Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).By similarity

GO - Molecular functioni

  • ubiquinol-cytochrome-c reductase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Gene namesi
Name:UQCR10
Synonyms:UCRC
ORF Names:HSPC119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184076.12
HGNCiHGNC:30863 UQCR10
MIMi610843 gene
neXtProtiNX_Q9UDW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184076
PharmGKBiPA165378374

Chemistry databases

ChEMBLiCHEMBL2388
DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaiUQCR10
DMDMi9297078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001935532 – 63Cytochrome b-c1 complex subunit 9Add BLAST62

Proteomic databases

EPDiQ9UDW1
PaxDbiQ9UDW1
PeptideAtlasiQ9UDW1
PRIDEiQ9UDW1
TopDownProteomicsiQ9UDW1-1 [Q9UDW1-1]
Q9UDW1-2 [Q9UDW1-2]

PTM databases

iPTMnetiQ9UDW1
SwissPalmiQ9UDW1

Expressioni

Gene expression databases

BgeeiENSG00000184076
GenevisibleiQ9UDW1 HS

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi11892028 interactors.
IntActiQ9UDW1 7 interactors.
MINTiQ9UDW1
STRINGi9606.ENSP00000332887

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Turni14 – 16Combined sources3
Helixi18 – 47Combined sources30
Turni48 – 51Combined sources4
Turni53 – 56Combined sources4
Helixi57 – 59Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40D/Q2-63[»]
5XTHelectron microscopy3.90AD/AQ2-63[»]
5XTIelectron microscopy17.40AD/AQ2-63[»]
ProteinModelPortaliQ9UDW1
SMRiQ9UDW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Phylogenomic databases

eggNOGiKOG3494 Eukaryota
ENOG410XUZE LUCA
GeneTreeiENSGT00390000014052
HOGENOMiHOG000215187
HOVERGENiHBG056661
InParanoidiQ9UDW1
KOiK00419
OMAiNRGKLWK
PhylomeDBiQ9UDW1
TreeFamiTF324385

Family and domain databases

Gene3Di1.20.5.2601 hit
InterProiView protein in InterPro
IPR008027 QCR9
IPR036656 QCR9_sf
PANTHERiPTHR12980 PTHR12980, 1 hit
PfamiView protein in Pfam
PF05365 UCR_UQCRX_QCR9, 1 hit
SUPFAMiSSF81514 SSF81514, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATLTSKL YSLLFRRTST FALTIIVGVM FFERAFDQGA DAIYDHINEG
60
KLWKHIKHKY ENK
Length:63
Mass (Da):7,308
Last modified:January 23, 2007 - v3
Checksum:i12CCBC666F54E464
GO
Isoform 2 (identifier: Q9UDW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-63: KLWKHIKHKYENK → VRACAIPDLGPA

Show »
Length:62
Mass (Da):6,739
Checksum:i720BD2B766B03458
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05244447I → V. Corresponds to variant dbSNP:rs14115Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04142951 – 63KLWKH…KYENK → VRACAIPDLGPA in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028598 mRNA Translation: BAB20672.1
AF161468 mRNA Translation: AAF29083.1
AC004882 Genomic DNA No translation available.
BC005402 mRNA Translation: AAH05402.1
BC015971 mRNA Translation: AAH15971.1
CCDSiCCDS46680.1 [Q9UDW1-1]
CCDS46681.1 [Q9UDW1-2]
RefSeqiNP_001003684.1, NM_001003684.1 [Q9UDW1-2]
NP_037519.2, NM_013387.3 [Q9UDW1-1]
UniGeneiHs.284292

Genome annotation databases

EnsembliENST00000330029; ENSP00000332887; ENSG00000184076 [Q9UDW1-1]
ENST00000401406; ENSP00000384962; ENSG00000184076 [Q9UDW1-2]
GeneIDi29796
KEGGihsa:29796
UCSCiuc003agp.2 human [Q9UDW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiQCR9_HUMAN
AccessioniPrimary (citable) accession number: Q9UDW1
Secondary accession number(s): B5MCM5, Q9T2V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome