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Q9UDV6

- ZN212_HUMAN

UniProt

Q9UDV6 - ZN212_HUMAN

Protein

Zinc finger protein 212

Gene

ZNF212

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 212
    Alternative name(s):
    Zinc finger protein C2H2-150
    Gene namesi
    Name:ZNF212
    Synonyms:ZNFC150
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13004. ZNF212.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Zinc finger protein 212PRO_0000047456Add
    BLAST

    Proteomic databases

    PaxDbiQ9UDV6.
    PRIDEiQ9UDV6.

    PTM databases

    PhosphoSiteiQ9UDV6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UDV6.
    BgeeiQ9UDV6.
    CleanExiHS_ZNF212.
    GenevestigatoriQ9UDV6.

    Organism-specific databases

    HPAiHPA049807.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1640204,EBI-1640204
    SUV39H2Q9H5I12EBI-1640204,EBI-723127
    ZNF3P170364EBI-1640204,EBI-1640965

    Protein-protein interaction databases

    BioGridi113698. 21 interactions.
    IntActiQ9UDV6. 18 interactions.
    MINTiMINT-8417735.
    STRINGi9606.ENSP00000338572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UDV6.
    SMRiQ9UDV6. Positions 307-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini141 – 21979KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri316 – 33823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG326300.
    HOGENOMiHOG000013125.
    HOVERGENiHBG055724.
    InParanoidiQ9UDV6.
    KOiK09228.
    OMAiWDGQGSS.
    OrthoDBiEOG73JKWC.
    PhylomeDBiQ9UDV6.
    TreeFamiTF337777.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR022137. DUF3669_Znf.
    IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF12417. DUF3669. 1 hit.
    PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UDV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA    50
    VEKKMESQAA RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL 100
    LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGEAPKVS RSLENDGVCF 150
    TEQEWENLED WQKELYRNVM ESNYETLVSL KVLGQTEGEA ELGTEMLGDL 200
    EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE QAFLSPEQTE 250
    LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ 300
    ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE 350
    ESLRPRPRLK PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ 400
    HVQERFSPNS LVALPGHIPW RKSRSSLICG YCGKSFSHPS DLVRHQRIHT 450
    GERPYSCTEC EKSFVQKQHL LQHQKIHQRE RGGLALEPGR PNGLL 495
    Length:495
    Mass (Da):55,447
    Last modified:November 23, 2004 - v3
    Checksum:iAF0F7EEC8A482F8A
    GO

    Sequence cautioni

    The sequence AAC51296.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAD45826.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931H → Y.
    Corresponds to variant rs34185245 [ dbSNP | Ensembl ].
    VAR_052794

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315086 mRNA. Translation: BAG37551.1.
    AC004890 Genomic DNA. Translation: AAD45826.2. Different initiation.
    CH471146 Genomic DNA. Translation: EAW80054.1.
    BC022785 mRNA. Translation: AAH22785.2.
    U38864 mRNA. Translation: AAC51296.1. Different initiation.
    CCDSiCCDS5896.1.
    PIRiI39199.
    RefSeqiNP_036388.2. NM_012256.3.
    UniGeneiHs.490510.

    Genome annotation databases

    EnsembliENST00000335870; ENSP00000338572; ENSG00000170260.
    GeneIDi7988.
    KEGGihsa:7988.
    UCSCiuc003wfp.3. human.

    Polymorphism databases

    DMDMi55977888.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315086 mRNA. Translation: BAG37551.1 .
    AC004890 Genomic DNA. Translation: AAD45826.2 . Different initiation.
    CH471146 Genomic DNA. Translation: EAW80054.1 .
    BC022785 mRNA. Translation: AAH22785.2 .
    U38864 mRNA. Translation: AAC51296.1 . Different initiation.
    CCDSi CCDS5896.1.
    PIRi I39199.
    RefSeqi NP_036388.2. NM_012256.3.
    UniGenei Hs.490510.

    3D structure databases

    ProteinModelPortali Q9UDV6.
    SMRi Q9UDV6. Positions 307-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113698. 21 interactions.
    IntActi Q9UDV6. 18 interactions.
    MINTi MINT-8417735.
    STRINGi 9606.ENSP00000338572.

    PTM databases

    PhosphoSitei Q9UDV6.

    Polymorphism databases

    DMDMi 55977888.

    Proteomic databases

    PaxDbi Q9UDV6.
    PRIDEi Q9UDV6.

    Protocols and materials databases

    DNASUi 7988.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335870 ; ENSP00000338572 ; ENSG00000170260 .
    GeneIDi 7988.
    KEGGi hsa:7988.
    UCSCi uc003wfp.3. human.

    Organism-specific databases

    CTDi 7988.
    GeneCardsi GC07P148936.
    HGNCi HGNC:13004. ZNF212.
    HPAi HPA049807.
    MIMi 602386. gene.
    neXtProti NX_Q9UDV6.
    PharmGKBi PA37583.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326300.
    HOGENOMi HOG000013125.
    HOVERGENi HBG055724.
    InParanoidi Q9UDV6.
    KOi K09228.
    OMAi WDGQGSS.
    OrthoDBi EOG73JKWC.
    PhylomeDBi Q9UDV6.
    TreeFami TF337777.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF212. human.
    GenomeRNAii 7988.
    NextBioi 30524.
    PROi Q9UDV6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UDV6.
    Bgeei Q9UDV6.
    CleanExi HS_ZNF212.
    Genevestigatori Q9UDV6.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR022137. DUF3669_Znf.
    IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF12417. DUF3669. 1 hit.
    PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1."
      Becker K.G., Nagle J.W., Canning R.D., Dehejia A.M., Polymeropoulos M.H., Gado A.M., Biddison W.E., Drew P.D.
      Genomics 41:502-504(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-495.
    6. "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain."
      Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K., Drew P.D.
      Hum. Mol. Genet. 4:685-691(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiZN212_HUMAN
    AccessioniPrimary (citable) accession number: Q9UDV6
    Secondary accession number(s): B2RCF4, Q13396, Q8N664
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3