Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CAP-Gly domain-containing linker protein 2

Gene

CLIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 2
Alternative name(s):
Cytoplasmic linker protein 115
Short name:
CLIP-115
Cytoplasmic linker protein 2
Williams-Beuren syndrome chromosomal region 3 protein
Williams-Beuren syndrome chromosomal region 4 protein
Gene namesi
Name:CLIP2
Synonyms:CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2586. CLIP2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Localizes preferentially to the ends of tyrosinated microtubules.By similarity

GO - Cellular componenti

  • cytoplasmic microtubule Source: Ensembl
  • microtubule associated complex Source: ProtInc
  • microtubule plus-end Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

DisGeNETi7461.
MalaCardsiCLIP2.
OpenTargetsiENSG00000106665.
Orphaneti904. Williams syndrome.
PharmGKBiPA27085.

Polymorphism and mutation databases

BioMutaiCLIP2.
DMDMi74753268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835151 – 1046CAP-Gly domain-containing linker protein 2Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei923PhosphoserineCombined sources1
Modified residuei973PhosphoserineBy similarity1
Modified residuei979PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UDT6.
PaxDbiQ9UDT6.
PeptideAtlasiQ9UDT6.
PRIDEiQ9UDT6.

PTM databases

iPTMnetiQ9UDT6.
PhosphoSitePlusiQ9UDT6.
SwissPalmiQ9UDT6.

Expressioni

Gene expression databases

BgeeiENSG00000106665.
CleanExiHS_CLIP2.
ExpressionAtlasiQ9UDT6. baseline and differential.
GenevisibleiQ9UDT6. HS.

Organism-specific databases

HPAiCAB020767.
HPA020430.

Interactioni

Subunit structurei

Interacts with CLASP1 and CLASP2 (PubMed:11290329). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113300. 10 interactors.
IntActiQ9UDT6. 8 interactors.
STRINGi9606.ENSP00000223398.

Structurei

Secondary structure

11046
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi73 – 75Combined sources3
Beta strandi84 – 86Combined sources3
Helixi87 – 89Combined sources3
Beta strandi92 – 100Combined sources9
Beta strandi102 – 104Combined sources3
Beta strandi106 – 116Combined sources11
Beta strandi118 – 124Combined sources7
Turni134 – 136Combined sources3
Beta strandi137 – 140Combined sources4
Helixi142 – 144Combined sources3
Beta strandi224 – 227Combined sources4
Turni228 – 230Combined sources3
Beta strandi231 – 240Combined sources10
Beta strandi242 – 256Combined sources15
Beta strandi259 – 264Combined sources6
Beta strandi267 – 270Combined sources4
Turni274 – 276Combined sources3
Beta strandi277 – 281Combined sources5
Helixi282 – 284Combined sources3
Beta strandi285 – 287Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CP2NMR-A68-149[»]
2CP3NMR-A219-289[»]
ProteinModelPortaliQ9UDT6.
SMRiQ9UDT6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UDT6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 141CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini239 – 281CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili354 – 524Sequence analysisAdd BLAST171
Coiled coili561 – 636Sequence analysisAdd BLAST76
Coiled coili673 – 1016Sequence analysisAdd BLAST344

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi314 – 345Ser-richAdd BLAST32

Sequence similaritiesi

Contains 2 CAP-Gly domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4568. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000092755.
HOVERGENiHBG007123.
InParanoidiQ9UDT6.
KOiK10422.
OMAiNMIESND.
OrthoDBiEOG091G0J1Y.
PhylomeDBiQ9UDT6.
TreeFamiTF326096.

Family and domain databases

Gene3Di2.30.30.190. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view]
PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
PfamiPF01302. CAP_GLY. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 2 hits.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 2 hits.
PROSITEiPS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UDT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKPSGLKPP GRGGKHSSPM GRTSTGSASS SAAVAASSKE GSPLHKQSSG
60 70 80 90 100
PSSSPAAAAA PEKPGPKAAE VGDDFLGDFV VGERVWVNGV KPGVVQYLGE
110 120 130 140 150
TQFAPGQWAG VVLDDPVGKN DGAVGGVRYF ECPALQGIFT RPSKLTRQPT
160 170 180 190 200
AEGSGSDAHS VESLTAQNLS LHSGTATPPL TSRVIPLRES VLNSSVKTGN
210 220 230 240 250
ESGSNLSDSG SVKRGEKDLR LGDRVLVGGT KTGVVRYVGE TDFAKGEWCG
260 270 280 290 300
VELDEPLGKN DGAVAGTRYF QCPPKFGLFA PIHKVIRIGF PSTSPAKAKK
310 320 330 340 350
TKRMAMGVSA LTHSPSSSSI SSVSSVASSV GGRPSRSGLL TETSSRYARK
360 370 380 390 400
ISGTTALQEA LKEKQQHIEQ LLAERDLERA EVAKATSHIC EVEKEIALLK
410 420 430 440 450
AQHEQYVAEA EEKLQRARLL VESVRKEKVD LSNQLEEERR KVEDLQFRVE
460 470 480 490 500
EESITKGDLE TQTQLEHARI GELEQSLLLE KAQAERLLRE LADNRLTTVA
510 520 530 540 550
EKSRVLQLEE ELTLRRGEIE ELQQCLLHSG PPPPDHPDAA EILRLRERLL
560 570 580 590 600
SASKEHQRES GVLRDKYEKA LKAYQAEVDK LRAANEKYAQ EVAGLKDKVQ
610 620 630 640 650
QATSENMGLM DNWKSKLDSL ASDHQKSLED LKATLNSGPG AQQKEIGELK
660 670 680 690 700
AVMEGIKMEH QLELGNLQAK HDLETAMHVK EKEALREKLQ EAQEELAGLQ
710 720 730 740 750
RHWRAQLEVQ ASQHRLELQE AQDQRRDAEL RVHELEKLDV EYRGQAQAIE
760 770 780 790 800
FLKEQISLAE KKMLDYERLQ RAEAQGKQEV ESLREKLLVA ENRLQAVEAL
810 820 830 840 850
CSSQHTHMIE SNDISEETIR TKETVEGLQD KLNKRDKEVT ALTSQTEMLR
860 870 880 890 900
AQVSALESKC KSGEKKVDAL LKEKRRLEAE LETVSRKTHD ASGQLVLISQ
910 920 930 940 950
ELLRKERSLN ELRVLLLEAN RHSPGPERDL SREVHKAEWR IKEQKLKDDI
960 970 980 990 1000
RGLREKLTGL DKEKSLSDQR RYSLIDRSSA PELLRLQHQL MSTEDALRDA
1010 1020 1030 1040
LDQAQQVEKL MEAMRSCPDK AQTIGNSGSA NGIHQQDKAQ KQEDKH
Length:1,046
Mass (Da):115,837
Last modified:May 1, 2000 - v1
Checksum:i7A0B3C796E1C6E25
GO
Isoform 2 (identifier: Q9UDT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-495: Missing.

