDX3.
PhosphoSitePlusiQ9UDX3.

Polymorphism and mutation databases

BioMutaiSEC14L4.
DMDMi29337003.

Proteomic databases

EPDiQ9UDX3.
PaxDbiQ9UDX3.
PeptideAtlasiQ9UDX3.
PRIDEiQ9UDX3.

Protocols and materials databases

DNASUi284904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255858; ENSP00000255858; ENSG00000133488. [Q9UDX3-1]
ENST00000381982; ENSP00000371412; ENSG00000133488. [Q9UDX3-2]
GeneIDi284904.
KEGGihsa:284904.
UCSCiuc003aid.4. human. [Q9UDX3-1]

Organism-specific databases

CTDi284904.
GeneCardsiSEC14L4.
HGNCiHGNC:20627. SEC14L4.
HPAiHPA069748.
MIMi612825. gene.
neXtProtiNX_Q9UDX3.
OpenTargetsiENSG00000133488.
PharmGKBiPA134979694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000232201.
HOVERGENiHBG055336.
InParanoidiQ9UDX3.
OMAiHECELQT.
OrthoDBiEOG091G0MI9.
PhylomeDBiQ9UDX3.
TreeFamiTF313988.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133488-MONOMER.

Miscellaneous databases

GenomeRNAii284904.
PROiQ9UDX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133488.
CleanExiHS_SEC14L4.
ExpressionAtlasiQ9UDX3. baseline and differential.
GenevisibleiQ9UDX3. HS.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS14L4_HUMAN
AccessioniPrimary (citable) accession number: Q9UDX3
Secondary accession number(s): A5D6W7, A6NCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.