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Protein

Zinc finger protein 282

Gene

ZNF282

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 540C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155665-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 282
Alternative name(s):
HTLV-I U5RE-binding protein 1
Short name:
HUB-1
Gene namesi
Name:ZNF282
Synonyms:HUB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13076. ZNF282.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8427.
OpenTargetsiENSG00000170265.
PharmGKBiPA37652.

Polymorphism and mutation databases

BioMutaiZNF282.
DMDMi116242858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475061 – 671Zinc finger protein 282Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UDV7.
PaxDbiQ9UDV7.
PeptideAtlasiQ9UDV7.
PRIDEiQ9UDV7.

PTM databases

iPTMnetiQ9UDV7.
PhosphoSitePlusiQ9UDV7.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000170265.
CleanExiHS_ZNF282.
ExpressionAtlasiQ9UDV7. baseline and differential.
GenevisibleiQ9UDV7. HS.

Organism-specific databases

HPAiHPA024374.

Interactioni

Protein-protein interaction databases

BioGridi114010. 6 interactors.
IntActiQ9UDV7. 6 interactors.
MINTiMINT-8247561.
STRINGi9606.ENSP00000262085.

Structurei

3D structure databases

ProteinModelPortaliQ9UDV7.
SMRiQ9UDV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 271KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 540C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG061389.
InParanoidiQ9UDV7.
KOiK09228.
OMAiPCVWEQH.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ9UDV7.
TreeFamiTF337777.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQFVSTRPQP QQLGIQGLGL DSGSWSWAQA LPPEEVCHQE PALRGEMAEG
60 70 80 90 100
MPPMQAQEWD MDARRPMPFQ FPPFPDRAPV FPDRMMREPQ LPTAEISLWT
110 120 130 140 150
VVAAIQAVER KVDAQASQLL NLEGRTGTAE KKLADCEKTA VEFGNHMESK
160 170 180 190 200
WAVLGTLLQE YGLLQRRLEN LENLLRNRNF WVLRLPPGSK GEAPKVPVTF
210 220 230 240 250
VDIAVYFSED EWKNLDEWQK ELYNNLVKEN YKTLMSLDAE GSVPKPDAPV
260 270 280 290 300
QAEPREEPCV WEQRHPEERE IPMDPEAGAE PLVPAQDASS QVKREDTLCV
310 320 330 340 350
RGQRGLEERA IPTESITDSP ISAQDLLSRI KQEEHQCVWD QQDLADRDIP
360 370 380 390 400
TDPNSESLIS AHDILSWIKQ EEQPYPWGPR DSMDGELGLD SGPSDSLLMV
410 420 430 440 450
KNPPPAPPQP QPQPQPPQPQ LQSQPQPQSL PPIAVAENPG GPPSRGLLDD
460 470 480 490 500
GFQVLPGERG SGEAPPGGDR STGGGGGDGG GGGGGAEAGT GAGGGCGSCC
510 520 530 540 550
PGGLRRSLLL HGARSKPYSC PECGKSFGVR KSLIIHHRSH TKERPYECAE
560 570 580 590 600
CEKSFNCHSG LIRHQMTHRG ERPYKCSECE KTYSRKEHLQ NHQRLHTGER
610 620 630 640 650
PFQCALCGKS FIRKQNLLKH QRIHTGERPY TCGECGKSFR YKESLKDHLR
660 670
VHSGGPGPGA PRQLPPPPER D
Length:671
Mass (Da):74,295
Last modified:October 17, 2006 - v3
Checksum:iFBD6001DC12CB26E
GO
Isoform 2 (identifier: Q9UDV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-463: VLPGERGSGE → PHQGAALRVR
     464-671: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):51,908
Checksum:iD25F8FB4885942BC
GO

Sequence cautioni

The sequence BAA24380 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35E → Q in BAA24380 (PubMed:9396811).Curated1
Sequence conflicti414P → R in BAA24380 (PubMed:9396811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052805273M → V.Corresponds to variant rs1202418dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056545454 – 463VLPGERGSGE → PHQGAALRVR in isoform 2. 1 Publication10
Alternative sequenceiVSP_056546464 – 671Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30612 mRNA. Translation: BAA24380.1. Different initiation.
AK299280 mRNA. Translation: BAG61297.1.
AK316282 mRNA. Translation: BAH14653.1.
AC004890 Genomic DNA. No translation available.
BC073805 mRNA. Translation: AAH73805.1.
CCDSiCCDS5895.1. [Q9UDV7-1]
CCDS78284.1. [Q9UDV7-2]
RefSeqiNP_001290410.1. NM_001303481.1. [Q9UDV7-2]
NP_003566.1. NM_003575.3. [Q9UDV7-1]
UniGeneiHs.729056.

Genome annotation databases

EnsembliENST00000479907; ENSP00000418840; ENSG00000170265. [Q9UDV7-2]
ENST00000610704; ENSP00000477841; ENSG00000170265. [Q9UDV7-1]
GeneIDi8427.
KEGGihsa:8427.
UCSCiuc011kun.2. human. [Q9UDV7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30612 mRNA. Translation: BAA24380.1. Different initiation.
AK299280 mRNA. Translation: BAG61297.1.
AK316282 mRNA. Translation: BAH14653.1.
AC004890 Genomic DNA. No translation available.
BC073805 mRNA. Translation: AAH73805.1.
CCDSiCCDS5895.1. [Q9UDV7-1]
CCDS78284.1. [Q9UDV7-2]
RefSeqiNP_001290410.1. NM_001303481.1. [Q9UDV7-2]
NP_003566.1. NM_003575.3. [Q9UDV7-1]
UniGeneiHs.729056.

3D structure databases

ProteinModelPortaliQ9UDV7.
SMRiQ9UDV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114010. 6 interactors.
IntActiQ9UDV7. 6 interactors.
MINTiMINT-8247561.
STRINGi9606.ENSP00000262085.

PTM databases

iPTMnetiQ9UDV7.
PhosphoSitePlusiQ9UDV7.

Polymorphism and mutation databases

BioMutaiZNF282.
DMDMi116242858.

Proteomic databases

EPDiQ9UDV7.
PaxDbiQ9UDV7.
PeptideAtlasiQ9UDV7.
PRIDEiQ9UDV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000479907; ENSP00000418840; ENSG00000170265. [Q9UDV7-2]
ENST00000610704; ENSP00000477841; ENSG00000170265. [Q9UDV7-1]
GeneIDi8427.
KEGGihsa:8427.
UCSCiuc011kun.2. human. [Q9UDV7-1]

Organism-specific databases

CTDi8427.
DisGeNETi8427.
GeneCardsiZNF282.
HGNCiHGNC:13076. ZNF282.
HPAiHPA024374.
MIMi603397. gene.
neXtProtiNX_Q9UDV7.
OpenTargetsiENSG00000170265.
PharmGKBiPA37652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG061389.
InParanoidiQ9UDV7.
KOiK09228.
OMAiPCVWEQH.
OrthoDBiEOG091G0P6J.
PhylomeDBiQ9UDV7.
TreeFamiTF337777.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155665-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF282. human.
GenomeRNAii8427.
PROiQ9UDV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170265.
CleanExiHS_ZNF282.
ExpressionAtlasiQ9UDV7. baseline and differential.
GenevisibleiQ9UDV7. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN282_HUMAN
AccessioniPrimary (citable) accession number: Q9UDV7
Secondary accession number(s): B4DRI5, O43691, Q6DKK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.