Show »
Length:1,011
Mass (Da):111,782
Checksum:i2CFCD1B101162B1C
GO

Sequence cautioni

The sequence BAA22960 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055636961D → E.Corresponds to variant rs17145468dbSNPEnsembl.1
Natural variantiVAR_023618977R → P.1 PublicationCorresponds to variant rs2522943dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015682461 – 495Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006629 mRNA. Translation: BAA22960.2. Different initiation.
AC005015 Genomic DNA. Translation: AAF03524.1.
AF041059
, AF041055, AF041056, AF041057, AF041058 Genomic DNA. Translation: AAB96784.1.
CCDSiCCDS5569.1. [Q9UDT6-1]
CCDS5570.1. [Q9UDT6-2]
RefSeqiNP_003379.3. NM_003388.4.
NP_115797.1. NM_032421.2.
UniGeneiHs.647018.

Genome annotation databases

EnsembliENST00000223398; ENSP00000223398; ENSG00000106665. [Q9UDT6-1]
ENST00000361545; ENSP00000355151; ENSG00000106665. [Q9UDT6-2]
ENST00000395060; ENSP00000378500; ENSG00000106665. [Q9UDT6-1]
GeneIDi7461.
KEGGihsa:7461.
UCSCiuc003uam.3. human. [Q9UDT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006629 mRNA. Translation: BAA22960.2. Different initiation.
AC005015 Genomic DNA. Translation: AAF03524.1.
AF041059
, AF041055, AF041056, AF041057, AF041058 Genomic DNA. Translation: AAB96784.1.
CCDSiCCDS5569.1. [Q9UDT6-1]
CCDS5570.1. [Q9UDT6-2]
RefSeqiNP_003379.3. NM_003388.4.
NP_115797.1. NM_032421.2.
UniGeneiHs.647018.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CP2NMR-A68-149[»]
2CP3NMR-A219-289[»]
ProteinModelPortaliQ9UDT6.
SMRiQ9UDT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113300. 10 interactors.
IntActiQ9UDT6. 8 interactors.
STRINGi9606.ENSP00000223398.

PTM databases

iPTMnetiQ9UDT6.
PhosphoSitePlusiQ9UDT6.
SwissPalmiQ9UDT6.

Polymorphism and mutation databases

BioMutaiCLIP2.
DMDMi74753268.

Proteomic databases

EPDiQ9UDT6.
PaxDbiQ9UDT6.
PeptideAtlasiQ9UDT6.
PRIDEiQ9UDT6.

Protocols and materials databases

DNASUi7461.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223398; ENSP00000223398; ENSG00000106665. [Q9UDT6-1]
ENST00000361545; ENSP00000355151; ENSG00000106665. [Q9UDT6-2]
ENST00000395060; ENSP00000378500; ENSG00000106665. [Q9UDT6-1]
GeneIDi7461.
KEGGihsa:7461.
UCSCiuc003uam.3. human. [Q9UDT6-1]

Organism-specific databases

CTDi7461.
DisGeNETi7461.
GeneCardsiCLIP2.
HGNCiHGNC:2586. CLIP2.
HPAiCAB020767.
HPA020430.
MalaCardsiCLIP2.
MIMi603432. gene.
neXtProtiNX_Q9UDT6.
OpenTargetsiENSG00000106665.
Orphaneti904. Williams syndrome.
PharmGKBiPA27085.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4568. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000092755.
HOVERGENiHBG007123.
InParanoidiQ9UDT6.
KOiK10422.
OMAiNMIESND.
OrthoDBiEOG091G0J1Y.
PhylomeDBiQ9UDT6.
TreeFamiTF326096.

Miscellaneous databases

ChiTaRSiCLIP2. human.
EvolutionaryTraceiQ9UDT6.
GeneWikiiCLIP2.
GenomeRNAii7461.
PROiQ9UDT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106665.
CleanExiHS_CLIP2.
ExpressionAtlasiQ9UDT6. baseline and differential.
GenevisibleiQ9UDT6. HS.

Family and domain databases

Gene3Di2.30.30.190. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR028394. CLIP2.
[Graphical view]
PANTHERiPTHR18916:SF10. PTHR18916:SF10. 1 hit.
PfamiPF01302. CAP_GLY. 2 hits.
[Graphical view]
SMARTiSM01052. CAP_GLY. 2 hits.
[Graphical view]
SUPFAMiSSF74924. SSF74924. 2 hits.
PROSITEiPS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9UDT6
Secondary accession number(s): O14527, O43611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.