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Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).By similarity

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, ubiquinol to cytochrome c Source: UniProtKB
  4. respiratory electron transport chain Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Gene namesi
Name:UQCR10
Synonyms:UCRC
ORF Names:HSPC119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:30863. UQCR10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex III Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165378374.

Polymorphism and mutation databases

BioMutaiUQCR10.
DMDMi9297078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6362Cytochrome b-c1 complex subunit 9PRO_0000193553Add
BLAST

Proteomic databases

MaxQBiQ9UDW1.
PaxDbiQ9UDW1.
PeptideAtlasiQ9UDW1.
PRIDEiQ9UDW1.

Expressioni

Gene expression databases

BgeeiQ9UDW1.
ExpressionAtlasiQ9UDW1. baseline and differential.
GenevestigatoriQ9UDW1.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi118920. 5 interactions.
IntActiQ9UDW1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9UDW1.
SMRiQ9UDW1. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Phylogenomic databases

eggNOGiNOG274563.
GeneTreeiENSGT00390000014052.
HOGENOMiHOG000215187.
HOVERGENiHBG056661.
InParanoidiQ9UDW1.
KOiK00419.
OMAiGKLWKHI.
OrthoDBiEOG7VMP8B.
PhylomeDBiQ9UDW1.
TreeFamiTF324385.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATLTSKL YSLLFRRTST FALTIIVGVM FFERAFDQGA DAIYDHINEG
60
KLWKHIKHKY ENK
Length:63
Mass (Da):7,308
Last modified:January 23, 2007 - v3
Checksum:i12CCBC666F54E464
GO
Isoform 2 (identifier: Q9UDW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-63: KLWKHIKHKYENK → VRACAIPDLGPA

Show »
Length:62
Mass (Da):6,739
Checksum:i720BD2B766B03458
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471I → V.
Corresponds to variant rs14115 [ dbSNP | Ensembl ].
VAR_052444

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei51 – 6313KLWKH…KYENK → VRACAIPDLGPA in isoform 2. CuratedVSP_041429Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028598 mRNA. Translation: BAB20672.1.
AF161468 mRNA. Translation: AAF29083.1.
AC004882 Genomic DNA. No translation available.
BC005402 mRNA. Translation: AAH05402.1.
BC015971 mRNA. Translation: AAH15971.1.
CCDSiCCDS46680.1. [Q9UDW1-1]
CCDS46681.1. [Q9UDW1-2]
RefSeqiNP_001003684.1. NM_001003684.1. [Q9UDW1-2]
NP_037519.2. NM_013387.3. [Q9UDW1-1]
UniGeneiHs.284292.

Genome annotation databases

EnsembliENST00000330029; ENSP00000332887; ENSG00000184076. [Q9UDW1-1]
ENST00000401406; ENSP00000384962; ENSG00000184076. [Q9UDW1-2]
GeneIDi29796.
KEGGihsa:29796.
UCSCiuc003agp.1. human. [Q9UDW1-2]
uc003agq.1. human. [Q9UDW1-1]

Polymorphism and mutation databases

BioMutaiUQCR10.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028598 mRNA. Translation: BAB20672.1.
AF161468 mRNA. Translation: AAF29083.1.
AC004882 Genomic DNA. No translation available.
BC005402 mRNA. Translation: AAH05402.1.
BC015971 mRNA. Translation: AAH15971.1.
CCDSiCCDS46680.1. [Q9UDW1-1]
CCDS46681.1. [Q9UDW1-2]
RefSeqiNP_001003684.1. NM_001003684.1. [Q9UDW1-2]
NP_037519.2. NM_013387.3. [Q9UDW1-1]
UniGeneiHs.284292.

3D structure databases

ProteinModelPortaliQ9UDW1.
SMRiQ9UDW1. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118920. 5 interactions.
IntActiQ9UDW1. 1 interaction.

Chemistry

ChEMBLiCHEMBL2388.

Polymorphism and mutation databases

BioMutaiUQCR10.
DMDMi9297078.

Proteomic databases

MaxQBiQ9UDW1.
PaxDbiQ9UDW1.
PeptideAtlasiQ9UDW1.
PRIDEiQ9UDW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330029; ENSP00000332887; ENSG00000184076. [Q9UDW1-1]
ENST00000401406; ENSP00000384962; ENSG00000184076. [Q9UDW1-2]
GeneIDi29796.
KEGGihsa:29796.
UCSCiuc003agp.1. human. [Q9UDW1-2]
uc003agq.1. human. [Q9UDW1-1]

Organism-specific databases

CTDi29796.
GeneCardsiGC22P030163.
HGNCiHGNC:30863. UQCR10.
MIMi610843. gene.
neXtProtiNX_Q9UDW1.
PharmGKBiPA165378374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274563.
GeneTreeiENSGT00390000014052.
HOGENOMiHOG000215187.
HOVERGENiHBG056661.
InParanoidiQ9UDW1.
KOiK00419.
OMAiGKLWKHI.
OrthoDBiEOG7VMP8B.
PhylomeDBiQ9UDW1.
TreeFamiTF324385.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiUQCR10. human.
GeneWikiiUCRC.
GenomeRNAii29796.
NextBioi52331.
PROiQ9UDW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UDW1.
ExpressionAtlasiQ9UDW1. baseline and differential.
GenevestigatoriQ9UDW1.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a human cDNA homologous to the bovine ubiquinol-cytochrome c reductase 7.2kDa protein."
    Nakamura Y.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow and Urinary bladder.
  5. "Ubiquinol-cytochrome-c reductase from human and bovine mitochondria."
    Schaegger H., Brandt U., Gencic S., von Jagow G.
    Methods Enzymol. 260:82-96(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16.
    Tissue: Heart and Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiQCR9_HUMAN
AccessioniPrimary (citable) accession number: Q9UDW1
Secondary accession number(s): B5MCM5, Q9T2V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.