Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UD71

- PPR1B_HUMAN

UniProt

Q9UD71 - PPR1B_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

PPP1R1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibitor of protein-phosphatase 1.

    GO - Molecular functioni

    1. protein kinase inhibitor activity Source: UniProtKB
    2. protein phosphatase inhibitor activity Source: UniProtKB
    3. protein phosphatase type 1 regulator activity Source: Reactome

    GO - Biological processi

    1. intracellular signal transduction Source: Ensembl
    2. negative regulation of catalytic activity Source: GOC
    3. negative regulation of female receptivity Source: Ensembl
    4. negative regulation of protein kinase activity Source: GOC
    5. regulation of catalytic activity Source: GOC
    6. response to amphetamine Source: Ensembl
    7. signal transduction Source: UniProtKB
    8. transcription, DNA-templated Source: Ensembl
    9. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_15334. DARPP-32 events.
    SignaLinkiQ9UD71.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1B
    Alternative name(s):
    DARPP-32
    Dopamine- and cAMP-regulated neuronal phosphoprotein
    Gene namesi
    Name:PPP1R1B
    Synonyms:DARPP32
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:9287. PPP1R1B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. neuronal cell body Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33639.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Protein phosphatase 1 regulatory subunit 1BPRO_0000071473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei34 – 341Phosphothreonine; by PKABy similarity
    Modified residuei75 – 751Phosphothreonine; by CDK51 Publication

    Post-translational modificationi

    Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
    Phosphorylation of Thr-34 is required for activity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UD71.
    PaxDbiQ9UD71.
    PRIDEiQ9UD71.

    PTM databases

    PhosphoSiteiQ9UD71.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UD71.
    BgeeiQ9UD71.
    CleanExiHS_PPP1R1B.
    GenevestigatoriQ9UD71.

    Organism-specific databases

    HPAiCAB004026.
    HPA048630.

    Interactioni

    Protein-protein interaction databases

    BioGridi123915. 4 interactions.
    IntActiQ9UD71. 2 interactions.
    MINTiMINT-1380912.
    STRINGi9606.ENSP00000254079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UD71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 13618Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG39986.
    HOGENOMiHOG000290193.
    HOVERGENiHBG099182.
    KOiK15494.
    OMAiRAQLNSH.
    OrthoDBiEOG7PCJJG.
    PhylomeDBiQ9UD71.
    TreeFamiTF332576.

    Family and domain databases

    InterProiIPR015670. Dopamine/cAMP_neuron_P-prot.
    IPR008466. PPI_1DARPP-32.
    [Graphical view]
    PANTHERiPTHR15417. PTHR15417. 1 hit.
    PTHR15417:SF2. PTHR15417:SF2. 1 hit.
    PfamiPF05395. DARPP-32. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UD71-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE    50
    ASPHQRASGE GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ 100
    ASEEEDELGE LRELGYPREE DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG 150
    QKTTCGQGLE GPWERPPPLD ESERDGGSED QVEDPALSEP GEEPQRPSPS 200
    EPGT 204
    Length:204
    Mass (Da):22,963
    Last modified:October 10, 2002 - v2
    Checksum:iE1CE7DDD29D2D4FB
    GO
    Isoform 2 (identifier: Q9UD71-2) [UniParc]FASTAAdd to Basket

    Also known as: t-DARPP

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:168
    Mass (Da):18,738
    Checksum:iF139B0673543BFE2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1573CGQ → RGL(PubMed:8120638)Curated
    Sequence conflicti204 – 2041T → R(PubMed:8120638)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. 5 PublicationsVSP_005117Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464196 mRNA. Translation: AAM76683.1.
    AY070271 mRNA. Translation: AAL59016.1.
    AF435972 mRNA. Translation: AAP35094.1.
    AF435973 mRNA. Translation: AAP35095.1.
    AF435974 mRNA. Translation: AAP35096.1.
    AF435975 Genomic DNA. Translation: AAP35097.1.
    AF435975 Genomic DNA. Translation: AAP35098.1.
    AK024593 mRNA. Translation: BAB14931.1.
    BT007076 mRNA. Translation: AAP35739.1.
    BC001519 mRNA. Translation: AAH01519.1.
    CCDSiCCDS11339.1. [Q9UD71-1]
    CCDS11340.1. [Q9UD71-2]
    RefSeqiNP_001229393.1. NM_001242464.1. [Q9UD71-2]
    NP_115568.2. NM_032192.3. [Q9UD71-1]
    NP_852606.1. NM_181505.3. [Q9UD71-2]
    XP_006722200.1. XM_006722137.1. [Q9UD71-1]
    UniGeneiHs.286192.

