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Q9UDW1

- QCR9_HUMAN

UniProt

Q9UDW1 - QCR9_HUMAN

Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 By similarity.By similarity

    GO - Molecular functioni

    1. ubiquinol-cytochrome-c reductase activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. hydrogen ion transmembrane transport Source: GOC
    3. mitochondrial electron transport, ubiquinol to cytochrome c Source: UniProtKB
    4. respiratory electron transport chain Source: Reactome
    5. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Alternative name(s):
    Complex III subunit 9
    Complex III subunit X
    Cytochrome c1 non-heme 7 kDa protein
    Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
    Gene namesi
    Name:UQCR10
    Synonyms:UCRC
    ORF Names:HSPC119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:30863. UQCR10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrial respiratory chain complex III Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165378374.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6362Cytochrome b-c1 complex subunit 9PRO_0000193553Add
    BLAST

    Proteomic databases

    MaxQBiQ9UDW1.
    PaxDbiQ9UDW1.
    PeptideAtlasiQ9UDW1.
    PRIDEiQ9UDW1.

    Expressioni

    Gene expression databases

    BgeeiQ9UDW1.
    GenevestigatoriQ9UDW1.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    BioGridi118920. 6 interactions.
    IntActiQ9UDW1. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UDW1.
    SMRiQ9UDW1. Positions 5-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR10/QCR9 family.Curated

    Phylogenomic databases

    eggNOGiNOG274563.
    HOGENOMiHOG000215187.
    HOVERGENiHBG056661.
    KOiK00419.
    OMAiGNQSANE.
    OrthoDBiEOG7VMP8B.
    PhylomeDBiQ9UDW1.
    TreeFamiTF324385.

    Family and domain databases

    Gene3Di1.20.5.260. 1 hit.
    InterProiIPR008027. QCR9.
    [Graphical view]
    PANTHERiPTHR12980. PTHR12980. 1 hit.
    PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view]
    SUPFAMiSSF81514. SSF81514. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UDW1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAATLTSKL YSLLFRRTST FALTIIVGVM FFERAFDQGA DAIYDHINEG   50
    KLWKHIKHKY ENK 63
    Length:63
    Mass (Da):7,308
    Last modified:January 23, 2007 - v3
    Checksum:i12CCBC666F54E464
    GO
    Isoform 2 (identifier: Q9UDW1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-63: KLWKHIKHKYENK → VRACAIPDLGPA

    Show »
    Length:62
    Mass (Da):6,739
    Checksum:i720BD2B766B03458
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471I → V.
    Corresponds to variant rs14115 [ dbSNP | Ensembl ].
    VAR_052444

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei51 – 6313KLWKH…KYENK → VRACAIPDLGPA in isoform 2. CuratedVSP_041429Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028598 mRNA. Translation: BAB20672.1.
    AF161468 mRNA. Translation: AAF29083.1.
    AC004882 Genomic DNA. No translation available.
    BC005402 mRNA. Translation: AAH05402.1.
    BC015971 mRNA. Translation: AAH15971.1.
    CCDSiCCDS46680.1. [Q9UDW1-1]
    CCDS46681.1. [Q9UDW1-2]
    RefSeqiNP_001003684.1. NM_001003684.1. [Q9UDW1-2]
    NP_037519.2. NM_013387.3. [Q9UDW1-1]
    UniGeneiHs.284292.

    Genome annotation databases

    EnsembliENST00000330029; ENSP00000332887; ENSG00000184076. [Q9UDW1-1]
    ENST00000401406; ENSP00000384962; ENSG00000184076. [Q9UDW1-2]
    GeneIDi29796.
    KEGGihsa:29796.
    UCSCiuc003agp.1. human. [Q9UDW1-2]
    uc003agq.1. human. [Q9UDW1-1]

    Polymorphism databases

    DMDMi9297078.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028598 mRNA. Translation: BAB20672.1 .
    AF161468 mRNA. Translation: AAF29083.1 .
    AC004882 Genomic DNA. No translation available.
    BC005402 mRNA. Translation: AAH05402.1 .
    BC015971 mRNA. Translation: AAH15971.1 .
    CCDSi CCDS46680.1. [Q9UDW1-1 ]
    CCDS46681.1. [Q9UDW1-2 ]
    RefSeqi NP_001003684.1. NM_001003684.1. [Q9UDW1-2 ]
    NP_037519.2. NM_013387.3. [Q9UDW1-1 ]
    UniGenei Hs.284292.

    3D structure databases

    ProteinModelPortali Q9UDW1.
    SMRi Q9UDW1. Positions 5-62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118920. 6 interactions.
    IntActi Q9UDW1. 1 interaction.

    Chemistry

    ChEMBLi CHEMBL2388.

    Polymorphism databases

    DMDMi 9297078.

    Proteomic databases

    MaxQBi Q9UDW1.
    PaxDbi Q9UDW1.
    PeptideAtlasi Q9UDW1.
    PRIDEi Q9UDW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330029 ; ENSP00000332887 ; ENSG00000184076 . [Q9UDW1-1 ]
    ENST00000401406 ; ENSP00000384962 ; ENSG00000184076 . [Q9UDW1-2 ]
    GeneIDi 29796.
    KEGGi hsa:29796.
    UCSCi uc003agp.1. human. [Q9UDW1-2 ]
    uc003agq.1. human. [Q9UDW1-1 ]

    Organism-specific databases

    CTDi 29796.
    GeneCardsi GC22P030163.
    HGNCi HGNC:30863. UQCR10.
    MIMi 610843. gene.
    neXtProti NX_Q9UDW1.
    PharmGKBi PA165378374.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274563.
    HOGENOMi HOG000215187.
    HOVERGENi HBG056661.
    KOi K00419.
    OMAi GNQSANE.
    OrthoDBi EOG7VMP8B.
    PhylomeDBi Q9UDW1.
    TreeFami TF324385.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi UQCR10. human.
    GeneWikii UCRC.
    GenomeRNAii 29796.
    NextBioi 52331.
    PROi Q9UDW1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UDW1.
    Genevestigatori Q9UDW1.

    Family and domain databases

    Gene3Di 1.20.5.260. 1 hit.
    InterProi IPR008027. QCR9.
    [Graphical view ]
    PANTHERi PTHR12980. PTHR12980. 1 hit.
    Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81514. SSF81514. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a human cDNA homologous to the bovine ubiquinol-cytochrome c reductase 7.2kDa protein."
      Nakamura Y.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow and Urinary bladder.
    5. "Ubiquinol-cytochrome-c reductase from human and bovine mitochondria."
      Schaegger H., Brandt U., Gencic S., von Jagow G.
      Methods Enzymol. 260:82-96(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16.
      Tissue: Heart and Liver.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQCR9_HUMAN
    AccessioniPrimary (citable) accession number: Q9UDW1
    Secondary accession number(s): B5MCM5, Q9T2V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3