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Protein

Zinc finger matrin-type protein 5

Gene

ZMAT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri51 – 7929C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 5
Alternative name(s):
U11/U12 small nuclear ribonucleoprotein 20 kDa protein
Short name:
U11/U12 snRNP 20 kDa protein
Short name:
U11/U12-20K
Gene namesi
Name:ZMAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28046. ZMAT5.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • U12-type spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670524.

Polymorphism and mutation databases

BioMutaiZMAT5.
DMDMi74753269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Zinc finger matrin-type protein 5PRO_0000254114Add
BLAST

Proteomic databases

MaxQBiQ9UDW3.
PaxDbiQ9UDW3.
PRIDEiQ9UDW3.

PTM databases

iPTMnetiQ9UDW3.
PhosphoSiteiQ9UDW3.

Expressioni

Gene expression databases

BgeeiQ9UDW3.
CleanExiHS_ZMAT5.
ExpressionAtlasiQ9UDW3. baseline and differential.
GenevisibleiQ9UDW3. HS.

Organism-specific databases

HPAiHPA004858.

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome.1 Publication

Protein-protein interaction databases

BioGridi121007. 20 interactions.
IntActiQ9UDW3. 1 interaction.
MINTiMINT-8330010.
STRINGi9606.ENSP00000344241.

Structurei

3D structure databases

ProteinModelPortaliQ9UDW3.
SMRiQ9UDW3. Positions 1-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri51 – 7929C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3454. Eukaryota.
COG5136. LUCA.
GeneTreeiENSGT00390000009869.
HOGENOMiHOG000039495.
HOVERGENiHBG083477.
InParanoidiQ9UDW3.
KOiK13152.
OMAiFSHMSEQ.
OrthoDBiEOG7KWSKN.
PhylomeDBiQ9UDW3.
TreeFamiTF332784.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UDW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRYFCDYC DRSFQDNLHN RKKHLNGLQH LKAKKVWYDM FRDAAAILLD
60 70 80 90 100
EQNKRPCRKF LLTGQCDFGS NCRFSHMSER DLQELSIQVE EERRAREWLL
110 120 130 140 150
DAPELPEGHL EDWLEKRAKR LSSAPSSRAE PIRTTVFQYP VGWPPVQELP
160 170
PSLRAPPPGG WPLQPRVQWG
Length:170
Mass (Da):19,971
Last modified:May 1, 2000 - v1
Checksum:iFEBF7BD946EFA5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160311 mRNA. Translation: CAB77284.1.
CR456353 mRNA. Translation: CAG30239.1.
CR457393 mRNA. Translation: CAG33674.1.
AK292671 mRNA. Translation: BAF85360.1.
CH471095 Genomic DNA. Translation: EAW59837.1.
BC009717 mRNA. Translation: AAH09717.1.
BK005198 mRNA. Translation: DAA05496.1.
CCDSiCCDS13868.1.
RefSeqiNP_001003692.1. NM_001003692.1.
NP_001305058.1. NM_001318129.1.
NP_061976.1. NM_019103.2.
UniGeneiHs.713647.

Genome annotation databases

EnsembliENST00000344318; ENSP00000344241; ENSG00000100319.
GeneIDi55954.
KEGGihsa:55954.
UCSCiuc003agn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160311 mRNA. Translation: CAB77284.1.
CR456353 mRNA. Translation: CAG30239.1.
CR457393 mRNA. Translation: CAG33674.1.
AK292671 mRNA. Translation: BAF85360.1.
CH471095 Genomic DNA. Translation: EAW59837.1.
BC009717 mRNA. Translation: AAH09717.1.
BK005198 mRNA. Translation: DAA05496.1.
CCDSiCCDS13868.1.
RefSeqiNP_001003692.1. NM_001003692.1.
NP_001305058.1. NM_001318129.1.
NP_061976.1. NM_019103.2.
UniGeneiHs.713647.

3D structure databases

ProteinModelPortaliQ9UDW3.
SMRiQ9UDW3. Positions 1-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121007. 20 interactions.
IntActiQ9UDW3. 1 interaction.
MINTiMINT-8330010.
STRINGi9606.ENSP00000344241.

PTM databases

iPTMnetiQ9UDW3.
PhosphoSiteiQ9UDW3.

Polymorphism and mutation databases

BioMutaiZMAT5.
DMDMi74753269.

Proteomic databases

MaxQBiQ9UDW3.
PaxDbiQ9UDW3.
PRIDEiQ9UDW3.

Protocols and materials databases

DNASUi55954.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344318; ENSP00000344241; ENSG00000100319.
GeneIDi55954.
KEGGihsa:55954.
UCSCiuc003agn.4. human.

Organism-specific databases

CTDi55954.
GeneCardsiZMAT5.
HGNCiHGNC:28046. ZMAT5.
HPAiHPA004858.
neXtProtiNX_Q9UDW3.
PharmGKBiPA142670524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3454. Eukaryota.
COG5136. LUCA.
GeneTreeiENSGT00390000009869.
HOGENOMiHOG000039495.
HOVERGENiHBG083477.
InParanoidiQ9UDW3.
KOiK13152.
OMAiFSHMSEQ.
OrthoDBiEOG7KWSKN.
PhylomeDBiQ9UDW3.
TreeFamiTF332784.

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiZMAT5. human.
GenomeRNAii55954.
PROiQ9UDW3.

Gene expression databases

BgeeiQ9UDW3.
CleanExiHS_ZMAT5.
ExpressionAtlasiQ9UDW3. baseline and differential.
GenevisibleiQ9UDW3. HS.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
    Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
    RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiZMAT5_HUMAN
AccessioniPrimary (citable) accession number: Q9UDW3
Secondary accession number(s): A8K9F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.