    Genome annotation databases

    EnsembliENST00000254079; ENSP00000254079; ENSG00000131771. [Q9UD71-1]
    ENST00000394265; ENSP00000377808; ENSG00000131771. [Q9UD71-2]
    ENST00000394267; ENSP00000377810; ENSG00000131771. [Q9UD71-2]
    ENST00000580825; ENSP00000462137; ENSG00000131771. [Q9UD71-1]
    GeneIDi84152.
    KEGGihsa:84152.
    UCSCiuc002hrz.3. human. [Q9UD71-1]

    Polymorphism databases

    DMDMi23831292.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464196 mRNA. Translation: AAM76683.1 .
    AY070271 mRNA. Translation: AAL59016.1 .
    AF435972 mRNA. Translation: AAP35094.1 .
    AF435973 mRNA. Translation: AAP35095.1 .
    AF435974 mRNA. Translation: AAP35096.1 .
    AF435975 Genomic DNA. Translation: AAP35097.1 .
    AF435975 Genomic DNA. Translation: AAP35098.1 .
    AK024593 mRNA. Translation: BAB14931.1 .
    BT007076 mRNA. Translation: AAP35739.1 .
    BC001519 mRNA. Translation: AAH01519.1 .
    CCDSi CCDS11339.1. [Q9UD71-1 ]
    CCDS11340.1. [Q9UD71-2 ]
    RefSeqi NP_001229393.1. NM_001242464.1. [Q9UD71-2 ]
    NP_115568.2. NM_032192.3. [Q9UD71-1 ]
    NP_852606.1. NM_181505.3. [Q9UD71-2 ]
    XP_006722200.1. XM_006722137.1. [Q9UD71-1 ]
    UniGenei Hs.286192.

    3D structure databases

    ProteinModelPortali Q9UD71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123915. 4 interactions.
    IntActi Q9UD71. 2 interactions.
    MINTi MINT-1380912.
    STRINGi 9606.ENSP00000254079.

    PTM databases

    PhosphoSitei Q9UD71.

    Polymorphism databases

    DMDMi 23831292.

    Proteomic databases

    MaxQBi Q9UD71.
    PaxDbi Q9UD71.
    PRIDEi Q9UD71.

    Protocols and materials databases

    DNASUi 84152.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254079 ; ENSP00000254079 ; ENSG00000131771 . [Q9UD71-1 ]
    ENST00000394265 ; ENSP00000377808 ; ENSG00000131771 . [Q9UD71-2 ]
    ENST00000394267 ; ENSP00000377810 ; ENSG00000131771 . [Q9UD71-2 ]
    ENST00000580825 ; ENSP00000462137 ; ENSG00000131771 . [Q9UD71-1 ]
    GeneIDi 84152.
    KEGGi hsa:84152.
    UCSCi uc002hrz.3. human. [Q9UD71-1 ]

    Organism-specific databases

    CTDi 84152.
    GeneCardsi GC17P037783.
    HGNCi HGNC:9287. PPP1R1B.
    HPAi CAB004026.
    HPA048630.
    MIMi 604399. gene.
    neXtProti NX_Q9UD71.
    PharmGKBi PA33639.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39986.
    HOGENOMi HOG000290193.
    HOVERGENi HBG099182.
    KOi K15494.
    OMAi RAQLNSH.
    OrthoDBi EOG7PCJJG.
    PhylomeDBi Q9UD71.
    TreeFami TF332576.

    Enzyme and pathway databases

    Reactomei REACT_15334. DARPP-32 events.
    SignaLinki Q9UD71.

    Miscellaneous databases

    ChiTaRSi PPP1R1B. human.
    GeneWikii PPP1R1B.
    GenomeRNAii 84152.
    NextBioi 73482.
    PROi Q9UD71.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UD71.
    Bgeei Q9UD71.
    CleanExi HS_PPP1R1B.
    Genevestigatori Q9UD71.

    Family and domain databases

    InterProi IPR015670. Dopamine/cAMP_neuron_P-prot.
    IPR008466. PPI_1DARPP-32.
    [Graphical view ]
    PANTHERi PTHR15417. PTHR15417. 1 hit.
    PTHR15417:SF2. PTHR15417:SF2. 1 hit.
    Pfami PF05395. DARPP-32. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue."
      Brene S., Lindefors N., Ehrlich M., Taubes T., Horiuchi A., Kopp J., Hall H., Sedvall G., Greengard P., Persson H.
      J. Neurosci. 14:985-998(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP."
      El-Rifai W., Smith M.F. Jr., Li G., Beckler A., Carl V.S., Montgomery E., Knuutila S., Moskaluk C.A., Frierson H.F. Jr., Powell S.M.
      Cancer Res. 62:4061-4064(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "A family of genes encoding PKC-dependent protein phosphatase 1 (PP1) inhibitors."
      Liu Q.-R., Uhl G.R.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Adipose tissue.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    7. Cited for: PHOSPHORYLATION AT THR-75 BY CDK5.

    Entry informationi

    Entry nameiPPR1B_HUMAN
    AccessioniPrimary (citable) accession number: Q9UD71
    Secondary accession number(s): Q547V9, Q547W0, Q9H7G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3