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Q9UDV6

- ZN212_HUMAN

UniProt

Q9UDV6 - ZN212_HUMAN

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Protein

Zinc finger protein 212

Gene

ZNF212

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 212
Alternative name(s):
Zinc finger protein C2H2-150
Gene namesi
Name:ZNF212
Synonyms:ZNFC150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13004. ZNF212.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Zinc finger protein 212PRO_0000047456Add
BLAST

Proteomic databases

MaxQBiQ9UDV6.
PaxDbiQ9UDV6.
PRIDEiQ9UDV6.

PTM databases

PhosphoSiteiQ9UDV6.

Expressioni

Gene expression databases

BgeeiQ9UDV6.
CleanExiHS_ZNF212.
ExpressionAtlasiQ9UDV6. baseline and differential.
GenevestigatoriQ9UDV6.

Organism-specific databases

HPAiHPA049807.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1640204,EBI-1640204
SUV39H2Q9H5I12EBI-1640204,EBI-723127
ZNF3P170364EBI-1640204,EBI-1640965

Protein-protein interaction databases

BioGridi113698. 21 interactions.
IntActiQ9UDV6. 18 interactions.
MINTiMINT-8417735.
STRINGi9606.ENSP00000338572.

Structurei

3D structure databases

ProteinModelPortaliQ9UDV6.
SMRiQ9UDV6. Positions 307-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 21979KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326300.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG055724.
InParanoidiQ9UDV6.
KOiK09228.
OMAiWDGQGSS.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9UDV6.
TreeFamiTF337777.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UDV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA
60 70 80 90 100
VEKKMESQAA RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL
110 120 130 140 150
LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGEAPKVS RSLENDGVCF
160 170 180 190 200
TEQEWENLED WQKELYRNVM ESNYETLVSL KVLGQTEGEA ELGTEMLGDL
210 220 230 240 250
EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE QAFLSPEQTE
260 270 280 290 300
LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ
310 320 330 340 350
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE
360 370 380 390 400
ESLRPRPRLK PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ
410 420 430 440 450
HVQERFSPNS LVALPGHIPW RKSRSSLICG YCGKSFSHPS DLVRHQRIHT
460 470 480 490
GERPYSCTEC EKSFVQKQHL LQHQKIHQRE RGGLALEPGR PNGLL
Length:495
Mass (Da):55,447
Last modified:November 23, 2004 - v3
Checksum:iAF0F7EEC8A482F8A
GO

Sequence cautioni

The sequence AAC51296.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAD45826.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931H → Y.
Corresponds to variant rs34185245 [ dbSNP | Ensembl ].
VAR_052794

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315086 mRNA. Translation: BAG37551.1.
AC004890 Genomic DNA. Translation: AAD45826.2. Different initiation.
CH471146 Genomic DNA. Translation: EAW80054.1.
BC022785 mRNA. Translation: AAH22785.2.
U38864 mRNA. Translation: AAC51296.1. Different initiation.
CCDSiCCDS5896.1.
PIRiI39199.
RefSeqiNP_036388.2. NM_012256.3.
UniGeneiHs.490510.

Genome annotation databases

EnsembliENST00000335870; ENSP00000338572; ENSG00000170260.
GeneIDi7988.
KEGGihsa:7988.
UCSCiuc003wfp.3. human.

Polymorphism databases

DMDMi55977888.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315086 mRNA. Translation: BAG37551.1 .
AC004890 Genomic DNA. Translation: AAD45826.2 . Different initiation.
CH471146 Genomic DNA. Translation: EAW80054.1 .
BC022785 mRNA. Translation: AAH22785.2 .
U38864 mRNA. Translation: AAC51296.1 . Different initiation.
CCDSi CCDS5896.1.
PIRi I39199.
RefSeqi NP_036388.2. NM_012256.3.
UniGenei Hs.490510.

3D structure databases

ProteinModelPortali Q9UDV6.
SMRi Q9UDV6. Positions 307-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113698. 21 interactions.
IntActi Q9UDV6. 18 interactions.
MINTi MINT-8417735.
STRINGi 9606.ENSP00000338572.

PTM databases

PhosphoSitei Q9UDV6.

Polymorphism databases

DMDMi 55977888.

Proteomic databases

MaxQBi Q9UDV6.
PaxDbi Q9UDV6.
PRIDEi Q9UDV6.

Protocols and materials databases

DNASUi 7988.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335870 ; ENSP00000338572 ; ENSG00000170260 .
GeneIDi 7988.
KEGGi hsa:7988.
UCSCi uc003wfp.3. human.

Organism-specific databases

CTDi 7988.
GeneCardsi GC07P148936.
HGNCi HGNC:13004. ZNF212.
HPAi HPA049807.
MIMi 602386. gene.
neXtProti NX_Q9UDV6.
PharmGKBi PA37583.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326300.
GeneTreei ENSGT00530000063032.
HOGENOMi HOG000013125.
HOVERGENi HBG055724.
InParanoidi Q9UDV6.
KOi K09228.
OMAi WDGQGSS.
OrthoDBi EOG73JKWC.
PhylomeDBi Q9UDV6.
TreeFami TF337777.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF212. human.
GenomeRNAii 7988.
NextBioi 30524.
PROi Q9UDV6.
SOURCEi Search...

Gene expression databases

Bgeei Q9UDV6.
CleanExi HS_ZNF212.
ExpressionAtlasi Q9UDV6. baseline and differential.
Genevestigatori Q9UDV6.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR022137. DUF3669_Znf.
IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1."
    Becker K.G., Nagle J.W., Canning R.D., Dehejia A.M., Polymeropoulos M.H., Gado A.M., Biddison W.E., Drew P.D.
    Genomics 41:502-504(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-495.
  6. "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain."
    Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K., Drew P.D.
    Hum. Mol. Genet. 4:685-691(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.

Entry informationi

Entry nameiZN212_HUMAN
AccessioniPrimary (citable) accession number: Q9UDV6
Secondary accession number(s): B2RCF4, Q13396, Q8N664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3